fluoxetine / Generic mfg. |
| Completed | N/A | | US | | National Heart, Lung, and Blood Institute (NHLBI) | Cardiovascular Diseases, Heart Diseases, Hypertension | | 06/95 | | |
NCT00227981: Maintenance Interpersonal Psychotherapy for Sustaining Remission of Depression |
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| Completed | N/A | 93 | US | Interpersonal Psychotherapy, Fluoxetine | University of Pittsburgh | Depression | | 03/01 | | |
NCT00009178: Treatment of Bulimia Nervosa in a Primary Care Setting |
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| Completed | N/A | | US | Fluoxetine, Guided Self-Help | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Bulimia Nervosa | | 12/01 | | |
NCT00113737: Fluoxetine as a Quit Smoking AID for Depression Prone |
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| Completed | N/A | | US | fluoxetine, cognitive behavioral therapy | National Heart, Lung, and Blood Institute (NHLBI) | Cardiovascular Diseases, Heart Diseases | | 01/02 | | |
NCT00004486: Randomized Study of Fluoxetine in Children and Adolescents With Autism |
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| Completed | N/A | 45 | US | fluoxetine | Icahn School of Medicine at Mount Sinai | Autism | | 12/02 | | |
NCT00778024: Bioequivalence Study of Fluoxetine HCL 40 mg Capsules Under Fasting Conditions |
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| Completed | N/A | 36 | US | fluoxetine HCL 40 mg capsules | Ranbaxy Laboratories Limited | Healthy | 10/03 | 12/03 | | |
NCT01237275: Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients |
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| Unknown status | N/A | 300 | RoW | SSRI treated group, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft | Samsung Medical Center | Depression, Continuous Antidepressant Abuse, Adverse Reaction to Drug | 12/03 | 12/16 | | |
NCT00714779: Fluoxetine vs. Brief Psychotherapy for Major Depression |
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| Completed | N/A | 85 | Europe | Fluoxetine, Short-term psychodynamic psychotherapy | University of Turku, KELA, Finnish State Grant | Major Depressive Disorder | 12/04 | 12/04 | | |
NCT00733525: Effectiveness of Stepped Care Versus Best Available Care for Bulimia Nervosa |
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| Completed | N/A | 293 | US | Cognitive Behavioral Therapy, Fluoxetine, Prozac, Guided Self-Help | University of Minnesota, National Institute of Mental Health (NIMH) | Eating Disorders | 04/05 | 08/05 | | |
NCT00004446: Study of Fluoxetine in Patients With Depersonalization Disorder |
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| Completed | N/A | 80 | US | fluoxetine | National Institute of Mental Health (NIMH), Icahn School of Medicine at Mount Sinai | Depersonalization Disorder | | | | |
NCT00027404: Study of Fluoxetine in Adults With Autistic Disorder |
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| Completed | N/A | 48 | US | Fluoxetine | Icahn School of Medicine at Mount Sinai | Autistic Disorder | | 08/05 | | |
| Withdrawn | N/A | 0 | US | Fluoxetine (Liquid Prozac) | US Department of Veterans Affairs | Depression | 09/05 | 09/05 | | |
NCT00332787: Determining Optimal Continuation Treatment Duration for Depressed Children and Adolescents |
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| Completed | N/A | 200 | US | Fluoxetine | University of Texas Southwestern Medical Center, National Institute of Mental Health (NIMH) | Depression | | 10/05 | | |
NCT00142779: Fluoxetine to Reduce Cocaine Use in Cocaine and Opioid Addicts |
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| Completed | N/A | 220 | US | Fluoxetine | National Institute on Drug Abuse (NIDA) | Cocaine-Related Disorders, Opioid-Related Disorders | 01/06 | 03/06 | | |
DMH, NCT00519051: A Randomized Clinical Trial for Depressed Mothers at Primary Care Level |
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| Completed | N/A | 345 | RoW | monitorized pharmacotherapy with antidepressants drugs (Fluoxetine), usual care | Fondo Nacional de Desarrollo Científico y Tecnológico, Chile | Depression | | 12/06 | | |
NCT00284791: Lamotrigine in Treatment Resistant Depression in Adolescents |
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| Terminated | N/A | 50 | US | Lamotrigine (drug), Fluoxetine (drug), sertraline (drug) | MaineHealth, GlaxoSmithKline | Adolescent Depression | 02/07 | 02/07 | | |
NCT01352559: Prediction of Antidepressant Response Using Pharmacogenetics and Peripheral Lymphocytic Phenotype |
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| Unknown status | N/A | 1000 | RoW | responders, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft, milnacipran, venlafaxine_Effexor, nortriptyline_Aventyl, Pamelor, Noritren, mirtazapine_Avanza, Zispin, Remeron, non-responders, SSRI nonresponders | Samsung Medical Center | Depression | 03/07 | 12/18 | | |
NCT00592670: Hypoglycemia Associated Autonomic Failure in Type 1 DM |
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| Completed | N/A | 48 | US | Fluoxetine, Prozac, Placebo | Vanderbilt University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type 1 Diabetes | 06/07 | 10/08 | | |
NCT00208897: Does Fluoxetine Have an Effect on the CNS CRF Systems in Women Abused in Childhood? |
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| Completed | N/A | 80 | US | Fluoxetine | Emory University, Eli Lilly and Company | Major Depressive Disorder | 11/07 | 11/07 | | |
NCT00158301: Cognitive Behavioral Therapy for Depression Relapse Prevention in Children and Adolescents |
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| Completed | N/A | 72 | US | Cognitive behavioral therapy (CBT), Drug therapy, fluoxetine | University of Texas Southwestern Medical Center, National Institute of Mental Health (NIMH) | Depression | 11/07 | 02/08 | | |
| Completed | N/A | 23 | US | Fluoxetine, Prozac | University of Pittsburgh, National Institute of Mental Health (NIMH) | Anorexia Nervosa | 12/08 | 12/08 | | |
NCT00676026: Impact of GABA-Enhancing Agents on Cortical GABA Concentrations Across the Menstrual Cycle in Women |
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| Completed | N/A | 8 | US | Fluoxetine, Prozac, Zolpidem, Ambien, Progesterone, Prometrium | University of Pennsylvania | Healthy | 02/09 | 02/09 | | |
NCT00909155: Brain Imaging Techniques That Predict Antidepressant Responsiveness |
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| Completed | N/A | 50 | US | Venlafaxine ERT, Effexor ER, Fluoxetine, Prozac | University of Wisconsin, Madison, Wyeth is now a wholly owned subsidiary of Pfizer | Major Depressive Disorder | 12/09 | 12/09 | | |
NCT01022632: Effect of Curcumin as Nutraceutical in Patients of Depression |
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| Completed | N/A | 60 | RoW | Curcumin, Fluoxetine, Curcumin and Fluoxetine | Government Medical College, Bhavnagar, Health and Family Welfare Department, Government of Gujarat, India, Arjuna Natural Extracts Ltd. | Major Depressive Disorder | 01/10 | 01/10 | | |
NCT00965562: Comparison of Fluoxetine, Calcium and Placebo for the Treatment of Moderate to Severe Premenstrual Syndrome (PMS) |
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| Completed | N/A | 49 | US | Fluoxetine, Prozac, Calcium, Placebo | Donaghue Medical Research Foundation, Yale University | Premenstrual Syndrome | 06/10 | 10/10 | | |
NCT00944996: Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major Depression |
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| Completed | N/A | 100 | RoW | SSRI; SNRI; TCA, paroxetine, fluoxetine, sertraline, escitalopram, citalopram, mirtrazapine, venlafaxine, anafranil | Tirat Carmel Mental Health Center, University of Michigan, Ariel University, The Nazareth Hospital, Israel | Major Depression | 06/10 | 07/12 | | |
NCT00218764: Cognitive Therapy Versus Medication Treatment for Preventing Depression Relapse |
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| Active, not recruiting | N/A | 500 | US | Fluoxetine (Prozac), Prozac, Cognitive therapy (CT), CT or CBT, Placebo | National Institute of Mental Health (NIMH) | Depression | 12/10 | 12/10 | | |
NCT00986310: Efficacy of Fluoxetine in Reducing Ictal Hypoventilation in Patients With Partial Epilepsy |
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| Completed | N/A | 2 | US | Fluoxetine, Prozac, Placebo | University of California, Davis | Uncontrolled Partial Epilepsy, Ictal Hypoventilation | 02/12 | 06/12 | | |
NCT01361217: The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity |
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| Completed | N/A | 10 | NA | Fluoxetine, Lovastatin, Omeprazole, caffeine, midazolam, dextromethorphan, Prozac | University of Washington, National Institute of General Medical Sciences (NIGMS) | Drug-Drug Interaction, Healthy Volunteers | 06/12 | 06/12 | | |
NCT01488266: Aripiprazole Augmentation Versus Switching to Different Class of Antidepressants in Major Depressive Disorder |
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| Unknown status | N/A | 90 | RoW | Aripiprazole, abilify, switching to different class of antidepressant, escitalopram, fluoxetine, paroxetine, sertraline, bupropion XL, mirtazapine, venlafaxine, milnacipran, duloxetine | Korea University, Korea OIAA, Taiwan Otsuka Pharm. Co., Ltd | Major Depressive Disorder | 01/13 | 03/13 | | |
NCT00612313: Sequential Treatment of Pediatric MDD to Increase Remission and Prevent Relapse |
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| Completed | N/A | 144 | US | Fluoxetine, Prozac, Relapse prevention cognitive behavioral therapy (CBT), CBT | University of Texas Southwestern Medical Center, National Institute of Mental Health (NIMH) | Depression | 02/13 | 01/14 | | |
NCT01174394: Electroacupuncture Combined With Antidepressants for Post-stroke Depression |
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| Completed | N/A | 43 | RoW | DCEAS (Hwato®/ Dongbang®), Hwato®, Dongbang®, Body electro-acupuncture (Hwato®/ Dongbang®), n-CEA (Strietberger®), Strietberger®, Fluoxetine, Prozac, Sarafem, Fontex, Zactin, Lovan, Fluohexal, Auscap, Depreks, Floxet, Flunil, Fluox, Fluzac, Fluxen | The University of Hong Kong, Tung Wah Hospital, Kowloon Hospital, Hong Kong | Depression, Stroke | 02/13 | 02/13 | | |
| Completed | N/A | 292 | US | aripiprazole; fluoxetine; bupropion; sertraline; lamotrigine, Abilify, Prozac, Welbutrin, Zoloft, Lamictal, Psychoeducational multifamily group treatment, Family psychoeducation,, Family behavioral therapy, Multiple family group therapy, Supported employment and education, Supported employment, Supported education | MaineHealth, Robert Wood Johnson Foundation | Schizophrenia, Bipolar Disorder, Depression, Psychotic Disorders | 05/13 | 09/13 | | |
SMART, NCT01148316: Developing Adaptive Treatment Strategies for Children and Adolescents With Obsessive-compulsive Disorder. |
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| Completed | N/A | 144 | RoW | fluoxetine, Group cognitive-behavioral therapy | Roseli Shavitt, University of Pernambuco | Obsessive-Compulsive Disorder | 06/13 | 12/13 | | |
ChiCTR-TRC-12002503: RESEARCH ON CLINICAL CURATIVE EFFECTS EVALUATION OF KAIXIN JIEYU DECOCTION ON VASCULAR DEPRESSION |
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| Completed | N/A | 60 | | PHARMACOTHERAPY ;FLUOXETINE HYDROCHLORIDE | CHINESE MEDICAL SCIENCES GUANGAN MEN HOSPITAL; CHINESE MEDICAL SCIENCES GUANG'AN MEN HOSPITAL, SELF-FINANCING | VASCULAR DEPRESSION | | | | |
NCT01740726: Comparison of Behavioral Activation and Antidepressant Medication in the Treatment of Adolescents With Depression |
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| Terminated | N/A | 3 | US | Behavioral Activation, Behavioral Activation Therapy, BA, Fluoxetine, Prozac, Sarafem, Rapiflux, Selfemra | Emory University | Major Depressive Disorder | 03/14 | 03/14 | | |
NCT01724372: The Role of Antidepressants or Antipsychotics in Preventing Psychosis |
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| Withdrawn | N/A | 0 | US | Antidepressant, Fluoxetine, Antipsychotic, Aripiprazole | St. Luke's-Roosevelt Hospital Center, The Zucker Hillside Hospital | Psychotic Disorder | 05/14 | 05/14 | | |
NCT01896349: Interpersonal Psychotherapy for Treatment Resistant Depression |
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| Unknown status | N/A | 74 | RoW | IPT+ antidepressant drugs, Interpersonal Psychotherapy, Antidepressant drugs, fluoxetine, sertraline, paroxetine, Citalopram, escitalopram, fluvoxamine, Venlafaxine, Duloxetine, Bupropion, Lithium, Risperidone, tranylcypromine, Imipramine, amitriptyline, Clomipramine, nortriptyline, trazodone, Mirtazapine, sulpiride | Hospital de Clinicas de Porto Alegre | Treatment Resistant Depression | 08/14 | 11/14 | | |
ChiCTR-TRC-14005228: Abdominal Acupuncture on moderate and severe depression female patients: A randomized controlled blind clinical trial |
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| Recruiting | N/A | 40 | | acupuncture andFluoxetine ;acupuncture andFluoxetine | Guangdong Provincal hospital of Traditional Chinese Medicine; Guangdong Provincal hospital of Traditional Chines, Comprehensive and Integrative Medicine Institute (CIMI), Republic of Korea | depression | | | | |
| Completed | N/A | 3255526 | Canada | Duloxetine, Venlafaxine, Desvenlafaxine, Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline | Canadian Network for Observational Drug Effect Studies, CNODES, Drug Safety and Effectiveness Network, Canada, Canadian Institutes of Health Research (CIHR) | Depression, Acute Kidney Injury | 12/14 | 12/14 | | |
ChiCTR-TRC-12002679: To explore the mechanism of action of liver controlling dispersion and regulating emotions from the point of view of the liver to treat Premenstral dysphoric disorder |
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| Completed | N/A | 240 | | Baixiangdan Capsule ;Cortex Moutan Capsule ;Fluoxetine | Shan Dong University of Treadtional Chinese Medicine; Shan Dong University of Treadtional Chinese Medicine, The Ministry of Science and Technology, China | Premenstral dysphoric disorde | | | | |
ChiCTR-TRC-12002684: To explore the mechanism of action of liver controlling dispersion and regulating emotions from the viewpoint of the liver to treat mild and moderate depression |
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| Completed | N/A | 240 | | Shuyu granule ;Modified Shuyu granule ;fluoxetine | Shandong University of Traditional Chinese Medicine; Level of the institution:, The ministry of science and technology, China | mild and moderate depression | | | | |
NCT01479920: A Positron Emission Topographic (PET) Study on Depression Patient With Electroacupuncture |
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| Completed | N/A | 36 | RoW | Fluoxetine, Prozac, Sarafem, Fontex, Zactin, Lovan, Fluohexal, Auscap, Depreks, Floxet, Flunil, Fluox, Fluzac, Fluxen, DCEAS (Hwato®/ Dongbang®), Hwato®, Dongbang®, n-CEA (Strietberger®), Strietberger® | The University of Hong Kong, Queen Mary Hospital, Hong Kong, Kowloon Hospital, Hong Kong, Southern Medical University, China | Major Depressive Disorder, Depression | 05/15 | 05/15 | | |
ChiCTR-TRC-14004171: A clinical randomized controlled trial to assess the effect and to explore the mechanism based on Traditional Chinese Medicine theory about |
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| Completed | N/A | 240 | | Shu-gan Mianjian granule + fluoxetine ;Oral Fluoxetine | Shandong University of Traditional Chinese Medicine; Level of the institution:, The ministry of science and technology of the People’s Republic of China | mild-to-moderate depression | | | | |
ChiCTR-TRC-14004172: A clinical randomized controlled trial to assess the effect and to explore the mechanism based on Traditional Chinese Medicine theory about 'liver Qi Yu zheng' on the treatment of severe premenstrual syndrome |
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| Completed | N/A | 240 | | Shu-gan Mianjian granule + fluoxetine ;Oral Fluoxetine | Shandong University of Traditional Chinese Medicine; Level of the institution:, The ministry of science and technology of the People’s Republic of China | premenstrual syndrome | | | | |
EFLUSTIM, NCT02063425: "Evaluation by Transcranial Magnetic Stimulation of the Benefit of Fluoxetine on Motor Recovery After Stroke" |
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| Terminated | N/A | 6 | Europe | Fluoxetine, Patients receiving fluoxetine, Placebo of fluoxetine, Patients receiving placebo | Centre Hospitalier St Anne | Cerebral Infarction | 08/15 | 08/15 | | |
| Completed | N/A | 166 | RoW | Integrated Depression/Microfinance Group, LIFE-DM Group, Treatment as Usual, Guideline antidepressant care, Fluoxetine, Amitrytaline, other antidepressants, Livelihood Support, Microfinance loans | RAND, National Institute of Mental Health (NIMH), Danang Psychiatric Hospital | Depression | 09/15 | 09/16 | | |
| Completed | N/A | 32 | NA | Fluoxetine, Prozac, Peppermint syrup | University of Oxford | Depression | 11/15 | 11/15 | | |
FLAN, NCT01674868: Fluoxetine for Motor, Aphasia, and Neglect Recovery After Ischemic Stroke |
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| Withdrawn | N/A | 0 | US | fluoxetine, placebo | Spaulding Rehabilitation Hospital | Stroke | 12/15 | 12/15 | | |
NCT02285699: The Gut Microbiota in Obsessive-Compulsive Disorder |
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| Completed | N/A | 43 | Canada | SSRIs, Fluoxetine, Paroxetine, Fluvoxamine, Escitalopram, Citalopram, Sertraline | McMaster University, Hamilton Health Sciences Corporation | Obsessive-Compulsive Disorder | 03/16 | 03/16 | | |
NCT02476136: Initial Severity and Antidepressant Efficacy for Anxiety Disorders: an Individual Patient Data Meta-analysis |
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| Unknown status | N/A | 8800 | NA | paroxetine, duloxetine, fluoxetine or venlafaxine, Paxil, Cymbalta, Prozac, Effexor | prof. Peter de Jonge | Anxiety Disorders, Panic Disorder, Obsessive-compulsive Disorder, Post-traumatic Stress Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder | 03/16 | 12/16 | | |
ChiCTR-IOR-15006313: Wrist-Ankle Acupuncture combined with Prozac in the treatment of Post-stroke Depression: clinical research |
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| Not yet recruiting | N/A | 105 | | thick needle+Prozac ;Fine needle+Prozac ;Sham needle+Prozac | Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University; Shanghai Changhai Hospital, Health and Family Planning Commission of Shanghai | Post-stroke Depression | | | | |
| Not yet recruiting | N/A | 80 | | Acupuncture group of patients will be treated 2 times a week, 30 minutes per time.We use Yintang and Baihui witch are verified to be effective in our previous study, and the match points are Taichong, Neiguan, Zusanli, Shenmen, Sanyinjiao. The parameter of electric acupuncture: frequency of 20Hz. The current intensity is based on the slightly shaking in the skin. ;We use SSRIs antidepressants including fluoxetine,Paroxetine, fluvoxamine, sertraline and citalopram. The dosage was follow the doctor's advice. | Peking University Sixth Hospital; Beijing University of Chinese Medicine, Self-raised funds | Depression | | | | |
PG, NCT00817011: Development of Pharmacogenomic Method to Predict Antidepressant Responsiveness |
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| Unknown status | N/A | 1000 | RoW | SSRI treated group, Other Names:, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft, citalopram_Celexa, non-SSRI treated group, venlafaxine_Effexor, nortriptyline_Aventyl, Pamelor, Noritren, mirtazapine_Avanza, Zispin, Remeron, bupropion_amfebutamone, Wellbutrin, Zyban, duloxetine_Cymbalta, Yentreve, trazodone_Desyrel, Beneficat, Deprax | Samsung Medical Center | Depression, Antidepressant Drug Adverse Reaction | 12/16 | 03/18 | | |
ChiCTR-TRC-14004450: The influence of low frequency repetitive transcranial magnetic stimulation by magnetic resonance on adolescent depression patients‘ attention networks |
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| Recruiting | N/A | 160 | | Neuropsychological assessmen ;active rTMS combined with prozac ;sham rTMS combined with prozac | First Affiliated Hospital, College of Medicine, Zhejiang University; First Affiliated Hospital, College of Medicine, Zhejiang University, National Natural Science Foundation (81301158) | Depression | | | | |
NCT02934035: Early Improvement in Individual Symptoms and Response to Antidepressants in Patients With Major Depressive Disorder |
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| Unknown status | N/A | 10000 | NA | Antidepressant, Duloxetine, Paroxetine, Escitalopram, Fluoxetine, Venlafaxine | University Medical Center Groningen | Major Depressive Disorder | 09/17 | 09/17 | | |
NCT02593695: Deep Brain Stimulation of Nucleus Accumbens to Treat Severe Anorexia Nervosa |
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| Unknown status | N/A | 10 | RoW | Deep brain stimulation, DBS, Fluoxetine | Tang-Du Hospital | Anorexia Nervosa | 12/17 | 12/17 | | |
NCT02601677: Deep Brain Stimulation of NAc/ALIC to Prevent Treatment-Refractory Obsessive Compulsive Disorder |
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| Unknown status | N/A | 10 | NA | Deep brain stimulation, Fluoxetine | Tang-Du Hospital | Obsessive Compulsive Disorder | 11/18 | 11/18 | | |
| Not yet recruiting | N/A | 60 | | nothing ;Jiaotai pill + fluoxetine hydrochloride; fluoxetine hydrochloride | Tianjin University of Traditional Chinese Medicine; Tianjin University of Traditional Chinese Medicine, National Natural Science Foundation | depression | | | | |
NCT01352572: Effects of Antidepressant on Postsynaptic Signal Transduction in Serotonergic System of Depressed Patients |
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| Unknown status | N/A | 300 | RoW | antidepressant response, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft, milnacipran, venlafaxine_Effexor, nortriptyline_Aventyl, Pamelor, Noritren, mirtazapine_Avanza, Zispin, Remeron, antidepressant non-response, fluoxetine, paroxetine, sertraline, milnacipran, venlafaxine, nortriptyline, mirtazapine | Samsung Medical Center | Depression | 12/18 | 12/18 | | |
NCT00817375: Pharmacogenomic Study to Predict Antidepressant Responsiveness in Depressed Patients |
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| Unknown status | N/A | 1000 | RoW | SSRI treated group, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft, non-SSRI treated group, milnacipran, venlafaxine_Effexor, nortriptyline_Aventyl, Pamelor, Noritren, mirtazapine_Avanza, Zispin, Remeron | Samsung Medical Center | Depression, Adverse Reaction to Drug | 12/18 | 12/18 | | |
NCT01228357: Predict Antidepressant Responsiveness Using Pharmacogenomics |
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| Unknown status | N/A | 1000 | RoW | SSRI treated group, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft, non-SSRI treated group, milnacipran, venlafaxine_Effexor, nortriptyline_Aventyl, Pamelor, Noritren, mirtazapine_Avanza, Zispin, Remeron | Samsung Medical Center | Depression, Depressive Symptoms | 12/18 | 12/18 | | |
NCT03072264: Randomized Clinical Trial of a Mindfulness Based Intervention in Generalized Anxiety Disorder |
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| Completed | N/A | 200 | RoW | Body in Mind Training (BMT), Mindfulness Based Intervention, Fluoxetine, Control Group, Quality of Life Group | Hospital de Clinicas de Porto Alegre | Generalized Anxiety Disorder | 12/18 | 12/18 | | |
NCT02188225: Comparison of Acupuncture and Fluoxetine on Quality of Life in Menopausal Women |
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| Unknown status | N/A | 140 | RoW | acupuncture, Manual acupuncture, fluoxetine, flouxetine | Gonabad University of Medical Sciences | Hot Flash, Quality of Life | 02/19 | 12/19 | | |
ChiCTR1800015237: The efficacy and safety of light therapy in the treatment of non seasonal depressive disorder |
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| Not yet recruiting | N/A | 60 | | light therapy combined with fluoxetine ;fluoxetine | Beijing Anding Hospital affiliated to Capital Medical University; Beijing Anding Hospital affiliated to Capital Medical University, Beijing Municipal Administration of Hospitals’ Youth Programme (QML20151801) | major depressive disorder | | | | |
ChiCTR1900023641: Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder |
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| Completed | N/A | 40 | | rTMS combined with SSRI treatment ;Simulated stimulate treatment | Wuxi Mental Health Center; None, Research and Development Project of Medical and Public Health Technology of Wuxi Science and Technology Bureau | Obsessive-compulsive disorder | | | | |
TSOS6, NCT02655354: A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity |
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| Completed | N/A | 635 | US | Motivational Interviewing, Cognitive Behavioral Therapy Elements, Care Management, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Citalopram, Venlafaxine, Duloxetine, Mirtazapine, Diphenhydramine, Trazodone, Prazosin | University of Washington, National Institutes of Health (NIH), National Institute of Mental Health (NIMH), National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation, Substance-Related Disorders, Mild Cognitive Impairment, Quality of Life, Pain, Wounds and Injury, Brain Injuries, Chronic Disease | 11/19 | 11/19 | | |
NCT02472613: Acupuncture for Ischemic Post-stroke Depression |
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| Completed | N/A | 208 | RoW | acupuncture, placebo, sham-acupoint acupuncture, Fluoxetine | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine of the People's Republic of China, Tianjin Academy of Tradional Chinese Medicine Afflicated Hospital, Beijing Hospital of Traditional Chinese Medicine | Post-stroke Depression | 12/19 | 12/19 | | |
ChiCTR-ROC-17013002: Case-control study for mechanism of depression with liver qi stagnation and kidney qi deficiency using biomarker and fMRI |
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| Not yet recruiting | N/A | 120 | | xiaoyaosan ;Jinkuishenqiwan ;fluoxetine ;none | Beijing University of Chinese Medicine 3rd Affiliated Hospital; Beijing University of Chinese Medicine 3rd Affiliated Hospital, National Naural Science Foundation of China | depression | | | | |
NCT03455088: The Effect of G-DBT on the Patients With BN : A Multicenter Randomized Controlled Study |
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| Completed | N/A | 101 | RoW | Dialectical Behavioral Group Therapy, Drug: fluoxetine | Shanghai Mental Health Center, Peking University Sixth Hospital, Shanghai Tongji Hospital, Tongji University School of Medicine | Feeding and Eating Disorders | 12/20 | 12/21 | | |
ChiCTR1900026600: Multidimensional diagnosis, individualized treatment and management techniques based on the Clinicopathological Characteristics of depressive disorder |
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| Recruiting | N/A | 1002 | | mirtazapine ;Open therapy ;fluoxetine ;Open therapy ;fluvoxamine ;Open therapy | The First Hospital of Shanxi Medical University; Shanghai Jiaotong University, Special funds from the central government | depressive disorder | | | | |
ChiCTR-INR-17011091: Index development and transformation of diagnosis and treatment of depressive disorder, based on biomarkers and clinical charachteristics |
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| Recruiting | N/A | 800 | | fluoxetine ;fluoxetine+cognitive behavior treatment ;fluoxetine+amfebutamone ;fluvoxamine ;fluvoxamine+cognitive behavior treatment ;fluoxetine+amfebutamone+physical therapy ;fluvoxamine+Lithium/AAP ;fluvoxamine+lithium/AAP+physical therapy ;mirtazapine ;mirtazapine/SNRIs+cognitive behavior treatment ;mirtazapine+SNRIs ;mirtazapine+SNRIs+physical therapy ;optionally make up the treatment plan with accessory methods | Shanghai Jiaotong University; Shanghai Jiaotong University, Special funds from central finance | Depressive disorder | | | | |
ChiCTR1900026169: Study on the mechanism of premenstrual dysphoric disorder (PMDD) and the observation of curative effect of traditional chinese medicine |
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| Not yet recruiting | N/A | 120 | | placebo ;fluoxetine ;Xiangshao granule | Shandong University of Traditional Chinese Medicine; Shandong University of Traditional Chinese Medicine, The ministry of science and technology of the People’s Republic of China | Premenstrual dysphoric disorder (PMDD) | | | | |
NCT05346445: Comparison of Fluoxetine Versus Citalopram Therapy to Control Postmenopausal Vasomotor Syndrome |
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| Completed | N/A | 91 | RoW | Fluoxetine 20 MG, Generic PISA®, Citalopram 20mg, PREPRAM® | Hospital Regional 1o de Octubre, Universidad Nacional Autonoma de Mexico, National Polytechnic Institute, Mexico | Postmenopause, Hot Flashes | 11/21 | 12/21 | | |
NCT04154813: Study on the Optimal Strategy of Chinese Patients With Bulimia Nervosa After Fluoxetine Treatment |
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| Recruiting | N/A | 550 | RoW | Topiramate, Fluoxetine, cognitive behavioral therapy (CBT), dialectical behavior therapy (DBT) | Shanghai Mental Health Center, Huadong Hospital, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | Fluoxetine | 11/21 | 11/22 | | |
ChiCTR1900027384: Efficacy and safety of Intermittent theta burst stimulation (iTBS) and Fluoxetine Hydrochloride Dispersible Tablet (Prozac) in the treatment of depressive patients: a randomized controlled trial |
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| Not yet recruiting | N/A | 90 | | Intermittent theta burst stimulation(iTBS) and Fluoxetine Hydrochloride Dispersible Tablet (Prozac) ;Sham and and Fluoxetine Hydrochloride Dispersible Tablet (Prozac) ;Fluoxetine Hydrochloride Dispersible Tablet (Prozac) | The First Affiliated Hospital of Air Force Military Medical University; The First Affiliated Hospital of Air Force Military Medical University, The First Affiliated Hospital of Air Force Military Medical University | depression | | | | |
ChiCTR1800019467: The effect and mechanism of fluoxetine on the automatic regulation of cerebral blood flow for ischemic stroke |
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| Not yet recruiting | N/A | 248 | | Conventional therapy ;Fluoxetine (20mg/day, for 90 days), and conventional therapy | Shenzhen People's Hospital; Shenzhen People's Hospital, Self-finance | Ischemic stroke | | | | |
ChiCTR2000038551: Neuroendocrine axis-biological clock system and NDRG2-glutamate transport system participate in functional gastrointestinal disease/gastrointestinal motility disorders and stress-related visceral hypersensitivity |
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| Recruiting | N/A | 600 | | conventional therapy ;Fluoxetine combined conventional treatment | Army Medical Center of PLA; Army Medical Center of PLA, Daping Hospital, Army Medical University, Chongqing basic research and foreword exploration project, China (Grant No.CSTC2018jcyjAX0620) | Functional Gastrointestinal Disease/Gastrointestinal Motility Disorder | | | | |
ChiCTR2100046336: Clinical study of Kaixin Changyu granule in the treatment of post-stroke depression |
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| Recruiting | N/A | 63 | | Kaixinchangyu granule + capsule placebo ;Fluoxetine hydrochloride capsule + granule placebo ;Capsule and granule placebo | The First Affiliated Hospital of Dalian Medical University; The First Affiliated Hospital of Dalian Medical University, Enterprise subsidy | Post stroke depression | | | | |
ChiCTR1900025175: Study for effect of probiotics on depressive symptoms and its inflammatory mechanism |
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| Recruiting | N/A | 90 | | clostridium tyrosinate ;fluoxetine ;clostridium tyrosinate+fluoxetine | The First Hospital of Shanxi Medical University; The First Hospital of Shanxi Medical University, National natural science foundation of China | Depressive disorder | | | | |
CAR-BIG, NCT04446039: Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea |
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| Completed | N/A | 405349 | RoW | Escitalopram, Paroxetine, Fluoxetine, Mirtazapine, Duloxetine, Sertraline, Venlafaxine, Tianeptine, Vortioxetine, Desvenlafaxine, Bupropion | Pfizer | Major Depression | 11/22 | 11/22 | | |
NCT06185361: Selective Serotonin Reuptake Inhibitors, Fluoxetine Versus the Standard Oral Desmopressin for Management of Mono-symptomatic Nocturnal Enuresis. |
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| Active, not recruiting | N/A | 60 | RoW | Fluoxetine 20 MG, Desmopressin | Fayoum University Hospital | Nocturnal Enuresis, Enuresis, Enuresis, Nocturnal | 03/24 | 03/24 | | |
ChiCTR2100043474: Clinical Study on Xinyue Prescription Improving Cognitive Impairment of Senile Depression |
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| Recruiting | N/A | 116 | | Fluoxetine hydrochloride capsule, 20mg, once/day Xinyue Granule 1 bag/time, twice/day. ;Fluoxetine hydrochloride capsule, 20mg, once/day | Xiyuan Hospital, China Academy of Chinese Medical Sciences; Xiyuan Hospital, China Academy of Chinese Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences | Improving Cognitive Impairment of Senile Depression | | | | |
ChiCTR1800014637: Efficacy and safety of antidepressant combined with inosine for depressive disorders in children, adolescents and adults: a randomised, double-blind, placebo-controlled trial |
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| Recruiting | N/A | 300 | | Fluoxetine+inosine ;Fluoxetine+inosine placebo ;Fluoxetine+inosine ;Fluoxetine+inosine placebo | Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, National Key Research and Development Programm of China (Grant No.2017YFA0505700) | Depressive disorders | | | | |
NCT05361330: A Multicenter Clinical Study on Shuganjieyu Capsule Combined With Fluoxetine in the Treatment of Depression |
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| Not yet recruiting | N/A | 160 | RoW | Shuganjieyu capsule, Fluoxetine | Peking University, Sichuan Jishengtang Pharmaceutical Co., Ltd. | Outpatients / Inpatients With Depression | 04/23 | 09/23 | | |
NCT05952713: Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder |
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| Completed | N/A | 73336 | Europe | Antidepressant, sertraline, citalopram, fluoxetine, paroxetine, escitalopram, reboxetine, venlafaxine, duloxetine, mirtazapine, vortioxetine, agomelatine, amitriptyline, imipramine | Mental Health Services in the Capital Region, Denmark, University of Copenhagen | Major Depressive Disorder | 07/23 | 07/23 | | |
NCT05499117: Efficacy and Safety of Light Therapy in the Treatment of Non-seasonal Depressive Disorder in Chinese Population |
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| Recruiting | N/A | 80 | RoW | Light terapy, fluoxetine, pseudo-light therapy | Shanghai Mental Health Center | Major Depressive Disorder | 07/23 | 07/23 | | |
NCT05588102: Electronic Training of Elderly Depression With Cognitive Impairment |
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| Recruiting | N/A | 128 | RoW | Selective Serotonin Reuptake Inhibitor(SSRIs,Fluoxetine, paroxetine, fluvoxamine, sertraline, citalopram, escitalopram), Electronic cognitive training | Capital Medical University | Geriatric Depression, Cognitive Impairment | 01/24 | 01/24 | | |
NCT06221722: Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation |
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| Recruiting | N/A | 150 | RoW | BOLD-fMRI, Regular treatment of functional constipation, fluoxetine | Xijing Hospital of Digestive Diseases | Constipation - Functional, Refractory Constipation, Fluoxetine, fMRI, Brain Connectivity, Treatment Efficacy, Somatic Symptom, Mental Symptom | 09/25 | 09/26 | | |
NCT02431845: Pharmaco(Epi)Genetic Study of Obsessive-Compulsive Disorder |
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| Recruiting | N/A | 200 | RoW | SSRIs, five kinds of SSRIs including fluoxetine | Severance Hospital | Obsessive-Compulsive Disorder | 12/23 | 12/23 | | |
NCT05127369: Clinical Study on the Safety and Efficacy of Dental Pulp Mesenchymal Cells in the Treatment of Depression |
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| Not yet recruiting | N/A | 48 | NA | Dental pulp mesenchymal cell injection, Dental pulp mesenchymal cell vehicle, fluoxetine hydrochloride capsule | CAR-T (Shanghai) Biotechnology Co., Ltd. | Depression | 12/23 | 06/24 | | |
ChiCTR2000036944: A Randomized Controlled Clinical Study of Nerve Fuyuan Decoction in the Treatment of Post-Ischemic Depression After Stroke |
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| Not yet recruiting | N/A | 120 | | Chinese Medicine of Nerve Fuyuan Prescription ;Fluoxetine capsules | Shanghai Traditional Chinese Medicine Hospital; Shanghai Traditional Chinese Medicine Hospital, Shanghai Shenkang Hospital Development Center | Post-ischemic Depression after Stroke | | | | |
ChiCTR2100053830: The Clinical Value of Serum Exosome Noncoding RNA in Adolescent Depression |
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| Not yet recruiting | N/A | 200 | | Fluoxetine ;Fluoxetine combined with cognitive behavior psychotherapy ;None | University City Hospital of Chongqing Medical University; University City Hospital of Chongqing Medical University, Chongqing Science and Health Joint Medical Research Project | Major depressive disorder | | | | |
| Recruiting | N/A | 1000 | | Antidepressants (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, esitalopram, venlafaxine) ;None | West China Hospital, Sichuan University ; West China Hospital of Sichuan University, National Natural Science Foundation of China | depression | | | | |
ChiCTR2300069699: Clinical exploratory study on rapid antidepression effect of a kind of Chinese medicine, code-named ZHS |
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| Recruiting | N/A | 60 | | Day 1: saffron brew (0.005 g); Day 2 - day 8: fluoxetine (20 mg/day)+saffron brew (0.01 g/day) ;Day 1: saffron brew (1.5 g); Day 2 - day 8: fluoxetine (20 mg/day) + saffron brew (3 g/day) | Jiangsu Province Hospital of Chinese Medicine ; Jiangsu Province Hospital of Chinese Medicine, The Leading Technology Foundation Research Project of Jiangsu Province (BK20192005) | Depression | | | | |
DAPPER, NCT03466346: SMART- Leveraging the Depression And Primary-care Partnership for Effectiveness-implementation Research Project |
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| Completed | N/A | 2162 | RoW | Fluoxetine, Interpersonal Psychotherapy, IPT | University of California, San Francisco, University of Nairobi, National Institute of Mental Health (NIMH), Kenya Medical Research Institute, University of California, San Diego, Makerere University | Depression, Unipolar, Posttraumatic Stress Disorder, Trauma | 05/24 | 05/24 | | |
| Enrolling by invitation | N/A | 1 | Canada | Fluoxetine | Holland Bloorview Kids Rehabilitation Hospital, The Hospital for Sick Children | KCNC1 Related Disorder, Genetic Disease, Rare Diseases | 12/24 | 12/25 | | |
LYMPHODEP, NCT06337539: Precision Psychiatry for Depression: Immune Response and Affective Symptoms as Predictors of Response to Antidepressants |
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| Not yet recruiting | N/A | 50 | Europe | SSRI, Sertraline, Citalopram, Escitalopram, Fluoxetine, Paroxetine, Fluvoxamine | Germans Trias i Pujol Hospital | Depression, Inflammation, Antidepressants, Immunity | 12/26 | 07/27 | | |
| Not yet recruiting | N/A | 296 | RoW | Friendship Bench intervention, Antidepressants -Fluoxetine, Antidepressants-Sertraline | University of Bern, University of Zimbabwe, Swiss National Science Foundation | Major Depressive Disorder, Severe Depressive Episode Without Psychotic Symptoms | 12/26 | 02/27 | | |
NCT03283930: A Clinical Trial of a Gamified Attention Bias Modification Training in Anxious Youth |
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| Completed | N/A | 121 | US | Active Attention Bias Modification Training, Placebo Attention Bias Modification Training | National Institutes of Health Clinical Center (CC) | Anxiety Disorders | 09/23 | 09/23 | | |