| Zynrelef (bupivacaine/meloxicam ER) / Heron Therapeutics |
| Completed | 2b | 243 | US | HTX-011, Bupivacaine HCl without epinephrine, Saline Placebo | Heron Therapeutics | Postoperative Pain | 02/18 | 03/18 | | |
NCT03015532: Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia |
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| Completed | 2b | 285 | US | HTX-011, Saline Placebo, Bupivicaine HCl, Ropivacaine | Heron Therapeutics | Postoperative Pain | 04/18 | 05/18 | | |
NCT02471898: A Phase 2, Two-Part Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy |
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| Completed | 2 | 71 | US | HTX-011, Placebo | Heron Therapeutics | Analgesia | 09/15 | 09/15 | | |
NCT02762929: Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy |
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| Completed | 2 | 430 | US | HTX-011A, Saline Placebo, HTX-011B, HTX-002, Bupivacaine HCl, HTX-009 | Heron Therapeutics | Postoperative Pain, Bunions | 02/17 | 03/17 | | |
NCT02504580: A Pilot Study to Investigate the Safety, Efficacy, Pharmacokinetics and Bioavailability of HTX-011, HTX-002, or HTX-009 Administered Via Injection and/or Topical Application Following Unilateral Open Inguinal Herniorrhaphy |
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| Completed | 2 | 463 | US | HTX-011, Placebo, HTX-002, Bupivacaine HCI (Marcaine), HTX-011A, HTX-011B, HTX-009 | Heron Therapeutics | Postoperative Pain | 03/17 | 04/17 | | |
NCT02689258: Evaluation of the Efficacy and Safety of HTX-011 for Postoperative Analgesia Following Abdominoplasty Surgery |
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| Completed | 2 | 277 | US | HTX-011B, Placebo, HTX-011A, HTX-002, Bupivicaine HCl | Heron Therapeutics | Postoperative Pain | 03/17 | 04/17 | | |
NCT03695367: Phase 2 Herniorrhaphy Study for Opioid Elimination |
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| Completed | 2 | 63 | US | HTX-011, Luer lock applicator, Vial access device, Ibuprofen, Acetaminophen, Ketorolac | Heron Therapeutics | Postoperative Pain | 11/18 | 12/18 | | |
NCT03718039: Phase 2 Bunionectomy HTX-011 Administration Study |
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| Completed | 2 | 78 | US | HTX-011, Luer Lock applicator, Vial access device, aprepitant | Heron Therapeutics | Postoperative Pain | 01/19 | 03/19 | | |
NCT03955211: HTX-011 Administration Study in Planned Caesarean Section Procedure |
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| Completed | 2 | 25 | US | HTX-011, Cohort 1, Cohort 2, Luer Lock Applicator, Ibuprofen, Acetaminophen | Heron Therapeutics | Analgesia | 12/21 | 12/21 | | |
| Completed | 2 | 32 | US | Bupivacaine HCI without epinephrine, HTX-011, Luer Lock Applicator | Heron Therapeutics | Post-Operative Pain, Lumbar Laminectomy | 07/22 | 08/22 | | |
NCT03922048: Pediatric Postoperative Analgesia Herniorrhaphy Study |
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| Withdrawn | 2 | 336 | NA | HTX-011, Bupivacaine HCl, Luer Lock Applicator | Heron Therapeutics | Analgesia | 11/25 | 12/25 | | |
