| midomafetamine (MDMA) / Multidisciplinary Association for Psychedelic Studies (MAPS) |
NCT06189027: Epigenetics and MDMA-Assisted Psychotherapy for PTSD |
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| Active, not recruiting | 3 | 45 | US | MDMA, Psychotherapy | University of Southern California, Multidisciplinary Association for Psychedelic Studies | PTSD | 11/23 | 12/24 | | |
| Completed | 3 | 85 | Canada, US, RoW | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA | Lykos Therapeutics | PTSD | 11/23 | 11/23 | | |
ACTRN12619001334190: Effect of 3, 4-Methylenedioxymethamphetamine (MDMA)-assisted therapy on Mood and Anxiety symptoms in patients with advanced-stage Cancer Study (EMMAC Study) |
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| Recruiting | 2 | 32 | | | University of Otago, University of Otago, Individual donor, Multidisciplinary Association for Psychedelic Studies (MAPS), Individual donor, Multidisciplinary Association for Psychedelic Studies (MAPS) | Depression symptoms, Anxiety symptoms, Advanced-stage cancer | | | | |
ACTRN12623000971639: MDMA-assisted therapy for Post-Traumatic Stress Disorder in Military Veterans and First Responders |
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| Recruiting | 2 | 24 | | | Monash University, Monash University, Philanthropic - private, Multidisciplinary Association for Psychedelic Studies | Post-Traumatic Stress Disorder | | | | |
| Completed | 2 | 21 | Europe, RoW | MDMA, 3,4-methylenedioxymethamphetamine | MAPS Europe B.V., Multidisciplinary Association for Psychedelic Studies | PTSD | 12/23 | 12/23 | | |
| Recruiting | 2 | 10 | US | 3,4-methylenedioxymethamphetamine, MDMA | VA Loma Linda Health Care System, Multidisciplinary Association for Psychedelic Studies | Post Traumatic Stress Disorder, Combat Stress Disorders | 12/24 | 04/25 | | |
NCT05067244: A Phase 2 Open-Label Treatment Development Study of MDMA-Assisted Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder (PTSD) |
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| Active, not recruiting | 2 | 10 | Canada | MDMA | Remedy, Multidisciplinary Association for Psychedelic Studies | Post Traumatic Stress Disorder | 06/24 | 06/24 | | |
| Active, not recruiting | 2 | 90 | US | MDMA, 3,4-Methylenedioxymethamphetamine, Psychotherapy | Jason B Luoma, Oregon Research Institute Center for Evaluation Services, Multidisciplinary Association for Psychedelic Studies, Portland Psychotherapy Clinic, Research, and Training Center | Social Anxiety Disorder | 08/25 | 08/25 | | |
MPG1, NCT05173831: Study of Feasibility and Safety of MDMA-Assisted Group Therapy for the Treatment of PTSD in Veterans |
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| Withdrawn | 2 | 18 | NA | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Therapy | Lykos Therapeutics | PTSD | 12/24 | 12/24 | | |
NCT05219175: MDMA for Co-occurring PTSD and OUD After Childbirth |
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| Active, not recruiting | 2 | 15 | US | MDMA Assisted Therapy | University of New Mexico, Multidisciplinary Association for Psychedelic Studies | Stress Disorders, Post-Traumatic, Opioid Use Disorder | 04/25 | 11/25 | | |
MPVA6, NCT04784143: Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSD |
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| Active, not recruiting | 2 | 26 | US | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Psychotherapy | Lykos Therapeutics | PTSD | 07/25 | 07/25 | | |
| Not yet recruiting | 2 | 36 | NA | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Non-directive therapy, Manualized MDMA-assisted therapy, Therapy | Lykos Therapeutics | Anorexia Nervosa Restricting Type, Binge-Eating Disorder | 08/28 | 08/28 | | |
NCT03606538: MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function |
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| Not yet recruiting | 1 | 16 | US | Midomafetamine, MDMA, 3,4-methylenedioxymethamphetamine | Lykos Therapeutics | Pharmacokinetics, Hepatic Impairment | 12/28 | 12/28 | | |
NCT04073433: Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers (MT-2) |
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| Not yet recruiting | 1 | 150 | NA | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Therapy | Lykos Therapeutics | Psychological Effects of Study Drug | 12/25 | 12/25 | | |
| Not yet recruiting | 1 | 20 | US | MDMA | Spaulding Rehabilitation Hospital, Multidisciplinary Association for Psychedelic Studies | Fibromyalgia | 03/26 | 12/26 | | |
EAMP1, NCT04438512: A Multi-site Expanded Access Program for MDMA-assisted Psychotherapy for Patients With Treatment-resistant PTSD |
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| No Longer Available | N/A | | US | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Psychotherapy | Lykos Therapeutics | Post Traumatic Stress Disorder | | | | |
| Enrolling by invitation | N/A | 400 | Canada, US, RoW | | Lykos Therapeutics | PTSD | 09/24 | 09/24 | | |
| Recruiting | N/A | 40 | US | MDMA, 3,4-Methyl enedioxy methamphetamine, ecstasy | Stanford University, National Institute on Drug Abuse (NIDA), Multidisciplinary Association for Psychedelic Studies (MAPS) | Healthy | 11/24 | 11/25 | | |