Leukemia  >>  Phase 1
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406 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Leukemia
ME-401-002, NCT02914938: A Study of ME-401 in Subjects With CLL/SLL, FL, and B-cell Non Hodgkin's Lymphoma

Terminated
1
97
Europe, US
ME-401, Rituximab, Rituxan, Zanubrutinib
MEI Pharma, Inc.
Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Follicular Lymphoma (FL), Marginal Zone B Cell Lymphoma, Diffuse Large B-cell Lymphoma (DLBCL), High Grade Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma (MCL)
03/23
03/23
NCT04626765: CAR-T for Children With Relapsed and Refractory Acute Lymphoblastic Leukemia

Recruiting
1
50
RoW
CD19 CAR-T, Senl_19, CD22 CAR-T, Senl_22, CD 19+22, Senl_19+22, Fludarabine, flu, Cyclophosphamide, ctx
Hebei Senlang Biotechnology Inc., Ltd., The Second Hospital of Hebei Medical University
Childhood Acute Lymphoblastic Leukemia
03/23
05/23
NCT03884829: A Phase I Study of CYC140, a PLK-1 Inhibitor, in Advanced Leukemias or MDS

Recruiting
1
50
US
CYC140
Cyclacel Pharmaceuticals, Inc., M.D. Anderson Cancer Center
AML, Adult, Myelodysplastic Syndromes, ALL, Adult, CML, Refractory, CLL, Refractory
04/23
09/23
NCT04017546: CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory AML or MDS

Completed
1
14
US
CYC065, Venetoclax
Cyclacel Pharmaceuticals, Inc., M.D. Anderson Cancer Center
AML, MDS
11/22
04/23
NCT02848001: A Dose-finding Study of CC-90009 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-risk Myelodysplastic Syndromes

Terminated
1
101
Europe, Canada, US
CC-90009
Celgene
Leukemia, Myeloid, Acute, Myelodysplastic Syndromes
04/23
04/24
NCT03236857 / 2017-000439-14: A Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young Adult Patients With Relapsed or Refractory Malignancies

Completed
1
143
Europe, Canada, US, RoW
chemotherapy, venetoclax, ABT-199, GDC-0199, Venclexta
AbbVie, Roche-Genentech
Malignancies, Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Non-Hodgkin's Lymphoma, Neuroblastoma
04/23
04/23
LOXO-BCL-20001, NCT05024045: Study of Oral LOXO-338 in Patients With Advanced Blood Cancers

Active, not recruiting
1
316
Europe, US
LOXO-338, LY3847429, Pirtobrutinib, LOXO-305, LY3527727
Eli Lilly and Company, Loxo Oncology, Inc.
Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, B-cell Marginal Zone, Lymphoma, Non-Hodgkin, Multiple Myeloma, B-cell Lymphoma, Waldenstrom Macroglobulinemia, Lymphoma, Mantle-Cell
06/23
12/24
CARTHIAE-1, NCT05705570: A Phase I Clinical Trial Using Genetically Engineered Autologous T Cells to Express Chimeric Antigen Receptor (CAR) for Treatment of Patients With Refractory or Relapsed CD19-positive B Lymphoid Malignancies

Not yet recruiting
1
30
RoW
Cyclophosphamide, Fludarabine, Chimeric antigen receptor T cells to be implemented in a "3 + 3" design on day 0
Hospital Israelita Albert Einstein, Miltenyi Biotec, Inc.
Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia Refractory, B-cell Lymphoma Recurrent, B-cell Lymphoma Refractory, Chronic Lymphocytic Leukemia Recurrent, Chronic Lymphocytic Leukemia Refractory
05/23
12/28
NCT05244070: A Study to Evaluate the Safety and Tolerability of BMS-986403 in Participants With Relapsed and/or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Terminated
1
5
Europe, US
BMS-986403, Fludarabine, Cyclophosphamide
Bristol-Myers Squibb
Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma
05/23
05/23
NCT04912063: Study to Evaluate Adverse Events and Movement of Lemzoparlimab in Body When Used Intravenously (IV) With Azacitidine Subcutaneously or IV and Venetoclax Orally in Participants With Acute Myeloid Leukemia and With Azacitidine With or Without Venetoclax in Participants With Myelodysplastic Syndrome

Terminated
1
40
Europe, Japan, US, RoW
Lemzoparlimab, TJ011133, ABBV-IMAB-TJC4, Azacitidine, Venetoclax, Venclexta, Venclyxto, ABT-199, GDC-0199
AbbVie
Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)
05/23
05/23
NCT04626726: Adult B-ALL Treated by CART Cell Bridging Allogeneic Hematopoietic Stem Cell Transplantation

Recruiting
1
50
RoW
CD19 CAR-T, Senl_19, CD22 CAR-T, Senl_22, CD19+CD22 CAR-T, Senl_19+22, Fludarabine, fiu, Cyclophosphamide, ctx
Hebei Senlang Biotechnology Inc., Ltd.
Adult B Acute Lymphoblastic Leukemia
05/23
05/23
NCT04934774: Non-gene Edited Anti-CD7 CAR T Cells for Relapsed/Refractory T Cell Malignances

Recruiting
1
20
RoW
CD7 CAR T cells
iCell Gene Therapeutics, iCAR Bio Therapeutics Ltd., Peking University Shenzhen Hospital
T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma, T-cell Non-Hodgkin Lymphoma
06/23
06/23
NCT04766840: Donor-derived CAR-T Cells in the Treatment of AML Patients

Not yet recruiting
1
9
RoW
CAR-T cells, IM73 CAR-T Cells
Beijing Immunochina Medical Science & Technology Co., Ltd.
AML
06/23
12/23
NCT05432401: TAA05 Injection in the Treatment of Adult Patients With FLT3-positive Relapsed/Refractory Acute Myeloid Leukemia

Recruiting
1
18
RoW
T cell injection targeting FLT3 chimeric antigen receptor, TAA05 Injection
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
FLT3-positive Relapsed/Refractory Acute Myeloid Leukemia
06/23
06/25
NCT05223686: To Evaluate the Safety and Tolerability of Human CD19-CD22 Targeted T Cells Injection for Subjects With R/R B-ALL.

Not yet recruiting
1
18
RoW
Human CD19-CD22 Targeted T Cells Injection, CD19-CD22 CAR-T
Hrain Biotechnology Co., Ltd., Ruijin Hospital
Acute Lymphoblastic Leukemia
06/23
03/25
LP-168-US-I01, NCT04775745: Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

Recruiting
1
60
US
LP-168
Newave Pharmaceutical Inc
CLL/SLL, Waldenstrom Macroglobulinemia, Follicular Lymphoma, Diffuse Large B Cell Lymphoma, Mantle Cell Lymphoma, Marginal Zone Lymphoma, Hairy Cell Leukemia
07/25
12/25
NCT04603001: Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

Active, not recruiting
1
260
Europe, Canada, US, RoW
LY3410738, Venetoclax, Azacitidine
Eli Lilly and Company, Loxo Oncology, Inc.
Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Chronic Myelomonocytic Leukemia (CMML), Myeloproliferative Neoplasms (MPNs)
07/23
05/25
NCT03755154: Study of a New Intravenous Drug, Called S65487, in Patients With Acute Myeloid Leukemia, Non Hodgkin Lymphoma, Multiple Myeloma or Chronic Lymphocytic Leukemia

Completed
1
60
Europe, RoW
S65487- initial scheme, S65487 - alternative scheme
Institut de Recherches Internationales Servier, ADIR, a Servier Group company
Relapsed or Refractory Acute Myeloid Leukemia, Relapsed or Refractory Non-Hodgkin Lymphoma, Relapsed or Refractory Multiple Myeloma, Relapsed or Refractory Chronic Lymphocytic Leukemia
11/23
11/23
SELCLAX, NCT04898894: Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Recruiting
1
42
US
Venetoclax, Venclextra®, ABT-199, Selinexor, KPT-330, Cytarabine, Cytosine arabinoside, Ara-C, Cytosar®, Fludarabine, Fludara®, Fludarabine phosphate, 2-fluoro-ara-AMP, Filgrastim, G-CSF, Methotrexate, MTX, amethopterin, Trexall®, methotrexate/hydrocortisone/cytarabine, ITMHA, Intrathecal triples
St. Jude Children's Research Hospital, Karyopharm Therapeutics Inc, AbbVie, Gateway for Cancer Research
Acute Leukemia of Ambiguous Lineage in Relapse, Acute Myeloid Leukemia, in Relapse, Refractory Acute Leukemia of Ambiguous Lineage, Refractory Acute Myeloid Leukemia
07/23
07/25
NCT04614636: FT538 in Subjects With Advanced Hematologic Malignancies

Terminated
1
42
US
FT538, Cyclophosphamide, Fludarabine, Daratumumab, Darzalex, Elotuzumab, Empliciti
Fate Therapeutics
Acute Myeloid Leukemia, AML, Adult, Multiple Myeloma, Myeloma
07/23
08/23
ALL 001, NCT03962465: Phase I Study of Inotuzumab With Augmented BFM Re-Induction for Patients With Relapsed/Refractory B-cell ALL

Active, not recruiting
1
36
US
Inotuzumab ozogamicin, Besponsa, Prednisone Pill, Deltasone, Daunorubicin, Cerubidine, daunomycin, rubidomycin, Vincristine, Oncovin, Vincasar, Leurocristine, Cytarabine, Ara-C, Cytosar-U, Methotrexate, Otrexup, Rasuvo, Rheumatrex, Trexall, MTX, Amethopterin, Pegaspargase, Oncospar
University of Virginia, Pfizer, Vanderbilt University, University of Wisconsin, Madison, Virginia Commonwealth University
B-cell Acute Lymphoblastic Leukemia
07/23
07/26
NCT03654716: Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer

Completed
1
21
US
ALRN-6924, Cytarabine, Cytosar
Dana-Farber Cancer Institute, TeamConnor Childhood Cancer Foundation, Cookies for Kids' Cancer, Aileron Therapeutics, Inc.
Leukemia, Brain Tumor, Solid Tumor, Lymphoma
07/23
07/23
NCT04402541: Study of CB-5339 in Acute Myeloid Leukemia or Myelodysplastic Syndrome

Completed
1
55
US, RoW
CB-5339, CB-5339 Tosylate
Cleave Therapeutics, Inc.
Acute Myeloid Leukemia, in Relapse, Myelodysplastic Syndromes
07/23
07/23
NCT03064269: CAR-T Therapy for Central Nervous System B-cell Acute Lymphocytic Leukemia

Recruiting
1
10
RoW
CD19 CAR-T cells
Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd, The First Affiliated Hospital of Soochow University
B-cell Acute Lymphocytic Leukemia
12/24
12/25
NCT03422393: Venetoclax With High-dose Ibrutinib for CLL Progressing on Single Agent Ibrutinib

Active, not recruiting
1
24
US
Venetoclax, Venclexta, Ibrutinib, Imbruvica
Michael Choi, Pharmacyclics LLC.
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
08/23
08/28
NCT05225831: Safety and Efficacy of CD19/CD22 Dual Targeted CAR-T Cell Therapy in R/R B-Cell Acute Lymphoblastic Leukemia

Recruiting
1
100
RoW
Autologous CD19/CD22 Chimeric Antigen Receptor T-cells, SL19+22 CAR-T, Cyclophosphamide,Fludarabine
Hebei Senlang Biotechnology Inc., Ltd., Hebei Yanda Ludaopei Hospital
CD19+ and CD 22+ B-ALL
08/23
11/23
NCT04100187: Immunotherapy With CD19 CAR T-cells for B-Cell Leukemia

Not yet recruiting
1
100
NA
Anti-CD19-CAR
Kecellitics Biotech Company Ltd, Hebei Yanda Ludaopei Hospital
Leukemia
08/23
08/24
NCT04532268: A Study of Humanized CD19 CAR-T Cells Therapy for Patients With Relapsed and/or Refractory B-cell ALL and B-cell NHL

Recruiting
1
72
RoW
Humanized CD19 CAR-T cells, Humanized CD19 CAR-T cells injection
Zhejiang University, Yake Biotechnology Ltd.
Acute Lymphoblastic Leukemia, Non-hodgkin Lymphoma,B Cell
08/23
08/26
NCT04980404: Inqovi Maintenance Therapy in Myeloid Neoplasms

Recruiting
1
22
US
Inqovi, decitabine, cedazuridine
Massachusetts General Hospital, Taiho Oncology, Inc.
Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, Stem Cell Leukemia
08/23
08/24
NCT04806659: A Phase 1 Study of SH1573 Capsules in Subjects With Refractory or Relapsed Acute Myelogenous Leukemia

Recruiting
1
41
RoW
SH1573 Capsules
Nanjing Sanhome Pharmaceutical, Co., Ltd.
Acute Myelogenous Leukemia
08/23
12/23
BISECT, NCT05456269: A Study of Bisantrene Combined With Cytarabine or With Decitabine for Adult Subjects With Extramedullary AML and MDS

Withdrawn
1
60
RoW
Bisantrene Dihydrochloride (high dose), RC110, Zantrene®, Xantrene®, Bisantrene Dihydrochloride (low dose), Cytarabine Hydrochloride, Ara-C, Cytarabine arabinoside, Cytosar-U®, Decitabine and cedazuridine, ASTX727
Race Oncology Ltd, Astex Pharmaceuticals, Inc.
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia, Higher Risk Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia
08/23
08/23
waveLINE-001, NCT03833180: A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)

Completed
1
91
US
Zilovertamab vedotin, VLS-101, MK-2140
VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Marginal Zone Lymphoma, Diffuse Large B-cell Lymphoma, Richter Transformation Lymphoma, Burkitt Lymphoma, Lymphoplasmacytoid Lymphoma, T-cell Non-Hodgkin Lymphoma, Acute Lymphoid Leukemia, Acute Myeloid Leukemia, Waldenstrom Macroglobulinemia
12/23
12/23
NCT03571321: Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia

Recruiting
1
15
US
Ruxolitinib, Jakafi, Cyclophosphamide, Cytarabine, Mercaptopurine, Vincristine, Pegaspargase, Rituximab, Methotrexate (Intrathecal Administration), Methotrexate (Intravenous Administration), Dexamethasone, Doxorubicin, Thioguanine, Methotrexate Oral Product
University of Chicago, Incyte Corporation
Acute Lymphoblastic Leukemia, ALL, Childhood, ALL
09/26
09/27
NCT05426798: Clinical Study of TQB2618 Injection in Combination With Demethylation Drugs in Patients With Recurrent/Refractory Acute Myeloid Leukemia, Myelodysplastic Syndromes

Recruiting
1
73
RoW
TQB2618 injection azacitidine, AZA decitabine, DAC
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Recurrent/Refractory Acute Myeloid Leukemia, Myelodysplastic Syndromes
09/23
12/23
NCT05144334: A Study of BTX-1188 in Subjects With Advanced Malignancies

Terminated
1
8
US
BTX-1188
BioTheryX, Inc.
Advanced Solid Tumor, Non Hodgkin Lymphoma, Acute Myeloid Leukemia
09/23
09/23
NCT03720366: A Study of Perpetrator Drug Interactions of Enasidenib in AML Patients

Completed
1
40
RoW
enasidenib, CC-90007, AG-221, Arm 1 probes, Arm 2 Probes, Arm 3 probes
Celgene
Leukemia, Myeloid, Acute
09/23
12/23
NCT05731219: UTAA06 Injection in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia

Recruiting
1
18
RoW
B7-H3 target, CAR gene modified gdT cell injection, UTAA06 injection
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Relapsed/Refractory Acute Myeloid Leukemia
09/23
09/25
NCT04245722: FT596 as a Monotherapy and in Combination With Anti-CD20 Monoclonal Antibodies

Terminated
1
98
US
FT596, Cyclophosphamide, Fludarabine, Rituximab, Rituxan, Truxima, Ruxience, Obinutuzumab, Gazyva, Bendamustine, Bendeka, Treanda
Fate Therapeutics
Lymphoma, B-Cell, Chronic Lymphocytic Leukemia
09/23
09/23
NCT02957032: A Study of the Tumor-targeting Human F16IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Very Low-dose Cytarabine in Patients With AML Relapse After Allogeneic Hematopoietic Stem Cell Transplantation

Terminated
1
30
Europe
F16IL2, cytarabine
Philogen S.p.A.
Acute Myeloid Leukemia, Relapsed, Adult
09/23
09/23
NCT03893682: A Study of CG-806 in Patients With Relapsed or Refractory CLL/SLL or Non-Hodgkin's Lymphomas

Active, not recruiting
1
160
US
CG-806, Luxeptinib
Aptose Biosciences Inc.
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Non-Hodgkin's Lymphoma
02/24
12/24
NCT04070768: Study of the Safety and Efficacy of Gemtuzumab Ozogamicin (GO) and Venetoclax in Patients With Relapsed or Refractory CD33+ Acute Myeloid Leukemia:Big Ten Cancer Research Consortium BTCRC-AML17-113

Active, not recruiting
1
18
US
Gemtuzumab Ozogamicin, GO, Venetoclax
John Quigley, Pfizer, AbbVie
Acute Myeloid Leukemia
10/23
10/24
NCT04477291: A Study of CG-806 in Patients With Relapsed or Refractory AML or Higher-Risk MDS

Active, not recruiting
1
80
US
CG-806
Aptose Biosciences Inc.
Acute Myeloid Leukemia, Myelodysplastic Syndromes
02/24
12/24
NCT05961696: A Phase I Study of Mosunetuzumab for Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

Withdrawn
1
22
US
Mosunetuzumab, RO7030816
M.D. Anderson Cancer Center, Genentech, Inc.
Refractory B-cell Acute Lymphoblastic Leukemia
10/23
10/23
NCT05712278: A Study to Investigate Use of Off-the-shelf Natural Killer (NK) Cells (SAR445419) in Relapsed/Refractory Acute Myeloid Leukemia

Terminated
1
7
US
SAR445419, fludarabine, fludara, cytarabine, cytosar-U
Sanofi
Acute Myeloid Leukaemia
02/24
03/24
NCT04336982: A Safety and Efficacy Study of CC-90009 Combinations in Subjects With Acute Myeloid Leukemia

Terminated
1
22
Europe, Canada, US
CC-90009, Venetoclax, Azacitidine, Gilteritinib
Celgene, AbbVie
Leukemia, Myeloid, Acute
10/23
04/24
NCT03760523: Dose Escalation Study of Minnelide in Relapsed or Refractory Acute Myeloid Leukemia

Terminated
1
27
US
Minnelide
H. Lee Moffitt Cancer Center and Research Institute, Minneamrita Therapeutics LLC
Acute Myeloid Leukemia
10/23
10/23
JSP-CP-003, NCT04429191: JSP191 Antibody Conditioning Regimen in MDS/AML Subjects Undergoing Allogenic Hematopoietic Stem Cell Transplantation

Recruiting
1
40
US
Humanized anti-CD117 Monoclonal Antibody (JSP191), JSP191
Jasper Therapeutics, Inc.
MYELODYSPLASTIC SYNDROME; MDS, ACUTE MYELOID LEUKEMIA; AML
10/23
12/23
NCT04473911: Haplo Peripheral Blood Sct In GVHD Prevention

Active, not recruiting
1
25
US
FLUDARABINE, Fludara®, CYCLOPHOSPHAMIDE, Cytoxan®, Neosar®, TBI, Melphalan, Alkeran®, L-PAM, L-Sarcolysin, Phenylalanine Mustard, Sirolimus, Rapamune, Mycophenolate mofetil, CellCept, Myfortic, RGI-2001
Zachariah Michael DeFilipp, Regimmune Corporation
GVHD, AML, ALL, MDS, MPN, CMML, Hodgkin Lymphoma, Non Hodgkin Lymphoma, Blood Stem Cell Transplant Failure, Graft Vs Host Disease, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, Myeloproliferative Disorder, Chronic Myelomonocytic Leukemia, Chemosensitive Hodgkin Lymphoma
10/23
10/24
FT516-101, NCT04023071: FT516 in Subjects With Advanced Hematologic Malignancies

Terminated
1
72
US
FT516, Rituximab, Rituxan, MabThera, Obinutuzumab, Gazyva, Cyclophosphamide, Fludarabine, IL-2, Bendamustine, Bendeka, Treanda
Fate Therapeutics
Acute Myelogenous Leukemia, B-cell Lymphoma
10/23
10/23
NCT03900598: A Study of JNJ-67856633 in Participants With Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

Active, not recruiting
1
226
Europe, Japan, US, RoW
JNJ-67856633
Janssen Research & Development, LLC
Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Non-Hodgkin
12/24
01/26
NCT04540796: A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

Active, not recruiting
1
147
Europe, US, RoW
JNJ-75348780
Janssen Research & Development, LLC
Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell
04/25
05/25
NCT04628338: IFN-γ to Treat Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) That Has Relapsed After Allogeneic Hematopoietic Stem Cell Transplantation

Completed
1
8
US
IFN-γ (interferon gamma-1b) injection, ACTIMMUNE®
Sawa Ito, MD, Horizon Pharma USA, Inc.
Myelodysplastic Syndromes, Myeloid Leukemia, Allogeneic Stem Cell Transplantation
10/23
10/23
NCT05727683: CD19-targeted CAR T Cells for Patients With Relapsed or Refractory in B-cell Acute Lymphoblastic Leukemia

Recruiting
1
33
RoW
CD19-targeted Chimeric Antigen Receptor (CAR) T Cells, Fludarabine, Cyclophosphamide
Shanghai Ming Ju Biotechnology Co., Ltd.
Acute Lymphocytic Leukemia
10/23
07/25
NCT03595917: ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML

Recruiting
1
40
US
ABL001, Dasatinib, Sprycel, Prednisone, Blinatumomab
Marlise Luskin, MD, Novartis
B-cell Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia (CML) in Lymphoid Blast Crisis, Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Ph+ ALL
11/25
11/26
NCT04532281: A Study of Murine CD19 CAR-T Therapy for Patients With Relapsed or Refractory CD19+ B-cell Hematological Malignancies

Recruiting
1
120
RoW
Murine CD19 CAR-T cells, Murine CD19 CAR-T cells injection
Zhejiang University, Yake Biotechnology Ltd.
Acute Lymphoblastic Leukemia, Non-Hodgkin Lymphoma of Soft Tissue
11/23
11/26
NCT04603872: CAR-T Cells Combined With Dasatinib for Patients With Relapsed and/or Refractory B-cell Hematological Malignancies

Recruiting
1
120
RoW
CD19/BCMA Targeted CAR T-cells and dasatinib, Administration of CD19/BCMA Targeted CAR T-cells and dasatinib, CD19/BCMA Targeted CAR T-cells, CD19/BCMA Targeted CAR T-cells infusion
Zhejiang University, Yake Biotechnology Ltd.
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory, Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphocytic Leukaemia Refractory, Non-Hodgkin's Lymphoma, Relapsed, Non-Hodgkin's Lymphoma Refractory
11/23
11/26
NCT04876092: A Study of the MALT1 Inhibitor JNJ-67856633 and Ibrutinib in Combination in B-cell NHL and CLL

Active, not recruiting
1
45
Europe
JNJ-67856633, Ibrutinib, JNJ-54179060
Janssen Research & Development, LLC
Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Non-Hodgkin
11/24
11/24
NCT04599543: IL3 CAR-T Cell Therapy for Patients With CD123 Positive Relapsed and/or Refractory Acute Myeloid Leukemia

Not yet recruiting
1
36
RoW
IL3 CAR T-cells, IL3 CAR-T cells injection
Zhejiang University, Yake Biotechnology Ltd.
Acute Myeloid Leukemia
11/23
11/26
NCT04609241: CD79b CAR-T Cell Therapy for Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia and B-cell Non-Hodgkin's Lymphoma

Not yet recruiting
1
72
RoW
CD79b CAR-T Cells
Zhejiang University, Yake Biotechnology Ltd.
Relapsed and/or Refractory Acute Lymphoblastic Leukemia, Relapsed and/or Refractory B-cell Non-Hodgkin's Lymphoma
11/23
11/26
AUTO1-PY1, NCT06173518: A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)

Recruiting
1
24
Europe, US
AUTO1, Obecabtagene autoleucel (obe-cel)
Autolus Limited
Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia, Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
11/27
11/27
CD5CAR-T, NCT04594135: Anti-CD5 CAR T Cells for Relapsed/Refractory T Cell Malignancies

Recruiting
1
20
RoW
anti-CD5 CAR T cells
iCell Gene Therapeutics, iCAR Bio, Peking University Shenzhen Hospital
T-cell Acute Lymphoblastic Leukemia, T-cell Non-Hodgkin Lymphoma
11/23
11/23
NCT00819546: RAD001 in Combination With PKC412 in Patients With Relapsed, Refractory or Poor Prognosis AML or MDS

Checkmark P1 data - ASH 2012
Nov 2012 - Nov 2012: P1 data - ASH 2012
Active, not recruiting
1
29
US
RAD001, everolimus, PKC412, midostaurin
Richard Stone, MD, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Brigham and Women's Hospital, Novartis
Acute Myeloid Leukemia, Myelodysplastic Syndrome
12/25
12/25
NCT03063944: STAT Inhibitor OPB-111077, Decitabine and Venetoclax in Treating Patients With Acute Myeloid Leukemia That Is Refractory, Relapsed or Newly Diagnosed and Ineligible for Intensive Chemotherapy

Completed
1
37
US
STAT Inhibitor OPB-111077, OPB-111077, Decitabine, 2'-Deoxy-5-azacytidine, 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one, 2353-33-5, 5-Aza-2'-deoxycytidine, 5-Aza-2'deoxycytidine, 5-Aza-2-deoxycytidine, 5-Azadeoxycytidine, Dacogen, Decitabine for Injection, Deoxyazacytidine, Dezocitidine, Venetoclax, 1257044-40-8, 4-(4-((2-(4-Chlorophenyl)-4, 4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2,3-b)pyridin-5-yloxy)benzamide, ABT-0199, ABT-199, ABT199, GDC-0199, RG7601, Venclexta, Venclyxto, Laboratory Biomarker Analysis
Sidney Kimmel Cancer Center at Thomas Jefferson University, Otsuka America Pharmaceutical
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
01/24
03/24
NCT03740334: Ribociclib in Combination With Everolimus and Dexamethasone in Relapsed ALL

Active, not recruiting
1
45
US
Ribociclib, LEE011, Dexamethasone, Everolimus, Zortress
Dana-Farber Cancer Institute, Novartis
Acute Lymphoblastic Leukemia ALL
03/23
09/24
PBCAR0191-01, NCT03666000: Dose-escalation, Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Patients With r/r NHL and r/r B-cell ALL

Recruiting
1
129
US
Azer-cel, Allogeneic Anti-CD19 CAR T cells, PBCAR0191, Fludarabine, Cyclophosphamide, IL-2, Bendamustine
Imugene Limited
Non-Hodgkin Lymphoma, B-cell Acute Lymphoblastic Leukemia
03/26
03/28
NCT03955783: Venetoclax and Selinexor in Treating Patients With Relapsed or Refractory High Risk Hematologic Malignancies

Active, not recruiting
1
78
US
Venetoclax, Selinexor
Sanjay Mohan, Karyopharm Therapeutics Inc, AbbVie
Diffuse Large B-cell Lymphoma, Acute Myeloid Leukemia, Non-Hodgkin's Lymphoma
09/24
12/24
NCT03940352: HDM201 in Combination With MBG453 or Venetoclax in Patients With Acute Myeloid Leukemia (AML) or High-risk Myelodysplastic Syndrome (MDS)

Active, not recruiting
1
52
Europe, US, RoW
HDM201, MBG453, Venetoclax
Novartis Pharmaceuticals
Acute Myeloid Leukemia (AML), High-risk Myelodysplastic Syndrome (MDS)
06/24
06/24
NCT04034446: CD19-CD22 Chimeric Antigen Receptor T (CAR-T) Cell for Treatment of B Cell Acute Lymphoblastic Leukemia (B-ALL)

Active, not recruiting
1
2
RoW
CD19-CD22 CAR-T cells
Institute of Hematology & Blood Diseases Hospital, Juventas Cell Therapy Ltd.
Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia
12/23
12/23
BR-101801-CT-101, NCT04018248: BR101801 in Adult Patients With Advanced Hematologic Malignancies( Phase I)

Active, not recruiting
1
30
US, RoW
BR101801 (Phase Ia), BR101801 (Phase Ib)
Boryung Pharmaceutical Co., Ltd
Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, B Cell Lymphoma, Marginal Zone Lymphoma, Waldenstrom Macroglobulinemia, Peripheral T Cell Lymphoma
09/23
03/24
LP-108-I-01, NCT04356846: A Phase I Study of LP-108 in Patients With Relapsed or Refractory B-cell Lymphoma

Recruiting
1
74
RoW
LP-108 tablet
The First Affiliated Hospital with Nanjing Medical University, Guangzhou Lupeng Pharmaceutical Company LTD., Newave Pharmaceutical Inc
Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia
12/23
12/23
IO-202-CL-001, NCT04372433: IO-202 as Monotherapy and IO-202 Plus Azacitidine ± Venetoclax in Patients in AML and CMML

Recruiting
1
106
US
IO-202, IO-202 and Azacitidine, IO-202 and AZA, IO-202 and Azacitidine + Venetoclax, IO-202 and AZA + Ven
Immune-Onc Therapeutics, California Institute for Regenerative Medicine (CIRM)
AML With Monocytic Differentiation, CMML
01/26
01/27
NVG111-101, NCT04763083 / 2020-000820-20: First in Human Study of NVG-111 in Relapsed/Refractory ROR1+ Malignancies

Recruiting
1
90
Europe
NVG-111
NovalGen Ltd.
Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B Cell Lymphoma, Non-small Cell Lung Cancer (NSCLC), Malignant Melanoma
12/23
12/25
NKX019-101, NCT05020678: NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers

Recruiting
1
150
US, RoW
NKX019
Nkarta Inc.
Lymphoma, Non-Hodgkin, B-cell Acute Lymphoblastic Leukemia, Large B-cell Lymphoma, Mantle Cell Lymphoma, Indolent Lymphoma, Waldenstrom Macroglobulinemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Aggressive Lymphoma, Large-cell Lymphoma
08/24
12/38
ANCHOR2, NCT05487651: Allogeneic NK T-Cells Expressing CD19 Specific CAR in B-Cell Malignancies

Recruiting
1
36
US
KUR-502, CD19.CAR-aNKT cells
Athenex, Inc.
NHL, Relapsed, Adult, B-cell Lymphoma, B-cell Leukemia, DLBCL - Diffuse Large B Cell Lymphoma, ALL, Adult B Cell, ALL, Childhood, CLL/SLL
12/23
12/24
CARDINAL, NCT06163430: - A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia

Not yet recruiting
1
80
US
TERN-701
Terns, Inc.
Chronic Myeloid Leukemia, Chronic Phase, Chronic Myeloid Leukemia
11/25
05/26
NCI-2014-01147, NCT02159495: Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

Hourglass Jul 2021 - Dec 2021 : Updated data for r/r AML and r/r BPDCN
Checkmark In CD123+ r/r AML and persistent/recurrent BPDCN at ASH 2018
Nov 2018 - Nov 2018: In CD123+ r/r AML and persistent/recurrent BPDCN at ASH 2018
Active, not recruiting
1
31
US
cyclophosphamide, CPM, CTX, Cytoxan, Endoxan, Endoxana, Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes, CD123R(EQ)28zeta/EGFRt+ T cells, Anti CD123-CAR/CD28-costimulatory Lentiviral Vector-transduced Autologous T Lymphocytes, laboratory biomarker analysis, Allogeneic CD123CAR-CD28-CD3zeta-EGFRt-expressing T-lymphocytes, Allogeneic CD123R(EQ)28zeta/EGFRt+ T Cells, Fludarabine Phosphate, 2-F-ara-AMP, 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, Beneflur, Fludara, Oforta, SH T 586
City of Hope Medical Center, National Cancer Institute (NCI), Mustang Bio, Inc.
Adult Acute Myeloid Leukemia in Remission, Acute Biphenotypic Leukemia, Early Relapse of Acute Myeloid Leukemia, Late Relapse of Acute Myeloid Leukemia, Recurrent Adult Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia, Blastic Plasmacytoid Dendritic Cell Neoplasm, Acute Myeloid Leukemia, Adult Acute Lymphoblastic Leukemia, Interleukin-3 Receptor Subunit Alpha Positive, Minimal Residual Disease, Refractory Acute Myeloid Leukemia, Untreated Adult Acute Myeloid Leukemia
12/24
12/24
NCT02675452: AMG 176 First in Human Trial in Participants With Relapsed or Refractory Multiple Myeloma and Participants With Relapsed or Refractory Acute Myeloid Leukemia

Active, not recruiting
1
142
Europe, Canada, Japan, US, RoW
AMG 176, Study Investigational Product (IP), Azacitidine, Itraconazole
Amgen
Relapsed or Refractory Multiple Myeloma, Relapsed or Refractory Acute Myeloid Leukemia
06/24
06/24
NCT04702425: VOB560-MIK665 Combination First in Human Trial in Patients With Hematological Malignancies (Relapsed/Refractory Non-Hodgkin Lymphoma, Relapsed/Refractory Acute Myeloid Leukemia, or Relapsed/Refractory Multiple Myeloma)

Active, not recruiting
1
37
Europe, Japan, US, RoW
VOB560, S65487, MIK665, S64315
Novartis Pharmaceuticals
Non-Hodgkin Lymphoma (NHL), Acute Myeloid Leukemia (AML), Multiple Myeloma (MM)
07/24
07/24
NCT05722171: Clinical Study of UTAA06 Injection in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia

Recruiting
1
10
RoW
gdT cell injection targeting B7-H3 chimeric antigen receptor, UTAA06 injection
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Relapsed/Refractory Acute Myeloid Leukemia
12/23
12/24
NCT04609826: A Study of JNJ-74856665 in Participants With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

Active, not recruiting
1
153
Europe, RoW
JNJ-74856665, AZA, VEN
Janssen Research & Development, LLC
Acute Myeloid Leukemia, Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia
07/24
07/24
RIVER-51, NCT04021368: RVU120 in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Syndrome

Active, not recruiting
1
112
Europe, US
RVU120(SEL120)
Ryvu Therapeutics SA
Acute Myeloid Leukemia, High-risk Myelodysplastic Syndrome
12/24
12/24
APG-2575-CN-001, NCT03913949: A Study to Evaluate the Safety,PK and PD of APG-2575 in Patients With Hematologic Malignancies

Active, not recruiting
1
74
RoW
APG-2575
Ascentage Pharma Group Inc., Suzhou Yasheng Pharmaceutical Co., Ltd.
Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma
12/24
12/25
NCI-2019-03272, NCT03874052: Ruxolitinib and Venetoclax in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Active, not recruiting
1
31
US
Ruxolitinib, INCB-18424, INCB18424, Jakafi, Oral JAK Inhibitor INCB18424, Venetoclax, ABT-0199, ABT-199, ABT199, GDC-0199, RG7601, Venclexta, Venclyxto
Brian Druker, AbbVie, Incyte Corporation, Oregon Health and Science University
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
12/24
12/24
NCT04220684: Trial Testing Safety of IL-21 NK Cells for Induction of R/R AML

Recruiting
1
21
US
Cytarabine Hydrochloride, Ara-C HCl, Arabinosylcytosine Hydrochloride, Aracytidine Hydrochloride, CHX-3311, Cytosar Hydrochloride, Cytosine Arabinosine Hydrochloride, U-19920A, Fludarabine, Fluradosa, Membrane-bound Interleukin-21-Expanded Haploidentical Natural Killer Cells, (mbIL21)-expanded Haploidentical NK Cells, Donor mbIL21-expanded NK Cells, mbIL21-expanded Haploidentical NK Cells
Sumithira Vasu, Kiadis Pharma
Allogeneic Stem Cell Transplant Recipient, Blasts 10 Percent or More of Bone Marrow Nucleated Cells, Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
12/24
12/24
NCT05471323: Phase I Clinical Trial of RC1012 Injection in Patients With r/r AML

Recruiting
1
36
RoW
RC1012 injection (allo-DNT cells)
Guangdong Ruishun Biotech Co., Ltd, First Affiliated Hospital of Zhejiang University
Acute Myeloid Leukemia
12/23
12/24
NCT05434312: TGRX-678 Chinese Phase I in Chronic Myelogenous Leukemia (CML) Patients

Recruiting
1
90
RoW
TGRX-678
Shenzhen TargetRx, Inc., Peking University People's Hospital
Chronic Myelogenous Leukemia
12/24
06/25
NCT04825496: Clinical Study of ssCART-19 Cells in Patients With CD19 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia

Recruiting
1
18
RoW
ssCART-19 Cells, Fludarabine, FA, Cyclophosphamide, CTX
Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd, The First Affiliated Hospital of Soochow University
Relapsed or Refractory Acute Lymphoblastic Leukemia
12/23
12/24
NCT01976520: Vaccine Therapy for Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL)

Active, not recruiting
1
30
US
Oncoquest-CLL vaccine, ATCE Vaccine, ATCEV, Autologous Tumor Vaccine, Oncoquest-CLL
XEME Biopharma Inc., National Cancer Institute (NCI)
Chronic Lymphocytic Leukemia (CLL)
01/24
01/24
NCT03709758: Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve AML

Recruiting
1
64
US
Venetoclax, Venclexta, Daunorubicin, Cerubidine, Cytarabine, Cytosar-U
Dana-Farber Cancer Institute, AbbVie, Genentech, Inc.
Acute Myeloid Leukemia
07/24
06/25
NCT03533816: Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide

Recruiting
1
38
US
EAGD T-cell infusion (Phase I), CliniMACS-Prodigy, CliniMACS Alpha Beta T-Cell Depletion System, EAGD T-cell infusion (Expansion)
University of Kansas Medical Center, In8bio Inc.
Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes
01/24
01/25
NCT04789408: Study of KITE-222 in Participants With Relapsed/Refractory Acute Myeloid Leukemia

Terminated
1
15
Europe, US
Cyclophosphamide, Fludarabine, KITE-222
Kite, A Gilead Company
Acute Myeloid Leukemia
05/24
05/24
NCT04996030: A Study for Oral SY-2101 for Participants With Acute Promyelocytic Leukemia

Suspended
1
16
US
SY-2101, Oral ATO, Oral Arsenic Trioxide, Arsenic Trioxide, IV ATO, Trisenox®, IV Arsenic Trioxide
Syros Pharmaceuticals
Acute Promyelocytic Leukemia
01/24
04/24
COVALENT-101, NCT05153330: Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL

Recruiting
1
177
Europe, US
BMF-219, Covalent Menin Inhibitor
Biomea Fusion Inc.
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Acute Mixed-Phenotype Leukemia, Cancer, Refractory, Progression, Diffuse Large B Cell Lymphoma, Multiple Myeloma, Lymphoma, Lymphoma, Non-Hodgkin, Myeloma, Plasma-Cell, Myelomatosis, Plasma Cell Myeloma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
12/24
03/25
NCT06146257: A Study of GLB-001 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher Risk Myelodysplastic Syndromes

Recruiting
1
48
US
GLB-001, GLB-C183-A-2
GluBio Therapeutics Inc.
Acute Myeloid Leukemia, Myelodysplastic Syndromes
10/25
10/26
NCT04658004: NKG2D CAR-T Cell Therapy for Patients With Relapsed and/or Refractory Acute Myeloid Leukemia

Not yet recruiting
1
36
RoW
NKG2D CAR T-cells, NKG2D CAR-T cells injection
Zhejiang University, Yake Biotechnology Ltd.
Acute Myeloid Leukemia
01/24
01/27
NCT04662294: CD 70 CAR T for Patients With CD70 Positive Malignant Hematologic Diseases

Recruiting
1
108
RoW
CD70 CAR T-cells, CD70 CAR-T cells injection
Zhejiang University, Yake Biotechnology Ltd.
Acute Myeloid Leukemia, Non-hodgkin's Lymphoma, Multiple Myeloma
01/24
01/27
NCT06209671: INS19 CAR-T Cells for the Treatment of Relapsed or Refractory Acute B Lymphoblastic Leukemia

Not yet recruiting
1
12
NA
INS19 CAR-T Cells
Beijing Immunochina Medical Science & Technology Co., Ltd., Peking University People's Hospital
Leukemia, B-cell
01/25
01/26
NCT05226468: An Early Phase Study of NEI-01 in Patients With Solid Tumors or Acute Myeloid Leukemia

Active, not recruiting
1
24
RoW
NEI-01
New Epsilon Innovation Limited
Advanced Solid Tumor, Relapsed AML, Refractory AML
01/24
07/24
FRIDA, NCT05546580: Study of Iadademstat and Gilteritinib in Patients With R/R AML With FMS-like Tyrosine Kinase Mutation (FLT3 Mut+)

Checkmark First-patient-in of FRIDA trial in combination with gilteritinib for r/r AML
Nov 2022 - Nov 2022: First-patient-in of FRIDA trial in combination with gilteritinib for r/r AML
Recruiting
1
50
US
Iadademstat, ORY-1001, RO7051790, Gilteritinib Oral Tablet, XOSPATA®
Oryzon Genomics S.A.
Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory
01/25
07/25
HY-XY0206-Ⅰ-02, NCT04471064: A Study of XY0206 Tablets in Patients With Relapsed / Refractory Acute Myeloid Leukemia

Recruiting
1
60
RoW
XY0206
Shijiazhuang Yiling Pharmaceutical Co. Ltd, Proswell Medical Corporation
Acute Myeloid Leukemia
02/24
02/24
 

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