| Endostar (recombinant human endostatin) / Simcere |
NCT00657423: Impact of Endostar Combined With Chemotherapy on the Angiogenesis of Advanced Non-small Cell Lung Cancer (NSCLC) |
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| Unknown status | 3 | 80 | RoW | Treated by endostar combined with docetaxel and cisplatin, Endostar, Taxotere, Treated by docetaxel and cisplatin | Xijing Hospital, Yantai Medgenn Ltd. | Lung Neoplasms | 12/08 | 04/09 | | |
Dengshan, NCT01124253: Adjuvant Vinorelbine Plus Cisplatin(NP) Versus NP Plus Endostar in Patients With Completely Resected Stage IB-IIIA Non-small Cell Lung Cancer(NSCLC) |
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| Completed | 3 | 250 | RoW | recombinant human endostatin, endostar | Shanghai Jiao Tong University School of Medicine, Shanghai Municipal Science and Technology Commission, Shanghai Chest Hospital, Simcere Pharmaceutical Co., Ltd | Non-small Cell Lung Cancer | 10/09 | 10/09 | | |
NCT00576914: Adjuvant Vinorelbine Plus Cisplatin (NP) Versus NP Plus Endostar in Patients With Completely Resected Stage IB-IIIA Non-small Cell Lung Cancer |
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| Unknown status | 3 | 1108 | RoW | recombinant human endostatin, endostar | Chinese Academy of Sciences, Chinese Academy of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Beijing Chao Yang Hospital | Non-small Cell Lung Cancer | 06/12 | 06/12 | | |
ChiCTR-TRC-11001703: Use MR functional imaging techniques to evaluate the efficacy of Endostar combined chemoradiotherapy |
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| Completed | 3 | 174 | | Concurrent chemotherapy, choose PP or NP, radiotherapy using conventional fractionation methods, PTV prescription dose 60-66Gy/6w, requires 95% PTV receiving 100% of the prescribed dose. ;Endostar started simultaneously with radiotherapy and chemotherapy ;Concurrent chemotherapy started 1 week before Endostar | Shandong Cancer Hospital; China International Medical Foundation（CIMF）, China International Medical Foundation (CIMF) | non-small cell lung cancer, NSCLC | | | | |
CBCRT01, NCT01479036: Trial of Neoadjuvant Endostar, Docetaxel and Epirubicin for Patients With Breast Cancer |
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| Unknown status | 3 | 800 | RoW | docetaxel and epirubicin, Docetaxel, Sanofi-Aventis, Epirubicin, Pfizer, docetaxel and epirubicin plus endostatin, Endostatin, Simcere-Medgenn (No. S20050088) | Xijing Hospital | Breast Cancer | 12/14 | 02/15 | | |
NCT02008422: Clinical Study of Endostar Injection Concomitant With SOX Protocols to Treat Advanced Gastric Cancer |
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| Unknown status | 3 | 120 | RoW | Oxaliplatin, L-OHP, Gimeracil and Oteracil Potassium Capsule, Tegafur Gimeracil Oteracil Potassium Capsule, Endostar injection, rh-Endostatin | Tang Xushan | Gastric Cancer | 05/16 | 08/16 | | |
NCT02283476: The Comparative Study on Rh-Endostatin (Endostar®) Continuous Intravenous Infusion and Routine i.v in Combination With GP Regimens for Phase III B/IV Squamous Cell Lung Cancer and Biological Markers Exploration. |
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| Unknown status | 3 | 200 | RoW | Endostar continuous intravenous infusion, Endostar routine intravenous infusion, Gemcitabine, Cisplatin | Jiangsu Simcere Pharmaceutical Co., Ltd. | Lung Cancer | 11/17 | 11/17 | | |
NCT03008109: Endostar Plus EGFR-TKI（Epidermal Growth Factor Receptor-Tyrosine-Kinase Inhibitor） as a Treatment of EGFR Mutation-positive NSCLC |
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| Unknown status | 3 | 80 | NA | EGFR-TK Inhibitor, Recombinant human endostatin | Zaiwen Fan | Advanced Cancer, Lung Cancer, Nonsmall Cell | 11/17 | 11/18 | | |
NCT02748772: Application of Two Anti-angiogenesis Drugs Combined With Chemotherapy in Advanced Colorectal Cancer Under the Background of Precision Medical |
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| Unknown status | 3 | 148 | RoW | Two Anti-angiogenesis Drugs（Endostar and Thalidomide）, rh-Endostatin；Distaval, Pure chemotherapy（Xelox）, CapeOX | The First People's Hospital of Hefei, Anhui Provincial Cancer Hospital, Anhui Jimin Cancer Hospital, Simcere Pharmaceutical Co., Ltd | Colorectal Neoplasms | 12/17 | 12/18 | | |
NCT02865304: The Efficacy and Safety of Endostar Combined With Taxane-based Regimens for HER-2-negative MBC Patients |
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| Unknown status | 3 | 80 | NA | endostar | Fujian Cancer Hospital | Angiogenesis, Breast Cancer | 12/17 | 12/18 | | |
NCT02579564: Systemic Chemotherapy Combined With Recombinant Human Adenovirus Type 5 and Endostatin Injections for Treatment Malignant Hydrothorax in NSCLC Patients |
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| Unknown status | 3 | 134 | NA | Gemcitabine, Vinorelbine, Paclitaxel, Pemetrexed, Oncorine, recombinant human adenovirus type 5 injection, Endostar, recombinant human endostatin injection, Cisplatin | Xinqiao Hospital of Chongqing | Malignant Hydrothorax, Non Small Cell Lung Cancer | 06/18 | 12/18 | | |
NCT02907710: Endostar Combined With Concurrent Chemoradiotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma |
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| Unknown status | 3 | 300 | RoW | Endostar, recombinant human endostatin, DDP | First Affiliated Hospital of Guangxi Medical University | Nasopharyngeal Carcinoma | 11/18 | 11/19 | | |
| Unknown status | 3 | 120 | RoW | Endostar, recombinant human endostatin, DDP, cisplatin | Yong Zhang,MD | Cervical Carcinoma | 02/20 | 02/20 | | |
NCT02001168: Comparison of Postoperative Adjuvant Chemotherapy With/Without Rh-endostatin on Non-small Cell Lung Cancer in PhaseⅠB |
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| Active, not recruiting | 3 | 392 | RoW | Pemetrexed, Alimta, Docetaxel, Taxotere, rh-Endostatin, Endostar, Cis-platinum, Platinol | Xinjiang Medical University | Non-small Cell Lung Cancer | 12/20 | 10/22 | | |
NCT04914598: A Phase Ⅲ Clinical Study of Combined Cisplatin Versus Placebo Combined With Intracavitary Cisplatin Injection in the Treatment of Malignant Pleural Effusions |
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| Not yet recruiting | 3 | 290 | RoW | ENDOSTAR，cisplatin, Placebo , cisplatin | Jiangsu Simcere Pharmaceutical Co., Ltd. | Malignant Pleural Effusion | 06/22 | 10/23 | | |
NCT02350361: Endostar Combination With Chemotherapy and EGFR-TKI in Lung Cancer Rechallenging Treatment After Acquired Resistance. |
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| Unknown status | 2/3 | 60 | RoW | Recombinant human endostatin, Endostar, Placebo | Peking University Third Hospital | Lung Cancer | 07/15 | 03/16 | | |
EXECC, NCT03577392: Recombinant Human Endostatin in Combination With XELOX Therapy in Patient With Advanced Colorectal Cancer. |
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| Unknown status | 2/3 | 120 | RoW | oxaliplatin + capecitabine (XELOX chemotherapy), rebombniant human endostatin | Sichuan Provincial People's Hospital, Jiangsu Simcere Pharmaceutical Co., Ltd. | Quality of Life | 08/19 | 08/21 | | |
NCT03588494: Endostar in Combination With Chemoradiotherapy in Patient With Advanced Non-small Cell Lung Cancer |
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| Unknown status | 2/3 | 318 | RoW | concurrent chemoradiotherapy (CCRT), Endostar for one cycle, Endostar for two cycles | Affiliated Hospital of North Sichuan Medical College, Jiangsu Simcere Pharmaceutical Co., Ltd. | Quality of Life | 09/19 | 09/21 | | |
NCT01907529: A Trail of Neoadjuvant Endostar in Combination With Chemotherapy in Breast Cancer |
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| Unknown status | 2/3 | 300 | RoW | docetaxel, epirubicin and cyclophosphamide, docetaxel, epirubicin and cyclophosphamide plus endostar | Hebei Medical University Fourth Hospital | Stage III Breast Cancer | 08/20 | 12/21 | | |
