| Bystolic (nebivolol) / Menarini, AbbVie |
NCT00924833: Effects of Nebivolol Versus Carvedilol on Cardiopulmonary Function at High Altitude in Healthy Subjects. |
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| Completed | 4 | 27 | Europe | placebo, Carvedilol, Nebivolol | Istituto Auxologico Italiano, Menarini Group | Hypoxia, Altitude, Heart Failure | 11/06 | 11/06 | | |
2004-004862-33: INFLUENCE OF NEBIVOLOL ON OCULAR PERFUSION IN PATIENTS WITH ARTERIAL HYPERTENSION AND GLAUCOMAA mono-center, active-substance controlled, randomized, double-blind, prospective phase IV parallel-group trial comparing Nebivolol with Bisoprolol |
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| Terminated | 4 | 60 | Europe | Nebivolol, Concor, Tablet | Berlin-Chemie Menarini | Arterial hypertension and glaucoma | | | | |
2007-004438-18: Comparative effects of Nebivolol and Carvedilol on orthostatic hypotension in hypertensive patients with type 2 diabetes mellitus (DIANECA) |
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| Completed | 4 | 404 | Europe | Capsule, hard, Nebilet, Carvedilolo Hexal | A. Menarini Farmaceutica Internazionale s.r.l., Menarini International Operations, Luxembourg S.A, Menarini International Operation Luxembourg S.A. | Orthostatic hypotension in hypertensive patients with type 2 diabetes mellitus | | | | |
| Completed | 4 | 80 | Europe | metoprolol succinate, Corvitol, Nebivolol, Nebilet | Berlin-Chemie AG Menarini Group | Hypertension | 12/08 | 12/09 | | |
MAPEC, NCT00295542: Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy |
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| Completed | 4 | 3344 | Europe | Ambulatory blood pressure monitoring, Chronotherapy, timing of antihypertensive medication, ACEI (including spirapril, enalapril, quinapril, lisinopril), ARB (including valsartan, telmisartan, olmesartan), beta blockers (including nebivolol, atenolol, carvedilol), diuretics (torasemide, indapamide, HTCZ) and doxazosin, Combination therapy in essential hypertension | University of Vigo, Hospital Clinico Universitario de Santiago, Xunta de Galicia, Ministerio de Educacion y Ciencia, Spain | Hypertension | 04/09 | 04/09 | | |
2007-003549-33: Efectos de Nebivolol y Atenolol sobre la Presión Central Aórtica en Pacientes Hipertensos |
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| Completed | 4 | 152 | Europe | Capsule*, Tablet, Lovibon 5 mg, Blokium 50 mg y Blokium 100 mg, Hidrosaluretil | Laboratorios MENARINI, S. A. | Hipertensión esencial leve o moderada | | | | |
NCT00785512: A Study on the Long-term Efficacy of Nebivolol After Withdrawal of Therapy |
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| Completed | 4 | 207 | US | Nebivolol, Bystolic® (nebivolol), Placebo | Forest Laboratories | Hypertension | 08/09 | | | |
NCT00673075: The Effect of Nebivolol in Hypertensive Patients With Coronary Artery Disease |
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| Completed | 4 | 39 | US | Nebivolol, Bystolic, Carvedilol, Coreg | Forest Laboratories | Hypertension, Coronary Artery Disease | 09/09 | | | |
NCT00770861: A Study on the Efficacy and Safety of Nebivolol Monotherapy in Hispanic Hypertensive Patients |
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| Completed | 4 | 277 | US | Nebivolol, Bystolic (TM), Placebo | Forest Laboratories | Hypertension | 11/09 | | | |
NCT00734630: Efficacy and Safety of Nebivolol (Added to Lisinopril or Losartan) in Hypertensive Patients |
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| Completed | 4 | 491 | US | nebivolol, Bystolic ™, Placebo, Lisinopril-other names: Prinivil, Zestril, Losartan-other name: Cozaar | Forest Laboratories | Hypertension | 03/10 | 05/10 | | |
| Completed | 4 | 60 | Europe | carvedilol, bisoprolol, Nebivolol | Centro Cardiologico Monzino | Chronic Heart Failure | | 05/10 | | |
NCT00744237: Study of the Glycemic Effects of Nebivolol Compared With Metoprolol and HCTZ in Diabetic Hypertensive Patients |
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| Completed | 4 | 231 | US | Nebivolol, Bystolic (TM), Metoprolol ER, HCTZ, Hydrochlorothorazide | Forest Laboratories | Hypertension, Type 2 Diabetes Mellitus | 07/10 | | | |
NCT00673790: The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose |
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| Completed | 4 | 537 | US | Nebivolol with concomitant losartan or lisinopril, HCTZ with concomitant losartan or lisinopril, Placebo with concomitant losartan or lisinopril | Forest Laboratories | Hypertension | 07/10 | 07/10 | | |
2004-004329-90: EARLY METABOLIC CHANGES WITH THIAZIDE OR BETA BLOCKER THERAPY FOR ESSENTIAL HYPERTENSION (MAIN STUDY). |
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| Completed | 4 | 66 | Europe | ATENOLOL, BENDROFLUMETHIAZIDE, Nebivolol Hydrochloride, Amiloride hydrochloride, Hydrochlorothiazide, N/A, PL 0289/0172, Film-coated tablet, Tablet, Nebilet, No trade name, Apo-Hydro | CAMBRIDGE UNIVERSITY HOSPITALS FOUNDATION NHS TRUST | ESSENTIAL HYPERTENSION | | | | |
| Completed | 4 | 433 | US | Nebivolol, Bystolic, Placebo | Forest Laboratories | Hypertension | 12/10 | 01/11 | | |
NCT00999102: Nebivolol Versus Metoprolol: Comparative Effects on Fatigue and Quality of Life |
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| Completed | 4 | 37 | US | Metoprolol, Lopressor, Toprol-XL, Nebivolol, Bystolic | Weill Medical College of Cornell University, Forest Laboratories | Hypertension | 01/11 | 01/11 | | |
2009-014643-36: Effects Of The Administration Of Nebivolol Versus Carvedilol On Microcirculatory Endothelial Function, Arterial Stiffness And Wave Reflection In Healthy Volunteers” (NeCaMic-study) |
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| Terminated | 4 | 16 | Europe | nebivolol, carvedilol, C07AB12, Tablet, Nobiten, Carvedilol HEXAL | MENARINI Benelux NV/SA | Microcirculatory Endothelial Function, Arterial Stiffness And Wave Reflection | | | | |
NCT01218100: Efficacy and Safety Study to Evaluate Combination Therapy With Nebivolol and Lisinopril vs. Placebo and Monotherapy in Patients With Stage 2 Diastolic Hypertension |
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| Completed | 4 | 664 | US | nebivolol and lisinopril (free combination), nebivolol monotherapy, lisinopril monotherapy, placebo | Forest Laboratories | Stage 2 Diastolic Hypertension | 05/11 | 06/11 | | |
NCT03635125: Efficacy and Safety of Nebivolol Versus Metoprolol in Hypertensive Subject Taking Amlodipine |
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| Completed | 4 | 40 | US | Nebivolol I, Metoprolol I, Nebivolol II, Metoprolol II, Baseline Washout Phase | Trinity Hypertension & Metabolic Research Institute | JNC 7 Stage 1 or 2 Hypertension | 05/11 | 07/11 | | |
NCT00775671: Comparative Effect of Nebivolol vs. Metoprolol on Insulin Sensitivity and Fibrinolytic Balance in Metabolic Syndrome |
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| Completed | 4 | 46 | US | placebo, Nebivolol, Metoprolol | Vanderbilt University | Metabolic Syndrome | 06/11 | 06/11 | | |
NCT00992056: Nebivolol Versus Metoprolol: Sodium Sensitivity |
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| Completed | 4 | 24 | US | nebivolol, Bystolic, Metoprolol, Toprol | University of Miami, Forest Laboratories | Hypertension | 02/12 | 05/12 | | |
NCT01415531: Study of the Efficacy and Safety of Nebivolol in Younger Patients (18 - 54 Years) |
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| Completed | 4 | 641 | US | Nebivolol, Placebo | Forest Laboratories | Hypertension | 03/12 | 04/12 | | |
| Terminated | 4 | 6 | US | Nebivolol, Bystolic | Minneapolis Heart Institute Foundation, Forest Laboratories | Coronary Artery Disease | 06/12 | 06/12 | | |
NCT01049009: The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension |
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| Completed | 4 | 91 | US | Nebivolol, Metoprolol XL | Emory University, Forest Laboratories | High Blood Pressure | 06/12 | 06/12 | | |
NCT01202175: Effects of the Beta-blocker Nebivolol (Bystolic) on Subjects With High Normal Blood Pressure and/or a Family History of Hypertension |
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| Completed | 4 | 50 | US | Nebivolol, Bystolic | University of California, San Diego, Forest Laboratories | Pre-hypertension, Hypertension | 06/12 | 06/13 | | |
NCT01920282: Nebivolol, Lifestyle Modification and Arterial Stiffness |
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| Completed | 4 | 45 | NA | Nebivolol, Bystolic, Lifestyle Modification, Weight loss, Sodium restriction, Physical activity, Nebivolol plus Lifestyle Modification, Bsytolic, Weight Loss | Virginia Polytechnic Institute and State University, Forest Laboratories | Hypertension | 08/12 | 08/12 | | |
NCT01206439: An Advanced Echocardiographic Evaluation of Nebivolol |
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| Terminated | 4 | 2 | US | nebivolol, Bystolic | Jack Rubinstein, Forest Laboratories | Hypertension | 08/12 | 08/12 | | |
| Terminated | 4 | 1 | US | Nebivolol, Bystolic, Metoprolol succinate, Toprol XL | Mayo Clinic, Forest Laboratories | Hypertension | 03/13 | 03/13 | | |
NCT01502787: Comparison of Nebivolol and Metoprolol With Exercise and Angiotensin II in Hypertensive Patients |
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| Completed | 4 | 46 | US | Metoprolol succinate, Toprol XL, Nebivolol, Bystolic, Forearm blood flow, Microneurography, Assessment of sympathetic nerve activity (SNA), Rhythmic handgrip exercise, Lower body negative pressure, LBNP, Angiotensin II, IND #103,935 | University of Texas Southwestern Medical Center, Forest Laboratories | Hypertension | 06/13 | 06/13 | | |
2010-023104-28: A study in multiple centres investigating the effect of two different active treatments for raised bloodpressure in elderly patients where it is unknown during the study which of both treatments is administered. |
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| Completed | 4 | 150 | Europe | Capsule, Nebilet Plus, Karvezide | Menarini International Operations Luxembourg S.A., Menarini International Operations Luxembourg S.A. | Isolated Systolic Hypertension, Isolated raised systolic bloodpressure, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT01230892: Evaluation of The Effects of Nebivolol in Comparison to Atenolol on Wall Shear Stress and Rupture Prone Coronary Plaques |
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| Completed | 4 | 29 | US | Nebivolol, Bystolic, Atenolol, Senormin, Tenormin | Emory University, Georgia Institute of Technology | Atherosclerosis, Endothelial Function | 09/13 | 09/13 | | |
NCT01041287: Effect of Nebivolol on Oxidative Stress and Endothelial Progenitor Cells |
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| Completed | 4 | 96 | US | Nebivolol, Bystolic, Metoprolol succinate, Toprol XL | Emory University, Forest Laboratories | Hypertension | 12/13 | 12/13 | | |
NCT01885988: Nebivolol Effects on Endothelial Function and Erectile Function |
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| Unknown status | 4 | 70 | US | Nebivolol, Bystolic, Sugar Pill, placebo | Martin M. Miner, MD, Forest Laboratories | Erectile Dysfunction | 03/14 | 06/14 | | |
NCT01157234: Nebivolol Effect on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients |
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| Completed | 4 | 32 | US | Nebivolol, Bystolic, Metoprolol, Lopressor | University of Florida, Forest Laboratories | Hypertension | 07/14 | 07/14 | | |
| Unknown status | 4 | 80 | Europe | TELMISARTAN, MICARDIS, NEBIVOLOL, LOBIVON | Aristotle University Of Thessaloniki | Hypertension | 01/15 | 01/17 | | |
NIRVANA, NCT01665508: Study to Evaluate Effect of Nebivolol on Angina in Women With Microvascular Disease |
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| Completed | 4 | 12 | US | Nebivolol, Bystolic | Massachusetts General Hospital, Forest Laboratories | Microvascular Angina | 05/15 | 05/15 | | |
NCT01501929: Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients |
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| Completed | 4 | 32 | US | Metoprolol succinate, Toprol XL, Nebivolol, Bystolic, Non-invasive measurement of Cardiac Output (CO), Cardiac output by thoracic electrical bioimpedance, Bioz, Cardio Dynamics International Corporation, Endothelial cell collection, Endocell collection, Microvascular perfusion assessment using Definity | University of Texas Southwestern Medical Center, Forest Laboratories | Hypertension | 12/15 | 12/15 | | |
2004-004863-32: EFFECTS OF NEBIVOLOL ON THE WALKING ABILITY IN PATIENTS WITH ESSENTIAL HYPERTENSION AND PERIPHERAL ARTERIAL DISEASE INTERMITTENT CLAUDICATION |
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| Completed | 4 | 180 | Europe | Nebilet, HCT Hexal, | Berlin-Chemie Menarini | ESSENTIAL HYPERTENSION AND PERIPHERAL ARTERIAL DISEASE INTERMITTENT CLAUDICATION | | 03/09 | | |
2005-001214-40: A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivity |
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| Ongoing | 4 | 50 | Europe | Atenolol, Atenolol, Nebliet, Atenolol, Nebliet | Imperial College London | Hypertension | | | | |
2007-006115-23: Effects of nebivolol on the cardiovascular functions, thermoregulation and blood flow during real and simulated conditions of microgravity |
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| Ongoing | 4 | 4 | Europe | Nebilet, Nebilet, Nebilet | Berlin-Chemie AG | Effects on the cardiovascular functions, thermoregulation and blood flow during microgravity | | | | |
2008-002314-21: VALUTAZIONE COMPARATIVA DEGLI EFFETTI SULLA FUNZIONE ENDOTELIALE DEL TRATTAMENTO CON NEBIVOLOLO E IDROCLOROTIAZIDE VS IRBESARTAN E IDROCLOROTIAZIDE IN PAZIENTI CON IPERTENSIONE ARTERIOSA NEO-DIAGNOSTICATA. Studio NINFE: Nebivololo, Irbesartan Nella Funzione Endoteliale. |
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| Completed | 4 | 68 | Europe | LOBIVON*28CPR 5MG, KARVEZIDE*28CPR 150MG+12,5MG, ESIDREX, LOBIVON*28CPR 5MG, KARVEZIDE*28CPR 150MG+12,5MG, ESIDREX | A. MENARINI I.F.R. | IPERTENSIONE ARTERIOSA | | | | |
2008-001509-40: Effects of beta blockers on central arterial pressure and vascular stiffness |
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| Ongoing | 4 | 60 | Europe | Nebilet, Talliton, Betaloc Zok, Nebilet, Talliton, Betaloc Zok | Hungarian Kidney Foundation | Patients with hypertension and/or ischemic heart disease | | | | |
2008-007516-15: Comparaison des effets du nébivolol et de l\'aténolol sur la fonction endothéliale vasomotrice des artères de conductance lors de l\'hypertension artérielle essentielle |
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| Ongoing | 4 | 100 | Europe | NEBILOX, ATENOLOL BIOGARAN 50 mg, NEBILOX, ATENOLOL BIOGARAN 50 mg | Laboratoires NEGMA | Hypertension artérielle | | | | |
2009-015824-27: The effects of Nebivolol/HCTZ on Central Arterial Pressure, a randomised double-blind cross-over trial |
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| Completed | 4 | 24 | Europe | Nebivolol, Metoprolol succinate, C07AB12, C07AB02, Nobiten tablets, Beloc-Zok 95 mg extended release film coated tablet, Nobiten tablets, Beloc-Zok 95 mg extended release film coated tablet | MENARINI Benelux NV/SA | Hypertension | | | | |
| Unknown status | 4 | 36 | Europe | Nebivolol, Continuous positive airway pressure (CPAP), Philips Respironics Remstar System One | Universitaire Ziekenhuizen Leuven | Hypertension, Endothelial Dysfunction, Obstructive Sleep Apnea | 02/16 | 02/16 | | |
NCT01961323: Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart |
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| Completed | 4 | 70 | US | Nebivolol | Icahn School of Medicine at Mount Sinai, Forest Laboratories | Hypertension, Left Ventricular Diastolic Dysfunction | 03/16 | 03/16 | | |
NCT02710071: Treatment of OSA Associated Hypertension With Nebivolol or Hydrochlorothiazide |
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| Completed | 4 | 41 | NA | Nebivolol, Bystolic, Hydrochlorothiazide, Hydrodiuril | University of California, San Diego | Hypertension | 04/16 | 04/16 | | |
2011-006090-25: The impact of heart rate on the effects of antihypertensive therapy on central and peripheral blood pressure Südame löögisageduse mõju vererõhuravimite mõjule tsentraalsele ja perifeersele vererõhule |
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| Completed | 4 | 100 | Europe | ivabradine, nebivolol, atenolol, Tablet, Procoralan, Nebilet, Atenolol-ratiopharm | Tartu Ülikooli kardioloogiakliinik, Eesti Teadusfond | Patients with dual chamber (atrium and ventricle) cardiac pacemaker placed due to sick sinus syndrome (at least 1 month after implantation) Patsiendid, kellele on siinussõlme nõrkuse sündroomi tõttu varasemalt paigaldatud koja ja vatsakese elektroodiga kardiostimulaator (vähemalt 1 kuu peale implantatsiooni), Patients who have been placed a permanent cardiac pacemaker due to heart rate problems (at least 1 month after implantation) Patsiendid, kellele on südame rütmihäire tõttu varasemalt paigaldatud püsikardiostimulaator (vähemalt 1 kuu pärast paigaldamist), Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT03245996: The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker |
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| Completed | 4 | 27 | NA | AAI 40 bpm, AAI 60 bpm, AAI 90 bpm, Atenolol Pill, Nebivolol Pill, Ivabradine Pill | Tartu University Hospital | Aortic Blood Pressure | 09/16 | 09/16 | | |
| Completed | 4 | 42 | US | Nebivolol, Bystolic, Metoprolol, Toprol-XL, Placebo, Forearm Blood Flow (FBF) response to BQ-123 (100 mol/min), BQ-123, FBF response to BQ-123 (100 nmol/min)+BQ-788(50 nmol/min), BQ-123+BQ-788, FBF response to Acetylcholine, ACh, FBF response to Sodium Nitroprusside, NTP, FBF response to BQ-123+BQ-788+ACh, BQ-123+BQ-788+ACh | University of Colorado, Boulder, Forest Laboratories | Prehypertension, Hypertension | 11/16 | 12/16 | | |
NCT01595516: Nebivolol and Endothelial Regulation of Fibrinolysis (NERF) |
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| Completed | 4 | 44 | US | Nebivolol, Bystolic, Metoprolol, Toprol-XL, Placebo, Bradykinin, BDK, Saline, Vitamin C | University of Colorado, Boulder, Forest Laboratories | Prehypertension, Hypertension | 10/17 | 10/17 | | |
BVreduce, NCT03180593: Efficacy and Safety of Valsartan and Nebivolol/Valsartan in Hypertensive Patients With LVH |
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| Completed | 4 | 30 | US | Valsartan 80 mg, Nebivolol/Valsartan 5/80mg | Trinity Hypertension & Metabolic Research Institute, Allergan Sales, LLC | Hypertension Complicated, Hypertrophy, Left Ventricular, Blood Pressure | 01/18 | 01/18 | | |
NCT03930433: The Effect of Nebivolol in Hypertensive Patients With Coronary Arterial Spasm |
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| Completed | 4 | 51 | RoW | Nebivolol, Diltiazem, Nebivolol+Diltiazem | Korea University Anam Hospital, Korea University Guro Hospital, Korea University Ansan Hospital, Severance Hospital | Coronary Vasospasm | 03/19 | 03/19 | | |
NCT04575675: Dapagliflozin on Hypotensive Heart Failure Patients After Sacubitril/Valsartan Therapy |
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| Completed | 4 | 78 | RoW | Dapagliflozin, Forxiga, Sacubitril-Valsartan, Entresto, Beta blocker, Concor, Betaloc zok, Nebilet, Carvedilol, Mineralocorticoid Receptor Antagonist, Aldactin, Inspra, Cardiac resynchronization therapy and/or implantable cardioverter defibrillator | Cheng-Hsin General Hospital | Hypotension, Heart Failure | 11/20 | 12/20 | | |
NCT02053246: Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure |
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| Terminated | 4 | 11 | US | Nebivolol | University of Florida, National Institute of General Medical Sciences (NIGMS) | Pulmonary Hypertension, Diastolic Heart Failure, Heart Failure With Preserved Ejection Fraction | 03/21 | 03/21 | | |
2020-002340-23: Effectiveness and safety of combination of nebivolol and zofenopril calcium in mild to moderate hypertensive patients Efficacia e sicurezza della combinazione di nebivololo e zofenopril calcio in pazienti affetti da ipertensione da lieve a moderata |
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| Not yet recruiting | 4 | 216 | Europe | Nebivolol, Zofenopril calcium, [na], Tablet, Film-coated tablet, LOBIVON - 28 COMPRESSE 5 MG, ZOPRANOL - 28 COMPRESSE RIVESTITE CON FILM 30 MG IN BLISTER (PVDC/PVC/AL) | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG SA, Menarini International Operations Luxembourg SA | Grade 1 and 2 hypertension Ipertenzione di grado 1 e 2, Hypertension Ipertensione, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT04845061: Evaluating the Outcome of Cardio Selective beta1- Blockers Use in Patients With Copd |
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| Recruiting | 4 | 30 | RoW | Nebivolol Tablets | Ain Shams University | Copd | 12/21 | 01/22 | | |
| Completed | 4 | 283 | Europe | Zofenopril 30 mg, Nebivolol 5 mg, Zofenopril 30 mg + Nebivolol 5 mg | Menarini International Operations Luxembourg SA, Menarini International Operations Luxembourg SA | Hypertension | 12/21 | 12/21 | | |
NCT04767061: Impact of Beta-blockers on Physical Function in HFpEF |
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| Completed | 4 | 9 | US | Beta blockers, atenolol, betaxolol, bisoprolol, metoprolol, nebivolol, nadolol, propranolol, acebutolol, penbutolol, pindolol, carvedilol, labetalol, sotalol, metoprolol succinate, metoprolol tartrate | Weill Medical College of Cornell University, The New York Community Trust | Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease | 04/22 | 04/23 | | |
2021-005077-10: Study on the effectiveness and safety of combined treatment with nebivolol and amlodipine in mild to moderate hypertensive patients. |
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| Not yet recruiting | 4 | 302 | Europe | Nebivolol, Amlodipine, Tablet, LOBIVON 5 mg tablets, AMLODIPINE EUROGENERIC 5 mg tablets, AMLODIPINE EUROGENERIC 10 mg tablets | Menarini International Operations Luxembourg SA, Menarini International Operations Luxembourg SA | Grade 1-2 hypertension, Hypertension, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
| Completed | 4 | 301 | Europe | Nebivolol, Amlodipine | Menarini International Operations Luxembourg SA, Menarini International Operations Luxembourg SA | Hypertension | 11/22 | 11/22 | | |
2022-003060-25: Study on the effectiveness and safety of combined treatment with Nebivolol and Ramipril in hypertensive patients |
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| Ongoing | 4 | 270 | Europe | Nebivolol, Ramipril, Tablet, LOBIVON 5 mg tablets, Ramipril Zentiva 2.5 mg, Ramipril Zentiva 5 mg, Ramipril Zentiva 10 mg | Menarini International Operations Luxembourg SA, Menarini International Operations Luxembourg SA | Cardiovascular DiseaseHypertensive patients, Hypertension, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT04757584: Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF |
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| Completed | 4 | 9 | US | Beta blockers, atenolol, betaxolol, bisoprolol, metoprolol, nebivolol, nadolol, propranolol, acebutolol, penbutolol, pindolol, carvedilol, labetalol, sotalol, metoprolol succinate, metoprolol tartrate | Weill Medical College of Cornell University, National Institute on Aging (NIA) | Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease | 04/23 | 04/23 | | |
| Active, not recruiting | 4 | 2760 | Europe | Metoprolol Succinate, Bisoprolol, Carvedilol, Nebivolol | Bispebjerg Hospital, Amager Hospital, University Hospital Bispebjerg and Frederiksberg, Bornholm Hospital, Gentofte Hospital, Glostrup University Hospital, Copenhagen, Herlev Hospital, Hvidovre University Hospital, Nordsjaelland Hospital, Holbaek Hospital, Nykoebing Hospital, Naestved Hospital, Nordsjaellands Hospital, Zealand University Hospital, Slagelse Hospital, Odense University Hospital, Svendborg Hospital, Sydvestjysk Sygehus, Hospital of Southern Jutland, Sygehus Lillebaelt (Vejle and Kolding), Aarhus University Hospital, Hospitalsenheden Midt, Hospitalsenheden Vest, Regionshospitalet Horsens, Silkeborg Sygehus, Aalborg University Hospital | Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI), ST Elevation Myocardial Infarction | 04/25 | 12/35 | | |
| Completed | 4 | 266 | Europe | Nebivolol 5 mg, Ramipril 2.5/5/10 mg | Menarini International Operations Luxembourg SA, Menarini International Operations Luxembourg SA | Hypertension | 02/24 | 02/24 | | |
| Not yet recruiting | 4 | 100 | Europe | Nebivolol, Placebo | Jagiellonian University, University Hospital in Krakow | Intracranial Aneurysm | 01/29 | 01/30 | | |
NCT02817360: NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients |
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| Recruiting | 4 | 2400 | Europe, RoW | RAS-antagonist and beta-blocker up-to maximal dosages, Enalapril 40mg/d, Ramipril 10mg/d, Lisinopril 40mg/d, Cilazapril 5mg/d, Perindopril 8mg/d, Captopril 150mg/d, Spirapril 24mg/d, Quinapril 40mg/d, Trandolapril 4mg/d, Zofenopril 60mg/d, Fosinopril 40mg/d, Candesartan 32mg/d, Valsartan 320mg/d, Irbesartan 300mg/d, Losartan 150mg/d, Eprosartan 800mg/d, Bisoprolol 10mg/d, Metoprololsuccinat 200mg/d, Carvedilol 50mg/d (100mg/d if weight is > 85kg), Nebivolol 10mg/d, RAS-antagonist and beta-blocker none or at stable dose | Martin Huelsmann | Heart Diseases, Diabetes Mellitus, Type 2 | 12/25 | 12/26 | | |
NCT06035978: Determination of Drug Levels for Pharmacotherapy of Heart Failure |
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| Not yet recruiting | 4 | 100 | RoW | Nebivolol, Nebilet, anatomical-therapeutic-chemical code (ATC) C07AB12, Valsartan and Sacubitril, Entresto, ATC C09DX04, Carvedilol, Dilatrend, ATC C07AG02, Bisoprolol, Concor, ATC C07AB07, Metoprolol, Betaloc ZOK, ATC C07AB02, Spironolactone, Verospiron, ATC C03DA01 | University Hospital Ostrava | Cardiovascular Diseases, Heart Failure With Reduced Ejection Fraction | 04/26 | 04/26 | | |
| Withdrawn | 4 | 0 | RoW | Bisoprolol versus Nebivolol | Clinical Hospital Center Zemun | Bisoprolol Adverse Reaction, Nebivolol Adverse Reaction | 12/30 | 12/30 | | |
