- |||||||||| levetiracetam / Generic mfg.
In vivo imaging of synaptic density changes in mouse using synaptic vesicle glycoprotein 2A tracer [18F]SynVesT1 (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_4116;
Interscan dosing of Levetiracetam displaced radiotracer from the brain seen as reduced radioactivity concentration.In summary, [18F]SynVesT1 was produced repeatably allowing imaging of multiple animals with the same synthesis batch. In vivo PET imaging of synaptic density in CNS models provides valuable tool for pre-clinical drug development and a translational method to observe development of neuro-psychiatric and neurodegenerative diseases.
- |||||||||| Impact of Paraclinical Investigations in the Management of CAR T-Cell-Associated Neurotoxicity: Lessons Learned from Real World Experience (SDCC - Halls G-H) - Nov 3, 2023 - Abstract #ASH2023ASH_6339;
One LP led to probabilistic antifungals introduction (voriconazole) in patient with ICANS grade 3 for a suspected Aspergillus spp...All EEG which found seizure or status epilepticus led to an increase in AE prophylaxis by levetiracetam or introduction of a new AE (mainly phenytoin)...Our study shows that EEG is the paraclinical assessment with the greatest therapeutic impact while MRI and LP appear to have a limited therapeutic impact. Our results emphasize the role of EEG in the current guidelines, but questions the need for systematic MRI and LP, which might be left to the discretion of the treating physician.
- |||||||||| levetiracetam / Generic mfg.
Journal: Effect of levetiracetam on ocular perfusion measure with optical coherence tomography angiography. (Pubmed Central) - Oct 29, 2023
Our results emphasize the role of EEG in the current guidelines, but questions the need for systematic MRI and LP, which might be left to the discretion of the treating physician. Choroidal perfusion was reduced in children taking levetiracetam compared with that in the control group, whereas retinal perfusion was not affected in this optical coherence tomography angiography study.
- |||||||||| levetiracetam / Generic mfg.
Journal: Early Postoperative Seizures Following Awake Craniotomy and Functional Brain Mapping for Lesionectomy. (Pubmed Central) - Oct 29, 2023
We report novel findings using ECoG and clinical features to predict EPS, including acute perioperative brain injury, persistent postoperative deficits and young age. Given worse outcomes with EPS, clinical indicators for EPS should alert clinicians of potential need for early postoperative EEG monitoring and perioperative ASM adjustment.
- |||||||||| Review, Journal: Anti-seizure medications for neonates with seizures. (Pubmed Central) - Oct 28, 2023
These RCTs should use EEG to diagnose seizures and should be adequately powered to assess long-term neurodevelopmental outcomes. We need separate RCTs evaluating the choice of ASM in preterm infants.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
Journal: Novel Genetic and Phenotypic Expansion in GOSR2-Related Progressive Myoclonus Epilepsy. (Pubmed Central) - Oct 28, 2023
The associated movement disorder progressed atypically slowly during adolescence compared to its usual speed, from initial intention tremor and myoclonus to ataxia, hyporeflexia, dysmetria, and dystonia. These findings expand the genotype-phenotype spectrum of GOSR2-related disorders and suggest that GOSR2 should be included in the consideration of monogenetic causes of dystonia, global developmental delay, and seizures.
- |||||||||| levetiracetam / Generic mfg.
Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date: Reducing Hippocampal Hyperactivity and Improving Cognition in Schizophrenia (clinicaltrials.gov) - Oct 23, 2023
P1/2, N=67, Active, not recruiting,
Among the 90 patients taking cenobamate at data cutoff, 50 % (45/90) discontinued ? Recruiting --> Active, not recruiting | N=50 --> 67 | Trial completion date: Sep 2023 --> Jun 2024 | Trial primary completion date: Sep 2023 --> Jun 2024
- |||||||||| Review, Journal: Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures. (Pubmed Central) - Oct 22, 2023
Second, among neonates with seizures not responding to first-line ASM, phenytoin, levetiracetam, midazolam, or lidocaine may be used as a second-line ASM (expert agreement)...Sixth, a trial of pyridoxine may be attempted in neonates presenting with clinical features of vitamin B6-dependent epilepsy and seizures unresponsive to second-line ASM (expert agreement). Additional considerations include a standardized pathway for the management of neonatal seizures in each neonatal unit and informing parents/guardians about the diagnosis of seizures and initial treatment options.
- |||||||||| levetiracetam / Generic mfg.
Review, Journal: Electroconvulsive therapy for super refractory status epilepticus in pregnancy: case report and review of literature. (Pubmed Central) - Oct 22, 2023
Treatment was initiated with standard regimen of benzodiazepine and levetiracetam, which was progressively expanded to include approximately 10 anti-epileptic drugs over the course of 30?days...Our case is the first reported case of ECT for successful treatment of SRSE in pregnancy. While majority AEDs pose a significant maternal and fetal risk during pregnancy, ECT could be a potential frontline therapy for SE in pregnancy.
- |||||||||| levetiracetam / Generic mfg.
Journal: A potential role of mechano-gated potassium channels in meningioma-related seizures. (Pubmed Central) - Oct 20, 2023
In addition, relative levels of KCNK4 in the cortical and tumor tissue appear to be lowered by the treatment with anti-seizure medication levetiracetam. These results imply that KCNK2 and KCNK4 may be involved in the development of meningioma-related seizures and may represent promising therapeutic targets.
- |||||||||| levetiracetam / Generic mfg., diazepam / Generic mfg.
Review, Journal: Brain Neuroplasticity after Treatment with Antiseizure: A Review. (Pubmed Central) - Oct 20, 2023
According to the findings, that several antiseizure, such as lamotrigine, diazepam, levetiracetam, and valproic acid, in addition to controlling seizures, can also act on neuroplasticity in different brain regions. The study of this topic becomes important, as it will help to understand the neuroplastic mechanisms of these drugs, in addition to helping to improve the effectiveness of these drugs in controlling the disease.
- |||||||||| levetiracetam / Generic mfg.
Journal: The relationship between psychiatric symptoms and the use of levetiracetam in people with epilepsy. (Pubmed Central) - Oct 14, 2023
Multivariate logistic regression revealed that severe depressive symptoms were associated with family history (OR = 2.47, 95% CI = 1.42-4.33, P = .001) and seizure type (OR = 1.69, 95% CI = 1.01-2.80, P = .04), severe anxiety symptoms were associated with family history (OR = 1.90, 95% CI = 1.12-3.23, P = .01), severe insomnia was associated with seizure type (OR = 2.16, 95% CI = 1.33-3.5, P = .002) and severe stress was associated with marital status (OR = 2.37, 95% CI = 1.31-4.29, P = .004). The high psychological burden of PWE is a challenging issue that requires attention and prompt action to control its risk factors.
- |||||||||| NN1213 / Novo Nordisk
Trial completion date, Trial primary completion date: SPAR: Seizure Prophylaxis in Aneurysm Repair (clinicaltrials.gov) - Oct 12, 2023
P4, N=79, Active, not recruiting,
It effectively exerted its anticancer effects by extending apoptosis on HepG2 cells. Trial completion date: Jun 2024 --> Nov 2023 | Trial primary completion date: Jun 2024 --> Nov 2023
- |||||||||| pregabalin / Generic mfg., levetiracetam / Generic mfg.
Review, Journal: Exploring the Complex Relationship Between Antiepileptic Drugs and Suicidality: A Systematic Literature Review. (Pubmed Central) - Oct 11, 2023
Although there were several methodological limitations, this review found an association between levetiracetam use and mental health comorbidities and the occurrence of suicidality in epilepsy. Larger prospective, randomized studies that overcome the limitations of current studies are required to provide definitive evidence on the occurrence of suicidality in patients with epilepsy and AED use.
- |||||||||| levetiracetam / Generic mfg.
Journal: Effects of levetiracetam treatment on autonomic nervous system functions in pediatric epilepsy patients. (Pubmed Central) - Oct 5, 2023
Our study suggests that the sympathovagal balance before treatment in the patient group is in favor of the sympathetic nervous system and that the sympathovagal imbalance improves after treatment. Our results show that LEV monotherapy and loading have no negative effect on HRV and potential cardiac arrhythmia risk in children with epilepsy.
- |||||||||| phenytoin / Generic mfg., levetiracetam / Generic mfg.
Review, Journal: The Concurrent Use of Phenytoin and Levetiracetam for Seizure Prophylaxis in ICU Patients: The "Arrowhead Rationale". (Pubmed Central) - Oct 4, 2023
Risk for drug interactions, increased incidence of renal and hepatic impairment, and higher need for patient monitoring are daily barriers that determine AED use. After analysis of past research, while the efficacy of concurrent use of levetiracetam and phenytoin is still not fully clear, we offer the "Arrowhead Rationale" for such dual therapy in a subset of patients at our tertiary care trauma and stroke center in Southern California.
- |||||||||| The Drug Hunt: An Exploration of New Medications for Treatment of Schizophrenia in Children and Adolescents (Sutton North (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_771;
An update on cutting-edge evidence on treatment developments in schizophrenia is vital to inform the pediatric prescription practices. The scope of the ongoing studies to bring novel pharmacological evidence to clinical practice will serve to be beneficial for clinicians treating children and adolescents with schizophrenia.
- |||||||||| levetiracetam / Generic mfg.
PK/PD data, Journal: Pharmacokinetics of Levetiracetam Seizure Prophylaxis in Severe Traumatic Brain Injury. (Pubmed Central) - Sep 30, 2023
Findings of this study suggest regimens of levetiracetam 500 mg every 6 hours, 1000 mg every 8 hours, or 2000 mg every 12 hours may be required for optimal therapeutic target attainment. Patient weight of 75 kg may serve as a breakpoint for weight-guided dosing to optimize levetiracetam therapeutic target attainment for seizure prophylaxis.
- |||||||||| trichostatin A (VTR-297) / Vanda
Journal: Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology. (Pubmed Central) - Sep 28, 2023
In silico bioinformatic analysis revealed five compounds substantially affecting TBI-induced transcriptomics regulation, including calpain inhibitor, chlorpromazine, geldanamycin, tranylcypromine, and trichostatin A (TSA)...In vivo assessment in a rat TBI model revealed that TSA as a monotherapy (1 mg/kg/d) or in combination with the antiseizure drug levetiracetam (LEV 150 mg/kg/d) mildly mitigated the increase in plasma levels of the neurofilament subunit pNF-H and cortical lesion area...This first preclinical intervention study on post-TBI acute seizures shows that a combination therapy with the tissue recovery enhancer TSA and LEV was safe but exhibited no clear benefit over LEV monotherapy on antiseizure efficacy. A longer follow-up is needed to confirm the possible beneficial effects of LEV monotherapy and combination therapy with TSA on chronic post-TBI structural and functional outcomes, including epileptogenesis.
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date: Levetiracetam Treatment of Neonatal Seizures (clinicaltrials.gov) - Sep 21, 2023
P1/2, N=100, Recruiting,
Initiation date: Jul 2023 --> Dec 2023 Trial completion date: Dec 2021 --> Dec 2025 | Trial primary completion date: Dec 2021 --> Dec 2025
- |||||||||| levetiracetam / Generic mfg., thyroxine / Generic mfg.
SEIZING THE DIAGNOSIS: A CASE OF METASTATIC COLUMNAR CELL VARIANT PAPILLARY THYROID CARCINOMA INDUCED SEIZURES () - Sep 20, 2023 - Abstract #ATA2023ATA_417;
After admission the patient was started on levetiracetam, and brain MRI was ordered showing a 2cm right occipital mass with associated hemorrhage and midline shift...After surgery the patient was started on supplemental calcium, levothyroxine and was seen by radiation oncology...He will be following up with oncology and endocrinology in their office to have a multidisciplinary discussion on role for RAI and tyrosine kinase inhibitor therapy. At the time of neurosurgery follow up the patient was ambulating well on his own and had only very minimal aphasia.Our case reinforces that PTC should be on the differential when evaluating a patient with brain metastasis despite its rarity.
- |||||||||| levetiracetam / Generic mfg.
Journal: Contingency learning in zebrafish exposed to apomorphine- and levetiracetam. (Pubmed Central) - Sep 18, 2023
The main findings of this experiment were that 1) all four exposure groups performed similarly with respect to reward- and cue-directed learning over the first two study phases, 2) compared to the CTRL group, all drug interventions, but notably the APO + LEV combination, lowered the degree of reward-directed behaviour during a dissociated presentation of the cue and reward, and 3) temporal and spatial factors influenced the manner in which zebrafish responded to the presentation of the reward. Future studies are needed to explore the relevance of these findings for our understanding of the potential cognitive effects of LEV.
- |||||||||| levetiracetam / Generic mfg.
Journal: Safe and Effective Management of Epilepsy in Pregnancy (Pubmed Central) - Sep 15, 2023
Levetiracetam and lamotrigine are often used as less teratogenic agents...Generally, women taking antiepileptic drugs for epilepsy treatment may undergo natural delivery and breastfeeding. We should collaborate with obstetricians and other professionals to help ensure a safe environment for pregnancy and childbirth.
- |||||||||| levetiracetam / Generic mfg.
Observational data, Journal, Adverse events: Adverse events of undiluted intravenous push levetiracetam - A prospective observational study. (Pubmed Central) - Sep 14, 2023
Randomized, controlled studies are needed to further investigate the role of valproic acid for this indication, including standards for dosing regimens, serum drug monitoring, and the relationship between valproic acid treatment and mortality. This study found that the rapid administration of undiluted IV levetiracetam in ED patients was associated with few adverse events.
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