| ligufalimab (AK117) / Akesobio |
| Recruiting | 2 | 104 | RoW | AK112, AK117, Oxaliplatin, Capecitabine, Irinotecan, Leucovorin, 5-fluorouracil | Akeso | Metastatic Colorectal Cancer | 12/24 | 12/26 | | |
NCT05227664: A Study of AK117/AK112 in Metastatic Triple-Negative Breast Cancer |
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| Recruiting | 2 | 80 | RoW | AK117, AK112, Nab paclitaxel, paclitaxel | Akeso | Metastatic Triple-negative Breast Cancer, Locally Advanced Triple-negative Breast Cancer | 01/23 | 10/23 | | |
NCT06196203: A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes |
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| Recruiting | 2 | 90 | US, RoW | AK117, Placebo, Azacitidine | Akeso | Higher-risk Myelodysplastic Syndromes | 01/26 | 06/26 | | |
NCT05960955: Cadonilimab Combination With Chemotherapy With or Without AK117 in Resectable Gastric or Gastroesophageal Junction Adenocarcinoma |
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| Recruiting | 2 | 90 | RoW | Cadonilimab, AK117, Oxaliplatin, Tegafur-gimeracil-oteracil potassium, Docetaxel, 5-Fluorouracil | Akeso | Resectable Gastric or Gastroesophageal Junction Adenocarcinoma | 11/24 | 11/27 | | |
| Recruiting | 1/2 | 250 | RoW | AK112, AK117, Chemotherapy | Akeso | Advanced Malignant Tumors | 08/24 | 01/25 | | |
NCT05229497: A Phase Ib/II Study of AK112 in Combination With AK117 in Advanced Malignant Tumors |
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| Recruiting | 1/2 | 114 | RoW | AK112, AK117, Carboplatin, Cisplatin, 5-Fluorouracil | Akeso | Advanced Malignant Tumors | 02/23 | 02/24 | | |
NCT05235542: A Phase Ib/II Study of AK104 and AK117 in Combination With or Without Chemotherapy in Advanced Malignant Tumors |
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| Recruiting | 1/2 | 130 | RoW | AK104, AK117, Capecitabine tablets, Oxaliplatin, Cisplatin, Paclitaxel, Irinotecan, Docetaxel, 5-FU | Akeso | Advanced Malignant Tumors | 03/23 | 03/24 | | |
| Recruiting | 1/2 | 190 | RoW | AK117, Azacitidine | Akeso | Myelodysplastic Syndrome | 05/23 | 05/24 | | |
| Recruiting | 1/2 | 160 | RoW | AK117, Azacitidine | Akeso | Acute Myeloid Leukemia | 07/23 | 07/24 | | |
NCT06387420: A Study of AK117 in Combination With Azactidine Plus Venetoclax in Patients With Acute Myeloid Leukemia |
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| Not yet recruiting | 1/2 | 180 | RoW | AK117, Azacitidine, Venetoclax, Placebo | Akeso | ACUTE MYELOID LEUKEMIA; AML | 04/26 | 04/27 | | |
NCT04728334: A Phase 1 Dose Escalation and Expansion Study of AK117 |
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| Completed | 1 | 49 | RoW | AK117 | Akeso | Neoplasms Malignant | 01/22 | 05/23 | | |