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288 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Sarcoma
NCT05159518: A Study of PRT2527 in Participants With Advanced Solid Tumors

Completed
1
30
US
PRT2527
Prelude Therapeutics
Sarcoma, Castrate Resistant Prostate Cancer, Hormone Receptor Positive HER2 Negative Breast Cancer, Non-small Cell Lung Cancer, Solid Tumors With Known MYC Amplification
12/23
12/23
NCT05643417: Camrelizumab Combined With Bevacizumab and HAIC in Patients With Metastatic Liver Cancer Who Failed Standard Therapy

Not yet recruiting
1
80
RoW
HAIC、Bevacizumab、Camrelizumab, Camrelizumab brand name: ai rui ka; Bevacizumab brand name: ai rui tuo
Fudan University
Metastatic Liver Cancer
10/23
10/24
NCT05492682: START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer

Recruiting
1
15
Europe
PeptiCRAd-1, Cyclophosphamide, Pembrolizumab
Valo Therapeutics Oy
Melanoma (Skin), Triple-Negative Breast Cancer, Non-Small Cell Lung Cancer, Synovial Sarcoma, Myxoid Liposarcoma, Colorectal Cancer
06/25
09/25
NCT05210374: Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

Recruiting
1
24
US
Disulfiram, Copper Gluconate, Liposomal Doxorubicin (Doxil), Pegylated Liposomal Doxorubicin (PLD), Doxorubicin HCl Liposome Injection, Dox-SL
Case Comprehensive Cancer Center
Relapsed Sarcomas
10/24
11/24
NCT02595866: Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancer

Active, not recruiting
1
56
US
Antiretroviral Therapy, Anti-Retroviral Therapy, ART, Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, CT, CT Scan, tomography, Pembrolizumab, BCD-201, Keytruda, Lambrolizumab, MK-3475, Pembrolizumab Biosimilar BCD-201, SCH 900475, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT
National Cancer Institute (NCI)
AIDS-Related Non-Hodgkin Lymphoma, Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Hepatocellular Carcinoma, HIV Infection, Kaposi Sarcoma, Locally Advanced Lung Non-Small Cell Carcinoma, Locally Advanced Malignant Solid Neoplasm, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Non-Hodgkin Lymphoma, Recurrent Classic Hodgkin Lymphoma, Recurrent Malignant Neoplasm, Refractory Classic Hodgkin Lymphoma, Refractory Malignant Neoplasm, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Unresectable Melanoma
10/23
10/24
AflacST1501, NCT02644460: Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors

Completed
1
53
US
Abemaciclib, LY2835219
Emory University
Diffuse Intrinsic Pontine Glioma, Brain Tumor, Recurrent, Solid Tumor, Recurrent, Neuroblastoma, Recurrent, Refractory, Ewing Sarcoma, Recurrent, Refractory, Rhabdomyosarcoma, Recurrent, Refractory, Osteosarcoma, Recurrent, Refractory, Rhabdoid Tumor, Recurrent, Refractory
10/23
10/23
NYESO SCT, NCT03240861: Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer

Terminated
1
5
US
18F-FHBG, Reporter Probe 18F-FHBG, Aldesleukin, 125-L-Serine-2-133-interleukin 2, Proleukin, r-serHuIL-2, Recombinant Human IL-2, Recombinant Human Interleukin-2, Busulfan, 1, 4-Bis[methanesulfonoxy]butane, BUS, Bussulfam, Busulfanum, Busulfex, Busulphan, CB 2041, CB-2041, Glyzophrol, GT 41, GT-41, Joacamine, Methanesulfonic Acid Tetramethylene Ester, Methanesulfonic acid, tetramethylene ester, Mielucin, Misulban, Misulfan, Mitosan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Tetramethylene Bis(methanesulfonate), Tetramethylene bis[methanesulfonate], WR-19508, Cellular Therapy, Cell Therapy, Computed Tomography, CAT, CAT Scan, Computerized Axial Tomography, Computerized Tomography, CT, CT SCAN, tomography, Filgrastim, Filgrastim XM02, Filgrastim-sndz, G-CSF, Granix, Neupogen, r-metHuG-CSF, Recombinant Methionyl Human Granulocyte Colony Stimulating Factor, rG-CSF, Tbo-filgrastim, Tevagrastim, Zarxio, Fludarabine, Fluradosa, Leukapheresis, Leukocytopheresis, Therapeutic Leukopheresis, Plerixafor, AMD 3100, JM-3100, Mozobil, SDZ SID 791, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET SCAN, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging
Jonsson Comprehensive Cancer Center, California Institute for Regenerative Medicine (CIRM)
HLA-A*0201 Positive Cells Present, Locally Advanced Malignant Neoplasm, NY-ESO-1 Positive, Unresectable Malignant Neoplasm, Sarcoma
10/23
10/23
NCT06156410: Cabozantinib With Ifosfamide in Ewing's Sarcoma and Osteosarcoma

Recruiting
1
30
US
Cabozantinib
Children's Hospital of Philadelphia, Children's Hospital Colorado, Exelixis, Alex's Lemonade Stand Foundation
Ewing Sarcoma, Osteosarcoma
11/27
11/28
NCT05122546: CBM588 in Combination With Nivolumab and Cabozantinib for the Treatment of Advanced or Metastatic Kidney Cancer

Active, not recruiting
1
31
US
Cabozantinib S-malate, BMS-907351, Cabometyx, Cometriq, XL-184, XL184, Clostridium butyricum CBM 588 Probiotic Strain, C. butyricum CBM 588 Probiotic Strain, C. butyricum MIYAIRI Strain, C. butyricum Strain MIYAIRI 588, CBM 588, CBM588, Clostridium butyricum MIYAIRI 588, Clostridium butyricum MIYAIRI 588 Probiotic Strain, MIYAIRI 588, MIYAIRI 588 Strain of C. butyricum, Nivolumab, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo
City of Hope Medical Center, National Cancer Institute (NCI)
Advanced Clear Cell Renal Cell Carcinoma, Advanced Papillary Renal Cell Carcinoma, Advanced Renal Cell Carcinoma, Advanced Sarcomatoid Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Papillary Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Metastatic Sarcomatoid Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Unresectable Clear Cell Renal Cell Carcinoma, Unresectable Renal Cell Carcinoma
10/24
10/24
NCT04037527: Gemcitabine and Docetaxel With Radiation in Adults With Soft Tissue Sarcoma of the Extremities

Suspended
1
27
US
Gemcitabine, Docetaxel, Taxotere, Radiation, Surgical Resection, Blood draws
Wake Forest University Health Sciences, National Cancer Institute (NCI)
Soft Tissue Sarcoma
09/24
09/24
NCT04893018: NT-I7 for Kaposi Sarcoma in Patients With or Without HIV

Terminated
1
8
US
Efineptakin alfa, 2026634-47-7, GX-I7, Hyleukin-7 (TM), Il-7 Hybrid Fc, IL-7-hyFc, NT-I7, rhIL-7-hyFc
Fred Hutchinson Cancer Center, Cancer Immunotherapy Trials Network (CITN), National Cancer Institute (NCI)
AIDS-Related Kaposi Sarcoma, HIV Infection, Kaposi Sarcoma
12/23
12/23
NCT02073994: Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation

Checkmark From P1 study of ivosidenib in patients with IDH1-mutant advanced hematologic malignancies at ASCO 2018 [screenshot]
Jun 2018 - Jun 2018: From P1 study of ivosidenib in patients with IDH1-mutant advanced hematologic malignancies at ASCO 2018 [screenshot]
Checkmark From study for recurrent or progressive IDH1 mutant glioma at SNO 2017 [screenshot]
Nov 2017 - Nov 2017: From study for recurrent or progressive IDH1 mutant glioma at SNO 2017 [screenshot]
Checkmark Frst data from expansion cohort in cholangiocarcinoma at ASCO 2017
More
Completed
1
174
Europe, US
AG-120
Institut de Recherches Internationales Servier
Cholangiocarcinoma, Chondrosarcoma, Glioma, Other Advanced Solid Tumors
01/24
01/24
NCT04908176: A Drug-drug Interaction Study of Avapritinib and Midazolam

Active, not recruiting
1
10
US
Avapritinib, BLU-285, midazolam
Blueprint Medicines Corporation
Gastrointestinal Stromal Tumors, GIST, Non-resectable Advanced Solid Tumors, Recurrent or Unresectable Central Nervous System (CNS) Tumors
03/24
09/25
NCT02013336: Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid Tumors

Recruiting
1
30
US
MM-398 (Irinotecan Sucrosofate Liposome Injection) plus cyclophosphamide
South Plains Oncology Consortium
Recurrent or Refractory Solid Tumors, Ewing Sarcoma, Rhabdomyosarcoma, Neuroblastoma, Osteosarcoma
12/23
12/23
NCT02508038: Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

Recruiting
1
22
US
TCRαβ+/CD19+ depleted Haploidentical HSCT, Zoledronate, Zoledronic Acid, Zometa
University of Wisconsin, Madison
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Myelodysplastic Syndrome, Myeloproliferative Syndrome, Rhabdomyosarcoma, Ewing Sarcoma, Primitive Neuroectodermal Tumor, Osteosarcoma, Neuroblastoma
12/24
12/25
NCT03054792: Molecular-Functional Imaging of Hypoxia in Childhood Sarcomas

Enrolling by invitation
1
18
Canada
18F-FAZA (F18-Fluoroazomycin Arabinoside), 18F- FAZA, Blood Oxygen Level Dependent [BOLD] MRI, Diffusion-Weighted [DW] MRI, Magnetic Resonance Spectroscopy [MRS]
The Hospital for Sick Children
Rhabdomyosarcoma, Non-Rhabdo. Soft Tissue Sarcoma
12/23
12/24
NCT03454451: CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers

Completed
1
117
US, RoW
CPI-006, CPI-006 + ciforadenant, CPI-006 + pembrolizumab
Corvus Pharmaceuticals, Inc.
Non-Small Cell Lung Cancer, Renal Cell Cancer, Colorectal Cancer, Triple Negative Breast Cancer, Cervical Cancer, Ovarian Cancer, Pancreatic Cancer, Endometrial Cancer, Sarcoma, Squamous Cell Carcinoma of the Head and Neck, Bladder Cancer, Metastatic Castration Resistant Prostate Cancer, Non-hodgkin Lymphoma
12/22
02/23
NCT04149691: Safety, Tolerability and Pharmacokinetics of Oral CPL304110, in Adult Subjects With Advanced Solid Malignancies

Recruiting
1
42
Europe
CPL304110, PG19
Celon Pharma SA, National Center for Research and Development, Poland
Gastric Cancer, Bladder Cancer, Squamous Non-small Cell Lung Cancer, Cholangiocarcinoma, Sarcoma, Endometrial Cancer, Other Solid Tumours
06/24
06/24
DOXO75, NCT04032964: Dose Finding Study of L19TNF and Doxorubicin in Patients With STS

Active, not recruiting
1
2
US
L19TNF, DOXORUBICIN
Philogen S.p.A.
Soft Tissue Sarcoma
12/24
12/24
NCT05578820: Safety, Tolerability and Pharmacokinetics Investigation of Stimotimagene Copolymerplasmid

Recruiting
1
12
RoW
Intratumoral administration of Stimotimagene copolymerplasmid, Intravenous administration of Ganciclovir (Cymeven®)
Gene Surgery LLC
Sarcoma, Melanoma, Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms, Uterine Cervical Neoplasms, Vulvar Neoplasms, Penile Neoplasms, Anus Neoplasms
12/23
12/23
FRONTIER, NCT05432193: FAPi Radioligand OpeN-Label, Phase 1 Study to Evaluate Safety, Tolerability and DosImetry of [Lu-177]-PNT6555; A Dose Escalation Study for TReatment of Patients With Select Solid Tumors

Active, not recruiting
1
10
Canada, US
[Ga-68]-PNT6555, [Lu-177]-PNT6555
POINT Biopharma
Pancreatic Ductal Adenocarcinoma, Colorectal Cancer, Esophageal Cancer, Melanoma (Skin), Soft Tissue Sarcoma, Head and Neck Squamous Cell Carcinoma, Cholangiocarcinoma
12/23
12/26
ThernSarc, NCT05420727: Theranostics in Soft Tissue Sarcoma Using a Vascular Disruption Approach

Completed
1
14
Europe
Ga-68-PSMA-11 PET/CT, Lu-177-ITG-PSMA-1
John O. Prior
Soft Tissue Sarcoma
04/24
04/24
NCT05010694: Dose Finding Study of GH35 in Patients With Advanced Solid Tumors

Active, not recruiting
1
18
RoW
GH35 Tablet
Suzhou Genhouse Bio Co., Ltd.
AdvAdvanced Solid Tumors, Kirsten Rat Sarcoma
03/23
12/25
CEB-01-RLS01-CT, NCT04619056: First-in-man Clinical Trial of CEB-01 PLGA Membrane in Recurrent or Locally Advanced Retroperitoneal Soft Tissue Sarcoma

Active, not recruiting
1
21
Europe
CEB-01 membrane loaded with SN-38
CEBIOTEX
Locally Advanced Soft Tissue Sarcoma, Recurrent Soft Tissue Sarcoma
05/25
05/25
NCT05139056: Multiple Doses of Neural Stem Cell Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas

Recruiting
1
36
US
Neural Stem Cells-expressing CRAd-S-pk7, CRAd-S-pk7 loaded NSCs, NSC-CRAd-S-pk7, NSC-CRAd-S-pk7 Virotherapeutic, NSCs loaded with CRAd-S-pk7, SC-CRAd-Survivin-pk7, Resection, Surgical Resection
City of Hope Medical Center, National Cancer Institute (NCI)
Recurrent Anaplastic Astrocytoma, Recurrent Anaplastic Oligoastrocytoma, Recurrent Anaplastic Oligodendroglioma, Recurrent Glioblastoma, Recurrent Gliosarcoma, Recurrent Malignant Glioma, Recurrent WHO Grade II Glioma, Recurrent WHO Grade III Glioma
08/25
08/25
NCT04000529: Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies

Terminated
1
122
Europe, Japan, US, RoW
TNO155, Spartalizumab, PDR001, Ribociclib, LEE011
Novartis Pharmaceuticals
Non-small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, Esophageal SCC, Gastrointestinal Stromal Tumors, Colorectal Cancer
01/24
01/24
NCT02384473: Real-Time Contrast-Enhanced Ultrasonography and Shear Wave Elastography in Predicting Treatment Response in Patients With Soft Tissue Sarcoma

Completed
1
25
US
Real-Time CEUS, SWE, Shear Wave Elastography, Definity Suspension for Injection, Perflutren Lipid Microsphere, Philips Shear Wave Elastography, Shear Wave Elagstography
University of Southern California, National Cancer Institute (NCI)
Adult Soft Tissue Sarcoma, Bone Sarcoma, Retroperitoneal Sarcoma
01/24
01/24
NCT01661400: Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid Tumors

Completed
1
14
US
Metronomic Cyclophosphamide, Cytoxan®, CPM, Thalidomide, Thalomid®
Washington University School of Medicine
Glioma, Neuroectodermal Tumors, Primitive, Wilms Tumor, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Retinoblastoma
12/23
12/23
NCT02192359: Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas

Active, not recruiting
1
18
US
Carboxylesterase-expressing Allogeneic Neural Stem Cells, CE-secreting Allogeneic NSCs, hCE1m6-NSC, Irinotecan, Irinotecan Hydrochloride, Campto, Camptosar, Camptothecin 11, Camptothecin-11, CPT 11, CPT-11, Irinomedac, U-101440E, Irinotecan Hydrochloride Trihydrate, Irinotecan Monohydrochloride Trihydrate, Laboratory Biomarker Analysis, Pharmacological Study
City of Hope Medical Center, National Cancer Institute (NCI)
Recurrent Anaplastic Astrocytoma, Recurrent Anaplastic Oligoastrocytoma, Recurrent Anaplastic Oligodendroglioma, Recurrent Glioblastoma, Recurrent Gliosarcoma, Recurrent Malignant Glioma, Recurrent WHO Grade III Glioma
02/22
12/24
NCT02298959: Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

Active, not recruiting
1
78
Canada, US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Elastography, MRE, Pembrolizumab, BCD-201, GME 751, GME751, Keytruda, Lambrolizumab, MK-3475, Pembrolizumab Biosimilar BCD-201, Pembrolizumab Biosimilar GME751, Pembrolizumab Biosimilar QL2107, QL2107, SCH 900475, Ziv-Aflibercept, Aflibercept, AVE0005, Eylea, Vascular Endothelial Growth Factor Trap, VEGF Trap, VEGF Trap R1R2, VEGF-Trap, Zaltrap
National Cancer Institute (NCI)
Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Colorectal Carcinoma, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Metastatic Ovarian Carcinoma, Metastatic Renal Cell Carcinoma, Platinum-Resistant Ovarian Carcinoma, Recurrent Melanoma, Recurrent Renal Cell Carcinoma, Refractory Melanoma, Refractory Renal Cell Carcinoma, Sarcoma, Stage IV Colorectal Cancer AJCC v8, Stage IV Ovarian Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
12/24
12/24
NYMC195, NCT04308330 / 2008-003800-73: Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

Recruiting
1
30
US
Vorinostat, Zolinza
New York Medical College
Ewing Sarcoma, Rhabdomyosarcoma, Wilms Tumor, Neuroblastoma, Hepatoblastoma, Germ Cell Tumor
12/23
12/24
NRG-DT001, NCT03217266: Navtemadlin and Radiation Therapy in Treating Patients With Soft Tissue Sarcoma

Active, not recruiting
1
38
US
Navtemadlin, (3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((1S)-2-methyl-1-(((1-methylethyl)sulfonyl)methyl)propyl)-2-oxo-3-piperidineacetic Acid, AMG 232, AMG-232, KRT 232, KRT-232, KRT232, MDM2 Inhibitor KRT-232, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation
National Cancer Institute (NCI), NRG Oncology
Resectable Soft Tissue Sarcoma, Soft Tissue Sarcoma
08/23
02/25
ALLIANCE-ABTC-1604, NCT03107780: Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

Recruiting
1
86
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Navtemadlin, (3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((1S)-2-methyl-1-(((1-methylethyl)sulfonyl)methyl)propyl)-2-oxo-3-piperidineacetic Acid, AMG 232, AMG-232, KRT 232, KRT-232, KRT232, MDM2 Inhibitor KRT-232, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation
National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma, MGMT-Unmethylated Glioblastoma, Recurrent Glioblastoma
12/24
12/24
NCI-2019-01493, NCT03864419: Rituximab Hyaluronidase in Combination With Chemotherapy in Treating Aggressive B-cell Lymphoma in Uganda

Terminated
1
18
RoW
Rituximab and Hyaluronidase Human, Rituxan Hycela, Rituximab Plus Hyaluronidase, Rituximab/Hyaluronidase, Rituximab/Hyaluronidase Human, Cyclophosphamide, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Vincristine, LEUROCRISTINE, VCR, Vincrystine, Methotrexate, Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, Emthexat, Emtexate, Methotrexate LPF, Methylaminopterin, Methotrexatum, Doxorubicin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Doxorubicin Hydrochloride, Adriamycine, Adriblastina, Doxolem, Doxorubicin.HCl, Prednisone, Deltacortene, Decorton, Decortisyl, DeCortin, Deltacortisone, Econosone, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Vepesid, Rituximab, BI 695500, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT-P10, IDEC-C2B8 Monoclonal Antibody, MabThera, Monoclonal Antibody IDEC-C2B8, Rituxan, Rituximab ABBS, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar JHL1101, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SIBP-02, rituximab biosimilar TQB2303, RTXM83, Truxima
Fred Hutchinson Cancer Center
Burkitt Lymphoma, KSHV-associated Multicentric Castleman Disease, Diffuse Large B-Cell Lymphoma
07/23
07/23
DIPG, NCT04341311: Phase I Study of Marizomib + Panobinostat for Children With

Terminated
1
4
US
Marizomib, salinosporamide A, salinosporin A, Panobinostat, Farydak
Dana-Farber Cancer Institute, Celgene, Secura Bio, Inc.
Diffuse Intrinsic Pontine Glioma, Pediatric Brainstem Glioma, Pediatric Brainstem Gliosarcoma, Recurrent, Pediatric Cancer, Pediatric Brain Tumor, Diffuse Glioma
02/24
02/24
ChiCTR2200057036: A multicenter, randomized, double-blind, positive controlled phase II/III clinical study to evaluate the safety and efficacy of Laikubicin for injection in patients with advanced soft tissue sarcoma

Not yet recruiting
1
172
 
Legubicin ;Doxorubicin hydrochloride
Shanghai Sixth People's Hospital; Shanghai Avidity Bio-pharmaceutical Technology Co., Ltd., Shanghai Avidity Bio-pharmaceutical Technology Co., Ltd.
Soft tissue sarcoma
 
 
NCT05427513: Efficacy of Tranexamic Acid in Preventing Post Operative Blood Loss in Bone Sarcoma Patient

Recruiting
1
42
RoW
Tranexamic acid injection, normal saline
Shaukat Khanum Memorial Cancer Hospital & Research Centre
Blood Loss, Surgical
12/23
02/24
ChiCTR2200063055: Safety and efficacy of Tislelizumab in combination with doxorubicin in the first-line treatment of locally advanced or metastatic undifferentiated pleomorphic sarcoma: a prospective, single-arm, phase I study

Not yet recruiting
1
10
China
Tislelizumab, 200 mg, every three weeks
Beijing Jishuitan Hospital ; Beijing Jishuitan Hospital, Beigene Company
undifferentiated polymorphic sarcoma
 
 
SELISARC, NCT04595994: Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma and Osteosarcoma

Recruiting
1
14
Europe
Selinexor, Gemcitabine
Grupo Espanol de Investigacion en Sarcomas
Sarcoma,Soft Tissue
11/25
05/26
HFB-301001-01, NCT05229601: A Study of HFB301001 in Adult Patients With Advanced Solid Tumors

Active, not recruiting
1
84
Europe, US
HFB301001
HiFiBiO Therapeutics
Soft Tissue Sarcoma, Renal Cell Carcinoma, Uterine Carcinosarcoma, Hepatocellular Carcinoma, Head and Neck Squamous Cell Carcinoma, Melanoma
01/25
01/25
Cytalux, NCT06235125: Safety and Feasibility of Intraoperative Visualization With in Children

Not yet recruiting
1
10
NA
Cytalux, Pafolacianine injection, OTL38 injection
Ann & Robert H Lurie Children's Hospital of Chicago, On Target Laboratories, LLC
Osteosarcoma, Pulmonary Metastasis, Fluorescence, Metastatic Sarcoma, Pediatrics
01/26
01/26
NCT04242238: Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas

Active, not recruiting
1
32
US
DCC-3014, Avelumab
Memorial Sloan Kettering Cancer Center, ENABLE MEDICINE
Sarcoma, Advanced Sarcoma, High Grade Sarcoma, Leiomyosarcoma, Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma, Dedifferentiated Liposarcoma
01/25
01/25
NCT03761095: A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)

Completed
1
41
US
Unesbulin, PTC596, Dacarbazine, DTIC
PTC Therapeutics
Leiomyosarcoma
02/24
02/24
NCI-2019-08556, NCT04420975: Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

Active, not recruiting
1
14
US
Definitive Surgical Resection, Nanoplexed Poly I:C BO-112, BO 112, BO-112, BO112, Nanoplexed Poly IC BO-112, Nanoplexed Polyinosinic:Polycytidylic Acid BO-112, Nivolumab, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo, Radiation Therapy, Cancer Radiotherapy, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation
Jonsson Comprehensive Cancer Center, National Cancer Institute (NCI), Highlight Therapeutics
Leiomyosarcoma, Malignant Peripheral Nerve Sheath Tumor, Myxofibrosarcoma, Pleomorphic Rhabdomyosarcoma, Resectable Dedifferentiated Liposarcoma, Resectable Soft Tissue Sarcoma, Resectable Undifferentiated Pleomorphic Sarcoma, Soft Tissue Fibrosarcoma, Spindle Cell Sarcoma, Stage I Retroperitoneal Sarcoma AJCC (American Joint Committee on Cancer) v8, Stage I Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IA Retroperitoneal Sarcoma AJCC v8, Stage IA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IB Retroperitoneal Sarcoma AJCC v8, Stage IB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage II Retroperitoneal Sarcoma AJCC v8, Stage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage III Retroperitoneal Sarcoma AJCC v8, Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IIIA Retroperitoneal Sarcoma AJCC v8, Stage IIIA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IIIB Retroperitoneal Sarcoma AJCC v8, Stage IIIB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Storiform-Pleomorphic Malignant Fibrous Histiocytoma, Synovial Sarcoma, Undifferentiated High Grade Pleomorphic Sarcoma of Bone, Undifferentiated Pleomorphic Sarcoma, Undifferentiated Pleomorphic Sarcoma With Osteoclast-Like Giant Cells, Undifferentiated Pleomorphic Sarcoma, Inflammatory Variant, Undifferentiated Spindle Cell Sarcoma
01/25
01/26
NCT04991870: Engineered NK Cells Containing Deleted TGF-BetaR2 and NR3C1 for the Treatment of Recurrent Glioblastoma

Recruiting
1
25
US
Cord Blood-derived Expanded Allogeneic Natural Killer Cells, Allogeneic CB-derived Ex vivo-expanded NK Cells, CB-derived Expanded Allogeneic NK Cells, UCB-derived Expanded Allogeneic NK Cells, Umbilical Cord Blood-derived Expanded Allogeneic Natural Killer Cells, Resection, Surgical Resection
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Recurrent Gliosarcoma, Recurrent Supratentorial Glioblastoma, Supratentorial Gliosarcoma
01/26
01/26
NCT01543763: Pazopanib in Combination With PCI-24781 in Patients With Metastatic Solid Tumors

Checkmark ASCO 2016
May 2016 - May 2016: ASCO 2016
Checkmark ASCO 2015
May 2015 - May 2015: ASCO 2015
Checkmark ASCO 2014
More
Active, not recruiting
1
90
US
PZP115891, PCI-24781, abexinostat, S 78454, GW786034, Votrient™, Pazopanib
Pamela Munster, Pharmacyclics LLC., Novartis, Xynomic Pharmaceuticals, Inc., GlaxoSmithKline Research and Education Foundation for Cardiovascular Disease
Metastatic Solid Tumors
01/24
12/24
NCT03900793: Losartan + Sunitinib in Treatment of Osteosarcoma

Recruiting
1
41
US
Losartan, Sunitinib, Sunitinib Malate
University of Colorado, Denver
Osteosarcoma
08/26
02/27
NCT05698524: A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

Recruiting
1
18
US
PCI 24781, Abexinostat, Temozolomide, Temodar
University of Nebraska, Xynomic Pharmaceuticals, Inc.
Recurrent High Grade Glioma, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Glioblastoma, Gliosarcoma
02/25
06/27
NCT03462316: NY-ESO-1-specific T Cell Receptor (TCR) T Cell in Sarcoma

Active, not recruiting
1
20
RoW
NY-ESO-1（TCR Affinity Enhancing Specific T cell Therapy）
Sun Yat-sen University, Guangdong Xiangxue Precision Medical Technology Co., Ltd.
Bone Sarcoma, Soft Tissue Sarcoma
02/24
05/24
TQB2928-ALTN-Ib-01, NCT06438783: TQB2928 Injection Combined Anlotinib Hydrochloride Capsule in Recurrent/Metastatic Osteosarcoma and Other Solid Tumors

Recruiting
1
43
RoW
1200mg of TQB2928 injection+Anlotinib, 1800mg of TQB2928 injection+Anlotinib
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Osteosarcoma, Other Solid Tumors
10/25
02/26
NCT01738139: Ipilimumab and Imatinib Mesylate in Advanced Cancer

Completed
1
68
US
Imatinib Mesylate, CGP 57148, CGP57148B, Gleevec, Glivec, STI 571, STI-571, STI571, Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS-734016, MDX-010, MDX-CTLA4, Yervoy
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm, C-KIT Tyrosine Kinase Protein Overexpression, Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Gastrointestinal Stromal Tumor, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Pathologic Stage IV Cutaneous Melanoma AJCC v8, Unresectable Melanoma, Unresectable Solid Neoplasm
12/22
12/23
NCT04176016: Phase I Study of Radiolabeled OTSA101-DTPA in Patients With Relapsed or Refractory Synovial Sarcoma

Terminated
1
12
Japan
OTSA101-DTPA-111In, OTSA101-DTPA-90Y
OncoTherapy Science, Inc.
Relapsed or Refractory Synovial Sarcoma
01/24
01/24
NCT04389281: X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma

Recruiting
1
12
US
X-PACT
Immunolight, LLC
Advanced Solid Tumor Cancer
09/24
08/25
SADDRIN-1, NCT05116254 / 2021-000042-17: Sarcomas and DDR-Inhibition; a Combined Modality Study

Recruiting
1
30
Europe
AZD1390 + radiotherapy, AZD1390 + durvlaumab + radiotherapy
The Netherlands Cancer Institute, Leiden University Medical Center, University Medical Center Nijmegen
Soft Tissue Sarcoma Adult
03/26
07/28
NCT05130255: GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2

Recruiting
1
60
US
GD2-SADA:177Lu-DOTA Complex, two-step radioimmunotherapy
Y-mAbs Therapeutics
SCLC, Malignant Melanoma, Sarcoma
03/27
04/27
FLARES, NCT06252727: Fluorescent Aided Resection and Evaluation of Soft Tissue Sarcomas

Not yet recruiting
1
20
US
Aminolevulinic Acid, 5-ALA, Gleolan
Steven W Thorpe, National Cancer Institute (NCI)
Soft Tissue Sarcoma, Soft Tissue Sarcoma Adult
02/26
05/26
NCT06242470: A Study of MGC026 in Participants With Advanced Solid Tumors

Recruiting
1
230
US, RoW
MGC026 Dose Escalation, MGC026 Dose for Expansion
MacroGenics
Advanced Solid Tumor, Advanced Cancer, Metastatic Cancer, Squamous Cell Carcinoma of Head and Neck, Non Small Cell Lung Cancer, Small-cell Lung Cancer, Bladder Cancer, Sarcoma, Endometrial Cancer, Melanoma, Castration Resistant Prostatic Cancer, Cervical Cancer, Colorectal Cancer, Gastric Cancer, Gastro-esophageal Cancer, Pancreas Cancer, Clear Cell Renal Cell Carcinoma, Hepatocellular Carcinoma, Platinum-resistant Ovarian Cancer
05/28
10/28
NCT06340204: Weekly Irinotecan Liposomes in Recurrent or Refractory Ewing Sarcoma

Recruiting
1
44
RoW
Irinotecan Hydrochloride Liposome Injection, duo en yi
Peking University People's Hospital, Peking University Shougang Hospital, Shandong Cancer Hospital and Institute
Ewing Sarcoma
03/26
12/26
NCT04511871: A Phase I Trial of CCT303-406 in Patients With Relapsed or Refractory HER2 Positive Solid Tumors

Recruiting
1
15
RoW
CCT303-406
Shanghai PerHum Therapeutics Co., Ltd., Shanghai Zhongshan Hospital
Solid Tumor, Gastric Cancer, Breast Cancer, Ovarian Cancer, Sarcoma
03/24
03/25
NCT05227326: AOH1996 for the Treatment of Refractory Solid Tumors

Active, not recruiting
1
92
US
PCNA Inhibitor AOH1996, AOH 1996, AOH-1996, AOH1996, Proliferating Cell Nuclear Antigen Inhibitor AOH1996
City of Hope Medical Center, National Cancer Institute (NCI)
Refractory Malignant Solid Neoplasm, Osteosarcoma, Leiomyosarcomas, Synovial Sarcomas, Ovarian Cancer, Non-Small Cell Lung Cancer, Pancreatic Cancer
09/24
09/24
NCT01552434: Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Active, not recruiting
1
155
US
Bevacizumab, Anti-VEGF, Anti-VEGF Humanized Monoclonal Antibody, Anti-VEGF rhuMAb, Avastin, Bevacizumab Biosimilar BEVZ92, Bevacizumab Biosimilar BI 695502, Bevacizumab Biosimilar CBT 124, Bevacizumab Biosimilar FKB238, Bevacizumab Biosimilar MIL60, Bevacizumab Biosimilar QL 1101, BEVACIZUMAB, LICENSE HOLDER UNSPECIFIED, Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer, Recombinant Humanized Anti-VEGF Monoclonal Antibody, rhuMab-VEGF, Cetuximab, Cetuximab Biosimilar CMAB009, Chimeric Anti-EGFR Monoclonal Antibody, Chimeric MoAb C225, Chimeric Monoclonal Antibody C225, Erbitux, IMC-C225, Laboratory Biomarker Analysis, Pharmacological Study, Temsirolimus, CCI-779, CCI-779 Rapamycin Analog, Cell Cycle Inhibitor 779, Rapamycin Analog, Rapamycin Analog CCI-779, Torisel, Valproic Acid, Depakene, Stavzor, Valproate
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Advanced Malignant Neoplasm, Castleman Disease, Digestive System Carcinoma, Erdheim-Chester Disease, Lip and Oral Cavity Carcinoma, Lymphangioleiomyomatosis, Malignant Endocrine Neoplasm, Malignant Female Reproductive System Neoplasm, Malignant Male Reproductive System Neoplasm, Malignant Neoplasm, Malignant Respiratory Tract Neoplasm, Malignant Thoracic Neoplasm, Malignant Urinary System Neoplasm, Mesothelial Neoplasm, Metastatic Malignant Neoplasm, Metastatic Urothelial Carcinoma, Neurofibromatosis Type 2, Recurrent Adult Soft Tissue Sarcoma, Recurrent Breast Carcinoma, Recurrent Childhood Soft Tissue Sarcoma, Recurrent Digestive System Carcinoma, Recurrent Female Reproductive System Carcinoma, Recurrent Male Reproductive System Carcinoma, Recurrent Malignant Neoplasm, Recurrent Pharyngeal Carcinoma, Recurrent Thyroid Gland Carcinoma, Refractory Malignant Neoplasm, Soft Tissue Neoplasm, Stage III Breast Cancer AJCC v7, Stage III Pharyngeal Cancer, Stage IIIA Breast Cancer AJCC v7, Stage IIIB Breast Cancer AJCC v7, Stage IIIC Breast Cancer AJCC v7, Stage IV Breast Cancer AJCC v6 and v7, Stage IV Pharyngeal Cancer, Stage IVA Pharyngeal Cancer, Stage IVB Pharyngeal Cancer, Stage IVC Pharyngeal Cancer, Thyroid Gland Neoplasm
03/26
03/26
ChiCTR2100049429: Umbilical cord blood mononuclear cells alleviate adverse reactions of bone and soft tissue sarcoma and bone metastases: a randomized controlled, open-ended, multi-center phase I study

Recruiting
1
100
 
Receive neoadjuvant or adjuvant chemotherapy ;After receiving neoadjuvant or adjuvant chemotherapy, infusion of umbilical cord blood mononuclear cells is given within 24 hours
Affiliated Sixth People's Hospital, Shanghai Jiaotong University; Affiliated Sixth People's Hospital, Shanghai Jiaotong University, self-funded
Bone and soft tissue sarcoma and bone metastasis cancer in new aided and chemotherapy-assisted chemotherapy
 
 
NCT05567601: Doxil/Caelyx BE Study

Not yet recruiting
1
36
NA
DOXIL/CAELYX, doxorubicin hydrochloride liposome injection 2 mg/mL
Baxter Healthcare Corporation
Ovarian Cancer, AIDS-related Kaposi Sarcoma, Multiple Myeloma, Metastatic Breast Cancer
04/24
04/24
NCT06008483: A Dose Finding Study to Treat Bone Tumor(s)

Recruiting
1
17
US
153-Sm-DOTMP (Samarium-153-DOTMP)
QSAM Therapeutics, Inc.
Bone Cancer, Bone Tumor, Solid Tumor, Metastatic Cancer to the Bone, Metastatic Tumor to the Bone
04/24
11/24
NCT06228326: A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs

Recruiting
1
80
US
KB707
Krystal Biotech, Inc.
Lung Cancer, Non-small Cell, Lung Cancer Metastatic, Solid Tumor, Adult, Advanced Cancer, Lung Cancer, Small Cell, Metastatic Colorectal Cancer, Metastatic Renal Cell Carcinoma, Metastatic Hepatocellular Carcinoma, Metastatic Sarcoma, Metastatic Osteosarcoma
02/27
02/27
NCT04397679: Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma

Active, not recruiting
1
2
US
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Radiation, 3D Conformal, Intensity-Modulated Radiation Therapy (IMRT), IMRT, Intensity Modulated RT, INTENSITY-MODULATED RADIATION THERAPY, Intensity-Modulated Radiotherapy, Temozolomide, 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 362856, 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, 85622-93-1, CCRG-81045, imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, Imidazo[5,1-d], 1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temomedac, TMZ, Chloroquine, 54-05-7, Tumor Treating Fields Therapy (TTF), Alternating Electric Field Therapy, TTF, TTFields
Barbara Ann Karmanos Cancer Institute, National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma
04/25
04/26
PBL-0405-01, NCT06273852: A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors

Recruiting
1
15
US
PBA-0405, PB004.22.0405.aF
Pure Biologics S.A., Presage Biosciences
Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult, Triple Negative Breast Cancer
03/25
03/25
NCT01590069: Aerosolized Aldesleukin in Treating Patients With Lung Metastases

Active, not recruiting
1
70
US
Aerosolized Aldesleukin, Aerosolized Recombinant IL-2, Laboratory Biomarker Analysis
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Metastatic Malignant Neoplasm in the Lung, Metastatic Melanoma, Metastatic Osteosarcoma, Metastatic Renal Cell Cancer, Sarcoma, Stage IV Cutaneous Melanoma AJCC v6 and v7, Stage IV Osteosarcoma AJCC v7, Stage IV Renal Cell Cancer AJCC v7
04/26
04/26
NCT04999761: AB122 Platform Study

Recruiting
1
715
Japan
AB122, TAS-116, TAS-120, TAS-115, TAS-102, Ramucirumab, Bevacizumab
Taiho Pharmaceutical Co., Ltd.
Advanced or Metastatic Solid Tumor, Pancreatic Ductal Adenocarcinoma, Colorectal Cancer, Non-small Cell Lung Cancer, Gastric Cancer, Alveolar Soft Part Sarcoma
05/26
05/26
STARKAP, NCT05646082: Preliminary Assessment of Safety and Tolerability of Dostarlimab in Combination Antiretroviral Therapy (cART) Refractory HIV Associated Kaposi Sarcoma

Recruiting
1
20
Europe
Dostarlimab in Combination Antiretroviral Therapy
Imperial College London
Refractory HIV Associated Kaposi Sarcoma
05/24
09/25
NCT06299163: NM32-2668 in Adult Patients With Selected Advanced Solid Tumors

Recruiting
1
180
US
NM32-2668
Numab Therapeutics AG
Ovarian Carcinoma, Fallopian Tube Carcinoma, Peritoneal Carcinoma, Endometrial Cancer, Adenocarcinoma of Lung, Triple Negative Breast Cancer, Liposarcoma, Leiomyosarcoma, Mesothelioma, Malignant, Adenocarcinoma - Gastroesophageal Junction (GEJ), Adenocarcinoma of the Stomach, Melanoma, Malignant, Renal Cell Carcinoma
12/27
12/27
NCT04299113: Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma

Recruiting
1
38
US
Vinorelbine, 3'',4''-Didehydro-4''-deoxy-C''-norvincaleukoblastine, 5''-Nor-Anhydrovinblastine, 71486-22-1, Dihydroxydeoxynorvinkaleukoblastine, nor-5''-Anhydrovinblastine, vinorelbine, VINORELBINE, Mocetinostat, 726169-73-9, Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-, MG-0103, MGCD0103, MGCD0103, N-(2-aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide
Jonsson Comprehensive Cancer Center, Mirati Therapeutics Inc., Phase One Foundation
Rhabdomyosarcoma
05/25
05/26
NCT03120624: VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Stage IV or Recurrent Endometrial Cancer

Active, not recruiting
1
34
US
Biopsy, Biopsy Type, BIOPSY_TYPE, Bx, Computed Tomography, CAT, CAT Scan, Computerized Axial Tomography, Computerized Tomography, CT, CT Scan, tomography, Fluorine F 18 Tetrafluoroborate, 18F-Tetrafluoroborate, 18F-TFB, Pharmacological Study, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter, Oncolytic VSV-hIFNbeta-NIS, Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter, Voyager-V1, VSV-expressing hIFNb and NIS, VSV-hIFNb-NIS, VSV-hIFNbeta-NIS, VV1, Ruxolitinib Phosphate, 1092939-17-7, INCB-18424 Phosphate, Jakafi, Jakavi, Technetium Tc-99m Sodium Pertechnetate, Pertscan-99m, Sodium Pertechnetate (Na99mtco4), Tc 99m Generator, Ultra-Technekow FM, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection
Mayo Clinic, National Cancer Institute (NCI)
Metastatic Endometrial Carcinoma, Recurrent Endometrial Adenocarcinoma, Recurrent Endometrial Carcinoma, Recurrent Endometrial Clear Cell Adenocarcinoma, Recurrent Endometrial Endometrioid Adenocarcinoma, Recurrent Endometrial Mixed Cell Adenocarcinoma, Recurrent Endometrial Serous Adenocarcinoma, Recurrent Endometrial Undifferentiated Carcinoma, Recurrent Uterine Corpus Carcinosarcoma, Stage IV Uterine Corpus Cancer AJCC v7
06/24
07/24
NCT03604783: Phase 1, First-in-human Study of Oral TP-1287 in Patients With Advanced Solid Tumors

Terminated
1
74
US
TP-1287
Sumitomo Pharma America, Inc.
Advanced Solid Tumors, Sarcoma, Ewing Sarcoma, Dedifferentiated Liposarcoma, Synovial Sarcoma
01/24
01/24
NCT03635632: C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma and Other GD2 Positive Cancers (GAIL-N)

Active, not recruiting
1
94
US
C7R-GD2.CART cells
Baylor College of Medicine, Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital Research Institute, Cancer Prevention Research Institute of Texas
Relapsed Neuroblastoma, Refractory Neuroblastoma, Relapsed Osteosarcoma, Relapsed Ewing Sarcoma, Relapsed Rhabdomyosarcoma, Uveal Melanoma, Phyllodes Breast Tumor
06/24
12/39
STRIvE-01, NCT03618381: EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Recruiting
1
44
US
second generation 4-1BBζ EGFR806-EGFRt, second generation 4-1BBζ EGFR806-EGFRt and a second generation 4 1BBζ CD19-Her2tG
Seattle Children's Hospital
Pediatric Solid Tumor, Germ Cell Tumor, Retinoblastoma, Hepatoblastoma, Wilms Tumor, Rhabdoid Tumor, Carcinoma, Osteosarcoma, Ewing Sarcoma, Rhabdomyosarcoma, Synovial Sarcoma, Clear Cell Sarcoma, Malignant Peripheral Nerve Sheath Tumors, Desmoplastic Small Round Cell Tumor, Soft Tissue Sarcoma, Neuroblastoma
06/25
06/40
NCT04337177: Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Recruiting
1
20
US
VAL-413, Orotecan®, Temozolomide, Temodar, Temodal, Temcad, TMZ
Valent Technologies, LLC
Solid Tumors, Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma, Hepatoblastoma, Medulloblastoma
06/24
06/24
IMPACT, NCT06193759: Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy

Active, not recruiting
1
12
US
Multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalized tumor-specific antigens (TSA)
Children's National Research Institute
Medulloblastoma, Childhood, Atypical Teratoid/Rhabdoid Tumor of CNS, Embryonal Tumor With Multilayered Rosettes, Pineoblastoma, Embryonal Tumor of CNS
12/32
12/33
NCT02936102: A Study of FAZ053 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies.

Active, not recruiting
1
154
Europe, Canada, Japan, US, RoW
FAZ053, PDR001
Novartis Pharmaceuticals
Advanced Solid Tumors, Triple Negative Breast Cancer, Chordoma and Alveolar Soft Part Sarcoma
11/24
11/24
NCT06412458: IM83 Clinical Study of CAR-T Cell Therapy in Patients With Relapsed or Refractory Osteosarcoma

Not yet recruiting
1
9
RoW
IM83 CAR-T Cells
Beijing Immunochina Medical Science & Technology Co., Ltd., Guangdong Provincial People's Hospital
Refractory Osteosarcoma, Recurrent Osteosarcoma
06/25
06/26
NCT03721068: Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma

Recruiting
1
18
US
iC9.GD2.CAR.IL-15 T-cells, Cyclophosphamide, Fludarabine
UNC Lineberger Comprehensive Cancer Center, United States Department of Defense, Bellicum Pharmaceuticals, University Cancer Research Fund at Lineberger Comprehensive Cancer Center
Neuroblastoma, Osteosarcoma
06/24
06/39
NCT06399419: CBM588 Capsules in Combination With Nivolumab and Ipilimumab for the Treatment of Advanced Stage Kidney Cancer

Recruiting
1
28
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Scan, Bone Scintigraphy, CBM588 Capsules, CBM588, Clostridium butyricum MIYAIRI 588, C. butyricum MIYAIRI 588, C. butyricum strain MIYAIRI 588, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS-734016, Ipilimumab Biosimilar CS1002, MDX-010, MDX-CTLA4, Yervoy, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo
Osel, Inc., City of Hope Medical Center, Miyarisan Pharmaceuticals, Co., Ltd., National Cancer Institute (NCI)
Advanced Clear Cell Renal Cell Carcinoma, Advanced Renal Cell Carcinoma, Advanced Sarcomatoid Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Metastatic Sarcomatoid Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
10/26
10/26
NCT02020707: Nab-Paclitaxel and Bevacizumab in Treating Patients With Unresectable Stage IV Melanoma or Gynecological Cancers

Active, not recruiting
1
73
US
Bevacizumab, ABP 215, Anti-VEGF, Anti-VEGF Humanized Monoclonal Antibody, Anti-VEGF Monoclonal Antibody SIBP04, Anti-VEGF rhuMAb, Avastin, Bevacizumab awwb, Bevacizumab Biosimilar ABP 215, Bevacizumab Biosimilar BEVZ92, Bevacizumab Biosimilar BI 695502, Bevacizumab Biosimilar CBT 124, Bevacizumab Biosimilar CT-P16, Bevacizumab Biosimilar FKB238, Bevacizumab Biosimilar GB-222, Bevacizumab Biosimilar HD204, Bevacizumab Biosimilar HLX04, Bevacizumab Biosimilar IBI305, Bevacizumab Biosimilar LY01008, Bevacizumab Biosimilar MIL60, Bevacizumab Biosimilar Mvasi, Bevacizumab Biosimilar MYL-1402O, Bevacizumab Biosimilar QL 1101, Bevacizumab Biosimilar RPH-001, Bevacizumab Biosimilar SCT501, Bevacizumab Biosimilar Zirabev, Bevacizumab-awwb, Bevacizumab-bvzr, BP102, BP102 Biosimilar, HD204, Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer, Mvasi, MYL-1402O, Recombinant Humanized Anti-VEGF Monoclonal Antibody, rhuMab-VEGF, SCT501, SIBP 04, SIBP-04, SIBP04, Zirabev, Laboratory Biomarker Analysis, Nab-paclitaxel, ABI 007, ABI-007, Abraxane, Albumin-bound Paclitaxel, Albumin-Stabilized Nanoparticle Paclitaxel, Nanoparticle Albumin-bound Paclitaxel, Nanoparticle Paclitaxel, Paclitaxel Albumin, paclitaxel albumin-stabilized nanoparticle formulation, Protein-bound Paclitaxel, Pharmacological Study
Mayo Clinic, National Cancer Institute (NCI)
Cervical Adenocarcinoma, Cervical Adenosarcoma, Cervical Adenosquamous Carcinoma, Cervical Carcinosarcoma, Cervical Squamous Cell Carcinoma, Clinical Stage IV Cutaneous Melanoma AJCC v8, Endometrial Adenosquamous Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Mixed Cell Adenocarcinoma, Endometrial Mucinous Adenocarcinoma, Endometrial Serous Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fallopian Tube Adenocarcinoma, Fallopian Tube Carcinosarcoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Fallopian Tube Squamous Cell Carcinoma, Fallopian Tube Transitional Cell Carcinoma, Fallopian Tube Undifferentiated Carcinoma, Malignant Female Reproductive System Neoplasm, Malignant Ovarian Clear Cell Tumor, Malignant Ovarian Endometrioid Tumor, Malignant Ovarian Epithelial Tumor, Malignant Ovarian Mucinous Tumor, Malignant Peritoneal Neoplasm, Malignant Solid Neoplasm, Ovarian Carcinosarcoma, Ovarian Clear Cell Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian High Grade Serous Adenocarcinoma, Ovarian Mucinous Adenocarcinoma, Ovarian Serous Adenocarcinoma, Ovarian Transitional Cell Carcinoma, Ovarian Undifferentiated Carcinoma, Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Platinum-Sensitive Ovarian Carcinoma, Primary Peritoneal Carcinosarcoma, Primary Peritoneal Clear Cell Adenocarcinoma, Primary Peritoneal Serous Adenocarcinoma, Primary Peritoneal Transitional Cell Carcinoma, Primary Peritoneal Undifferentiated Carcinoma, Unresectable Melanoma, Uterine Corpus Carcinosarcoma
06/24
06/25
NCT02408861: Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Recruiting
1
96
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Biopsy, Biopsy of Bone Marrow, Biopsy, Bone Marrow, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS-734016, Ipilimumab Biosimilar CS1002, MDX-010, MDX-CTLA4, Yervoy, Nivolumab, ABP 206, BCD-263, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT
National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm, Anal Carcinoma, HIV Infection, Kaposi Sarcoma, Lung Carcinoma, Metastatic Malignant Solid Neoplasm, Recurrent Classic Hodgkin Lymphoma, Refractory Classic Hodgkin Lymphoma, Unresectable Solid Neoplasm
07/24
07/24
NCT03173976: Anti-Osteoclast Therapy as Neoadjuvant in Treatment of Chondrosarcoma - Phase 1b Trial

Active, not recruiting
1
17
US
Zoledronic Acid, Zometa®
Mohammed Milhem, Rising Tide Foundation
Chondrosarcoma
07/24
07/24
NCT04047251: A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors

Recruiting
1
96
US
FF-10850 Topotecan Liposome Injection, FF-10850
Fujifilm Pharmaceuticals U.S.A., Inc.
Advanced Solid Tumors
03/25
07/26
NCT04457258: 68Ga-FAPi-46 PET/CT Scan in Imaging Patients With Sarcoma

Recruiting
1
30
US
Computed Tomography, CAT, CAT Scan, Computerized Axial Tomography, Computerized Tomography, CT, CT Scan, tomography, Gallium Ga 68 FAPi-46, 68Ga-FAPi-46, Gallium-68-FAPi-46, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, 18F-FDG, 18F-fluorodeoxyglucose
Jonsson Comprehensive Cancer Center, National Cancer Institute (NCI)
Metastatic Sarcoma, Recurrent Sarcoma, Sarcoma
07/24
07/25
NCT03500991: HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

Active, not recruiting
1
10
US
HER2-specific chimeric antigen receptor (CAR) T cell
Seattle Children's Hospital
Central Nervous System Tumor, Pediatric, Glioma, Ependymoma, Medulloblastoma, Germ Cell Tumor, Atypical Teratoid/Rhabdoid Tumor, Primitive Neuroectodermal Tumor, Choroid Plexus Carcinoma, Pineoblastoma
07/24
07/39
NCT06308419: A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Not yet recruiting
1
12
US
Gemcitabine, Gemcitabine Hydrochloride, Gemzar®, Nab-Sirolimus
M.D. Anderson Cancer Center, Aadi Bioscience
Leiomyosarcoma, Soft-tissue Sarcomas
02/29
02/31
NCT01189643: Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell Tumor

Active, not recruiting
1
15
US
irinotecan, temozolomide, and bevacizumab incorporated into an existing schedule of high dose alkylator
Memorial Sloan Kettering Cancer Center, Genentech, Inc.
Sarcoma, Desmoplastic Small Round Cell Tumor (DSRCT)
08/24
08/24
NCT03463408: Immunotherapy + Radiation in Resectable Soft Tissue Sarcoma

Active, not recruiting
1
14
US
nivolumab, ipilimumab
University of Rochester
Sarcoma
08/24
08/25
NCT03715933: Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

Recruiting
1
240
US
INBRX-109, Carboplatin, Cisplatin, Pemetrexed, 5-fluorouracil, Irinotecan, Temozolomide
Inhibrx, Inc.
Solid Tumors, Malignant Pleural Mesothelioma, Gastric Adenocarcinoma, Colorectal Adenocarcinoma, Sarcoma, Pancreatic Adenocarcinoma, Ewing Sarcoma, Chondrosarcoma, GIST, SDH-deficient Solid Tumors
12/25
07/26
NCT04530981: A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients With Advanced GIST

Active, not recruiting
1
13
US
Ripretinib, QINLOCK, Repaglinide
Deciphera Pharmaceuticals LLC
GIST - Gastrointestinal Stromal Tumor
11/23
03/25
NCT05488366: Immunotherapy Combined With Radiotherapy for Metastatic Sarcoma

Recruiting
1
12
US
Pembrolizumab, MK-3475, Radiation therapy, RT
University of California, Irvine
Sarcoma, Soft Tissue
08/24
08/24
BrUOG 387, NCT05655598: TAS-116 Plus Palbociclib in Breast and Rb-null Cancer

Recruiting
1
27
US
Palbociclib Oral Product, TAS-116
Brown University
Advanced Breast Cancer, Treatment-Refractory Solid Tumors, Retinoblastoma Deficiency, SCLC, Soft Tissue Sarcoma, Endometrial Cancer, Bladder Cancer
08/24
08/25
NCT04074564: MASCT-I Combined With Apatinib and/or Camrelizumab in the Treatment of Bone and Soft Tissue Sarcoma

Recruiting
1
60
RoW
MASCT-I, Camrelizumab,Apatinib
HRYZ Biotech Co.
Sarcoma
08/24
12/24
NCI-2018-01928, NCT03727789: CBL0137 in Treating Patients With Advanced Extremity Melanoma or Sarcoma

Terminated
1
7
US
FACT Complex-targeting Curaxin CBL0137, CBL0137
Roswell Park Cancer Institute, Incuron
Advanced Cutaneous Melanoma of the Extremity, Advanced Sarcoma of the Extremity, Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Pathologic Stage IIIB Cutaneous Melanoma AJCC v8, Pathologic Stage IIIC Cutaneous Melanoma AJCC v8, Pathologic Stage IV Cutaneous Melanoma AJCC v8, Recurrent Cutaneous Melanoma of the Extremity, Recurrent Sarcoma of the Extremity, Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IIIA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IIIB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
01/24
01/24
NCT05128786: CCT301-38 CAR-T in Patients With Relapsed or Refractory AXL Positive Sarcomas

Recruiting
1
9
RoW
CCT301-38
Shanghai PerHum Therapeutics Co., Ltd., Shanghai Zhongshan Hospital
SAR
08/24
08/25
NCT05091866: Natural Progesterone for the Treatment of Recurrent Glioblastoma

Recruiting
1
32
US
Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Therapeutic Progesterone, Corlutina, Corluvite, Corpus luteum hormone, Cyclogest, Gestiron, Gestone, Lipo-Lutin, Luteohormone, Lutocyclin, Lutocylin M, Lutogyl, Lutromone, Progestasert, Progesterone, Progestin, Progestogel, Progestol, Progeston, Prolidon, Proluton, Syngesterone, Utrogestan
Emory University, National Cancer Institute (NCI)
Gliosarcoma, Recurrent Glioblastoma
08/25
08/26
NCT04634227: Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)

Recruiting
1
40
US
Ascorbate
Mohammed Milhem, MBBS, University of Iowa
Sarcoma, Soft Tissue Sarcoma, Unresectable Soft Tissue Sarcoma, Metastatic Bone Tumor, Bone Sarcoma
08/24
08/24
 

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