Recruiting

4

120

 

St Vincent's Hospital, Clinical Pharmacology Lexy Davies Trust Fund

Gout

 

 

Ongoing

4

4706

Europe

Feboxostat Trade Name: Adenuric, Allopurinol, Adenuric, Allopurinol, Adenuric, Allopurinol

University of Dundee, , Menarini

Chronic symptomatic hyperuricaemic

 

 

Recruiting

4

100

 

febuxostat ;allopurinol

the Affiliated Hospital of Qingdao University; the Affiliated Hospital of Qingdao University, raise independently

Hyperuricemia

 

 

Recruiting

4

804

 

Febuxostat + fenofibrate: febuxostat 20mg / day + fenofibrate capsule 200mg /day, oral,at breakfast ;Benzobromide tablets + fenofibrate: benzbromarone 25mg /day + fenofibrate capsules 200mg / day, oral,at breakfast

Affiliated Hospital of Qingdao University; Affiliated Hospital of Qingdao University，Shandong Gout Clinical Medical Center, Provided by the tester

gout

 

 

Not yet recruiting

4

120

 

patients treated with Febuxostat Tablets ;patients treated without Febuxostat Tablets

Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Jiangsu Hengrui pharmaceutical Limited by Share Ltd

hyperuricemia

 

 

Recruiting

4

275

 

stepwise dose increase of febuxostat ;febuxostat+colchicine ;febuxostat40mg/d

Anqing Hospital Affiliated to Anhui Medical University; Anqing Hospital Affiliated to Anhui Medical University, Scientific research foundation of anhui medical university

Gout

 

 

Recruiting

4

150

 

febuxostat tables ;Lifestyle

Chengdu University of Traditional Chinese Medicine; Chengdu University of Traditional Chinese Medicine, JIANG SU HENG RUI MEDICINE CO,.LTD

simple obesity with asymptomatic hyperuricemia

 

 

Ongoing

4

310

Europe

Tablet, Zyloric, Adenuric 80 mg, Desuric

VieCuri, ZonMW, ReumaNederland

gout, gout, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Not yet recruiting

4

168

 

Febuxostat 20mg, 2 tablets, qd; medicinal carbon tablets analog, 8 tablets, tid; oral ;Febuxostat 20mg, 1 tablet, febuxostat analog tablet, 1 tablet, qd; medicinal carbon tablets, 5 tablets, medicinal carbon tablets analog, 3 tablets, tid; oral ;Febuxostat 20mg, 1 tablet, febuxostat analog tablet, 1 tablet, qd;medicinal carbon tablets, 8 tablets, tid; oral ;Febuxostat 20mg, 1 tablet, febuxostat analog tablet, 1 tablet, qd; medicinal carbon tablets analog, 8 tablets, tid; oral

Affiliated Hospital of Qiingdao University; Affiliated Hospital of Qingdao University, Provided by the tester

gout

 

 

Recruiting

4

120

 

Paeonia total glycosides capsule 0.6g Tid ;Blank control group ;Febuxostat capsules 20mg Qd + total glucosides of paeony capsules 0.6g tid ;Febuxostat capsules 20mg Qd

The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital) Department of Rheumatology and Immunology; The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Ningbo Lihua Pharmaceutical Co., Ltd.

Gout

 

 

Recruiting

4

270

 

Febuxostat 20mg qd + citrate effervescent tablets 3.5g bid (initial treatment); Febuxostat 40mg qd + citrate effervescent tablets 3.5g bid (adjusted based on urate level) ;Febuxostat 20mg qd + sodium bicarbonate 1g tid (initial treatment); Febuxostat 40mg qd + sodium bicarbonate 1g tid (adjusted based on urate level) ;Febuxostat 20mg qd + tart cherrycitrate effervescent tablets 3.5g bid (initial treatment); Febuxostat 40mg qd + tart cherry citrate effervescent tablets 3.5g bid (adjusted based on urate level)

Affiliated Hospital of Qiingdao University; Affiliated Hospital of Qingdao University, Provided by the tester

gout

 

 

Ongoing

4

10

RoW

Tablet, Uloric, Allopurinol Alvogen

Landspitali - The National University Hospital of Iceland, Icelandic Research Fund

Adenine phosphoribosyltransferase deficiency, Adenine phosphoribosyltransferase deficiency is a hereditary disorder causing kidney stones and kidney failure in untreated patients., Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]

 

 

Recruiting

4

548

RoW

Febuxostat, Febuxostat Tablets, Placebo

Sun Yat-sen University

Hyperuricemia

12/22

12/22

Completed

4

90

RoW

Allopurinol (100 mg/day) plus lifestyle intervention, Allopurinol group, Febuxostat 40 mg plus lifestyle intervention, Febuxostat group, Life style intervention

Ain Shams University

Non-Alcoholic Fatty Liver Disease, Hyperuricemia

01/23

01/23

Not yet recruiting

4

132

 

Sixteen males are planned to be enrolled. Subjects took 2mg midazolam orally on an empty stomach in D1 to detect midazolam concentration ;Sixteen males are planned to be enrolled. Subjects took febuxostat 80mg orally on an empty stomach D1 to detect febuxostat concentration ;A total of 100 healthy subjects were included in the phase 1 clinical trial. 5 ml of venous blood was collected for the detection of drug metabolism enzyme related gene polymorphism, gene expression and metabonomics

Beijing Friendship Hospital, Capital Medical University; Beijing Friendship Hospital, Capital Medical University, Self-raised funds

Obesity

 

 

Recruiting

4

195

 

Febuxostat 20 mg bid + rebamipide 0.1 g tid; Febuxostat 20 mg bid + colchicine tablets 0.5 mg qd; Febuxostat 20 mg bid

Anqing Hospital Affiliated to Anhui Medical University; Anqing Hospital Affiliated to Anhui Medical University, self-finance

gout

 

 

Not yet recruiting

3

128

Europe

ADENURIC, AMM EU/1/08/447/024, Film-coated tablet, ADENURIC (fébuxostat) 80 mg

University Hospital Centre of Rouen, University Hospital Centre of Rouen

Patients with gout attacks Malades atteints d'une crise de goutte, Gout disease Maladie de la goutte, Diseases [C] - Nutritional and Metabolic Diseases [C18]

 

 

Not yet recruiting

3

750

NA

HR091506 tablets + placebo of febuxostat tablets, febuxostat tablets + placebo of HR091506 tablets

Jiangsu HengRui Medicine Co., Ltd.

Gout With Hyperuricemia in Adults

11/24

06/25

Not yet recruiting

3

128

NA

Adenuric

University Hospital, Rouen

Gout

08/25

08/25

Not yet recruiting

2

129

NA

SHR4640 tablet, febuxostat tablet, SHR4640 placebo tablet

Jiangsu HengRui Medicine Co., Ltd.

Primary Gout and Hyperuricemia

05/23

09/23

2

84

RoW

Febuxostat, IBI128

Innovent Biologics (Suzhou) Co. Ltd.

Gout, Hyperuricemia

01/25

02/25

Not yet recruiting

1

6

 

Prof Tim Florin

inflammatory bowel disease

 

 

Completed

1

60

 

In the fasting state, single and multiple oral doses of 40mg firstly, then single and multiple oral doses of 80mg, finally single oral dose of 120mg ;In the fasting state, single and multiple oral doses of 80mg firstly, then single oral dose of 120mg, finally singl and multiple oral doses of 40mg ;In the fasting state, single oral dose of 120mg firstly, then single oral dose of 40mg, finally single and multiple oral doses of 40mg ;Single oral dose of 80mg in the fasting state, then single oral dose of 80mg in the fed state ;Single oral dose of 80mg in the fed state, then single oral dose of 80mg in the fasting state

The first affiliated hospital, School of Medicine, Zhejiang University; Jiang Su Heng Rui Co. LTD, Provided by Jiang Su Heng Rui Co. LTD

gout

 

 

Not yet recruiting

1

90

NA

HR091506 tablets + placebo of febuxostat tablets, febuxostat tablets + placebo of HR091506 tablets

Jiangsu HengRui Medicine Co., Ltd.

Primary Gout With Hyperuricemia in Adults

07/22

07/22

Not yet recruiting

1

168

 

Oral Jianpi Qushi prescription + lifestyle adjustment (diet, exercise) ;Oral febuxostat treatment+lifestyle adjustment (diet, exercise）

Tianjin First Central Hospital; Tianjin First Central Hospital, Self-raised

hyperuricemia

 

 

Not yet recruiting

1

46

NA

Febuxostat-Test product, Febuxostat-Reference product

Bio-innova Co., Ltd

Healthy Subjects

10/24

10/24

Recruiting

N/A

120

 

Westen medical treatmentswith uricosuric ;Routine treatment of Westen medicine

The Affiliated Hospital of Qingdao University; The Affiliated Hospital of Qingdao University, Self-reliance

gout

 

 

Not yet recruiting

N/A

140

 

Diclofenac 75mg, b.i.d ;Diclofenac 75mg, b.i.d, + Febuxostat 40mg/d

Shenzhen Traditional Chinese Medicine Hospital, the fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen; The Second Affiliated Hospital Guiyang College of Traditional Chinese Medicine, This study was funded by the Sanming Project of Medicine in Shenzhen

Gout

 

 

Recruiting

N/A

 

Febuxostat ;Nil

Deyang People's Hospital; Deyang People's Hospital, Health Hommission of Sichuan Provincial

Prehypertension

 

 

Recruiting

N/A

162

 

4 weeks of low-dose colchicine for preventing ;12 weeks of low-dose colchicine for preventing ;24 weeks of low-dose colchicine for preventing

The Second Affiliated Hospital, Zhejiang University School of Medicine; The Second Affiliated Hospital, Zhejiang University School of Medicine, Self-funding

Gout

 

 

Recruiting

N/A

288

 

Febuxostat tablets

Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine; Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine, self-raised

CKD stages 2-4 patients with hyperuricemia

 

 

Not yet recruiting

N/A

60

 

Control ;benzene bromine Malone ;Febuxostat

Shanghai General Hospital; Shanghai General Hospital, Scientific research project funds

Diabetic retinopathy

 

 

Not yet recruiting

N/A

90

 

Jianpi Bushen Xiezhuo Fang ;Febuxostat ;benzbromarone

Chongqing Hospital of Traditional Chinese Medicine; Chongqing Hospital of Traditional Chinese Medicine, Scientific research project of Chongqing Health and Family Planning Commission

gout

 

 

Not yet recruiting

N/A

100

 

Control group: Participants were instructed to maintain a healthy lifestyle and limit their intake of high purine diets. A follow-up examination was conducted after twelve weeks. After reexamination, it is recommended that patients receive clinical standardized treatment for those who meet clinical treatment standards. ;Intervention group: 1. According to the "Chinese HUA and Gout Diagnosis and Treatment Guidelines (2019)" , guide all SUA > 420 μmol/L. Patients with mol/L maintain a healthy lifestyle, including weight control, limiting alcohol and high purine and fructose intake; Encourage the intake of dairy products, vegetables, and moderate drinking water; Do not recommend or limit the intake of soy products. 2. Patient's blood uric acid level > 540 μmol/L, use Febuxostat, the initial dose is 20 mg/time, once a day, and recheck for 2 weeks. According to the blood uric acid value, 20 mg/time can be increased, and the maximum daily dose is 80mg. Take continuously for 4 weeks. The goal is to control blood uric acid levels below 420 μmol/L. 3. Patients with a morning urine pH value of < 6.0 should take sodium bicarbonate at a dose of 1 g/time, twice a day, and drink no less than 2000mL of water per day. It is recommended to use a simple urine pH meter to self monitor the urine pH value, with the goal of maintaining the urine pH between 6.2 and 6.9. If self monitoring is not possible, the urine pH value should be rechecked at least every two weeks. 4. Regular follow-up, including blood uric acid levels and urine pH value. 5. According to the usual onset time of clinical uric acid lowering therapy, this intervention trial lasts for 42 weeks. Check and record all indicators before and after intervention, and keep two urine samples. The intervention experiment is over, and all clinical work continues according to diagnostic and treatment standards.

Xuzhou Central Hospital; Xuzhou Central Hospital, National Natural Science Foundation of China (82070854)

Renal Injury

 

 

Not yet recruiting

N/A

40

 

Febuxostat + Jianpi Shenshi Granule ;Febuxostat

The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine; The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Base funds

Gout Stone

 

 

Not yet recruiting

N/A

40

 

Febuxostat tablet 40mg once a day + Qizhi Gout granules, 1 dose a day, divided into 2 times, orally. ;Febuxostat tablet 40mg once a day + Qizhi gout granule placebo, 1 dose, 2 times a day, orally.

Fangshan Hospital Affiliated to Beijing University of Chinese Medicine; Fangshan Hospital Affiliated to Beijing University of Chinese Medicine, Capital Health development Scientific Research Independent innovation Project

Gout

 

 

Recruiting

N/A

90

 

Febuxostat (40mg/dose, once daily, oral); Qifu Huazhuo Formula (250ml/time, twice a day, oral); Febuxostat (40mg/dose, once daily, oral)+Qifu Huazhuo Formula (250ml/dose, twice daily, oral)

Guangdong Provincial Hospital of Chinese Medicine; Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine, raise independently

gout

 

 

Not yet recruiting

N/A

144

 

Quzhuo Tongbi Granules+Febuxostat; Chinese herbal placebo+Febuxostat

Zhejiang Chinese Medical University; Zhejiang Chinese Medical University, GK2024 Provincial Traditional Chinese Medicine Research Project (24-134)

gout