Sarcoma  >>  Phase 4
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48 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Sarcoma
ChiCTR-PRC-08000244: A randomized, controlled, multi-center study evaluating combined operation modality vs imatinib alone (COMVIA) in patients with recurrent/metastatic c-kit positive gastrointestinal stromal tumor

Completed
4
210
 
imatinib + surgery ;imatinib
Cancer hospital affiliated to Fudan University; Beijing Novartis Pharma Co., Ltd., Beijing Novartis Pharma Co.,Ltd. Cancer hospital affiliated to Fudan University
gastrointestinal stromal tumor(GIST)
 
 
2013-000052-17: Study to investigate the early prediction of toxicity following chemotherapy and differences in drug handling in Ewing's sarcoma patients

Ongoing
4
120
Europe
Cyclophosphamide, Etoposide, Doxorubicin, Vincristine, Ifosfamide, Powder for solution for injection, Concentrate for solution for infusion, Solution for infusion, Solution for injection, Powder for concentrate for solution for infusion, Cyclophosphamide, Eposin, Doxorubicin Hydrochloride, Vincristine Sulphate, Ifosfamide
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Ewing sarcoma patients, Bone cancer, Diseases [C] - Cancer [C04]
 
 
2014-001044-38: To study the effect of coca-cola on the exposure to imatinib in patients who underwent major gastrectomy.

Ongoing
4
11
Europe
Glivec
Radboud University Nijmegen Medical Center, Radboud University Nijmegen Medical Center
Patients who are treated or will be treated with imatinib, who previously underwent major gastrectomy., Patients who are treated or will be treated with imatinib, who previously underwent major gastrectomy., Diseases [C] - Cancer [C04]
 
 
2014-001561-27: Neuropathy caused by vincristine in children with leukemia: comparing one-hour infusions with short-term infusions Neuropathie door vincristine bij kinderen met leukemie: één-uurs infusen vergeleken met kortdurende infusies

Ongoing
4
88
Europe
Vincristine sulfate, Vincristine Sulphate, VCR, Solution for infusion, Solution for injection
VU university medical center, The Netherlands Organisation for Health Research and Development (in Dutch: ZonMw)
Pediatric oncology, acute lymphoblastic leukemia, nephroblastoma, medulloblastoma, low-grade glioma, Hodgkin lymphoma, rhabdomyosarcoma Kinderoncologie, acute lymfatische leukemie, nefroblastoom, medulloblastoom, laaggradig glioom, Hodgkin lymfoom en rhabdomyosarcoom, Childhood cancer Kinderkanker, Diseases [C] - Cancer [C04]
 
 
2006-005644-92: ENSAYO CLÍNICO ABIERTO, NO ALEATORIZADO, PILOTO, EN FASE II, DE LA COMBINACIÓN DE IFOSFAMIDA Y DOXORRUBICINA LIPOSÓMICA SEGUIDO DE RADIOTERAPIA COMO TRATAMIENTO ANTINEOPLÁSICO NEOADYUVANTE EN PACIENTES CON SARCOMA DE PARTES BLANDAS DE EXTREMIDADES DE ALTO GRADO (OPEN CLINICAL TEST, NOT RANDOMIZED, PILOT, IN PHASE II, OF IFOSFAMIDA AND DOXORRUBICINA LIPOSÓMICA COMBINATION FOLLOWED OF X-RAY LIKE NEOADJUVANT TREATMENT ANTINEOPLÁSICO IN PATIENTS WITH SARCOMA OF SOFT PARTS OF EXTREMITIES OF HIGH DEGREE)

Ongoing
4
36
Europe
Doxorrubicina Liposomal (doxorrubicine liposomal), Ifosfamida, Doxorrubicina liposomal. En el protocolo, el tratamiento está definido por el principio activo (In protocol, treatment is defined only by active substance), Doxorrubicina liposomal. Ifosfamida En el protocolo, el tratamiento está definido por el principio activo (In protocol, treatment is defined only by active substance), Doxorrubicina liposomal. En el protocolo, el tratamiento está definido por el principio activo (In protocol, treatment is defined only by active substance), Doxorrubicina liposomal. Ifosfamida En el protocolo, el tratamiento está definido por el principio activo (In protocol, treatment is defined only by active substance)
Antonio Cubillo Gracián (Servicio de Oncología Médica - Hospital MD Anderson)
PACIENTES CON SARCOMA DE PARTES BLANDAS DE EXTREMIDADES DE ALTO GRADO(PATIENTS WITH OF SOFT PARTS SARCOMA OF HIGH DEGREE EXTREMITIES)
 
 
2011-005554-62: A study investigating the pharmcokintetics (how the body processes with a drug) and pharmcodynamics (what effect the drug has on the body) of the chemotherapy drug doxorubicin, when used to treat children, adolescents and young adults with newly diagnosed cancers: osteosarcoma, Ewing\'s family of tumours, and Hodgkin lymphoma.

Ongoing
4
30
Europe
doxorubicin, Doxorubicin, Doxorubicin, Doxorubicin
Australian Sarcoma Group (ASSG), ASSG (Australian Sarcoma Study Group)
Ewing family of tumoursOsteosarcomaHodgkin lymphoma
 
 
2012-000425-45: Effect van ochtend- of avondinname van sunitinib op de medicijnspiegels in het bloed

Ongoing
4
18
Europe
Sunitinib, Midazolam, EU/1/06/347/001-008, PL 29831/0140, Sutent, Dormicum, Sutent, Dormicum
Renal Cell Cancer, GIST, pancreatic neuroendocrine tumor Niercelcarcinoom, GIST, p-NET
 
 
ChiCTR-RNC-14004667: Study of plasma concentration of Imatinib in Chinese patients with gastrointestinal stromal tumor

Completed
4
300
 
Imatinib
The First Affiliated Hospital of Nanjing Medical University; The First Affiliated Hospital of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Novartis China
Gastrointestinal stromal tumor
 
 
2016-005252-21: Increasing the amount of pazopanib in the blood by splitting intake moments Verhogen van de hoeveelheid pazopanib in het bloed door het spreiden van inname momenten

Ongoing
4
10
Europe
Tablet, Votrient
Netherlands Cancer Institute, Netherlands Cancer Institute
Patients for whom pazopanib is considered standard care (advanced renal cell carcinoma and advanced soft-tissue sarcoma). Patiënten voor wie behandeling met pazopanib standaard zorg is (gevorderd renaal cel carcinoom of gevorderd weke delen sarcoom)., Patients with advanced renal cell carcinoma or advanced soft-tissue sarcoma Patiënten met nierkanker of weke delen kanker, Diseases [C] - Cancer [C04]
 
 
ChiCTR-OPN-15006162: Detection for effective plasma drug concentration in the field for patients with gastrointestinal stromal tumor with intolerance to 400mg Imatinib

Not yet recruiting
4
200
 
Imatinib 300mg/d ;Imtinib 400mg/d
West China Hospital, Sichuan University; Level of the institution:, none
Gastrointestinal stromal tumor
 
 
ChiCTR-OPC-15006846: Study on preoperative plasma drug concentration for patients with giant gastrointestinal stromal tumors

Not yet recruiting
4
50
 
preoperative IM treatment
Department of gastrointestinal surgery, West China Hospital, Sichuan University; None, none
gastrointestinal stromal tumors
 
 
ChiCTR-OPC-16007953: Clinical study of apatinib mesylate tablets in the treatment of refractory soft tissue sarcoma

Not yet recruiting
4
30
 
Medical and nursing education for patients with soft tissue sarcoma
Qilu Hospital of Shandong University; Qilu Hospital of Shandong University, Henry csco- Cancer Research Fund
Refractory soft tissue sarcoma
 
 
2017-002437-36: Study for an innovative approach for the monitoring of patients with gastrointestinal stromal tumour treated with imatinib Studio per la valutazione di un nuovo approccio per il monitoraggio di pazienti affetti da tumore stromale gastrointestinale e trattati con il farmaco imatinib

Ongoing
4
58
Europe
imatinib, [035372059], Capsule, hard, GLIVEC - 100 MG 120 CAPSULE RIGIDE USO ORALE
CENTRO DI RIFERIMENTO ONCOLOGICO, Risorse dell'Istituto
Patients with gastrointestinal stromal tumour Pazienti affetti da tumore stromale gastrointestinale, Patients with gastrointestinal stromal tumour Pazienti affetti da tumore stromale gastrointestinale, Diseases [C] - Digestive System Diseases [C06]
 
 
ChiCTR-OPC-17010758: Mesylate apatinib combined with chemotherapy in the treatment of clinical study of osteosarcoma recurrence and metastasis

Recruiting
4
40
 
Apatinib or apatinib + chemotherapy
Xijing Hospital affiliated to The Fourth Military Medical University; Xijing Hospital affiliated to The Fourth Military Medical University, 经费自筹 Self financing
osteosarcoma
 
 
NCT03932071: Zoledronic Acid in Decrease the Lung Metastatic Rate of Osteosarcoma

Recruiting
4
150
RoW
Zoledronic Acid
Second Affiliated Hospital, School of Medicine, Zhejiang University
Lung Metastases, Tumor Necrosis
01/20
01/23
ChiCTR1900022667: A prospective randomized controlled trial for recombinant human thrombopoietin (rhTPO) at different intervening times to prevent and treat thrombocytopenia after chemotherapy with doxoburicin combined with isocyclophosphamide (AI) regimen in osteosarcoma and soft tissue sarcoma

Not yet recruiting
4
96
 
The patients distributed in group A was treated with rhTPO immediately at a dose of 300 U.d-1.kg-1, ih. ;The patients distributed in group B continued to observe and check blood every other day. When platelets were found to be less than 75*109/L, rhTPO was administered subcutaneously at a dose of 300 U.d-1.kg-1 once a day.
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Beijing Xisike Clinical Oncology Research Foundation
Osteosarcoma and soft tissue sarcoma
 
 
ChiCTR1800017424: Mesylate tablets of apatinib as first-line treatment of metastatic soft tissue sarcoma, randomized, crossover, multi center clinical study

Recruiting
4
80
 
IFO+EPI regimen ;Pan apatinib scheme
General Hospital of Shenyang Military Area Command; General Hospital of Shenyang Military Area Command, Self-raising
metastatic soft tissue sarcoma
 
 
ChiCTR1900022249: A prospective, single-arm, multi-center study for the efficacy and safety of Mecapegfilgrastim for the prevention of neutropenia 3 degrees and above in children with rhabdomyosarcoma or Ewing's sarcoma after chemotherapy

Not yet recruiting
4
30
 
Subcutaneous injection of Mecapegfilgrastim according to the patient's body weight 24-36 hours after chemotherapy
Capital Medical University, Beijing Children's Hospital; Capital Medical University, Beijing Children's Hospital, Researcher self-raising
Neutrophil reduction after chemotherapy
 
 
2020-005751-21: Clinical Trial Extension Study with Avapritinib for Patients with Gastrointestinal Stromal Tumors

Not yet recruiting
4
5
Europe
Avapritinib, BLU-285, Tablet
Blueprint Medicines, Blueprint Medicines
Locally Advanced Unresectable or Metastatic Gastrointestinal Stromal Tumor (GIST), Gastrointestinal Tumours, Diseases [C] - Cancer [C04]
 
 
ChiCTR1800016574: Comparative study of the efficacy of adriamycin and liposome doxorubicin in the treatment of osteosarcoma

Recruiting
4
150
 
Chemotherapy
Beijing Jishuitan Hospital; Beijing Jishuitan Hospital, None
Osteosarcoma
 
 
ChiCTR-IPR-16008568: A clinical trial for zoledronic acid added into new adjuvant chemotherapy on osteosarcoma patients

Recruiting
4
150
 
zoledronate ;placebo
2nd affiliated hospital of ZheJiang University; 2nd Affiliated Hospital, ZheJiang University, raise independently
osteosarcoma
 
 
ChiCTR1800016838: Clinical trial of secondary prevention of recombinant human thrombopoietin in the prevention of thrombocytopenia in advanced osteosarcoma with apatinib and docetaxel

Recruiting
4
60
 
rhTPO
Affiliated Sixth People's Hospital, Shanghai Jiaotong University; Shanghai Jiao Tong University Affiliated Sixth People's Hospital, funding
thrombocytopenia in advanced osteosarcoma
 
 
ChiCTR1800016856: A prospective, randomized, controlled clinical trial of thalidomide against small molecule VEGFR oral targeted drug grade III-IV adverse reactions

Recruiting
4
440
 
Apatinib + thalidomide 50~150mg/d, po.QN ;Apatinib ;Anlotinib Hydrochloride + thalidomide 50~150mg/d, po.QN ;Anlotinib ;Apatinib + thalidomide 50~150mg/d, po.QN ;Apatinib ;Anlotinib Hydrochloride + thalidomide 50~150mg/d, po.QN ;Anlotinib
Affiliated Sixth People's Hospital, Shanghai Jiaotong University; Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Self-raised
Patients with advanced gastric cancer, lung cancer, and osteosarcoma taking apatinib or antatinib
 
 
ChiCTR1800015245: Five Versus Three Years of Adjuvant Imatinib in Patients at Significant Risk for Recurrence Following Complete Resection of Primary Gastrointestinal Stromal Tumor: A Phase III, Randomized, Multicenter Study (FAITH study)

Recruiting
4
380
 
Prolonging the adjuvant duration of imatinib mesylate for 2 years ;not prolong the adjuvant duration and follow up
Sun Yat Sen University, Cancer Center; Sun Yat Sen University, Cancer Center, self-financing
Gastrointestinal Stromal Tumor
 
 
NCT04854018: Indo-cyanine Green (ICG) in Paediatric Oncology MIS

Completed
4
20
Europe
Indocyanine green, Verdye, Diagnostic Green
Birmingham Women's and Children's NHS Foundation Trust
Pediatric Renal Tumor, Metastatic Osteosarcoma, Metastatic Ewing Sarcoma, Pulmonary Metastasis, Rhabdomyosarcoma, Non-Rhabdo. Soft Tissue Sarcoma
09/22
09/22
ChiCTR1800019995: A Clinical Study for the Efficacy and Safety of Apatinib Combined with Gemcitabine plus Paclitaxel in Patients with Advanced Hepatosarcomatoid Carcinoma

Not yet recruiting
4
40
 
Apatinib 250mg, po, qd+Gemcitabine, iv, d1, d8+Paclitaxel, iv, d1
First Affiliated Hospital of Zhengzhou University; First Affiliated Hospital of Zhengzhou University, Self-pay
Advanced Hepatosarcomatoid Carcinoma
 
 
NCT04347122: Tranexamic Acid in Radical Resection and Endoprosthetic Reconstruction

Completed
4
16
US
Tranexamic Acid (TXA)
University of Kansas Medical Center
Musculoskeletal Cancer, Sarcoma,Soft Tissue
08/23
08/23
ChiCTR2100044810: A controlled clinical study the combination of first-line immunotherapy and targeted therapy for advanced sarcomatoid renal cell carcinoma

Recruiting
4
40
 
camrelizumab plus Pazopanib Tablets ;Pazopanib Tablets
Qilu Hospital of Shandong University; Qilu Hospital of Shandong University, Partially self-financing
Advanced sarcomatoid renal cell carcinoma
 
 
ChiCTR2100044367: Monitoring project of Anlotinib Hydrochloride Capsules (Fu Kewei)

Recruiting
4
1200
 
Nil
Jiangsu Cancer Hospital; Jiangsu Cancer Hospital, CTTQ Pharmaceutical Group Co., Ltd.
Non-small cell lung cancer, soft tissue sarcoma, thyroid like cancer or other
 
 
NCT01735955 / 2012-003902-28: Study to Allow Access to Nilotinib for Patients Who Are on Nilotinib Treatment in a Novartis-sponsored Study

Completed
4
57
Europe, Canada, US, RoW
Nilotinib, AMN107
Novartis Pharmaceuticals
Chronic Myelogenous Leukemia (CML), Metastatic Gastrointestinal Stromal Tumors (GIST), Acute Lymphoblastic Leukemia (ALL), Receptor Tyrosine Kinase (KIT) Mutated Melanoma
07/23
07/23
ChiCTR2100049974: An exploratory clinical study of Camrelizumab combined with AD chemotherapy in the first-line treatment of metastatic or inoperable undifferentiated pleomorphic sarcoma (UPS)

Not yet recruiting
4
30
 
Drug intervention
Peking University Cancer Hospital; Peking University Cancer Hospital, NA
undifferentiated pleomorphic sarcoma
 
 
ChiCTR2100052208: An observational clinical study of ripatinib in the treatment of patients with complex genetically mutated gastrointestinal stromal tumors

Not yet recruiting
4
30
 
Ripatinib
The First Affiliated Hospital of Nanjing Medical University; The First Affiliated Hospital of Nanjing Medical University, Zai Lab Pharmaceutical Trading (Suzhou) Co., Ltd.
gastrointestinal stromal tumor
 
 
Li2CO3, NCT01669369: Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma

Recruiting
4
400
RoW
Lithium Carbonate, Lithobid, Placebo, PLACEBO TREATMENT
Sun Yat-sen University, Qilu Hospital of Shandong University, Nanfang Hospital of Southern Medical University, Shenzhen Second People's Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine, Shanghai 6th People's Hospital
Osteosarcoma
12/23
12/23
NCT03244020: LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology

Enrolling by invitation
4
1434
US
Aspirin 325mg, ASA, Enoxaparin 40Mg/0.4mL Prefilled Syringe, Lovenox
Massachusetts General Hospital
Sarcoma, Soft Tissue Sarcoma, Bone Sarcoma, Bone Metastases, Venous Thromboembolism, Hematoma, Anticoagulant-induced Bleeding
12/27
07/28
SDCMK, NCT06236022: The Effects of Sirolimus in Patients With Dilated Cardiomyopathy Infected With Kaposi Sarcoma-associated Virus

Recruiting
4
276
RoW
Sirolimus
Tongji Hospital, Wuhan Central Hospital, Wuhan Fourth Hospital, Wuhan University
Dilated Cardiomyopathy, Kaposi's Sarcoma-Associated Herpesvirus Infection
12/28
12/28
ChiCTR2200060233: A prospective, parallel controlled study of DEB-TACE versus arterial infusion chemotherapy in the treatment of metastatic or recurrent soft tissue sarcoma

Not yet recruiting
4
70
 
Drug elution embolism-Transcatheter arterial chemoembolization, DEB-TACE group ;Arterial infusion chemotherapy
The Fifth Medical Center of PLA General Hospital; The Fifth Medical Center of PLA General Hospital, Beijing Medical Award Foundation
Soft tissue sarcoma
 
 
ChiCTR2100052825: Phase II clinical studies of single center, open, single arm of paclitaxel (albumin binding) in combination with camrelizumab second line and above line treatment of metastatic/locally unresectable soft tissue sarcoma

Not yet recruiting
4
40
 
Camrelizumab and chemotherapy
He'nan Tumor Hospital; He'nan Tumor Hospital, Self-funded
Soft tissue sarcoma
 
 
ChiCTR2300075388: Clinical study of trilaciclib for the prevention of severe myelosuppression after chemotherapy in patients with bone and soft tissue sarcoma

Recruiting
4
550
 
Patients with bone and soft tissue sarcoma who had IV-degree bone marrow suppression in previous chemotherapy did not receive Turacilli for preventive treatment. ;Patients with bone and soft tissue sarcoma who have experienced IV-degree bone marrow inhibition in chemotherapy should receive trarasili (240 mg/m2, intravenous administration within 4 hours before chemotherapy, and the number of days of medication is determined according to the number of days of chemotherapy) before the next chemotherapy. ;Patients with bone and soft tissue sarcoma will not receive prophylactic treatment until they plan to receive a high-risk chemotherapy regimen. ;Before patients with bone and soft tissue sarcoma are proposed to receive high-FN-risk chemotherapy, trarasili (240 mg/m2, intravenous administration within 4 hours before chemotherapy, and the number of days of medication is determined according to the number of days of chemotherapy) for preventive treatment.
Affiliated Sixth People's Hospital, Shanghai Jiaotong University; Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Self-finance
Bone and soft tissue sarcoma
 
 
ChiCTR1800017181: A prospective, single-arm, multi-center clinical study of adjuvant treatment of Gastrointestinal Stromal Tumors with Imatinib Mesylate (Gnical)

Not yet recruiting
4
150
 
adjuvant Gastrointestinal Stromal Tumors after Imatinib Mesylate
Henan Provincial People's Hospital; Henan Provincial People's Hospital, enterprise
Gastrointestinal Stromal Tumors
 
 
ChiCTR2000033298: A single-arm multicenter trial of the combination of anlotinib with chemotherapy in patients with Stage IIB classic osteosarcoma of the extremity

Recruiting
4
52
 
Anlotinib combined with Doxorubicin and cisplatin
West China Hospital of Sichuan University; West China Hospital of Sichuan University, CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD
Classic osteosarcoma
 
 
ChiCTR1900023489: The Protection Role of Metformin in Female Reproductive System Development and Fertility Preservation for children with malignant tumors with Chemotherapy: A Double-Blind, Randomized, Placebo-Controlled Study

Not yet recruiting
4
138
 
Placebo ;Metformin
Tongji Medical College, Huazhong University of Science and Technology; Tongji Medical College, Huazhong University of Science and Technology, Foundation of research pioneering project of Tongji hospital
Childhood malignancy (leukemia, lymphoma, rhabdomyosarcoma, etc.)
 
 
NCT04033081: Registry of Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet®

Recruiting
4
100
US
CivaSheet, brachytherapy, Intraoperative Radiation Therapy
CivaTech Oncology, TAB Clinical
Sarcoma
12/24
12/28
NCT00756509 / 2008-000358-11: Treatment of Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumors in First Line With Nilotinib

Active, not recruiting
4
34
Europe
Nilotinib
Novartis Pharmaceuticals
Gastrointestinal Stromal Tumors
12/24
12/24
NCT03144206: Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study

Recruiting
4
20
US
Hyperbaric oxygen
Duke University
Sarcoma, Hyperbaric Oxygen Therapy
12/26
12/26
ChiCTR2000033695: A prospective, one-arm, clinical study for letrozole in the treatment of uterine sarcoma

Not yet recruiting
4
20
 
letrozole
International Peace Maternal and Child Health Center affiliated to Shanghai Jiaotong University; International Peace Maternal and Child Health Center affiliated to Shanghai Jiaotong University, International Natural Science Foundation
uterine sarcoma
 
 
NCT04825574: Study for Patients Previously Treated in Avapritinib Clinical Trials

Active, not recruiting
4
5
Europe
Avapritinib, BLU-285
Blueprint Medicines Corporation
Gastrointestinal Stromal Tumors
08/25
08/25
NATARS, NCT05844813: Neoadjuvant Chemotherapy Combined With Targeted Treatment in High-risk Retroperitoneal Sarcoma

Enrolling by invitation
4
102
RoW
Doxorubicin+Ifosfamide+Anlotinib(AI+A), Radical Surgery
Peking University International Hospital, Shanghai Zhongshan Hospital, The Affiliated Hospital of Qingdao University, Peking University First Hospital, Shanghai Cancer Hospital, China, First Affiliated Hospital Xi'an Jiaotong University, Beijing Friendship Hospital
Retroperitoneal Sarcoma
11/25
11/27
NCT01742299 / 2012-002540-25: Study to Allow Access to Imatinib for Patients Who Are on Imatinib Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator

Active, not recruiting
4
155
Europe, US, RoW
imatinib mesylate, STI571
Novartis Pharmaceuticals
GIST and CML
04/33
04/33

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