| Completed | 2 | 31 | US | Buprenorphine, suboxone, buprenex, temgesic, subutex, Placebo | Jordan F. Karp, National Institute of Mental Health (NIMH) | Depression, Major Depressive Disorder | 04/17 | 02/18 | | |
| Completed | 1/2 | 56 | Canada | venlafaxine, Effexor, buprenorphine, Temgesic, Subutex, Suboxone, placebo | Centre for Addiction and Mental Health, Reckitt Benckiser LLC | Major Depressive Disorder, Depression | 01/17 | 05/18 | | |