- |||||||||| New-onset Refractory Status Epilepticus Induced by Synthetic Marijuana: A Case Report (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1690;
The patient's initial seizure episode was broken with 2 mg of Midazolam enroute to the emergency room...To control ongoing seizures, increase of levetiracetam, started fosphenytoin and phenobarbital, and provided as needed lorazepam...It highlights the need for heightened vigilance and a broader differential diagnosis in patients presenting with refractory seizures. Future research should investigate the incidence of NORSE associated with synthetic marijuana, potentially decreasing the number of NORSE determined as cryptogenic.
- |||||||||| Novel Use of Mini Convex EBUS Bronchoscope for Diagnosis and Staging of Thymic Neoplasms (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1469;
Levetiracetam was changed to lacosamide and clobazam for seizure prevention...Per oncology, the patient began chemotherapy with a 3-day course of cisplatin/doxorubicin/cyclophosphamide on day 16 with methylprednisolone, followed by IVIg...However, this comes with increased risk of complications given it is an open procedure. This case shows the possibility of using mini convex EBUS bronchoscopy as a less invasive option that could potentially reduce complications and improve patient outcomes.
- |||||||||| levetiracetam / Generic mfg.
A Case of Long QT Syndrome Masquerading as Epilepsy (San Diego Convention Center, Area K (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1279;
She was treated with levetiracetam for uncontrolled, tonic-clonic seizures...This is important as misdiagnosis can lead to delay in appropriate treatment and increased risk of cardiac arrest. Furthermore, inappropriate treatment with anti-epileptic medications can prolong the QT interval increasing the risk for fatal arrhythmia and sudden cardiac death.
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date: Treating Hyperexcitability in AD With Levetiracetam (clinicaltrials.gov) - Feb 15, 2024
P2, N=85, Recruiting,
Undiluted levetiracetam was not associated with an increased incidence of adverse effects compared to diluted levetiracetam in high-doses, up to 4500 mg given over 5 min in pediatric patients. Trial completion date: Nov 2023 --> Nov 2024 | Trial primary completion date: Aug 2023 --> Oct 2024
- |||||||||| Ovastat (treosulfan) / Medac, Medexus
VISCERAL TOXOCARIAS IN THE EARLY POST-TRANSPLANT COURSE (CLYDE) - Feb 14, 2024 - Abstract #EBMT2024EBMT_2844;
Improving diagnostic and knowing the serological Toxocara status of HSCT recipients may be useful to detect a neglected infection.(1) Haque E, et al. Parasitic infections in hematopoietic stem cell transplant recipients.
- |||||||||| Ovastat (treosulfan) / Medac, Medexus
VISCERAL TOXOCARIAS IN THE EARLY POST-TRANSPLANT COURSE (ePoster area) - Feb 14, 2024 - Abstract #EBMT2024EBMT_2843;
Improving diagnostic and knowing the serological Toxocara status of HSCT recipients may be useful to detect a neglected infection.(1) Haque E, et al. Parasitic infections in hematopoietic stem cell transplant recipients.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, Darzalex (daratumumab) / J&J
DELAYED ICANS IN POST BCMA CAR-T CELL THERAPY CHALLENGES (ePoster area) - Feb 14, 2024 - Abstract #EBMT2024EBMT_1284;
Late complications like Movement and Neurocognitive Toxicities (MNT) and Delayed ICANS are part of this but also the cytopenia and infection is another. High index of suspicion and close follow up is important for better support and adequate management for such patients
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Journal, Real-world evidence, Real-world: A real-world comparison among third-generation antiseizure medications: results from the COMPARE study. (Pubmed Central) - Feb 14, 2024
Benzodiazepines were associated with an increased use of subsequent ASM polytherapy. Comparative evidence from real-world studies may help clinicians to tailor treatments according to patients' demographic and clinical characteristics.
- |||||||||| Journal: The teratogenesis risk associated with antiseizure medication duotherapy in women with epilepsy. (Pubmed Central) - Feb 11, 2024
Leaving aside issues in relation to seizure control, our data suggest that it would be best to avoid using established teratogenic antiseizure medications (carbamazepine, valproate and topiramate) in combination with each other due to the increased FM risks. When combining an established teratogenic medication with a less teratogenic one, i.e. lamotrigine, levetiracetam or clonazepam, lamotrigine appears to be the safer option.
- |||||||||| levetiracetam / Generic mfg.
Preclinical, Journal, Gene Expression Profile: Changes in the Dentate Gyrus Gene Expression Profile Induced by Levetiracetam Treatment in Rats with Mesial Temporal Lobe Epilepsy. (Pubmed Central) - Feb 10, 2024
The RT-qPCR confirmed that LEV treatment reversed the increased expression of Hgf mRNA and decreased the expression of the Efcab1, Adam8, Slc24a1, and Serpinb1a genes in the DG. These results indicate that LEV could be involved in nonclassical mechanisms involved in Ca2+ homeostasis and the regulation of the mTOR pathway through Efcab1, Hgf, SLC24a1, Adam8, and Serpinb1a, contributing to reduced hyperexcitability in TLE patients.
- |||||||||| levetiracetam / Generic mfg.
Preclinical, Journal: Levetiracetam modulates brain metabolic networks and transcriptomic signatures in the 5XFAD mouse model of Alzheimer's disease. (Pubmed Central) - Feb 8, 2024
Overall, our results highlight non-linear kinetics based on dose and sex, where gene expression analysis demonstrated LEV dose- and concentration-dependent changes, along with cerebral metabolism, and/or cerebral homeostatic mechanisms relevant to human AD, which aligned closely with network covariance analysis of 18F-FDG images. Collectively, this study show cases the value of a multimodal connectomic, transcriptomic, and pharmacokinetic approach to further investigate dose dependent relationships in preclinical studies, with translational value toward informing clinical study design.
- |||||||||| levetiracetam / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Pharmacological Modulation of Hippocampal Activity in Psychosis 2 (clinicaltrials.gov) - Feb 5, 2024
P2, N=62, Completed,
Collectively, this study show cases the value of a multimodal connectomic, transcriptomic, and pharmacokinetic approach to further investigate dose dependent relationships in preclinical studies, with translational value toward informing clinical study design. Active, not recruiting --> Completed | Trial completion date: Sep 2025 --> Dec 2023 | Trial primary completion date: Sep 2025 --> Dec 2023
- |||||||||| Journal: Challenging Case: A Multidisciplinary Approach to Demystifying Chronic Sleep Impairment in an Infant with a Complex Medical and Behavioral Profile. (Pubmed Central) - Jan 30, 2024
At this time, an infant mental health consultant met with a sleep psychologist on the family's behalf to support family in considering systematic desensitization therapy to increase tolerance to wearing his BiPAP mask, as well as other behavioral and sleep hygiene strategies, which were tried on several occasions and again, resulted in limited improvement in functioning.At 19 months, X's multidisciplinary team reconsidered a night terror diagnosis after a failed trial of clonazepam and pursued a differential diagnosis of periodic limb movement disorder (PLMD)...He had been on iron supplementation since age 6 months and received an iron infusion at 22 months because of persistently low ferritin levels and PLMD in sleep.At 24 months, X was briefly trialed on levetiracetam...At 25 months, an evaluation with a movement disorder physiatrist resulted in a diagnosis of nocturnal paroxysmal dystonia, and he was started on baclofen, which has provided some, but not complete relief to nighttime symptoms...What are the implications of chronic sleep deprivation and stress on the behavior and development of infant with X's profile? What are important psychosocial considerations because it relates to children with medical complexity (CMC), particularly for X and his family to support caregiver, family, and X's quality of life and overall well-being?
- |||||||||| dexamethasone / Generic mfg., levetiracetam / Generic mfg.
Journal: Exoscopic resection of a parasagittal atypical meningioma. (Pubmed Central) - Jan 29, 2024
She awoke with a stable examination in the intensive care unit and worked with physical therapy on postoperative day 1. The video can be found here: https://stream.cadmore.media/r10.3171/2023.10.FOCVID23164.
- |||||||||| trimethoprim/sulfamethoxazole / Generic mfg., levetiracetam / Generic mfg.
Journal: Stevens-Johnson Syndrome in a Patient on (Pubmed Central) - Jan 26, 2024
CONCLUSIONS The concomitant use of Trimethoprim/sulfamethoxazole and levetiracetam might have been responsible for heightening the potential of these 2 medications to trigger an unfortunate adverse drug reaction, but no formal culprit was able to be identified and no in vivo study was performed, due to ethical considerations. Thus, through this case report we strive to increase awareness of the potential risk of simultaneously prescribing these 2 medications.
- |||||||||| lacosamide / Generic mfg.
LACOSAMIDE INDUCED COMPLETE HEART BLOCK IN A YOUNG FEMALE (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_3717;
We describe the youngest case of LCM induced complete heart block, ever reported.Case: A 33-year-old female with refractory epilepsy (maintained on lamotrigine, levetiracetam, LCM), cerebral palsy, and intellectual disability presented after a fall resulting in a left spiral tibial shaft fracture. The severity of LCM associated conduction abnormality highlights the importance of close monitoring of these patients.
- |||||||||| lacosamide / Generic mfg.
TRANSIENT LEFT BUNDLE BRANCH BLOCK AND ORGANIZATION OF ATRIAL FIBRILLATION TO ATRIAL FLUTTER WITH LACOSAMIDE INFUSION (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_333;
He underwent emergent decompressive hemicraniotomy for SDH evacuation, and levetiracetam was initiated for seizure prophylaxis...Lacosamide was held, resulting in resolution of LBBB and reversion of atrial rhythm to atrial fibrillation.Decision?making: Conduction system abnormalities, including bundle branch blocks, PR/QT prolongation and ventricular tachycardia (VT) are known side effects of the Class Ic antiarrhythmic agent flecainide, mediated via sodium channel blockade. Lacosamide may induce new bundle branch blocks and organization of AF to AFL; cessation of the medication and monitoring with serial EKGs results in resolution of these changes.
- |||||||||| levetiracetam / Generic mfg.
A SYNDROMIC POLYMORPHIC VENTRICULAR TACHYCARDIA (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_324;
He had episodes of seizure-like activity, preceding non-sustained polymorphic VT, which was treated with levetiracetam... In conclusion, this case underscores the critical importance of a multidisciplinary approach and the timely utilization of expertise from various subspecialties, which significantly enhanced the patient's overall outcome.
- |||||||||| JNJ-54175446 / J&J
Preclinical, Journal: Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice. (Pubmed Central) - Jan 23, 2024
Using a combination of immunohistochemistry and ex vivo radiotracer assay, we find that JNJ-54175446-treated mice at the end of recordings display a reduction in astrogliosis and altered microglia process morphology within the ipsilateral CA3 subfield of the hippocampus, but no difference in P2X7 receptor surface expression. The present study extends the characterisation of the drug-resistance profile of the intraamygdala kainic acid model in mice and provides further evidence that targeting the P2X7 receptor may have therapeutic applications in the treatment of temporal lobe epilepsy.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma
Review, Journal, HEOR: Therapeutic Strategies in Children with Epilepsy: A Quality-of-Life-Related Perspective. (Pubmed Central) - Jan 23, 2024
During antiseizure medication (ASM) selection and adjustment, physicians should strategize the therapeutic approach to controlling seizures and suppressing EEG abnormalities in children with epilepsy. Among various ASMs, novel ASMs, such as levetiracetam and perampanel, may suppress both clinical seizures and IEDs on EEG; thus, these novel ASMs may represent an important addition to the treatments available for epileptic children presenting with frontal IEDs and SBS.
- |||||||||| levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg., diazepam / Generic mfg.
Review, Journal: Evaluation of Febrile Seizures: A Therapeutic Review of Current Modalities. (Pubmed Central) - Jan 22, 2024
Certain investigations like computed tomography (CT) scans, magnetic resonance imaging (MRIs), and electroencephalography (EEG) are helpful, along with laboratory investigations, to rule out other causes of FS. After reviewing the current literature, we have tried to conclude whether the current pharmacotherapy is effective in treating FS.
- |||||||||| humanised dinutuximab (Hu14.18K322A) / Essential Pharma
Trial completion date, Metastases: Therapy for Children With Advanced Stage Neuroblastoma (clinicaltrials.gov) - Jan 16, 2024
P2, N=153, Active, not recruiting,
There was also no statistical difference in the median ICU LOS (2 Trial completion date: Dec 2023 --> Dec 2024
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg., brivaracetam / Generic mfg.
Journal: Predictors of clinically significant anhedonia in refractory epilepsy. (Pubmed Central) - Jan 15, 2024
High seizure burden in medication refractory epilepsy is significantly associated with anhedonia. Specific antiseizure medications are also associated with the development of anhedonia, but it is unclear whether their use is causative or influenced by the presence of anhedonia.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Review, Journal: Issues of Women with Epilepsy and Suitable Antiseizure Drugs. (Pubmed Central) - Jan 15, 2024
However, no single ASD is considered ideal for childbearing WWE. Lamotrigine and levetiracetam are relatively more suitable options for this situation.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Preclinical, Journal: Age-Dependent Phenomena of 6-Hz Corneal Kindling Model in Mice. (Pubmed Central) - Jan 12, 2024
These data demonstrate that both the acquisition and expression of 6-Hz corneal kindling are attenuated in middle-aged mice, while hippocampal astrogliosis and pharmacological resistance are more pronounced in this age group. These results underscore the importance of considering age-related factors when utilizing the 6-Hz corneal kindling model in mice of varying age groups.
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