mexiletine / Generic mfg.  >>  Phase 2
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11 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
mexiletine / Generic mfg.
NCT00000793: A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection

Completed
2
240
US, RoW
Mexiletine hydrochloride, Benztropine mesylate, Amitriptyline hydrochloride
National Institute of Allergy and Infectious Diseases (NIAID), Boehringer Ingelheim
HIV Infections, Peripheral Nervous System Disease
 
10/97
NCT00001784: Mexiletine for the Treatment of Focal Dystonia

Completed
2
24
US
Mexiletine
National Institute of Neurological Disorders and Stroke (NINDS)
Blepharospasm, Dystonia, Spasm
 
07/02
NCT00383682: Efficacy of Opioids and Mexiletine for the Treatment of Postamputation Pain

Completed
2
60
US
morphine and mexiletine
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Amputation, Chronic Pain
 
04/03
2009-011184-36: A Phase II Randomised, Double-Blind, Placebo Controlled, Cross-Over Study to Investigate the Efficacy of Mexiletine in Patients with Non-Dystrophic Myotonia.

Completed
2
60
Europe
Capsule, hard, MEXITIL*20CPS 200MG
University College London-Joint UCLH/UCL Biomedical (R&D) Unit, Dept. of Neurology - Univ. of Kansas Medical Center
Non-Dystrophic Myotonia (NDM).Non-dystrophic myotonias are a group of rare neuromuscular disorders that cause episodes of muscle stiffness (known as myotonia) and paralysis. Predominantly the muscles of the face, hands and legs are affected. In addition to these episodes a permanent and debilitating muscle weakness can develop. The optimal treatment for these disorders is unknown., Diseases [C] - Nervous System Diseases [C10]
 
 
NCT00832000: Effectiveness of Mexiletine for Treating People With Non-Dystrophic Myotonia

Completed
2
59
US, Canada, Europe
Mexiletine, Placebo
Richard Barohn, MD
Myotonia, Non-Dystrophic Myotonia
03/11
03/11
NCT01849770: Mexiletine in Sporadic Amyotrophic Lateral Sclerosis (SALS)

Completed
2
75
US
Mexiletine, Mexitil, Placebo
University of Washington
Sporadic Amyotrophic Lateral Sclerosis
08/14
08/14
NCT02045667 / 2010-024026-38: Combined N-of-1 Trials Mexiletine vs Placebo in Patients With Non-Dystrophic Myotonia (NDM)

Completed
2
30
Europe
Mexiletine, Mexitil, Ritalmex, Placebo, Dummy, Control-arm medication
Radboud University Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development
Non Dystrophic Myotonia
06/15
06/15
2014-002627-10: Pivotal study to evaluate the efficacy and safety of riluzole versus mexiletine in patients with non dystrophic myotonia mutated in SCN4A orCLCN1 genes. Studio clinico pilota per valutare l'efficacia e la sicurezza di riluzolo rispetto mexiletina in pazienti affetti da miotonia non distrofica mutati nei geniSCN4A o CLCN1.

Ongoing
2
58
Europe
RILUZOLO, Capsule, hard, RILUZOLO TEVA - 50 MG COMPRESSE RIVESTITE CON FILM 90 COMPRESSE IN BLISTER AL/PVC
FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA, MINISTERO DELLA SALUTE - FONDI 5 X 1000
NDM patients with mutations in SCN4A or CLCN1 gene Miotonie non distrofiche con mutazione nei geni SCN4A o CLCN1, Patients with myotonic phenomenon Pazienti con fenomeno miotonico, Diseases [C] - Nervous System Diseases [C10]
 
 
NCT02561702: Mexiletine for Muscle Cramps in Charcot Marie Tooth Disease

Completed
2
4
US
Placebo, lactose powder, Mexiletine
University of Rochester
Charcot Marie Tooth Disease
12/16
12/16
NCT01406873: Clinical Efficacy Trial of Mexiletine for Myotonic Dystrophy Type 1

Completed
2
42
US
Mexiletine, Generic name: mexiletine hydrochloride, Placebo
University of Rochester
Myotonic Dystrophy
02/17
03/17
NCT02781454: Mexiletine in Sporadic Amyotrophic Lateral Sclerosis

Completed
2
20
US
Mexiletine, Mexitil, Placebo
University of Washington, Massachusetts General Hospital
Sporadic Amyotrophic Lateral Sclerosis
09/18
09/18

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