Sarcoma  >>  Ayvakit (avapritinib) 
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10 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Ayvakit (avapritinib) / Blueprint Medicines
2020-005751-21: Clinical Trial Extension Study with Avapritinib for Patients with Gastrointestinal Stromal Tumors

Not yet recruiting
4
5
Europe
Avapritinib, BLU-285, Tablet
Blueprint Medicines, Blueprint Medicines
Locally Advanced Unresectable or Metastatic Gastrointestinal Stromal Tumor (GIST), Gastrointestinal Tumours, Diseases [C] - Cancer [C04]
 
 
NCT04825574: Study for Patients Previously Treated in Avapritinib Clinical Trials

Active, not recruiting
4
5
Europe
Avapritinib, BLU-285
Blueprint Medicines Corporation
Gastrointestinal Stromal Tumors
08/25
08/25
NCT04771520: Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

Recruiting
2
50
US
Avapritinib, (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1Hpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-yl)pyrimidin-5-yl)ethan-1-amine, AYVAKIT, BLU-285, CS3007, PDGFR alpha/KIT Mutant-specific Inhibitor BLU-285
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8, Locally Advanced Malignant Solid Neoplasm, Locally Advanced Melanoma, Locally Advanced Primary Malignant Central Nervous System Neoplasm, Locally Advanced Sarcoma, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Metastatic Primary Malignant Central Nervous System Neoplasm, Metastatic Sarcoma, Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8, Prognostic Stage IIIC Breast Cancer AJCC v8, Prognostic Stage IV Breast Cancer AJCC v8, Stage IIIC Colorectal Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Stage IV Colorectal Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Colorectal Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8, Stage IVC Colorectal Cancer AJCC v8
02/25
02/25
CS3007-101, NCT04254939: A Study of CS3007 in Subjects With Gastrointestinal Stromal Tumor

Checkmark Preliminary results from a bridging study in Chinese Patients with Unresectable or Metastatic GIST
Sep 2020 - Sep 2020: Preliminary results from a bridging study in Chinese Patients with Unresectable or Metastatic GIST
Checkmark Partial results from P1/2 bridging study in Chinese patients with unresectable or metastatic GIST at ASCO 2020
May 2020 - May 2020: Partial results from P1/2 bridging study in Chinese patients with unresectable or metastatic GIST at ASCO 2020
Completed
1/2
65
RoW
CS3007 (BLU-285)
CStone Pharmaceuticals, Blueprint Medicines Corporation
Gastrointestinal Stromal Tumors
04/20
04/23
NCT04908176: A Drug-drug Interaction Study of Avapritinib and Midazolam

Active, not recruiting
1
10
US
Avapritinib, BLU-285, midazolam
Blueprint Medicines Corporation
Gastrointestinal Stromal Tumors, GIST, Non-resectable Advanced Solid Tumors, Recurrent or Unresectable Central Nervous System (CNS) Tumors
03/24
09/25
NCT05381753: Safety and Efficacy of Avapritinib in Chinese Patients With Gastrointestinal Stromal Tumor (GIST) in the Real World

Recruiting
N/A
200
RoW
Avapritinib, Tyrosine kinase inhibitors other than avapritinib ( imatinib, sunitinib, et al )
CStone Pharmaceuticals
Gastrointestinal Stromal Tumors
05/25
10/25
ChiCTR2200062170: A Real-World study of Avapritinib in the treatment of D842V-Mutated gastrointestinal stromal tumors

Not yet recruiting
N/A
104
 
Nil ;Nil
Fujian Medical University Union Hospital; Fujian Medical University Union Hospital, Fujian Medical University Scientific Research Development Fund
Gastrointestinal stromal tumor
 
 
AVIATOR2020, NCT04927260: French Long Term Registry With Longitudinal Follow up of PDGFRA D842V-GIST Patients

Active, not recruiting
N/A
25
Europe
Patient treated by Avapritinib in real life
Centre Leon Berard, Blueprint Medicines Corporation
GIST, GIST, Malignant, PDGFR-Alpha D842V
04/24
12/24
NCT05464875: A Multicenter Study of Avapritinib Efficacy and Safety of Metastatic or Unresectable Gastrointestinal Stromal Tumors

Not yet recruiting
N/A
74
NA
Xinhua Zhang, MD, Beijing Cancer Hospital, Fudan University, Peking University People's Hospital, Chinese PLA General Hospital, Xiangya Hospital of Central South University, Peking University Shenzhen Hospital, Nanfang Hospital of Southern Medical University, West China Hospital, Jiangsu Cancer Institute & Hospital, Shanghai Zhongshan Hospital, Sun Yat-sen University, Xijing Hospital, Shengjing Hospital, Shanghai Jiao Tong University School of Medicine, Liaoning Cancer Hospital & Institute, Sixth Affiliated Hospital, Sun Yat-sen University, Fujian Medical University Union Hospital, Cancer Hospital of Guangxi Medical University, Wuhan Union Hospital, China, First Affiliated Hospital of Chongqing Medical University, Chongqing University Cancer Hospital
Gastrointestinal Stromal Tumors, Unresectable Solid Tumor, Recurrent Metastatic Malignant Neoplasm
08/24
08/24
NCT05461664: Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA

Not yet recruiting
N/A
74
NA
Xinhua Zhang, MD, Beijing Cancer Hospital, Fudan University, Peking University People's Hospital, Chinese PLA General Hospital, Xiangya Hospital of Central South University, Peking University Shenzhen Hospital, Nanfang Hospital of Southern Medical University, West China Hospital, Jiangsu Cancer Institute & Hospital, Shanghai Zhongshan Hospital, Sun Yat-sen University, Xijing Hospital, Shengjing Hospital, Shanghai Jiao Tong University School of Medicine, Liaoning Cancer Hospital & Institute, Sixth Affiliated Hospital, Sun Yat-sen University, Fujian Medical University Union Hospital, Cancer Hospital of Guangxi Medical University, Wuhan Union Hospital, China, First Affiliated Hospital of Chongqing Medical University, Chongqing University Cancer Hospital
Gastrointestinal Stromal Tumors, Unresectable Solid Tumor, Recurrent Metastatic Malignant Neoplasm
08/24
08/24

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