| Bystolic (nebivolol) / Menarini, AbbVie |
2020-003881-38: ESONIA - The evaluation of Efficacy and Safety Of Nebivolol in the treatment of arterial hypertension In Adolescents ESONIA - Ocena skuteczności i bezpieczeństwa nebiwololu w leczeniu nadciśnienia tętniczego u nastolatków. |
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| Not yet recruiting | 3 | 150 | Europe | Nebivolol 5 mg, Tablet, Nebilenin | Warszawski Uniwersytet Medyczny, Agencja Badań Medycznych | Arterial hypertension in adolescents Nadciśnienie tętnicze u nastolatków, Arterial hypertension in adolescents Nadciśnienie tętnicze u nastolatków, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
CTR20260928: Phase III Clinical Study of Nebivolol Hydrochloride Tablets |
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| Not yet recruiting | 3 | 320 | China | 1. Generic Chinese Name: Nebivolol Hydrochloride Tablets; Generic English Name: Nebivolol Hydrochloride Tablets; Trade Name: NA; 2. Generic Chinese Name: Nebivolol Hydrochloride Tablets; Generic English Name: Nebivolol Hydrochloride Tablets; Trade Name: NA; 1. Generic Chinese Name: Nebivolol Hydrochloride Tablets Analog; Generic English Name: NA; Trade Name: NA | Zhejiang Garden Pharmaceutical Co., Ltd. | Indications: Intended for the treatment of mild to moderate essential hypertension. | | | | |
CTR20140869: Clinical trial of nebivolol hydrochloride tablets for the treatment of mild to moderate essential hypertension |
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| Recruiting | 3 | 360 | China | 1. Generic Chinese name: Nebivolol Hydrochloride Tablets; 1. Generic Chinese name: Bisoprolol Fumarate Tablets; English name: Bisoprolol Fumarate Tablets; Brand name: Kangxin | Hefei Xinfeng Technology Development Co., Ltd. | Indications: Mild to moderate essential hypertension | | | | |
CTR20191808: Phase III study of the efficacy and safety of nebivolol in patients with essential hypertension |
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| Recruiting | 3 | 280 | China | 1. Generic Chinese Name: Nebilet; 2. Generic Chinese Name: Bisoprolol Analog Tablets (Placebo); 3. Generic Chinese Name: Nebilet Tablets; English Generic Name: Nebilet tablet; Trade Name: None; 4. Generic Chinese Name: Bisoprolol Analog Tablets (Placebo); English Generic Name: None; Trade Name: None; 1. Generic Chinese Name: Bisoprolol (Generic Name: Bisoprolol Fumarate Tablets; English Name: Bisoprolol Fumarale Tablets; Trade Name: Concor); 2. Generic Chinese Name: Nebilet Tablets (Placebo); 3. Generic Chinese Name: Bisoprolol Fumarate; English Generic Name: Bisoprolol Fumarale Tablets; Trade Name: Concor; 4. Generic Chinese Name: Nebilet Tablets (Placebo); English Generic Name: None; Trade Name: None | Menarini (China) Investment Co., Ltd. | Indications: Mild to moderate essential hypertension | | | | |
NCT00200473: A Study of the Safety and Efficacy of Nebivolol in Hypertensive Patients |
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| Completed | 3 | 800 | US | Nebivolol | Mylan Bertek Pharmaceuticals | Hypertension | | 03/03 | | |
NCT00200460: A Study Evaluating the Effects of Nebivolol on Blood Pressure in Hypertensive Patients |
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| Completed | 3 | 825 | US | Nebivolol | Mylan Bertek Pharmaceuticals | Hypertension | | 03/03 | | |
NCT00145236: Dosing Study of the Effects of Nebivolol on Blood Pressure in Black Patients With Mild to Moderate Hypertension |
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| Completed | 3 | 300 | US | Nebivolol | Mylan Bertek Pharmaceuticals | Hypertension | | 08/03 | | |
NCT00200499: A Study of the Safety and Efficacy of Long-Term Nebivolol Use in Hypertensive Patients |
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| Completed | 3 | 845 | US | Nebivolol | Mylan Bertek Pharmaceuticals | Hypertension | | 09/03 | | |
NCT00200434: A Study of the Efficacy and Safety of Nebivolol Added to Existing Antihypertensive Treatment in Patients With Hypertension |
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| Completed | 3 | 600 | US | Nebivolol | Mylan Bertek Pharmaceuticals | Hypertension | | 10/03 | | |
NCT00145210: Safety and Efficacy of Nebivolol in the Treatment of Hypertension in African Americans |
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| Completed | 3 | 630 | US | Nebivolol and Atenolol | Mylan Bertek Pharmaceuticals | Hypertension | 09/07 | 09/07 | | |
2004-004864-54: COMPARISON OF THE EFFECTS OF COMBINED RATE- AND RHYTHM-CONTROL TREATMENT WITH NEBIVOLOL AND ELECTRIC CARDIOVERSION TO RATE-CONTROL TREATMENT WITH NEBIVOLOL ALONE ON CLINICAL AND ECHOCARDIOGRAPHIC PARAMETERS IN PATIENTS WITH HYPERTENSION AND LEFT-VENTRICULAR DYSFUNCTION INDUCED BY TACHYCARDIANEBICAR-TRIAL |
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| Completed | 3 | 60 | Europe | Nebilet, Tablet | Berlin-Chemie Menarini | PATIENTS WITH HYPERTENSION AND LEFT-VENTRICULAR DYSFUNCTION INDUCED BY TACHYCARDIA | | | | |
NCT00547300: Study to Evaluate Symptoms in Patients Treated With Nebivolol or Metoprolol Extended-release (ER) for Hypertension |
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| Terminated | 3 | 49 | US | Metoprolol ER, Nebivolol | Forest Laboratories, Mylan Laboratories | Hypertension | 01/08 | 01/08 | | |
NCT00142584: Evaluation of the Long-term Safety and Tolerability of Metoprolol Versus Nebivolol in Patients With Hypertension |
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| Completed | 3 | 336 | US | Nebivolol (NEB), Metoprolol (MET) | Mylan Bertek Pharmaceuticals | Hypertension | 03/08 | 03/08 | | |
ENESYS, NCT00942487: Effects of Nebivolol on Subclinical Left Ventricular dySfunction: A Comparative Study Against Metoprolol |
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| Completed | 3 | 60 | Europe | Nebilet, Corvitol | Berlin-Chemie Menarini | Primary Arterial Hypertension | 12/08 | 07/09 | | |
NCT00648895: A Study of the Effect of Nebivolol to Evaluate Its Vasodilatory Effects in Hypertensive Patients |
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| Completed | 3 | 12 | US | Nebivolol, Bystolic (TM), Metoprolol ER (TM), Toprol XL (TM) | Forest Laboratories | Hypertension | 07/09 | | | |
NCT01415505: Combination of Nebivolol and Valsartan Given as Free Tablets for Stage 1 or Stage 2 Hypertension |
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| Completed | 3 | 812 | US | Nebivolol, Valsartan and Hydrochlorothiazide | Forest Laboratories | Hypertension | 01/13 | 04/13 | | |
NCT01508026: Study of the Efficacy and Safety of the Combination of Two FDA Approved Oral Medications, Nebivolol and Valsartan for Treatment of Stage 1 or 2 Hypertension |
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| Completed | 3 | 4161 | US | Nebivolol and Valsartan 1, Nebivolol and Valsartan 2, Nebivolol and Valsartan 3, Nebivolol 1, Nebivolol 2, Valsartan 1, Valsartan 2, Placebo | Forest Laboratories | Stage 1 Hypertension, Stage 2 Hypertension | 03/13 | 05/13 | | |
| Unknown status | 3 | 291 | Europe | Losartan and nebivolol, Losartan, Nebivolol | IRCCS Policlinico S. Matteo, Merck Sharp & Dohme LLC, Menarini Group | Marfan Syndrome | 07/13 | 07/13 | | |
ENCOMPASS, NCT01499134: Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure |
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| Completed | 3 | 17 | US | nebivolol, Bystolic, Metoprolol succinate, Toprol XL | Thomas Jefferson University, Forest Laboratories | Peripheral Artery Disease, Hypertension | 06/14 | 06/14 | | |
| Completed | 3 | 26 | US | Nebivolol, Bystolic, Valsartan, Diovan, Nebivolol/valsartan combination, Diovan/Bystolic | State University of New York at Buffalo | Hypertension | 09/14 | 12/14 | | |
2005-003583-31: NEBIVOLOL OR METOPROLOL IN ARTERIAL OCCLUSIVE DISEASEA DOUBLE-BLIND, RANDOMISED CLINICALDeutscher Titel: Nebivolol im Vergleich zu Metoprolol bei peripherer arterieller VerschlusskrankheitEine randomisierte, doppel-blinde klinische Studie |
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| Completed | 3 | 160 | Europe | Nebilet, Beloc Zok, Nebilet, Beloc Zok, Nebilet, Beloc Zok | Berlin-Chemie AG | Intermittent claudication (peripheral arterial disease) Fontaine’s stage II Deutsch: Periphere arterielle Verschlusskrankheit, Fontaine Staidum II | | 06/10 | | |
| Completed | 3 | 51 | Europe | Nebivolol, Placebo | Assistance Publique - Hôpitaux de Paris, Association Française contre les Myopathies (AFM), Paris, URC-CIC Paris Descartes Necker Cochin | Duchenne Muscular Dystrophy, Cardiomyopathy, Heart Failure | 07/21 | 07/21 | | |
| Active, not recruiting | 3 | 42 | RoW | Atorvastatin + L-arginine + Folic acid + Nicorandil + Nebivolol, Nicorandil, L-arginine, Folic acid, Nebivolol, Placebo | Lebanese American University Medical Center | Covid19 | 03/22 | 07/22 | | |
CONTROL, NCT05728632: Cardioprotective Effects of Nebivolol Versus Placebo in Patients Undergoing Chemotherapy With Anthracyclines |
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| Active, not recruiting | 3 | 80 | Europe | Nebivolol, Lobivon, Placebo | Giulio Stefanini, Agenzia Italiana del Farmaco | Breast Cancer, Lymphoma, Large B-Cell, Diffuse, Cardiotoxicity, Left Ventricular Dysfunction, Chemotherapy Effect | 02/23 | 02/23 | | |
2021-002487-46: Prophylactic frequent premature ventricular complexeS sUPPression on left ventriculaR function impairmEnt in aSymptomatic patientSSUPPRESS Traitement prophylactique des extrasystoles ventriculaires fréquentes sur l’incidence de la cardiomyopathie rythmique induite chez les patients asymptomatiques |
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| Not yet recruiting | 3 | 298 | Europe | Bisoprolol, Nebivolol, Flécaïnide, Verapamil, Diltiazem, Amiodarone, Sotalol, PROPAFENONE, C01BC03 | Assistance Publique - Hôpitaux de Paris, PHRC | Premature ventricular contractions (PVCs) Contractions ventriculaires prématurées (PVC), Premature ventricular contractions (PVCs) Contractions ventriculaires prématurées (PVC), Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2017-004618-24: Evaluation of the protective effect on the heart of a betablocker drug, nebivolol, in patients with breast cancer or diffuse B-cell lymphoma for which anthracyclinic chemotherapy has been planned Valutazione dell'effetto di protezione sul cuore di un farmaco betabloccante, nebivololo, in pazienti con tumore della mammella o linfoma diffuso a cellule B per i quali è stata pianificata chemioterapia con antracicline |
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| Completed | 3 | 80 | Europe | NEBIVOLOLO, NEBIVOLOLO, Capsule, hard, NEBIVOLOLO DOC GENERICI - 5 MG COMPRESSE "" 28 COMPRESSE IN BLISTER PVDC/PVC/AL | IRCCS ISTITUTO CLINICO HUMANITAS | To prevent cardiotoxicity of chemotherapeutic agents (anthracyclines) Prevenzione della cardiotossicità da chemioterapia (antracicline), To prevent cardiotoxicity of chemotherapeutic agents (anthracyclines) Prevenire la cardiotossicità da chemioterapia (antracicline), Diseases [C] - Cardiovascular Diseases [C14] | | | | |
| Not yet recruiting | 3 | 150 | NA | Nevibolol, Placebo | Spanish Society of Cardiology | ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD) | 03/26 | 09/26 | | |
2004-000746-20: Effects Of The Long-Term Administration Of Nebivolol On The Clinical Symptoms, Exercise Capacity And Left Ventricular Function Of The Patients With Diastolic Dysfunction (ELANDD) |
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| Completed | 2/3 | 180 | Europe | Nebivolol, Tablet, Nebilet | Menarini Benelux SA/NV, Menarini Benelux S.A/N.V. | Subjects with diastolic dysfunction | | | | |
EFFORT, NCT00829296: Safety Study to Lower the Risk of Heart Failure is Also Effective in Reducing Stiffness of the Arteries |
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| Completed | 2/3 | 70 | US | nebivolol, bystolic, Metoprolol, lopressor | University of Chicago, Forest Laboratories | Hypertension, Diabetes | 04/12 | 04/13 | | |
| Withdrawn | 2/3 | 0 | US | Placebo, Placebo is a sugar pill., Nebivolol, bystolic | University of Chicago, Forest Laboratories | High Blood Pressure | 03/13 | 03/13 | | |
| Recruiting | 2/3 | 150 | US | Amlodipine, Norvasc, Katerzia, Norliqva, Nebivolol, Bystolic, Placebo | Stanford University, American Heart Association | Angina Pectoris, Microvascular Angina, Vasospastic Angina, Myocardial Bridge of Coronary Artery | 12/26 | 12/26 | | |
| Recruiting | 2/3 | 120 | RoW | Nebivolol+ Standard care arm, Epalrestat + Alpha Lipoic Acid +Standard care, Standard care alone | St. John's Research Institute | Diabetic Neuropathy Peripheral | 12/25 | 03/26 | | |
| Completed | 2/3 | 2760 | Europe | Carvedilol STADA 3,125 mg t?flur., Metoprololsuccinat "Polpharma", depottabletter, Carvedilol STADA 12,5 mg t?flur, Carvedilol STADA 25 mg t?flur., Carvedilol STADA 6,25 mg Tabletten, Carvedilol STADA? 12,5 mg Tabletten, Bisoprolol Orion 2,5 mg tabletter, Bisoprolol Orion 5 mg tabletter, Bisoprolol Orion 10 mg tabletter, Carvedilol STADA 6,25 mg t?flur., Carvedilol STADA 12,5 mg tabletti, Carvedilol STADA 6,25 mg tabletti, Carvedilol STADA 3,125 mg tabletti, Carvedilol STADA? 6,25 mg Tabletten, Carvedilol STADA 25 mg tabletti, Carvedilol STADA? 25 mg Tabletten, Nebivolol Pliva 5 mg tablete, Bisoprolol Orion 2,5 mg tabletit, Bisoprolol Orion 10 mg tabletit, Carvedilol STADA 25 mg Tabletten, Bisoprolol Orion 5 mg tabletit, Carvedilol STADA 12,5 mg Tabletten | Frederiksberg Hospital, Danish Heart Foundation, Novo Nordisk Foundation | Myocardinal infarction | | | | |
| Completed | 2/3 | 150 | Europe | Nebilenin, 5 mg, tabletki, NEBIVOLOL HYDROCHLORIDE | Medical University Of Warsaw, Agencja Badań Medycznych | Tensile hypertension (HF) occurs in adolescents with a frequency of 10-13%. Subclinical organ lesions (left ventricular hypertrophy, microalbuminuria, hypertensive changes at the fundus of the eyes, changes in the taffin) are found in half of these patients at the time of diagnosis of hypertension and hypertension in the second decade of life is a significant risk factor for liver problems, strokes and renal failure in adulthood . | | | | |
