| midomafetamine (MDMA) / Multidisciplinary Association for Psychedelic Studies (MAPS) |
ACTRN12619001334190: Effect of 3, 4-Methylenedioxymethamphetamine (MDMA)-assisted therapy on Mood and Anxiety symptoms in patients with advanced-stage Cancer Study (EMMAC Study) |
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| Recruiting | 2 | 32 | | | University of Otago, University of Otago, Individual donor, Multidisciplinary Association for Psychedelic Studies (MAPS), Individual donor, Multidisciplinary Association for Psychedelic Studies (MAPS) | Depression symptoms, Anxiety symptoms, Advanced-stage cancer | | | | |
ACTRN12623000971639: MDMA-assisted therapy for Post-Traumatic Stress Disorder in Military Veterans and First Responders |
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| Recruiting | 2 | 24 | | | Monash University, Monash University, Philanthropic - private, Multidisciplinary Association for Psychedelic Studies | Post-Traumatic Stress Disorder | | | | |
NCT00090064: MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder |
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| Completed | 2 | 23 | US | Midomafetamine, MDMA, 3,4-methylenedioxymethamphetamine, Lactose placebo pill, Placebo, Therapy | Lykos Therapeutics | Posttraumatic Stress Disorder | 05/08 | 06/10 | | |
NCT00402298: Randomized Placebo-controlled Study of MDMA-assisted Therapy in People With PTSD - Israel |
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| Terminated | 2 | 5 | RoW | MDMA, midomafetamine, 3,4-methylenedioxymethamphetamine | Lykos Therapeutics | Posttraumatic Stress Disorder | 03/09 | 05/10 | | |
NCT00353938: Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder |
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| Completed | 2 | 14 | Europe | 3,4-methylenedioxymethamphetamine (125 mg), MDMA, 3,4-methyelendioxymethamphetamine (25 mg), Therapy | Lykos Therapeutics, Swiss Medical Association for Psycholytic Therapy | Posttraumatic Stress Disorder | 09/09 | 01/11 | | |
NCT01458327: Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial |
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| Completed | 2 | 3 | US | Midomafetamine, MDMA, 3,4-methylenedioxymethamphetamine, Therapy | Lykos Therapeutics | Posttraumatic Stress Disorder | 06/14 | 06/14 | | |
NCT01211405: Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress Disorder |
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| Completed | 2 | 26 | US | Low dose MDMA, MDMA, 3,4-methylenedioxymethamphetamine, midomafetamine, Medium dose MDMA, Full dose MDMA, Therapy | Lykos Therapeutics | Posttraumatic Stress Disorder | 06/15 | 08/16 | | |
NCT01958593: Randomized, Double-blind, Controlled of MDMA-assisted Psychotherapy in 12 Subjects With PTSD |
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| Terminated | 2 | 6 | Canada | Placebo, Inactive placebo, Midomafetamine, MDMA, 3,4-methylenedioxymethamphetamine, Psychotherapy | Lykos Therapeutics | Posttraumatic Stress Disorder | 09/15 | 10/16 | | |
NCT01793610: Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD |
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| Completed | 2 | 29 | US | Comparative-dose (40mg) MDMA, 3,4-methylenedioxymethamphetamine, midomafetamine, Active Dose 2 (100 mg) MDMA, Active Dose 1 (125 mg) MDMA, Psychotherapy, Manualized MDMA-assisted psychotherapy | Lykos Therapeutics | Posttraumatic Stress Disorder | 12/15 | 02/17 | | |
NCT01689740: Randomized, Double-blind, Active Placebo-Controlled Pilot Study of MDMA-assisted Psychotherapy in People With Chronic PTSD |
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| Completed | 2 | 10 | RoW | Active Placebo Dose MDMA (25 mg), 3,4-methylenedioxymethamphetamine, midomafetamine, MDMA, Full Dose MDMA (125 mg), Open Label Full Dose MDMA (125 mg), Psychotherapy, Manualized MDMA-assisted psychotherapy | Lykos Therapeutics | Posttraumatic Stress Disorder (PTSD) | 04/16 | 07/17 | | |
NCT02427568: MDMA-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening Illness |
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| Completed | 2 | 18 | US | MDMA (125 mg), 3,4-methylenedioxymethamphetamine, Midomafetamine, Placebo, Inactive placebo, Therapy | Lykos Therapeutics | Anxiety | 04/17 | 05/18 | | |
NCT02008396: Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic Adults |
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| Completed | 2 | 12 | US | Placebo, Inactive placebo, Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Therapy, Manualized therapy | Lykos Therapeutics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Social Anxiety in Autistic Adults | 04/17 | 04/17 | | |
NCT03485287: Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD (Canada) |
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| Completed | 2 | 4 | Canada | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Therapy | Lykos Therapeutics | Posttraumatic Stress Disorder | 06/19 | 06/19 | | |
NCT03282123: Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD |
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| Completed | 2 | 38 | US | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Therapy | Lykos Therapeutics | PTSD | 08/19 | 08/19 | | |
| Withdrawn | 2 | 0 | NA | 3,4-methylenedioxymethamphetamine, MDMA, midomafetamine | Lykos Therapeutics | Posttraumatic Stress Disorder | 08/23 | 08/23 | | |
| Completed | 2 | 21 | Europe, RoW | MDMA, 3,4-methylenedioxymethamphetamine | MAPS Europe B.V., Multidisciplinary Association for Psychedelic Studies | PTSD | 12/23 | 12/23 | | |
| Recruiting | 2 | 10 | US | 3,4-methylenedioxymethamphetamine, MDMA | VA Loma Linda Health Care System, Multidisciplinary Association for Psychedelic Studies | Post Traumatic Stress Disorder, Combat Stress Disorders | 12/24 | 04/25 | | |
NCT05067244: A Phase 2 Open-Label Treatment Development Study of MDMA-Assisted Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder (PTSD) |
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| Active, not recruiting | 2 | 10 | Canada | MDMA | Remedy, Multidisciplinary Association for Psychedelic Studies | Post Traumatic Stress Disorder | 06/24 | 06/24 | | |
| Active, not recruiting | 2 | 90 | US | MDMA, 3,4-Methylenedioxymethamphetamine, Psychotherapy | Jason B Luoma, Oregon Research Institute Center for Evaluation Services, Multidisciplinary Association for Psychedelic Studies, Portland Psychotherapy Clinic, Research, and Training Center | Social Anxiety Disorder | 08/25 | 08/25 | | |
MPG1, NCT05173831: Study of Feasibility and Safety of MDMA-Assisted Group Therapy for the Treatment of PTSD in Veterans |
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| Withdrawn | 2 | 18 | NA | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Therapy | Lykos Therapeutics | PTSD | 12/24 | 12/24 | | |
NCT05219175: MDMA for Co-occurring PTSD and OUD After Childbirth |
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| Active, not recruiting | 2 | 15 | US | MDMA Assisted Therapy | University of New Mexico, Multidisciplinary Association for Psychedelic Studies | Stress Disorders, Post-Traumatic, Opioid Use Disorder | 04/25 | 11/25 | | |
MPVA6, NCT04784143: Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSD |
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| Active, not recruiting | 2 | 26 | US | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Psychotherapy | Lykos Therapeutics | PTSD | 07/25 | 07/25 | | |
| Not yet recruiting | 2 | 36 | NA | Midomafetamine, 3,4-methylenedioxymethamphetamine, MDMA, Non-directive therapy, Manualized MDMA-assisted therapy, Therapy | Lykos Therapeutics | Anorexia Nervosa Restricting Type, Binge-Eating Disorder | 08/28 | 08/28 | | |
NCT02876172: MDMA-Assisted Cognitive-Behavioral Conjoint Therapy (CBCT) in Dyads in Which 1 Member Has Chronic PTSD |
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| Completed | 1/2 | 12 | US | MDMA, 3,4-Methylenedioxymethamphetamine, midomafetamine, CBCT, Cognitive behavioral conjoint therapy, Therapy | Lykos Therapeutics | Posttraumatic Stress Disorder | 12/17 | 05/18 | | |
