| Venclexta (venetoclax) / Roche, AbbVie |
| Not yet recruiting | 4 | 128 | | | Cairns Hospital , QLD health- Clinical research fellowship | Follicular lymphoma, Chronic Lymphocytic Leukaemia | | | | |
ChiCTR1900026095: Venetoclax + azacitidine combined with dose-adjusted HAG double induction therapy for relapsed/refractory acute myeloid leukemia |
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| Not yet recruiting | 4 | 10 | | Venetoclax + Azacitidine +HAG | The People's Hospital of Jiaozuo City; The People's Hospital of Jiaozuo City, Beijing Medical Award Foundation | Relapse/Refractory Acute Myeloid Leukemia | | | | |
2021-000722-96: changes in lymph nodes in patients with CLL treated with venetoclax-containing regimens Modificazioni del microambiente linfonodali in pazienti con leucemia linfatica cronica CLL in trattamento con regimi contenenti venetoclax |
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| Not yet recruiting | 4 | 30 | Europe | Venclyxto, [Venclyxto], Coated tablet, venclyxto | OSPEDALE SAN RAFFAELE, AbbVie | Chronic Lymphocytic Leukemia Leucemia Linfatica Cronica, Chronic Lymphocytic Leukemia Leucemia Linfatica Cronica, Diseases [C] - Cancer [C04] | | | | |
ChiCTR2100051018: The efficacy and safety of Venetoclax plus Azacitidine and LDAC in the treatment of relapsed and refractory acute myeloid leukaemia patients: Prospective, single arm, multicenter, phase 2 clinical study |
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| Completed | 4 | 31 | | VAA regimen | the First Affiliated Hospital of Zhejiang University School of Medicine; the First Affiliated Hospital of Zhejiang University School of Medicine, self-funded | Acute myeloid leukemia | | | | |
ChiCTR2100054356: Clinical Efficacy of Low-Dose Venetoclax Combinated with Posaconazole in Acute Myeloid Leukemia Patients: Evaluation of Dose Adjustments Guided by Venetoclax Blood Concentration |
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| Not yet recruiting | 4 | 60 | | oral venetoclax 100mg/d combined with posaconazole200mg tid ;oral venetoclax 400mg/d | Chengdu Third People's Hospital; Chengdu Third People's Hospital, Personal research funds | acute myeloid leukemia | | | | |
| Recruiting | 4 | 50 | | venetocax ;venetocax ;venetocax ;venetocax | Beijing Children's Hospital, Capital Medical University; Beijing Children's Hospital, Capital Medical University, Capital Health Development Research Project (No. 2022-1-20191) | Acute myeloid leukemia (AML) | | | | |
ChiCTR2200058721: Open-ended prospective clinical trial of skeleton scheme based on epigenetics in combination with DEL chemotherapy in relapsed/refractory children with acute T-lymphocyte leukemia (T-ALL) or T cell lymphoblastic lymphoma (T-NHL) |
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| Not yet recruiting | 4 | 60 | | Chidamide + HMAs + Venetoclax+Dex+VP16+Peg-Asp | Children's Hospital of Soochow University; Children's Hospital of Soochow University, Suzhou government and Children's Hospital of Soochow University | acute T-lymphocyte leukemia or T cell lymphoblastic lymphoma | | | | |
ChiCTR2100048966: Venetoclax combined with HAG regimen in the treatment of adult refractory/relapsed ETP-ALL |
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| Recruiting | 4 | 53 | | Venetoclax+HAG solution | The First Affiliated Hospital, Zhejiang University College of Medicine; The First Affiliated Hospital, Zhejiang University College of Medicine, Self-raised | Early precursor T-cell acute lymphoblastic leukemia | | | | |
ChiCTR2100050154: Clinical study of azacytidine combined with low-dose venetoclax in the treatment of untreated fragile senile AML |
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| Not yet recruiting | 4 | 30 | | Azacytidine plus low dose venetoclax | Beijing Hospital; Beijing Hospital, Raise independently | acute myeloid leukemia | | | | |
ChiCTR2100050627: Clinical study of azacytidine combined with low-dose venetoclax in the treatment of relapse / refractory senile acute myeloid leukemia |
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| Not yet recruiting | 4 | 20 | | azacytidine plus low dose venetoclax | Beijing Hospital; Beijing Hospital, self-funded | acute myeloid leukemia | | | | |
ChiCTR2200061294: A Prospective, Multicenter, Observational Clinical Study of the Pharmacokinetics and Pharmacodynamics of Venetoclax in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome |
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| Not yet recruiting | 4 | | | | The First Affiliated Hospital of Zhejiang University Medical College; The First Affiliated Hospital of Zhejiang University Medical College, Research funding | myelodysplastic syndromes, acute myeloid leukemia | | | | |
ChiCTR2200057796: Individualized administration of Venetoclax based on PK/PD in children with refractory/relapsed acute leukemia |
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| Recruiting | 4 | 20 | | Venetoclax-based regimen | Beijing Children's Hospital, Capital Medical University; Beijing Children's Hospital, Capital Medical University, Capital Health and Development of Special Grant | pediatric acute leukemia | | | | |
| Recruiting | 4 | 80 | | Venetoclax | Beijing Children's Hospital, Capital Medical University; Beijing Children's Hospital, Capital Medical University, self-raised | Acute promyelocytic leukemia (APL) | | | | |
ChiCTR2200056993: Prospective, single-arm, multicenter clinical study of the efficacy and safety of venetoclax combined with azacitidine in the treatment of adult patients with higher-risk myelodysplastic syndrome |
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| Recruiting | 4 | 28 | | venetoclax + azacitidine | The First Affiliated Hospital of Zhejiang University Medical College; The First Affiliated Hospital, College of Medicine, Zhejiang University, Research funding | Myelodysplastic Syndrome | | | | |
ChiCTR2100048811: Clinical trial of Venetoclax in combination with DA-EPOCH-R regimen for double/triple-hit high-grade B-cell lymphoma |
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| Recruiting | 4 | 48 | | Venetoclax combined with DA-EPOCH-R | The First Affiliated Hospital, Zhejiang University School of Medicine; The First Affiliated Hospital of Zhejiang University Medical college, Self-raised | Double-/Triple-Hit high-grade B-cell Lymphoma | | | | |
| Recruiting | 4 | 118 | RoW | Venetoclax, Allogeneic transplant | He Huang | Acute Myeloid Leukemia | 12/27 | 02/28 | | |
NCT05144243: Study to Assess Adverse Events and Change in Disease State of Oral Venetoclax in Combination With Subcutaneous (SC) Azacitidine in Newly Diagnosed Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Intensive Chemotherapy in China |
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| Active, not recruiting | 4 | 44 | RoW | Venetoclax, ABT-199, GDC-0199, Venclexta, Azacitidine | AbbVie, Genentech, Inc. | Acute Myeloid Leukemia (AML) | 03/26 | 03/26 | | |
| Not yet recruiting | 4 | 172 | RoW | Cladribine, 2-CdA, CdA, Cytarabine, Ara-C, G-CSF, Filgrastim, Granulocyte Colony-stimulating Factor, Venetoclax, Venclexta | Nanfang Hospital, Southern Medical University, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou No.12 People's Hospital, Guangzhou Panyu Central Hospital, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou First People's Hospital, Foresea Life Insurance Guangzhou General Hospital, Guangdong Second Provincial General Hospital, Jiangmen Central Hospital, Shantou Central Hospital, Maoming People's Hospital, First Affiliated Hospital of Guangxi Medical University, Hainan General Hospital, Dongguan People's Hospital, Tungwah Hospital of Sun Yat-Sen University, Shenzhen Hospital of Southern Medical University, Central People's Hospital of Zhanjiang, ZhuHai Hospital, Shenzhen Second People's Hospital, Zhongshan People's Hospital, Guangdong, China, LiuZhou People's Hospital, First People's Hospital of Foshan, Southern Medical University, China, Affiliated Hospital of Guangdong Medical University, Guilin Medical University, China, Yuebei People's Hospital, Huizhou Municipal Central Hospital, Second Affiliated Hospital of Guangzhou Medical University, Peking University Shenzhen Hospital | Relapsed/Refractory AML | 06/25 | 12/25 | | |
NCT06651970: Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure |
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| Recruiting | 4 | 60 | Europe, US, RoW | Acalabrutinib, Calquence, Investigator's choice of treatment, Investigator's choice of treatment : i.e venetoclax, Rituximab, Obinutuzumab, Zanubrutinib etc. | AstraZeneca, Fortrea, CALYX Inc., eResearch Technology, Inc., CISCRP | Chronic Lymphocytic Leukaemia, Heart Failure | 08/30 | 08/30 | | |
ChiCTR2400079363: A prospective, multicenter, single-arm clinical study of standard-dose Decitabine combined with Venetoclax for the treatment of myeloproliferative chronic myelomonocytic leukemia |
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| Not yet recruiting | 4 | 52 | | Standard-dose Decitabine (DEC) combined with Venetoclax (VEN) | Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College | myeloproliferative chronic myelomonocytic leukemia | | | | |
ChiCTR2200058557: A prospective, multicentre, randomised, controlled study of Venetoclax and Azacitidine versus Azacitidine as maintenance therapy after allogeneic stem cell transplantation in patients with high risk of recurrence of MDS, CMML and AML |
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| Recruiting | 4 | 118 | | Venetoclax and Azacitidine Combination ;Azacitidine | Blood Diseases Hospital, Institute of Hematology, Chinese Academy of Medical Sciences; Blood Diseases Hospital, Institute of Hematology, Chinese Academy of Medical Sciences, None | Myelodysplastic syndrome (MDS)/chronic monocytic leukemia (CMML)/acute myeloid leukemia (AML) | | | | |
ChiCTR2200061423: The validity and safety of Venetoclax combined with Azaciticidine for the treatment of de novo higher-risk chronic myelomonocytic leukemia: A prospective, single-arm, multicenter study |
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| Not yet recruiting | 4 | 48 | | venetoclax combined with azacytidine | The First Affiliated Hospital of Zhejiang University; Zhejiang Provincial Hospital of Chinese Medicine, None | Chronic myelomonocytic leukemia | | | | |
ChiCTR2400084836: A cohort study of azacitidine combined with different dosages of venetoclax in the treatment of elderly patients with AML unsuitable for chemotherapy |
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| Not yet recruiting | 4 | 320 | | None; None | Beijing Hospital; Beijing Hospital, Beijing Hospital Clinical Research "Navigation Aid" Special Project | AML | | | | |
NCT07044687: Study to Assess Adverse Events and Change in Disease Activity of Oral Venetoclax in Combination With Subcutaneous (SC) or Intravenous (IV) Azacitidine in Newly Diagnosed Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Standard Induction Therapy in India |
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| Recruiting | 4 | 100 | RoW | Venetoclax, Azacitidine | AbbVie | Acute Myeloid Leukemia | 11/27 | 11/27 | | |
| Not yet recruiting | 4 | 20 | | Venetoclax-based treatment protocol | Beijing Children's Hospital, Capital Medical University; Beijing Children's Hospital, Capital Medical University, self-raised | Acute promyelocytic leukemia in children and adolescents | | | | |
ChiCTR2300078643: Efficacy and safety of IVPD regimen in patients with relapsed/refractory multiple myeloma resistant to bortezomib and/or lenalidomide: a multicenter, single-arm, prospective clinical study |
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| Recruiting | 4 | 67 | | Ixazomib; Venetoclax; Pomalidomide; Dexamethasone | The Second Hospital of Hebei Medical University; The Second Hospital of Hebei Medical University, None | multiple myeloma | | | | |
ChiCTR2300069327: Prospective, Multicenter, Single-Arm Clinical Study of Venetoclax Combined with Cladribine + HAG Regimen in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia |
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| Not yet recruiting | 4 | 106 | | Venetoclax Combined With Cladribine + HAG | The First Affiliated Hospital of Army Medical University (Southwest Hospital); The First Affiliated Hospital of Army Medical University (Southwest Hospital), NA | Relapsed/refractory acute myeloid leukemia | | | | |
ChiCTR2200061524: Clinical study of venetoclax combined with chemotherapy in the treatment of newly diagnosed acute myeloid leukemia |
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| Recruiting | 4 | 60 | | Oral venetoclax ;Without venetoclax | Handan Central Hospital; Handan Central Hospital, Self-paying | Acute myeloid leukemia | | | | |
LymBIO, NCT04790045: Lymph Node Microenvironment Modifications in Patients With CLL Treated With Venetoclax-based Regimens |
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| Not yet recruiting | 4 | 30 | NA | Venetoclax, core-needle biopsy | Paolo Ghia | Chronic Lymphocytic Leukemia | 12/26 | 12/26 | | |
| Not yet recruiting | 4 | 816 | | The combination of targeted therapy and chemotherapy was applied in the treatment of reduction of volume, induction therapy, consolidation therapy and maintenance therapy, and venetoclax combined with RIF in maintenance period; The combination of targeted therapy and chemotherapy was applied in the treatment of reduction of volume, induction therapy, consolidation therapy and maintenance therapy, and only Venetoclax in maintenance period | Beijing Children's Hospital, Capital Medical University; Beijing Children's Hospital, Capital Medical University, self-raised | Acute myeloid leukemia in children | | | | |
| Not yet recruiting | 4 | 200 | | Targeted therapy with retinoic acid and arsenic in combination with venetoclax | Beijing Children's Hospital, Capital Medical University; Beijing Children's Hospital, Capital Medical University, self-raised | Acute promyelocytic leukemia in children and adolescents | | | | |
ChiCTR2400086528: A prospective, single-center, exploratory study of mitoxantrone hydrochloride liposome injection combined with standard-dose cytarabine and venetoclax in the treatment of relapsed/refractory acute myeloid leukemia |
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| Not yet recruiting | 4 | 20 | | Mitoxantrone hydrochloride liposome+standard-dose cytarabine+venetoclax | The First Affiliated Hospital, College of Medicine, Zhejiang University; The First Affiliated Hospital, College of Medicine, Zhejiang University, CSPC OUYI PHARMACEUTICAL CO., LTD. | Relapsed/Refractory Acute Myeloid Leukemia | | | | |
ChiCTR2400083301: A prospective multicenter cohort study of Venetoclax combined with DCAG regimen for the treatment of newly diagnosed high-risk acute myeloid leukemia |
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| Not yet recruiting | 4 | 38 | | Inducing by Venetolcax+DCAG regimen | Peking University People's Hospital; Peking University People's Hospital, People's Hospital, Institute of Hematology, Peking University | Hiigh-risk acute myeloid leukemia | | | | |
ChiCTR2400086497: Efficacy and safety of all-trans retinoic acid, decitabine combined with venetoclax for maintenance in non-transplant patients with acute myeloid leukemia |
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| Not yet recruiting | 4 | 60 | | all-trans retinoic acid, decitabine and venetoclax; none | The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University; The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Anti-Cancer Association Clinical Research (HENGRUI) Funding General Project of Sichuan Province (XH2023 3012) | acute myeloid leukemia | | | | |
ChiCTR2500109729: A multicenter, single-arm, phase II clinical study of mitoxantrone hydrochloride liposome injection combined with azacitidine and venetoclax in the treatment of relapsed/refractory acute myeloid leukemia after standard induction therapy |
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| Not yet recruiting | 4 | 38 | | Mitoxantrone hydrochloride liposome injection combined with azacitidine and venetoclax (MAV) | The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University, Subject of your choice (self-supporting) | Acute myeloid leukemia | | | | |
ChiCTR2500109360: A multicenter, single-arm, phase II clinical study of mitoxantrone hydrochloride liposome injection combined with azacitidine and venetoclax in the treatment of venetoclax-exposed refractory/relapsed acute myeloid leukemia |
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| Not yet recruiting | 4 | 30 | | Mitoxantrone hydrochloride liposome injection combined with azacitidine and venetoclax (MAV) | The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University, Subject of your choice (self-supporting) | Acute myeloid leukemia | | | | |
ChiCTR2400090947: Venetoclax combined with medium-dose cytarabine as consolidation therapy after standard induction chemotherapy in patients with Fit AML: a multicenter, prospective, observational clinical study |
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| Not yet recruiting | 4 | 180 | | | Qilu Hospital of Shandong University; Qilu Hospital of Shandong University, Self-financing | AML | | | | |
ChiCTR2400087347: Clinical Study Protocol for Venetoclax and Azacitidine for the Maintenance Treatment of Post-Remission AML |
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| Recruiting | 4 | 114 | | Venetoclax in combination with azacitidine for the maintenance treatment of post-remission AML | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Self-financing | Acute myeloid leukemia (AML) | | | | |
ChiCTR2500111194: Study on the Efficacy and Safety of Mitoxantrone Liposome-Containing Regimens in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia in the Real World |
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| Recruiting | 4 | 60 | | Mitoxantrone hydrochloride liposome+Azacitidine+Venetoclax | Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology; Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology, Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology | Acute myeloid leukemia | | | | |
ChiCTR2400091259: A prospective, single-center, single-arm study of mitoxantrone hydrochloride liposome injection combined with venetoclax and azacitidine in the treatment of newly diagnosed and relapsed/refractory acute myeloid leukemia |
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| Not yet recruiting | 4 | 40 | | mitoxantrone hydrochloride liposome+venetoclax+azacitidine | General Hospital of Chinese People's Liberation Army Northern Theater Command; General Hospital of Chinese People's Liberation Army Northern Theater Command, self-financed | Acute Myeloid Leukemia | | | | |
ChiCTR2500109764: A Prospective, Multicenter, Randomized Controlled, Phase II Clinical Study of Venetoclax and Azacitidine Combined with Mitoxantrone Hydrochloride Liposome Injection Versus Intensive Chemotherapy in the Treatment of Newly Diagnosed Intermediate- to High-Risk fit AML |
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| Not yet recruiting | 4 | 198 | | VMA therapy; Intensive therapy (IA or DA) | Tangdu Hospital, Fourth Military Medical University; Tangdu Hospital, Fourth Military Medical University, Shiyao Group Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. | Acute myeloid leukemia | | | | |
ChiCTR2400084237: A prospective, multi-center, randomized controlled clinical study of mitoxantrone liposome-based three-drug combination regimen for the treatment of relapsed and refractory acute myeloid leukemia |
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| Not yet recruiting | 4 | 100 | | Liposomal mitoxantrone combined with venetoclax and azacitidine; venetoclax combined with azacitidine. | Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology; Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology, Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology | acute myeloid leukemia | | | | |