Leukemia  >>  Thymoglobulin (anti-thymocyte globulin (rabbit))  >>  Phase 2
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75 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
NCT01056614: Fludarabine Phosphate, Busulfan, and Anti-Thymocyte Globulin Followed By Donor Peripheral Blood Stem Cell Transplant, Tacrolimus, and Methotrexate in Treating Patients With Myeloid Malignancies

Completed
2
23
US
fludarabine phosphate, 2-F-ara-AMP, Beneflur, Fludara, busulfan, BSF, BU, Misulfan, Mitosan, Myeloleukon, anti-thymocyte globulin, ATG, ATGAM, lymphocyte immune globulin, Thymoglobulin, tacrolimus, FK 506, Prograf, methotrexate, amethopterin, Folex, methylaminopterin, Mexate, MTX, peripheral blood stem cell transplantation, PBPC transplantation, PBSC transplantation, peripheral blood progenitor cell transplantation, transplantation, peripheral blood stem cell, allogeneic hematopoietic stem cell transplantation, laboratory biomarker analysis
Fred Hutchinson Cancer Center, National Heart, Lung, and Blood Institute (NHLBI), National Cancer Institute (NCI)
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22), Adult Acute Myeloid Leukemia With t(8;21)(q22;q22), Blastic Phase Chronic Myelogenous Leukemia, Childhood Acute Myeloid Leukemia in Remission, Childhood Chronic Myelogenous Leukemia, Childhood Myelodysplastic Syndromes, Chronic Phase Chronic Myelogenous Leukemia, de Novo Myelodysplastic Syndromes, Hematopoietic/Lymphoid Cancer, Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Previously Treated Myelodysplastic Syndromes, Recurrent Adult Acute Myeloid Leukemia, Recurrent Childhood Acute Myeloid Leukemia, Relapsing Chronic Myelogenous Leukemia
08/05
04/16
NCT00025038: Combination Chemotherapy Followed By Donor Bone Marrow or Umbilical Cord Blood Transplant in Treating Children With Newly Diagnosed Juvenile Myelomonocytic Leukemia

Completed
2
100
US
tipifarnib, R115777, Zarnestra, isotretinoin, 13-CRA, Amnesteem, Cistane, Claravis, Sotret, fludarabine phosphate, 2-F-ara-AMP, Beneflur, Fludara, cytarabine, ARA-C, arabinofuranosylcytosine, arabinosylcytosine, Cytosar-U, cytosine arabinoside, radiation therapy, irradiation, radiotherapy, therapy, radiation, cyclophosphamide, CPM, CTX, Cytoxan, Endoxan, Endoxana, anti-thymocyte globulin, ATG, ATGAM, lymphocyte immune globulin, Thymoglobulin, allogeneic bone marrow transplantation, bone marrow therapy, allogeneic, bone marrow therapy, allogenic, transplantation, allogeneic bone marrow, transplantation, allogenic bone marrow, double-unit umbilical cord blood transplantation, umbilical cord blood transplantation, cord blood transplantation, transplantation, umbilical cord blood, UCB transplantation, laboratory biomarker analysis
National Cancer Institute (NCI)
Juvenile Myelomonocytic Leukemia
10/07
 
NCT00133367: Study of Unrelated Cord Blood Transplantation Using Tacrolimus and Sirolimus

Completed
2
32
US
Tacrolimus, Sirolimus, G-CSF, Antithymocyte globulin, Thymoglobulin, Fludarabine, Melphalan
Massachusetts General Hospital, Dana-Farber Cancer Institute
Multiple Myeloma, Non-Hodgkin's Lymphoma, Hodgkin's Disease, Myelogenous Leukemia, Lymphoblastic Leukemia
11/07
11/11
NCT00346359: Fludarabine and Busulfan Followed by Donor Peripheral Stem Cell Transplant and Antithymocyte Globulin, Tacrolimus, and Methotrexate in Treating Patients With Myeloid Cancer

Completed
2
40
US
anti-thymocyte globulin, busulfan, fludarabine phosphate, methotrexate, tacrolimus, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
 
11/07
NCT00611351: Busulfan, Cyclophosphamide, & Antithymocyte Globulin Followed by Stem Cell Transplant in Treating Hematologic Cancer

Completed
2
5
US
anti-thymocyte globulin, immunosuppressant, busulfan, Busulfex, Myleran, cyclophosphamide, cytophosphane, mycophenolate mofetil, CellCept, tacrolimus, Protopic, Envarsus XR, Astagraf XL, polymerase chain reaction, polymorphism analysis, flow cytometry, laboratory biomarker analysis, pharmacogenomic studies, pharmacological study, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation
University of Nebraska, National Cancer Institute (NCI)
Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases, Secondary Myelofibrosis
02/08
09/08
NCT00582933: Phase II Trial of a Chemotherapy Alone Regimen of IV Busulfan (Busulfex), Melphalan and Fludarabine as Myeloablative Regimen Followed by an Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplant From an HLA-Identical, or HLA-Non Identical Related or Unrelated Donor

Completed
2
96
US
BUSULFAN, MELPHALAN, FLUDARABINE, G-CSF
Memorial Sloan Kettering Cancer Center
Leukemia, Myelodysplastic Syndrome, Non-Hodgkin's Lymphoma, Allogeneic Marrow Transplant
04/08
04/09
NCT00593645: Clofarabine, Cytarabine, and Thymoglobulin for Allogeneic Transplantation

Terminated
2
7
US
Clofarabine, Clolar, Cytarabine, Ara-C, Cytosar, Thymoglobulin, Anti-thymocyte globulin, Stem cell infusion, Stem cell transplant, Hematopoietic stem cell transplant, Peripheral blood stem cell transplant, Bone marrow transplant
Washington University School of Medicine
Myelodysplastic Syndromes, Acute Myeloid Leukemia
12/08
07/09
NCT00038857: Megadose CD34 Selected Progenitor Cells for Transplantation in Patients With Advanced Hematological Malignant Diseases

Completed
2
29
US
Megadose of CD34 Selected Progenitor Cells, Melphalan, Alkeran, Thiotepa, Fludarabine, Fludarabine Phosphate, Fludara, Rabbit ATG, Rabbit antithymocyte globulin, ATG, rATG, Genzyme, Thymoglobulin
M.D. Anderson Cancer Center
Leukemia, Lymphoma
06/09
06/09
NCT00795132: Hematopoietic Cell Transplantation for Pediatric Patients With Hematologic Malignancies

Completed
2
47
US
Busulfan, Busulfex, Anti-Thymocyte Globulin, Thymoglobulin® [Anti-thymocyte Globulin, (Rabbit)], Fludarabine, Fludara, Cyclosporine, Mycophenolate mofetil, MMF, CellCept
University of Utah
Acute Leukaemia, Chronic Disease, Leukemia, Myelodysplasia, Lymphoma
07/09
07/09
NCT00499889: Imatinib Mesylate, Busulfan, Fludarabine, and Antithymocyte Globulin for CML Patients

Terminated
2
42
US
Imatinib Mesylate, Gleevec, STI571, Fludarabine (Fludara), Fludarabine Phosphate, Fludara, Fludarabine, Busulfan, Busulfex, Myleran, Antithymocyte Globulin (ATG), ATG, Thymoglobulin, Tacrolimus, Prograf, Methotrexate, Donor lymphocyte infusion (DLI), buffy coat fusion, donor leukocyte infusion, apheresis, donor immune cell infusion, Stem Cell Transplant, stem cell infusion, stem cell transplantation, ALLOGENEIC STEM CELL TRANSPLANTATION, HSCT, hematopoietic stem cell transplant, Bone Marrow transplant, PBSC, Peripheral Blood Stem Cell
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Leukemia
11/09
11/09
NCT00787761: Early Administration of ATG Followed by Cyclophosphamide, Busulfan and Fludarabine Before a Donor Stem Cell Transplant in Patients With Hematological Cancer

Completed
2
24
US
anti-thymocyte globulin, Thymoglobulin, ATG, busulfan, cyclophosphamide, fludarabine phosphate, Fludara, methotrexate, Amethopterin, MTX, tacrolimus, Prograf, FK506, nonmyeloablative allogeneic HSCT
Northside Hospital, Inc., Blood and Marrow Transplant Group of Georgia
Myeloproliferative Disorders, Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
07/10
05/12
NCT00506948: Thymoglobulin, Sirolimus and Mycophenolate Mofetil for Prevention of Acute Graft-Versus-Host Disease (GVHD)

Terminated
2
13
US
Mycophenolate Mofetil (MMF), CellCept, MMF, Thymoglobulin, Antithymocyte Globulin, rATG, ATG, Sirolimus, Rapamune, Stem Cell Transplant, hematopoietic stem cell transplantation, HSCT, transplantation
M.D. Anderson Cancer Center, Genzyme, a Sanofi Company
Hematological Malignancies, Myelodysplastic Syndrome, Leukemia, Lymphoma
10/10
10/10
NCT00186628: Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD

Completed
2
36
US
Total lymphoid irradiation, TLI, Rituximab, Rituxan, Anti-thymoglobulin, rabbit (ATG, rabbit ATG), Cyclosporine, CSP, Sandimmune, Mycophenylate mofetil, MMF, CellCept, Filgrastim, G-CSF, Granulocyte-colony stimulating factor, Neupogen, Granisetron, Sancuso, Solumedrol, Medrol, Depo-Medrol, A-Methapred, Acetaminophen, Tylenol, Diphenhydramine, Benadryl, Hydrocortisone, Westcort
Stanford University, The Leukemia and Lymphoma Society, National Cancer Institute (NCI)
Leukemia, Mast-Cell, Mantle-cell Lymphoma
11/10
12/10
NCT00392782: Donor Stem Cell Transplant in Treating Patients With Myeloid Cancer or Other Disease

Terminated
2
24
US
anti-thymocyte globulin, ATG, fludarabine phosphate, Fludara, thiotepa, peripheral blood stem cell transplantation, PBSC, total-body irradiation, TBI
Masonic Cancer Center, University of Minnesota, Center for International Blood and Marrow Transplant Research
Leukemia, Myelodysplastic Syndromes
05/11
05/11
FB-ATG, NCT00915811 / 2006-004452-20: Pilot Study of Reduced Intensity Haematopoietic Stem Cell Transplantation in Patients With Poor Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukaemia (AML) Utilising Conditioning With Fludarabine, Busulphan and Thymoglobulin

Terminated
2
20
Europe
Fludarabine, Busulphan, Thymoglobuline (Anti-thymocyte globulin [rabbit]) - Genzyme, Haematopoietic stem cell infusion
King's College Hospital NHS Trust
Myelodysplastic Syndromes, Leukemia, Myeloid, Acute
06/11
06/11
NCT00589563: Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer

Completed
2
32
US
anti-thymocyte globulin, cyclophosphamide, etoposide, fludarabine phosphate, melphalan, methotrexate, sirolimus, tacrolimus, allogeneic hematopoietic stem cell transplantation, hematopoietic stem cell transplantation, nonmyeloablative allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, total-body irradiation
City of Hope Medical Center, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Infection, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Precancerous Condition, Secondary Myelofibrosis, Small Intestine Cancer
02/12
02/12
NCT00916045 / 2007-001657-26: Pilot Study of Unrelated Cord Blood Transplantation

Terminated
2
40
Europe
Thiotepa, Fludarabine, Intravenous busulphan, Busilvex, Thymoglobulin, Ciclosporin, Mycophenolate mofetil (MMF), Cyclophosphamide, Radiotherapy, Melphalan
King's College Hospital NHS Trust
Leukemia, Myeloid, Acute, Myelodysplastic Syndromes, Leukemia, Lymphoblastic, Acute, Lymphoma, Non-Hodgkin, Hodgkin Disease, Chronic Lymphocytic Leukemia
03/12
03/12
NCT00887042: Study of Reduced Toxicity Myeloablative Conditioning Regimen for Cord Blood Transplantation in Pediatric AML

Unknown status
2
35
RoW
Fludarabine, Busulfan, Thymoglobulin
The Korean Society of Pediatric Hematology Oncology
Acute Myeloid Leukemia
05/12
05/12
NCT01044745: Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer

Terminated
2
20
US
rituximab, IDEC-C2B8, IDEC-C2B8 monoclonal antibody, Mabthera, MOAB IDEC-C2B8, Rituxan, mycophenolate mofetil, Cellcept, MMF, tacrolimus, FK 506, Prograf, anti-thymocyte globulin, ATG, ATGAM, lymphocyte immune globulin, Thymoglobulin, allogeneic hematopoietic stem cell transplantation, laboratory biomarker analysis, graft versus host disease prophylaxis/therapy, prophylaxis/therapy, graft versus host disease, prophylaxis/therapy, GVHD, cyclophosphamide, CPM, CTX, Cytoxan, Endoxan, Endoxana, fludarabine phosphate, 2-F-ara-AMP, Beneflur, Fludara, busulfan, BSF, BU, Misulfan, Mitosan, Myeloleukon, total-body irradiation, TBI, graft-versus-tumor induction therapy, graft versus host disease induction, graft versus tumor induction, immunosuppressive therapy, immunosuppression
University of Nebraska, National Cancer Institute (NCI)
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Blastic Phase Chronic Myelogenous Leukemia, Contiguous Stage II Adult Burkitt Lymphoma, Contiguous Stage II Adult Diffuse Large Cell Lymphoma, Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma, Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma, Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma, Contiguous Stage II Adult Lymphoblastic Lymphoma, Contiguous Stage II Grade 1 Follicular Lymphoma, Contiguous Stage II Grade 2 Follicular Lymphoma, Contiguous Stage II Grade 3 Follicular Lymphoma, Contiguous Stage II Mantle Cell Lymphoma, Contiguous Stage II Marginal Zone Lymphoma, Contiguous Stage II Small Lymphocytic Lymphoma, de Novo Myelodysplastic Syndromes, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Graft Versus Host Disease, Nodal Marginal Zone B-cell Lymphoma, Noncontiguous Stage II Adult Burkitt Lymphoma, Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma, Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma, Noncontiguous Stage II Adult Lymphoblastic Lymphoma, Noncontiguous Stage II Grade 1 Follicular Lymphoma, Noncontiguous Stage II Grade 2 Follicular Lymphoma, Noncontiguous Stage II Grade 3 Follicular Lymphoma, Noncontiguous Stage II Mantle Cell Lymphoma, Noncontiguous Stage II Marginal Zone Lymphoma, Noncontiguous Stage II Small Lymphocytic Lymphoma, Previously Treated Myelodysplastic Syndromes, Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Acute Myeloid Leukemia, Recurrent Adult Burkitt Lymphoma, Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Adult Diffuse Mixed Cell Lymphoma, Recurrent Adult Diffuse Small Cleaved Cell Lymphoma, Recurrent Adult Grade III Lymphomatoid Granulomatosis, Recurrent Adult Immunoblastic Large Cell Lymphoma, Recurrent Adult Lymphoblastic Lymphoma, Recurrent Adult T-cell Leukemia/Lymphoma, Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma, Recurrent Marginal Zone Lymphoma, Recurrent Mycosis Fungoides/Sezary Syndrome, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia, Relapsing Chronic Myelogenous Leukemia, Secondary Myelodysplastic Syndromes, Splenic Marginal Zone Lymphoma, Stage I Adult Burkitt Lymphoma, Stage I Adult Diffuse Large Cell Lymphoma, Stage I Adult Diffuse Mixed Cell Lymphoma, Stage I Adult Diffuse Small Cleaved Cell Lymphoma, Stage I Adult Immunoblastic Large Cell Lymphoma, Stage I Adult Lymphoblastic Lymphoma, Stage I Adult T-cell Leukemia/Lymphoma, Stage I Chronic Lymphocytic Leukemia, Stage I Cutaneous T-cell Non-Hodgkin Lymphoma, Stage I Grade 1 Follicular Lymphoma, Stage I Grade 2 Follicular Lymphoma, Stage I Grade 3 Follicular Lymphoma, Stage I Mantle Cell Lymphoma, Stage I Marginal Zone Lymphoma, Stage I Mycosis Fungoides/Sezary Syndrome, Stage I Small Lymphocytic Lymphoma, Stage II Adult T-cell Leukemia/Lymphoma, Stage II Chronic Lymphocytic Leukemia, Stage II Cutaneous T-cell Non-Hodgkin Lymphoma, Stage II Mycosis Fungoides/Sezary Syndrome, Stage III Adult Burkitt Lymphoma, Stage III Adult Diffuse Large Cell Lymphoma, Stage III Adult Diffuse Mixed Cell Lymphoma, Stage III Adult Diffuse Small Cleaved Cell Lymphoma, Stage III Adult Immunoblastic Large Cell Lymphoma, Stage III Adult Lymphoblastic Lymphoma, Stage III Adult T-cell Leukemia/Lymphoma, Stage III Chronic Lymphocytic Leukemia, Stage III Cutaneous T-cell Non-Hodgkin Lymphoma, Stage III Grade 1 Follicular Lymphoma, Stage III Grade 2 Follicular Lymphoma, Stage III Grade 3 Follicular Lymphoma, Stage III Mantle Cell Lymphoma, Stage III Marginal Zone Lymphoma, Stage III Mycosis Fungoides/Sezary Syndrome, Stage III Small Lymphocytic Lymphoma, Stage IV Adult Burkitt Lymphoma, Stage IV Adult Diffuse Large Cell Lymphoma, Stage IV Adult Diffuse Mixed Cell Lymphoma, Stage IV Adult Diffuse Small Cleaved Cell Lymphoma, Stage IV Adult Immunoblastic Large Cell Lymphoma, Stage IV Adult Lymphoblastic Lymphoma, Stage IV Adult T-cell Leukemia/Lymphoma, Stage IV Chronic Lymphocytic Leukemia, Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma, Stage IV Grade 1 Follicular Lymphoma, Stage IV Grade 2 Follicular Lymphoma, Stage IV Grade 3 Follicular Lymphoma, Stage IV Mantle Cell Lymphoma, Stage IV Marginal Zone Lymphoma, Stage IV Mycosis Fungoides/Sezary Syndrome, Stage IV Small Lymphocytic Lymphoma, Untreated Adult Acute Lymphoblastic Leukemia, Untreated Adult Acute Myeloid Leukemia, Waldenström Macroglobulinemia
12/12
10/17
NCT00469014: Busulfan, Fludarabine, Clofarabine With Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia

Completed
2
72
US
Clofarabine, Clofarex, Clolar, Busulfan, Busulfex, Myleran, Fludarabine, Fludarabine Phosphate, Fludara, Stem Cell Infusion, Bone Marrow Transplant, BMT, peripheral blood progenitor cells, PBPC, Unstimulated bone marrow transplant, bone marrow transplantation, ABM transplantations, autologous bone marrow transplantation, Thymoglobulin (ATG), Thymoglobulin, Antithymocyte Globulin, Filgrastim, G-CSF, Granulocyte colony-stimulating factor, GCSF
M.D. Anderson Cancer Center, Genzyme, a Sanofi Company
Acute Myeloid Leukemia, Myelodysplastic Syndrome, Chronic Myeloid Leukemia
03/13
03/13
NCT01116232: Sirolimus, Tacrolimus, Thymoglobulin and Rituximab as Graft-versus-Host-Disease Prophylaxis in Patients Undergoing Haploidentical and HLA Partially Matched Donor Hematopoietic Cell Transplantation

Terminated
2
4
US
anti-thymocyte globulin, rituximab, Rituxan®, sirolimus, Rapamune®, tacrolimus, Prograf, laboratory biomarker analysis, allogeneic hematopoietic stem cell transplantation, management of therapy complications, peripheral blood stem cell transplantation
Barbara Ann Karmanos Cancer Institute, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma, Lymphoproliferative Disorder, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
05/13
06/13
Cloric, NCT00863148: Allogeneic Stem Cell Transplant With Clofarabine, Busulfan and Antithymocyte Globulin (ATG) for Adult Patients With High-risk Acute Myeloid Leukemia/Myelodysplastic Syndromes (AML/MDS) or Acute Lymphoblastic Leukemia (ALL)

Completed
2
30
Europe
Clofarabine in combination with IV busulfan and ATG
Nantes University Hospital
MDS, AML, ALL, BAL
06/13
06/13
NCT01534767: Sirolimus, Tacrolimus, Anti-Thymocyte Globulin, and Rituximab in Preventing Graft-versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant

Recruiting
2
19
US
sirolimus, AY 22989, Rapamune, rapamycin, SLM, tacrolimus, FK 506, Prograf, rituximab, IDEC-C2B8, IDEC-C2B8 monoclonal antibody, Mabthera, MOAB IDEC-C2B8, Rituxan, anti-thymocyte globulin, ATG, ATGAM, lymphocyte immune globulin, Thymoglobulin, laboratory biomarker analysis, flow cytometry
Barbara Ann Karmanos Cancer Institute, National Cancer Institute (NCI)
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22), Adult Acute Myeloid Leukemia With t(8;21)(q22;q22), Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative, Blastic Phase Chronic Myelogenous Leukemia, Chronic Eosinophilic Leukemia, Chronic Myelomonocytic Leukemia, Chronic Neutrophilic Leukemia, Chronic Phase Chronic Myelogenous Leukemia, Contiguous Stage II Adult Burkitt Lymphoma, Contiguous Stage II Adult Diffuse Large Cell Lymphoma, Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma, Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma, Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma, Contiguous Stage II Adult Lymphoblastic Lymphoma, Contiguous Stage II Grade 1 Follicular Lymphoma, Contiguous Stage II Grade 2 Follicular Lymphoma, Contiguous Stage II Grade 3 Follicular Lymphoma, Contiguous Stage II Mantle Cell Lymphoma, Contiguous Stage II Marginal Zone Lymphoma, Contiguous Stage II Small Lymphocytic Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma, de Novo Myelodysplastic Syndromes, Essential Thrombocythemia, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Hepatosplenic T-cell Lymphoma, Intraocular Lymphoma, Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Nodal Marginal Zone B-cell Lymphoma, Noncontiguous Stage II Adult Burkitt Lymphoma, Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma, Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma, Noncontiguous Stage II Adult Lymphoblastic Lymphoma, Noncontiguous Stage II Grade 1 Follicular Lymphoma, Noncontiguous Stage II Grade 2 Follicular Lymphoma, Noncontiguous Stage II Grade 3 Follicular Lymphoma, Noncontiguous Stage II Mantle Cell Lymphoma, Noncontiguous Stage II Marginal Zone Lymphoma, Noncontiguous Stage II Small Lymphocytic Lymphoma, Noncutaneous Extranodal Lymphoma, Peripheral T-cell Lymphoma, Polycythemia Vera, Previously Treated Myelodysplastic Syndromes, Primary Myelofibrosis, Progressive Hairy Cell Leukemia, Initial Treatment, Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Acute Myeloid Leukemia, Recurrent Adult Burkitt Lymphoma, Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Adult Diffuse Mixed Cell Lymphoma, Recurrent Adult Diffuse Small Cleaved Cell Lymphoma, Recurrent Adult Grade III Lymphomatoid Granulomatosis, Recurrent Adult Hodgkin Lymphoma, Recurrent Adult Immunoblastic Large Cell Lymphoma, Recurrent Adult Lymphoblastic Lymphoma, Recurrent Adult T-cell Leukemia/Lymphoma, Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma, Recurrent Marginal Zone Lymphoma, Recurrent Mycosis Fungoides/Sezary Syndrome, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia, Refractory Hairy Cell Leukemia, Refractory Multiple Myeloma, Relapsing Chronic Myelogenous Leukemia, Secondary Acute Myeloid Leukemia, Secondary Myelodysplastic Syndromes, Secondary Myelofibrosis, Small Intestine Lymphoma, Splenic Marginal Zone Lymphoma, Stage I Adult Burkitt Lymphoma, Stage I Adult Diffuse Large Cell Lymphoma, Stage I Adult Diffuse Mixed Cell Lymphoma, Stage I Adult Diffuse Small Cleaved Cell Lymphoma, Stage I Adult Hodgkin Lymphoma, Stage I Adult Immunoblastic Large Cell Lymphoma, Stage I Adult Lymphoblastic Lymphoma, Stage I Adult T-cell Leukemia/Lymphoma, Stage I Chronic Lymphocytic Leukemia, Stage I Cutaneous T-cell Non-Hodgkin Lymphoma, Stage I Grade 1 Follicular Lymphoma, Stage I Grade 2 Follicular Lymphoma, Stage I Grade 3 Follicular Lymphoma, Stage I Mantle Cell Lymphoma, Stage I Marginal Zone Lymphoma, Stage I Multiple Myeloma, Stage I Mycosis Fungoides/Sezary Syndrome, Stage I Small Lymphocytic Lymphoma, Stage II Adult Hodgkin Lymphoma, Stage II Adult T-cell Leukemia/Lymphoma, Stage II Chronic Lymphocytic Leukemia, Stage II Cutaneous T-cell Non-Hodgkin Lymphoma, Stage II Multiple Myeloma, Stage II Mycosis Fungoides/Sezary Syndrome, Stage III Adult Burkitt Lymphoma, Stage III Adult Diffuse Large Cell Lymphoma, Stage III Adult Diffuse Mixed Cell Lymphoma, Stage III Adult Diffuse Small Cleaved Cell Lymphoma, Stage III Adult Hodgkin Lymphoma, Stage III Adult Immunoblastic Large Cell Lymphoma, Stage III Adult Lymphoblastic Lymphoma, Stage III Adult T-cell Leukemia/Lymphoma, Stage III Chronic Lymphocytic Leukemia, Stage III Cutaneous T-cell Non-Hodgkin Lymphoma, Stage III Grade 1 Follicular Lymphoma, Stage III Grade 2 Follicular Lymphoma, Stage III Grade 3 Follicular Lymphoma, Stage III Mantle Cell Lymphoma, Stage III Marginal Zone Lymphoma, Stage III Multiple Myeloma, Stage III Mycosis Fungoides/Sezary Syndrome, Stage III Small Lymphocytic Lymphoma, Stage IV Adult Burkitt Lymphoma, Stage IV Adult Diffuse Large Cell Lymphoma, Stage IV Adult Diffuse Mixed Cell Lymphoma, Stage IV Adult Diffuse Small Cleaved Cell Lymphoma, Stage IV Adult Hodgkin Lymphoma, Stage IV Adult Immunoblastic Large Cell Lymphoma, Stage IV Adult Lymphoblastic Lymphoma, Stage IV Adult T-cell Leukemia/Lymphoma, Stage IV Chronic Lymphocytic Leukemia, Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma, Stage IV Grade 1 Follicular Lymphoma, Stage IV Grade 2 Follicular Lymphoma, Stage IV Grade 3 Follicular Lymphoma, Stage IV Mantle Cell Lymphoma, Stage IV Marginal Zone Lymphoma, Stage IV Mycosis Fungoides/Sezary Syndrome, Stage IV Small Lymphocytic Lymphoma, T-cell Large Granular Lymphocyte Leukemia, Testicular Lymphoma, Untreated Adult Acute Lymphoblastic Leukemia, Untreated Adult Acute Myeloid Leukemia, Untreated Hairy Cell Leukemia, Waldenstrom Macroglobulinemia
06/13
10/13
NCT01414127: Tacrolimus and ATG as GVHD Prophylaxis in Patients Undergoing Related Donor HSCT

Active, not recruiting
2
22
US
tacrolimus, FK 506, Prograf, anti-thymocyte globulin, ATG, ATGAM, lymphocyte immune globulin, Thymoglobulin, laboratory biomarker analysis, flow cytometry, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, PBPC transplantation, PBSC transplantation, peripheral blood progenitor cell transplantation, transplantation, peripheral blood stem cell
Barbara Ann Karmanos Cancer Institute
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22), Adult Acute Myeloid Leukemia With t(8;21)(q22;q22), Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Chronic Myelomonocytic Leukemia, Chronic Phase Chronic Myelogenous Leukemia, Contiguous Stage II Adult Burkitt Lymphoma, Contiguous Stage II Adult Diffuse Large Cell Lymphoma, Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma, Stage II Adult Diffuse Small Cleaved Cell Lymphoma, Stage II Adult Immunoblastic Large Cell Lymphoma, Contiguous Stage II Adult Lymphoblastic Lymphoma, Contiguous Stage II Grade 1 Follicular Lymphoma, Contiguous Stage II Grade 2 Follicular Lymphoma, Contiguous Stage II Grade 3 Follicular Lymphoma, Contiguous Stage II Mantle Cell Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma, de Novo Myelodysplastic Syndromes, Hepatosplenic T-cell Lymphoma, Intraocular Lymphoma, Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Nodal Marginal Zone B-cell Lymphoma, Noncontiguous Stage II Adult Burkitt Lymphoma, Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma, Noncontiguous Stage II Adult Lymphoblastic Lymphoma, Noncontiguous Stage II Grade 1 Follicular Lymphoma, Noncontiguous Stage II Grade 2 Follicular Lymphoma, Noncontiguous Stage II Grade 3 Follicular Lymphoma, Noncontiguous Stage II Mantle Cell Lymphoma, Peripheral T-cell Lymphoma, Post-transplant Lymphoproliferative Disorder, Previously Treated Myelodysplastic Syndromes, Primary Myelofibrosis, Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Acute Myeloid Leukemia, Recurrent Adult Burkitt Lymphoma, Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Adult Diffuse Mixed Cell Lymphoma, Recurrent Adult Diffuse Small Cleaved Cell Lymphoma, Recurrent Adult Grade III Lymphomatoid Granulomatosis, Recurrent Adult Hodgkin Lymphoma, Recurrent Adult Immunoblastic Large Cell Lymphoma, Recurrent Adult Lymphoblastic Lymphoma, Recurrent Adult T-cell Leukemia/Lymphoma, Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma, Recurrent Marginal Zone Lymphoma, Recurrent Mycosis Fungoides/Sezary Syndrome, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia, Refractory Hairy Cell Leukemia, Small Intestine Lymphoma, Splenic Marginal Zone Lymphoma, Stage I Adult Burkitt Lymphoma, Stage I Adult Diffuse Large Cell Lymphoma, Stage I Adult Diffuse Mixed Cell Lymphoma, Stage I Adult Diffuse Small Cleaved Cell Lymphoma, Stage I Adult Hodgkin Lymphoma, Stage I Adult Immunoblastic Large Cell Lymphoma, Stage I Adult Lymphoblastic Lymphoma, Stage I Adult T-cell Leukemia/Lymphoma, Stage I Chronic Lymphocytic Leukemia, Stage I Cutaneous T-cell Non-Hodgkin Lymphoma, Stage I Grade 1 Follicular Lymphoma, Stage I Grade 2 Follicular Lymphoma, Stage I Grade 3 Follicular Lymphoma, Stage I Mantle Cell Lymphoma, Stage I Marginal Zone Lymphoma, Stage I Multiple Myeloma, Stage I Mycosis Fungoides/Sezary Syndrome, Stage I Small Lymphocytic Lymphoma, Stage II Adult Hodgkin Lymphoma, Stage II Adult T-cell Leukemia/Lymphoma, Stage II Chronic Lymphocytic Leukemia, Stage II Cutaneous T-cell Non-Hodgkin Lymphoma, Stage II Multiple Myeloma, Stage II Mycosis Fungoides/Sezary Syndrome, Stage III Adult Burkitt Lymphoma, Stage III Adult Diffuse Large Cell Lymphoma, Stage III Adult Diffuse Mixed Cell Lymphoma, Stage III Adult Diffuse Small Cleaved Cell Lymphoma, Stage III Adult Hodgkin Lymphoma, Stage III Adult Immunoblastic Large Cell Lymphoma, Stage III Adult Lymphoblastic Lymphoma, Stage III Adult T-cell Leukemia/Lymphoma, Stage III Chronic Lymphocytic Leukemia, Stage III Cutaneous T-cell Non-Hodgkin Lymphoma, Stage III Grade 1 Follicular Lymphoma, Stage III Grade 2 Follicular Lymphoma, Stage III Grade 3 Follicular Lymphoma, Stage III Mantle Cell Lymphoma, Stage III Marginal Zone Lymphoma, Stage III Multiple Myeloma, Stage III Mycosis Fungoides/Sezary Syndrome, Stage III Small Lymphocytic Lymphoma, Stage IV Adult Burkitt Lymphoma, Stage IV Adult Diffuse Large Cell Lymphoma, Stage IV Adult Diffuse Mixed Cell Lymphoma, Stage IV Adult Diffuse Small Cleaved Cell Lymphoma, Stage IV Adult Hodgkin Lymphoma, Stage IV Adult Immunoblastic Large Cell Lymphoma, Stage IV Adult Lymphoblastic Lymphoma, Stage IV Adult T-cell Leukemia/Lymphoma, Stage IV Chronic Lymphocytic Leukemia, Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma, Stage IV Grade 1 Follicular Lymphoma, Stage IV Grade 2 Follicular Lymphoma, Stage IV Grade 3 Follicular Lymphoma, Stage IV Mantle Cell Lymphoma, Stage IV Marginal Zone Lymphoma, Stage IV Mycosis Fungoides/Sezary Syndrome, Stage IV Small Lymphocytic Lymphoma, T-cell Large Granular Lymphocyte Leukemia, Testicular Lymphoma, Waldenstrom Macroglobulinemia
10/13
10/13
NCT00709592: Reduced Intensity Total Body Irradiation + Thymoglobulin Followed by Allogeneic PBSCT

Completed
2
42
US
Thymoglobulin, anti-thymocyte globulin (rabbit), ATG, Genzyme, anti-thymocyte globulin, Rabbit, Rabbit-ATG, Total-Body Irradiation, Whole-Body Irradiation, Total Body Irradiation [TBI], Allogeneic PBSCT or BMT, PBPC transplantation, Peripheral Blood Progenitor Cell Transplantation, Peripheral Blood Stem Cell Transplantation [Allogenic PBSCT], Allogeneic Bone Marrow Transplantation [BMT], Allogeneic BMT, Allogeneic Hematopoietic Stem Cell Transplantation, HSCT, Tacrolimus, Fujimycin, Hecoria, Prograf, Protopic, Mycophenolate Mofetil, CellCept, MMF
Virginia Commonwealth University, Genzyme, a Sanofi Company
Non-Hodgkin's Lymphoma, Leukemia, Multiple Myeloma, Acute Myeloid Leukemia, Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Chronic Myelogenous Leukemia, Myelodysplastic Syndrome
02/14
06/17
NCT00185640: Allogeneic Transplantation Using Total Lymphoid Irradiation (TLI) and Anti-Thymocyte Globulin (ATG) for Older Patients With Hematologic Malignancies

Completed
2
303
US
Cyclosporine, Cyclosporin, Cyclosporin A, Anti-thymocyte globulin (ATG), Thymoglobulin, Mycophenolate mofetil (MMF), CellCept, Filgrastim, Neupogen, Granulocyte-colony stimulating factor (G-CSF; GCSF), colony-stimulating factor 3 (CSF-3), Total Lymphoid Irradiation (TLI)
Stanford University
Blood Cancer, Leukemia
04/14
01/16
NCT00691015: Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer Who Are Undergoing Donor Stem Cell Transplant

Completed
2
48
US
rituximab, Rituxan, MabThera, Zytux, busulfan, Busulfex, Myleran, carmustine, Bicnu, Gliadel, cyclophosphamide, Cytoxan, Cytoxan Lyophilized, Neosar, cytarabine, Depocyt, etoposide, Etopophos, Toposar, fludarabine phosphate, Fludara®, melphalan, Alkeran, total body irradiation (TBI), radiotherapy, anti-thymocyte globulin IV, Thymoglobulin
Barbara Ann Karmanos Cancer Institute, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
04/14
04/14
NCT00813124: Azacitidine After Allo Blood And Marrow Transplantation (BMT) for Chronic Myelogenous Leukemia (CML)

Completed
2
24
US
Fludarabine, Fludarabine Phosphate, Busulfan, Busulfex, Myleran, Thymoglobulin, Antithymocyte globulin, ATG, Azacitidine, 5-Azacitidine, 5-Aza, 5-AZC, Ladakamycin, NSC-102816, Vidaza, Stem Cell Transplant, allotx, allogeneic stem cell transplantation
M.D. Anderson Cancer Center, National Cancer Institute (NCI), Celgene Corporation
Stem Cell Transplantation, Leukemia
09/14
09/14
NCT01390402: Alloreactive Haploidentical Natural Killer (NK) Cells With Busulfan and Fludarabine/ATG

Completed
2
6
US
Fludarabine, Fludarabine Phosphate, Fludara, Busulfan, Busulfex, Myleran, NK cell infusion:, Interleukin-2, IL-2, Aldesleukin, Proleukin, Anti-Thymocyte Globulin, ATG, Thymoglobulin, Allogeneic related Stem Cell Transplant, Tacrolimus, Prograf, Methotrexate, G-CSF, Filgrastim, Neupogen
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Leukemia, Chronic Myelogenous Leukemia
11/14
11/14
AHCTALL, NCT01037764: Donor-specific Allogeneic Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia (ALL)

Terminated
2
100
RoW
alloHCT, allogeneic hematopoietic stem cell transplantation
Asan Medical Center
Acute Lymphoid Leukemia
12/14
12/16
NCT01745913: Randomized HaploCord Blood Transplantation vs. Double Umbilical Cord Blood Transplantation for Hematologic Malignancies

Terminated
2
2
US
CliniMACS® CD34 Reagent System, Miltenyi CliniMACS® device, Fludarabine, Melphalan, Rabbit ATG, rATG, Double Umbilical Cord Blood Transplantation, UCB SCT, Haplo-Identical Cord Transplantation, Haplo-cord transplant
Weill Medical College of Cornell University
Acute Myelogenous Leukemia, Myelodysplastic Syndrome, Acute Lymphocytic Leukemia, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma
04/15
04/15
NCT01093586: Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Completed
2
14
US
double-unit umbilical cord blood transplantation, cytogenetic analysis, bone marrow aspiration, fluorescence in situ hybridization, fluorescence in situ hybridization (FISH), busulfan, BSF, BU, Misulfan, Mitosan, Myeloleukon, Myelosan, cyclophosphamide, CPM, CTX, Cytoxan, Endoxan, Endoxana, Enduxan, anti-thymocyte globulin, ATG, ATGAM, lymphocyte immune globulin, Thymoglobulin, methylprednisolone, A-MethaPred, Depo-Medrol, Medrol, MePRDL, Solu-Medrol, Wyacort, cyclosporine, 27-400, ciclosporin, cyclosporin, cyclosporin A, CYSP, Sandimmune, mycophenolate mofetil, Cellcept, MMF, flow cytometry, allogeneic hematopoietic stem cell transplantation
Case Comprehensive Cancer Center
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b), Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With t(16;16)(p13;q22), Adult Erythroleukemia (M6a), Adult Nasal Type Extranodal NK/T-cell Lymphoma, Adult Pure Erythroid Leukemia (M6b), B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia, Blastic Phase Chronic Myelogenous Leukemia, Burkitt Lymphoma, Childhood Acute Erythroleukemia (M6), Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Megakaryocytic Leukemia (M7), Childhood Acute Minimally Differentiated Myeloid Leukemia (M0), Childhood Acute Monoblastic Leukemia (M5a), Childhood Acute Monocytic Leukemia (M5b), Childhood Acute Myeloid Leukemia in Remission, Childhood Chronic Myelogenous Leukemia, Childhood Diffuse Large Cell Lymphoma, Childhood Immunoblastic Large Cell Lymphoma, Childhood Myelodysplastic Syndromes, Childhood Nasal Type Extranodal NK/T-cell Lymphoma, Chronic Myelomonocytic Leukemia, Chronic Phase Chronic Myelogenous Leukemia, Cutaneous B-cell Non-Hodgkin Lymphoma, de Novo Myelodysplastic Syndromes, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Juvenile Myelomonocytic Leukemia, Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Nodal Marginal Zone B-cell Lymphoma, Previously Treated Myelodysplastic Syndromes, Prolymphocytic Leukemia, Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Acute Myeloid Leukemia, Recurrent Adult Burkitt Lymphoma, Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Adult Diffuse Mixed Cell Lymphoma, Recurrent Adult Diffuse Small Cleaved Cell Lymphoma, Recurrent Adult Grade III Lymphomatoid Granulomatosis, Recurrent Adult Immunoblastic Large Cell Lymphoma, Recurrent Adult Lymphoblastic Lymphoma, Recurrent Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Anaplastic Large Cell Lymphoma, Recurrent Childhood Grade III Lymphomatoid Granulomatosis, Recurrent Childhood Large Cell Lymphoma, Recurrent Childhood Lymphoblastic Lymphoma, Recurrent Childhood Small Noncleaved Cell Lymphoma, Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma, Recurrent Marginal Zone Lymphoma, Recurrent Mycosis Fungoides/Sezary Syndrome, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia, Relapsing Chronic Myelogenous Leukemia, Secondary Acute Myeloid Leukemia, Secondary Myelodysplastic Syndromes, Secondary Myelofibrosis, Splenic Marginal Zone Lymphoma, Stage I Chronic Lymphocytic Leukemia, Stage II Chronic Lymphocytic Leukemia, Stage III Chronic Lymphocytic Leukemia, Stage IV Chronic Lymphocytic Leukemia, T-cell Adult Acute Lymphoblastic Leukemia, T-cell Childhood Acute Lymphoblastic Leukemia, T-cell Large Granular Lymphocyte Leukemia, Waldenstrom Macroglobulinemia
12/15
12/15
NCT01621477: T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplant

Terminated
2
34
US
clofarabine, Cl-F-Ara-A, CAFdA, Clofarex, Clolar(TM), cytarabine, Ara-C, busulfan, Myleran(R), Busulfex, Plerixafor, AMD3100, Mozobil(R), cyclophosphamide, Cytoxan, antithymocyte globulin (rabbit), Rabbit ATG, Rabbit Thymoglobulin(R), stem cells, HSC infusion, Tacrolimus, FK506, Prograf(R), Protonic(R), mycophenolate mofetil, MMF, CellCept(R)
St. Jude Children's Research Hospital, Assisi Foundation
Acute Lymphoblastic Leukemia, Acute Myelocytic Leukemia, Chronic Myelocytic Leukemia, Juvenile Myelomonocytic Leukemia, Myelodysplastic Syndrome, Hodgkin or Non-Hodgkin Lymphoma, Sarcoma, Myeloid
12/15
12/15
2012-005538-12: A Randomised Trial of the FLAMSA-BU Conditioning Regimen in Patients with Acute Myeloid Leukaemia and Myelodysplasia Undergoing Allogeneic Stem Cell Transplantation

Ongoing
2
170
Europe
Alemtuzumab, Fludarabine, Melphalan, Busilvex, Cytarabine, Amsacrine, Thymoglobulin, Alemtuzumab, Fludarabine, Melphalan, Busulphan, Cytarabine, Amsacrine, Anti-thymocyte Globulin (Rabbit), Campath, Busilvex, Thymoglobulin, Campath, Busilvex, Thymoglobulin
University of Birmingham, Leukaemia and Lymphoma Research, Pierre Fabre
Acute Myeloid Leukaemia (AML) and Myelodysplasia (MDS)
 
 
2014-004849-26: Parachute trial: research on individualized dosing regimen of Thymoglobuline Parachute onderzoek: wetenschappelijk onderzoek naar een geïndividualiseerde dosering van het medicijn Thymoglobuline

Ongoing
2
53
Europe
Thymoglobuline, Thymoglobuline, Thymoglobuline
UMC Utrecht, Sanofi-Aventis
Leukemia and immunedeficiency syndromes Leukemie en immuundeficientie syndromen
 
 
NCT00961142 / 2007-006016-33: Haploidentical Stem Cell Transplantation With CD3/CD19 Depletion and Reduced Intensity Conditioning in Patients With Acute Leukemia

Terminated
2
23
Europe
Fludarabine, Thiotepa, Melphalan, Thymoglobuline (ATG)
University Hospital Tuebingen
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
12/15
12/15
NCT00566696: Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies

Completed
2
73
US
CliniMACS, Stem cell transplantation, Fludarabine, Fludara, Thioplex®, Thiotepa, TESPA, TSPA, L-phenylalanine mustard, Melphalan, Phenylalanine mustard, L-PAM, L-sarcolysin, Alkeran, Mycophenolate mofetil, MMF, CellCept®, Rituxan™, Rituximab, Alemtuzumab, Campath-1H, Campath®, Cyclophosphamide, Cytoxan, Anti-thymocyte globulin (Rabbit), Thymoglobulin®, Rabbit ATG, G-CSF, Filgrastim, Neupogen®, Muromonab, OKT3, Muromonab-CD3
St. Jude Children's Research Hospital
Leukemia, Acute Lymphocytic (ALL), Leukemia, Myeloid, Acute(AML), Leukemia, Myeloid, Chronic(CML), Juvenile Myelomonocytic Leukemia (JMML), Hemoglobinuria, Paroxysmal Nocturnal (PNH), Hodgkin Lymphoma, Lymphoma, Non-Hodgkin (NHL), Myelodysplastic Syndrome (MDS)
01/16
02/20
NCT00990249: Busulfan Plus Clofarabine Followed by Allogeneic Hematopoietic Stem Cell Transplantation

Completed
2
120
US
Busulfan, Busulfex, Myleran, Clofarabine, Clolar, Clofarex, Thymoglobulin, Anti-thymocyte globulin, ATG, Stem Cell Transplant, Allogeneic hematopoietic cell transplant, HCT
M.D. Anderson Cancer Center
Leukemia, Lymphoma, Allogeneic Haematopoietic Stem Cell Transplantation, Acute Lymphoblastic Leukemia
05/16
05/16
NCT00553202: Donor Stem Cell Transplant in Treating Young Patients With Acute Myeloid Leukemia With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory or Relapsed Acute Myelogenous Leukemia

Completed
2
158
Canada, US
anti-thymocyte globulin, Rabbit ATG, RATG-Rabbit, Antithymocyte Globulin, Thymoglobulin, NSC #720095, busulfan, Busulfex, NSC #750, cyclophosphamide, Cytoxan, NSC #26271, cyclosporine, CYA, Sandimmune, Neoral, Gengraf, NSC #290193, methotrexate, MTX, amethopterin, NSC #000740, methylprednisolone, Solu-Medrol, A-Methapred, Medrol, NSC #19987, tacrolimus, FK-506, Prograf, NSC #717865, laboratory biomarker analysis, pharmacological study, allogeneic bone marrow transplantation, bone marrow therapy, allogeneic, allogenic, transplantation, allogeneic bone marrow, allogenic bone marrow, allogeneic hematopoietic stem cell transplantation
Children's Oncology Group, National Cancer Institute (NCI)
Leukemia
06/16
03/20
NCT01392989: Post T-plant Infusion of Allogeneic Cytokine Induced Killer (CIK) Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorders

Completed
2
44
US
CIK cells, Cytokine-induced Killer Cells, Cyclosporine, cyclosporin, cyclosporin A, Mycophenolate Mofetil, MMF, CellCept, Thymoglobulin, Anti-thymocyte globulin, ATG, Total Lymphoid Irradiation (TLI)
Everett Meyer
Neural Tube Defects, Anemia, Leukemia, Myeloid, Bone Marrow Transplant Failure, Myelodysplastic Syndromes (MDS), Myeloproliferative Disorders
06/16
03/17
NCT00593554: Phase 2 Haplotype Mismatched HSCT in Patients With Hematological Malignancies

Terminated
2
9
US
Total Body Irradiation, Thiotepa, Fludarabine, Rabbit ATG, Antithymocyte globulin, Thymoglobulin, Palifermin, Recombinant human keratinocyte growth factor, Kepivance
Sherif S. Farag
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplasia, Chronic Myeloid Leukemia
08/16
07/17
NCT02877082: Tacrolimus, Bortezomib, & Thymoglobulin in Preventing Low Toxicity GVHD in Donor Blood Stem Cell Transplant Patients

Terminated
2
5
US
Thymoglobulin, Antithymocyte Globulin, Antithymocyte Serum, ATG, ATGAM, ATS, Anti-Thymocyte Globulin, Bortezomib, LDP 341, MLN341, PS-341, PS341, Velcade, Tacrolimus, FK 506, Fujimycin, Hecoria, Prograf, Protopic
Emory University
Acute Leukemia, Chronic Lymphocytic Leukemia, Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Diffuse Large B-Cell Lymphoma, Follicular Lymphoma, Graft Versus Host Disease, Mantle Cell Lymphoma, Marginal Zone Lymphoma, Myelodysplastic Syndrome, Myelofibrosis, Myeloproliferative Neoplasm, Small Lymphocytic Lymphoma
07/17
07/17
NCT02500550 / 2015-002821-20: Safety and Efficacy of Two Doses of ATIR101, a T-lymphocyte Enriched Leukocyte Preparation Depleted of Host Alloreactive T-cells, in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a Haploidentical Donor

Checkmark AIR-008 study for GVHD
Jan 2018 - Jan 2018: AIR-008 study for GVHD
Checkmark Safety data readout from CR-AIR-008 trial for GVHD in patients with hematologic malignancies post-HSCT
Dec 2016 - Dec 2016: Safety data readout from CR-AIR-008 trial for GVHD in patients with hematologic malignancies post-HSCT
Completed
2
15
Europe, Canada, RoW
ATIR101, Haploidentical hematopoietic stem cell transplantation (HSCT), TBI regime, Non-TBI regime
Kiadis Pharma
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome
07/18
12/18
NCT00899431: Nonmyeloablative Stem Cell Transplantation for Chronic Lymphocytic Leukemia (CLL)

Terminated
2
39
US
Lenalidomide, CC-5013, Revlimid, Fludarabine, Fludara, Fludarabine Phosphate, Rituximab, Rituxan, Thymoglobulin, ATG, rabbit anti-thymocyte globulin, Stem Cell Transplantation, SCT, Nonmyeloablative Stem Cell Transplantation, Bendamustine, Bendamustine Hydrochloride, Bendamustine HCL, CEP-18083, SDX-105, Treanda, Allopurinol, Lopurin, Zurinol, Zyloprim
M.D. Anderson Cancer Center, Celgene Corporation
Chronic Lymphocytic Leukemia
10/18
10/18
NCT01985061: Evaluation of 3 Different Doses of IV Busulfan

Unknown status
2
177
Europe
BX2, Busulfan Intravenous 2 days at 3.2 mg/kg/d, BX3, Busulfan Intravenous 3 days, BX4-Suspended, Busulfan intravenous 4 days
Institut Paoli-Calmettes
Myelodysplastic Syndrome, Acute Myeloid Leukemia
12/18
12/18
NCT00857389: Thiotepa-Clofarabine-Busulfan With Allogeneic Stem Cell Transplant for High Risk Malignancies

Completed
2
60
US
Thiotepa, Thio, Clofarabine, Clo, Clofarex, Clolar, Busulfan, Busulfex, Myleran, Allogeneic Stem Cell Transplantation, ASCT, SCT, Thymoglobulin (ATG), Antithymocyte globulin, G-CSF (Filgrastim), Neupogen, Tacrolimus, Prograf, Methotrexate, Cyclophosphamide, Cytoxan, Neosar, Mesna, Mesnex
M.D. Anderson Cancer Center
Stem Cell Transplantation, Leukemia, Lymphoma
03/19
03/19
NCT02627573: Trial of GVHD Prophylasxis With PTCy or Thymoglobulin in Unrelated SCT

Terminated
2
32
RoW
Unrelated allogeneic stem cell transplantation, Busulfan, Fludarabine monophosphate, Tacrolimus, Mycophenolate mofetil, Cyclophosphamide, Thymoglobulin
St. Petersburg State Pavlov Medical University
Leukemia, Chronic Myeloid, Myelodysplastic Syndromes, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
04/19
04/19
NCT01490723: Zevalin-Containing Nonmyeloablative Conditioning for Stem Cell Transplantation (SCT)

Completed
2
20
US
Rituximab, Rituxan, 111In Ibritumomab, Zevalin, Planar Scintigraphy Imaging, 90Y IbritumomabTiuxetan, Fludarabine, Fludarabine Phosphate, Fludara, Bendamustine, Bendamustine Hydrochoride, Bendamustine HCL, CEP-18083, SDX-105, Treanda, Thymoglobulin, ATG, Antithymocyte Globulin, Tacrolimus, Prograf, Methotrexate, Mycophenolate, MMF, Mycophenolate Mofetil, CellCept, G-CSF, Filgrastim, Neupogen, Stem Cell Transplantation, Allogeneic transplantation
M.D. Anderson Cancer Center, Spectrum Pharmaceuticals, Inc
Leukemia, Lymphoma
04/19
04/19
NCT02424968: CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

Completed
2
18
US
Anti-Thymocyte Globulin, Antithymocyte Globulin, Antithymocyte Serum, ATG, ATGAM, ATS, Thymoglobulin, Cyclosporine, 27-400, Ciclosporin, CsA, Cyclosporin, Cyclosporin A, Neoral, OL 27-400, Sandimmun, Sandimmune, SangCya, Mycophenolate Mofetil, Cellcept, MMF, Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplant, Non-myeloablative allogeneic transplant, Nonmyeloablative Stem Cell Transplant, NST, Peripheral Blood Stem Cell (PBSC) Transplant, Peripheral Stem Cell Support, Peripheral Stem Cell Transplant, Allogeneic Cluster of Differentiation 8 (CD8)+ Memory T-cells, Allogeneic Lymphocytes, Tumor-Derived Lymphocyte, Total Nodal Irradiation
Robert Lowsky, National Cancer Institute (NCI)
Acute Myeloid Leukemia, B-Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin Lymphoma, Myelodysplastic Syndrome, Myeloproliferative Neoplasm, T-Cell Non-Hodgkin Lymphoma
07/20
04/21
NCT03600909: A Study of the Effect of Blood Stem Cell Transplant After Chemotherapy Alone in Patients With Fanconi Anemia

Terminated
2
3
US
Busulfan, busulfex®, Fludarabine, FLUDARA®, Cyclophosphamide, Cytoxan®, Anti-Thymocyte Globulin (Rabbit), hymoglobulin®, The CliniMACS device, G-CSF, Granulocyte colony-stimulating factor, filgrastim
Memorial Sloan Kettering Cancer Center, Pediatric Brain Tumor Consortium
Fanconi Anemia, Myelodysplastic Syndrome (MDS), Acute Myelogenous Leukemia (AML)
04/21
04/21
NCT03412409: RIC Regimen for Elderly or High Comorbidity Burden Patients Receiving Haplo-HSCT

Recruiting
2
50
RoW
Cytarabine, Busulfan, Cyclophosphamide, Fludarabine, Semustine, Antithymocyte globulin
Peking University People's Hospital
Acute Leukemia, Myelodysplastic Syndromes
09/25
09/25
NCT02441803: Allogeneic Hematopoietic Stem Cell Transplantation (AlloSCT) Initial Salvage Therapy for Induction Failure Acute Myeloid Leukemia (AML)

Completed
2
11
US
Busulfan, Busulfex, Myleran, Fludarabine, Fludarabine Phosphate, Fludara, Clofarabine, Clofarex, Clolar, Total Body Irradiation (TBI), TBI, XRT, Thymoglobulin, ATG (Rabbit), Rabbit Antithymocyte Globulin, Rabbit Antilymphocyte Globulin, Rabbit ATG, rATG, Stem Cell Infusion, Cyclophosphamide, Cytoxan, Neosar, Tacrolimus, Prograf, Mycophenolate mofetil, MMF, CellCept, Decitabine, Dacogen, Cytarabine, Ara-C, Cytosar, DepoCyt, Cytosine Arabinosine Hydrochloride, Idarubicin, Idamycin
M.D. Anderson Cancer Center
Leukemia
09/20
09/21
NCT03096782: Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma

Completed
2
6
US
Anti-Thymocyte Globulin, Antithymocyte Globulin, Antithymocyte Serum, ATG, ATGAM, ATS, Thymoglobulin, Busulfan, 1, 4-Bis[methanesulfonoxy]butane, BUS, Bussulfam, Busulfanum, Busulfex, Busulphan, CB 2041, CB-2041, Glyzophrol, GT 41, GT-41, Joacamine, Methanesulfonic Acid Tetramethylene Ester, Methanesulfonic acid, tetramethylene ester, Mielucin, Misulban, Misulfan, Mitosan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Tetramethylene Bis(methanesulfonate), Tetramethylene bis[methanesulfonate], WR-19508, Clofarabine, Clofarex, Clolar, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, Filgrastim-sndz, Filgrastim Biosimilar Filgrastim-sndz, Zarxio, Fludarabine, Fluradosa, Melphalan, Alanine Nitrogen Mustard, CB-3025, L-PAM, L-Phenylalanine Mustard, L-sarcolysin, L-Sarcolysin Phenylalanine mustard, L-Sarcolysine, Melphalanum, Phenylalanine Mustard, Phenylalanine nitrogen mustard, Sarcoclorin, Sarkolysin, WR-19813, Mycophenolate Mofetil, Cellcept, MMF, Rituximab, ABP 798, BI 695500, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT-P10, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, MabThera, Monoclonal Antibody IDEC-C2B8, PF-05280586, Rituxan, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar IBI301, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, RTXM83, Tacrolimus, FK 506, Fujimycin, Hecoria, Prograf, Protopic, Total-Body Irradiation, Total Body Irradiation, Whole-Body Irradiation, Umbilical Cord Blood Transplantation, Cord Blood Transplantation, UCB transplantation
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia, Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Chemotherapy-Related Leukemia, Chronic Lymphocytic Leukemia, Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Chronic Myelomonocytic Leukemia, Hodgkin Lymphoma, Langerhans Cell Histiocytosis, Minimal Residual Disease, Myelodysplastic Syndrome, Myelodysplastic Syndrome With Excess Blasts, Non-Hodgkin Lymphoma, Recurrent Hodgkin Lymphoma, Refractory Acute Lymphoblastic Leukemia, Refractory Myelodysplastic Syndrome, Small Lymphocytic Lymphoma, Therapy-Related Myelodysplastic Syndrome
09/22
09/22
NCT04872595: A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant

Active, not recruiting
2
59
US
Personalized rATG (P-rATG), Hyper fractionated total body irradiation, Thiotepa, Cyclophosphamide, GCSF, Busulfan, Melphalan, Fludarabine
Memorial Sloan Kettering Cancer Center
Acute Myeloid Leukemia (AML), Acute Lymphoid Leukemia (ALL), Myelodysplastic Syndromes (MDS)
04/25
04/25
NCT03121014: Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes

Recruiting
2
38
US
Fludarabine, Fludara®, Busulfan, Busulfex®, ATG, Thymoglobulin®, Total Marrow Irradiation, Stem Cell Product Infusion, Tacrolimus, FK-506, Prograf®, Methotrexate, Trexall®
University of Illinois at Chicago
Acute Myeloid Leukemia, Myelodysplastic Syndromes
04/24
04/24
RAFA, NCT02143830: HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy

Recruiting
2
70
US
Busulfan, Myleran, Busulfex IV, Cyclophosphamide, Cytoxan, Fludarabine, Fludara, rabbit ATG, thymoglobulin, G-CSF, Granulocyte colony-stimulating factor, filgrastim, neupogen, Peripheral blood stem cell
Children's Hospital Medical Center, Cincinnati, Memorial Sloan Kettering Cancer Center, Fred Hutchinson Cancer Center
Fanconi Anemia, Severe Marrow Failure, Myelodysplastic Syndrome (MDS), Acute Myelogenous Leukemia (AML)
07/24
07/26
NCT02790515: Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

Recruiting
2
52
US
Anti-thymocyte globulin (rabbit), Thymoglobulin®, rabbit ATG, Blinatumomab, Blincyto, Cyclophosphamide, Cytoxan, Fludarabine, Fludara, G-CSF, Filgrastim, Neupogen®, Melphalan, L-phenylalanine mustard, Phenylalanine mustard, L-PAM, L-sarcolysin, Alkeran, Mesna, Mesnex, Rituximab, Rituxan™, Tacrolimus, FK506, Prograf®, Protopic®, Thiotepa, Thioplex® by Immunex, TESPA, TSPA, HPC,A Infusion, Transplant, CliniMACS, Cell Selection System, Sirolimus, Rapamycin, Rapamune®
St. Jude Children's Research Hospital
Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Myeloid Sarcoma, Chronic Myeloid Leukemia (CML), Juvenile Myelomonocytic Leukemia (JMML), Myelodysplastic Syndrome (MDS), Non-Hodgkin Lymphoma (NHL)
07/24
07/25
NCT03615105: Donor Stem Cell Transplantation Using α/β+ T-lymphocyte Depleted Grafts From HLA Mismatched Donors

Terminated
2
9
US
Hyperfractionated total body irradiation, Thiotepa, Cyclophosphamide, Busulfan, Fludarabine, Melphalan, Clofarabine, HPC(A) stem cell allograft, Rituximab, Rabbit antithymocyte globulin
Memorial Sloan Kettering Cancer Center
Acute Lymphoid Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia
03/24
03/24
HAP2HCT, NCT03849651: TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

Active, not recruiting
2
140
US
Cyclophosphamide, Cytoxan, Fludarabine, Fludara, Thiotepa, Thioplex, Melphalan, Alkeran, G-csf, Neupogen, Filgrastim, Mesna, Mesnex, CliniMACS, CliniMACS Prodigy, ATG (rabbit), Thymoglobulin, Blinatumomab, Blincyto, TCRα/β+, CD19+, CD45RA-depleted DLI
St. Jude Children's Research Hospital
Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), NK-Cell Leukemia, Hodgkin Lymphoma, Non Hodgkin Lymphoma (NHL), Juvenile Myelomonocytic Leukemia (JMML), Chronic Myeloid Leukemia (CML)
07/24
07/25
NCT04202835: ATG Plus PTCy vs ATG for CGVHD Prophylaxis

Recruiting
2
80
Canada, RoW
Cyclophosphamide, Anti-Thymocyte globulin (rabbit), Thymoglobulin
McMaster University, Cell Therapy Transplant Canada, Sanofi, Ozmosis Research Inc.
Acute Leukemia, Myelodysplasia, Chronic Graft-versus-host-disease
10/24
12/24
NCT04688021: A Single-arm Trial of Prophylactic Tocilizumab for Acute GVHD Prevention After Haploidentical HSCT.

Recruiting
2
46
RoW
Cytarabine, Busulfan, Cyclophosphamide, Me-CCNU, Rabbit antithymocyte globulin, Tocilizumab, Allogeneic HSCT, Cyclosporin A, Mycophenolate Mofetil, MTX
Yi Luo
Leukemia, Graft-versus-host-disease
12/24
12/24
MoTD, NCT04888741 / 2019-002419-24: Methods of T Cell Depletion Trial

Recruiting
2
400
Europe
Thymoglobulin, ATG, Cyclophosphamide, Cyclosporine, Sirolimus, Mycophenolate Mofetil, MMF
University of Birmingham, IMPACT (funded by NHS Blood & Transplant, Anthony Nolan and Leukaemia UK)
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes, Non Hodgkin Lymphoma, Hodgkin Lymphoma, Multiple Myeloma, Chronic Myelogenous Leukemia, Myelofibrosis
01/26
01/26
NCT03852407: Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioning

Recruiting
2
114
Europe
Thymoglobulin, ATG, Melphalan, alkeran, Fludarabine, Cyclophosphamid, PTCy
University of Liege, Belgian Hematological Society
Acute Myeloid Leukemia in Remission, Myelodysplastic Syndromes, Chronic Myeloid Leukemia in Remission, Myeloproliferative Syndrome, Myeloproliferative Disorder, Acute Lymphoid Leukemia in Remission, Multiple Myeloma, Chronic Lymphoid Leukemia, Non Hodgkin Lymphoma, Hodgkin Lymphoma
11/33
11/38
NCT00038831: Allo Transplantation With Mylotarg, Fludarabine and Melphalan for AML, CML and MDS

Completed
1/2
47
US
Mylotarg, Gemtuzumab, Gemtuzumab ozogamicin, Fludarabine, Fludara, Fludarabine Phosphate, Melphalan, Alkeran, Anti-thymocyte globulin, Rabbit anti-thymocyte globulin, Anti-thymocyte globulin (ATG), Stem cell transplant, alloBMT, Allo PBSCT
M.D. Anderson Cancer Center
Acute Myelogenous Leukemia, Myelodysplastic Syndrome, Chronic Lymphocytic Leukemia
03/05
10/06
NCT00054340: Combination Chemotherapy and Antithymocyte Globulin in Reducing Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplantation For Myelodysplastic Syndrome or Myeloproliferative Disorder

Completed
1/2
US
anti-thymocyte globulin, busulfan, cyclophosphamide, cyclosporine, methotrexate, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
 
09/06
NCT00801931: Double Cord Blood Transplant for Patients With Malignant and Non-malignant Disorders

Terminated
1/2
1
US
Alemtuzumab, Lemtrada, Campath, Total Body Irradiation, TBI, Melphalan, Alkeran, Busulfan, Busulfex, Myleran, Phenytoin, Fosphenytoin, Dilantin, Fludarabine, Fludara, Cyclophosphamide, Cytoxan, Neosar, Horse Antithymocyte Globulin, Atgam, ATG[horse], Rabbit Antithymocyte Globulin, Thymoglobulin, Thiotepa, Tepadina
Columbia University
Leukemia, Lymphoma, Neuroblastoma, Immunodeficiencies, Anemia
05/09
05/09
NCT00303667: Donor Natural Killer Cells and Aldesleukin in Treating Patients w/High Risk AML Undergoing Donor Stem Cell Transplant

Completed
1/2
50
US
aldesleukin, Interleukin-2, IL-2, natural killer cells, therapeutic allogeneic lymphocytes, cyclophosphamide, Cytoxan, fludarabine phosphate, Fludara, allogeneic hematopoietic stem cell transplantation, PBSC, total body irradiation, Thymoglobulin, rabbit ATG, Cyclosporin A, CSA
Masonic Cancer Center, University of Minnesota
Acute Myelogenous Leukemia
03/11
03/11
NCT01050764: Haploidentical Allogeneic Transplant With Post-transplant Infusion of Regulatory T-cells

Terminated
1/2
10
US
Regulatory T-cells, T-reg cells, Conventional T-cells, T-con cells, Melphalan, L-PAM, L-Sarcolysin, Phenylalanine Mustard, Thiotepa, thiophosphamide, TESPA, TSPA, Fludarabine, Fludarabine phosphate, Fludarabine 5'-monophosphate, FAMP, Fludara, Anti-thymocyte globulin, rabbit, Thymoglobulin, rATG, CliniMACS CD34 Reagent System
Everett Meyer, Doris Duke Charitable Foundation
Leukemia, Acute, Chronic Myelogenous Leukemia (CML), Myelodysplastic Syndrome (MDS), Non-Hodgkin Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL), Acute Myelogenous Leukemia (AML), Acute Lymphoblastic Leukemia (ALL)
08/12
06/14
NCT00822770: Plerixafor and Granulocyte Colony-stimulating Factor (G-CSF) With Busulfan, Fludarabine and Thymoglobulin

Completed
1/2
47
US
Plerixafor, AMD3100, Filgrastim, G-CSF, Neupogen, Fludarabine, Fludarabine Phosphate, Fludara, Busulfan, Busulfex™, Myleran®, Allogeneic blood stem cell transplant, Bone Marrow Transplantation, Blood Stem Cell Transplantation, ATG (Thymoglobulin), Antithymocyte globulin
M.D. Anderson Cancer Center, Genzyme, a Sanofi Company
Stem Cell Transplantation, Leukemia
10/12
10/12
ACTRN12613000338763: Haploidentical donor stem cell transplantation for haematological malignancies - a Phase 1/2 pilot study in an Australian population

Completed
1/2
5
 
St Vincent's Hospital,Sydney, St Vincent's Hospital,Sydney
Haematological malignancies
 
 
NCT00396968: AMD3100 With Busulfan, Fludarabine and Thymoglobulin for Allogeneic Stem Cell Transplant for AML and MDS

Withdrawn
1/2
0
US
AMD3100, Allogeneic Stem Cell Transplantation
Genzyme, a Sanofi Company, AnorMED
Acute Myelogenous Leukemia, Myelodysplastic Syndromes
 
 
NCT00679536: Allogeneic Transplantation for Pediatric Leukemias With Unrelated Donors

Unknown status
1/2
30
US
Busulfan, IV Busulfex, Fludarabine, Fludara, Thymoglobulin, Total Body Irradiation
Ann & Robert H Lurie Children's Hospital of Chicago
Leukemia
05/15
05/15
NCT00448357: Allogeneic Hematopoietic Cell Transplantation for Patients With Busulfex-based Regimen

Completed
1/2
54
US
rabbit anti-thymocyte globulin (ATG), therapeutic allogeneic lymphocytes, busulfan, fludarabine phosphate, tacrolimus, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, methotrexate
UNC Lineberger Comprehensive Cancer Center, National Cancer Institute (NCI), Otsuka America Pharmaceutical
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
11/15
11/15
NCT01629511: Allogeneic Stem Cell Transplant for CLL

Terminated
1/2
15
US
Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Cell Transplantation, Allogeneic Stem Cell Transplantation, HSC, HSCT, Anti-Thymocyte Globulin, Antithymocyte Globulin, Antithymocyte Serum, ATG, ATGAM, ATS, Thymoglobulin, Busulfan, 1, 4-Bis[methanesulfonoxy]butane, BUS, Bussulfam, Busulfanum, Busulfex, Busulphan, CB 2041, CB-2041, Glyzophrol, GT 41, GT-41, Joacamine, Methanesulfonic Acid Tetramethylene Ester, Methanesulfonic acid, tetramethylene ester, Mielucin, Misulban, Misulfan, Mitosan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Tetramethylene Bis(methanesulfonate), Tetramethylene bis[methanesulfonate], WR-19508, Clofarabine, Clofarex, Clolar, Filgrastim, FILGRASTIM, LICENSE HOLDER UNSPECIFIED, G-CSF, Neupogen, r-metHuG-CSF, Recombinant Methionyl Human Granulocyte Colony Stimulating Factor, rG-CSF, Tevagrastim, Gemcitabine, dFdC, dFdCyd, Difluorodeoxycytidine, Methotrexate, Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, CL 14377, CL-14377, Emtexate, Emthexat, Emthexate, Farmitrexat, Fauldexato, Folex, Folex PFS, Lantarel, Ledertrexate, Lumexon, Maxtrex, Medsatrexate, Metex, Methoblastin, Methotrexate LPF, Methotrexate Methylaminopterin, Methotrexatum, Metotrexato, Metrotex, Mexate, Mexate-AQ, MTX, Novatrex, Rheumatrex, Texate, Tremetex, Trexeron, Trixilem, WR-19039, Tacrolimus, FK 506, Fujimycin, Hecoria, Prograf, Protopic
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, Richter Syndrome
04/18
04/18
ABCD-NK, NCT06158828: Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML

Recruiting
1/2
48
US
Rabbit Anti thymocyte globulin, rATG, Busulfan, Fludarabine, Thiotepa, Melphalan, Evolema, Alkeran, TCR alpha beta / CD19+ depleted haploidentical hematopoietic progenitor cell graft, TCRab/CD19+ depleted haploidentical HPC graft, memory-like natural killer cells, ML NK cells, IL-2, Plerixafor, Granulocyte Colony-Stimulating Factor, G-CSF, CliniMACS
Washington University School of Medicine, The Leukemia and Lymphoma Society, Rising Tide Foundation, St. Louis Children's Hospital Foundation
AML, Childhood, Aml, Acute Myeloid Leukemia, Pediatric, Acute Myeloid Leukemia
09/28
05/30

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