| TNKASE (tenecteplase) / Roche, Boehringer Ingelheim |
NCT00252239: Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B) |
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| Terminated | 2b | 112 | US | tenecteplase, TNK, tissue plasminogen activator, tPA, tPA | University of Virginia, National Institute of Neurological Disorders and Stroke (NINDS) | Stroke | 03/09 | 09/09 | | |
| Withdrawn | 2b | 0 | US | Tenecteplase, TNKase, Alteplase, Activase, t-PA | Reza Behrouz, DO | Ischemic Stroke | 06/20 | 06/20 | | |
ACTRN12608000466347: Low-dose tenecteplase versus standard-dose alteplase for acute ischaemic stroke: an Imaging-Based Efficacy Trial. |
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| Recruiting | 2 | 75 | | | John Hunter Hospital, University of Newcastle, National Health and Medical Research Council (NHMRC) Project Grant: ID 510722 | Ischaemic stroke | | | | |
| Terminated | 2 | 180 | Europe | tenecteplase | University Of Perugia | Pulmonary Embolism | | 07/06 | | |
2005-001070-27: Open, randomised, monosite pilot trial for comparison of thrombolytic efficacy of tenecteplase and alteplase in patients with acute pulmonary embolism |
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| Completed | 2 | 20 | Europe | Tenecteplase, Powder and solvent for solution for infusion, Metalyse | Division of Angiology Graz | Patients with acute pulmonary embolism and indication for thrombolytic therapy are included in the study | | | | |
| Completed | 2 | 40 | US | Tenecteplase, Sterile Saline | C. Michael Gibson, MS, MD, Genentech, Inc. | Acute Myocardial Infarction | 11/11 | 11/11 | | |
| Completed | 2 | 104 | Europe | Tenecteplase, Metalyse, TNK, alteplase, Actilyse, recombinant tissue plasminogen activator (rtPA) | NHS Greater Glasgow and Clyde, University of Glasgow | Stroke | 12/13 | 12/13 | | |
| Completed | 2 | 50 | Canada | Tenecteplase, TNK-tPA | University of Calgary, Vancouver General Hospital, Ottawa Hospital Research Institute, Hopital Charles Lemoyne, Université de Sherbrooke, Vancouver Island Health Authority, CHU de Quebec-Universite Laval | Ischemic Stroke | 07/14 | 07/14 | | |
| Terminated | 2 | 40 | | | Lions Eye Institute, The Ophthalmic Research Institute of Australia (ORIA). | Branch retinal vein occlusion. | | | | |
| Completed | 2 | 202 | RoW | Tenecteplase, TNK, Tissue Plasminogen Activator, Alteplase, tPA | Neuroscience Trials Australia, The Florey Institute of Neuroscience and Mental Health | Ischemic Stroke | 10/17 | 02/18 | | |
| Completed | 2 | 20 | Canada | Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg) | University of Alberta | Cerebral Infarction, Brain Ischemia, Stroke | 11/17 | 11/17 | | |
DIVA, NCT02338466: Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion |
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| Withdrawn | 2 | 0 | NA | rt-PA, Actilyse, tenecteplase, Metalyse | University Hospital Center of Martinique | Nervous System Disorders, Cerebral Artery | 07/18 | 09/18 | | |
NCT03340493: Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke (EXTEND-IA TNK Part 2) |
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| Completed | 2 | 300 | RoW | Tenecteplase, TNK | Neuroscience Trials Australia, The Florey Institute of Neuroscience and Mental Health | Ischemic Stroke | 07/19 | 02/20 | | |
| Completed | 2 | 240 | RoW | TNK-tPA, rtPA | Beijing Tiantan Hospital, Guangzhou Recomgen Biotech Co., Ltd., The First Hospital Of Qiqihar, Hebei Medical University Third Hospital, Yantai Yuhuangding Hospital, Fudan University, First Affiliated Hospital of Jinan University, First Hospital of Jilin University, Huashan Hospital, West China Hospital, Inner Mongolia Baogang Hospital, Linyi People's Hospital, The First Affiliated Hospital of Zhengzhou University, Baotou Central Hospital | Acute Ischemic Stroke | 05/20 | 07/20 | | |
TASTEa, NCT04071613: Tenecteplase Versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance |
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| Completed | 2 | 104 | RoW | Tenecteplase, TNK, Intravenous tissue plasminogen activator (tPA), TPA, Alteplase | Melbourne Health | Stroke, Acute, Stroke Ischemic | 11/21 | 11/21 | | |
| Completed | 2 | 86 | RoW | Low dose tenecteplase, High dose tenecteplase | Huashan Hospital, The First Affiliated Hospital of Shanxi Medical University, Ningbo No. 1 Hospital, Zhejiang Province People's Hospital, Shanghai 5th People's Hospital, Shanghai 10th People's Hospital, Shanghai 6th People's Hospital, The Second Affiliated Hospital of Chongqing Medical University, The Second People's Hospital of Huai'an, Pu'er City People's Hospital, ShuGuang Hospital, Shanghai East Hospital, First People's Hospital of Shenyang | Stroke | 12/21 | 12/21 | | |
NCT05281549: Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-II） |
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| Active, not recruiting | 2 | 225 | RoW | Alteplase, rt-PA, Tenecteplase, TNK-tPA | Beijing Tiantan Hospital, Jiangsu FENG HUA Biotech Pharmaceutical Co., Ltd, The Place Pharmaceutical(Jiangsu) Co., Ltd | Acute Ischemic Stroke | 01/22 | 05/22 | | |
| Completed | 2 | 13 | US | Tenecteplase, Placebo | Hooman Poor, Genentech, Inc. | COVID-19, Respiratory Failure, ARDS | 03/22 | 03/22 | | |
ACTRN12621000696897: To assess if the administration of a clot busting medication (Tenecteplase) administered at the site of the clot in the brain following intravenous administration of the clot busting medication is safe and feasible in patients with acute ischaemic stroke within 4.5 hours of symptom onset. |
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| Terminated | 2 | 18 | | | Northern Sydney Local Health District, Royal North Shore Hospital | Ischaemic stroke | | | | |
| Completed | 2 | 224 | RoW | Tenecteplase, The best treatment selected by local doctors(Aspirin, Recombinant Tissue Plasminogen Activator, Urokinase, Thrombectomy) | Huashan Hospital, Puer People's Hospital, Shanghai 6th People's Hospital, Hexigten Traditional Chinese and Mongolian Medicine Hospital, Yangpu Hospital, School of Medicine, Tongji University, The First Affiliated Hospital of Shanxi Medical University, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Linyi People's Hospital, Shanghai 10th People's Hospital, Nanshi Hospital of Nanyang, Shanghai Fifth People's Hospital,Fudan University, Xuzhou Medical University Affiliated Hospital of Huaian, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, The First Affiliated Hospital of Soochow Medical University, Affiliated Haian People's Hospital of Nantong University, First Affiliated Hospital of Harbin Medical University, the Third Hospital of Mianyang, Zhejiang Province People's Hospital, Shanghai East Hospital, The Central Hospital of Jiaozuo Coal Group, Huizhou Municipal Central Hospital, Zhejiang University, The Second Affiliated Hospital of Chongqing Medical University, Ningbo No. 1 Hospital | Stroke | 09/23 | 09/23 | | |
ALLY, NCT05172934: Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial |
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| Completed | 2 | 20 | US | intra-arterial tenecteplase | ProMedica Health System, Genentech, Inc. | Ischemic Stroke | 09/23 | 11/23 | | |
NCT05580822: Additive Effects of Intra-arterial Tenecteplase for Successful Thrombectomy Due to Acute Basilar Artery Occlusion |
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| Not yet recruiting | 2 | 520 | NA | Tenecteplase for Injection, Saline | First Hospital of China Medical University | Basilar Artery Occlusion, Thrombectomy, Tenecteplase | 12/24 | 12/25 | | |
