RG6440 News - LARVOL Sigma

|||||||||| RG6440 / Roche
SOF10, selectively blocking latent TGF-?1 activation, potentiates the efficacy of checkpoint blockade therapy by modulating CAF dynamics and T cell infiltration (Exhibit Halls AB - George R. Brown Convention Center) - Oct 4, 2024 - Abstract #SITC2024SITC_604;
P1
Clinical studies of SOF10 are currently underway for patients with solid cancer (NCT05867121). Ethics Approval All animal studies were reviewed and approved by the Institutional Animal Care and Use Committee (IACUC) of Chugai Pharmaceutical.

|||||||||| RG6440 / Roche
Journal: The plant-unique protein DRIF1 coordinates with SNX1 to regulate membrane protein homeostasis. (Pubmed Central) - Dec 4, 2023
These mutants, sof10 and sof641, result in a premature stop codon or a missense mutation in AT5G10370, respectively...DRIF1 is a membrane-associated protein that coordinates with retromer component sorting nexin 1 (SNX1) to regulate PIN-FORMED2 (PIN2) recycling to the plasma membrane. Altogether, our data demonstrate that DRIF1 is a unique retromer interactor that orchestrates FREE1-mediated ILV formation of MVBs and vacuolar sorting of membrane proteins for degradation in plants.

||||||||||  RG6440 / Roche
Enrollment open, Combination therapy, Checkpoint inhibition, Metastases:  A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-Care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors (clinicaltrials.gov) -  Oct 4, 2023
P1, N=120, Recruiting,  Sponsor: Genentech, Inc.
Altogether, our data demonstrate that DRIF1 is a unique retromer interactor that orchestrates FREE1-mediated ILV formation of MVBs and vacuolar sorting of membrane proteins for degradation in plants. Not yet recruiting --> Recruiting



	Diseases Companies Products Productz Mechanisms of Action Sites