| fluoxetine / Generic mfg. |
| Completed | 2b | 445 | Europe | Amiloride, Riluzole, Fluoxetine, Placebo | University College, London, Medical Research Council, National Institute for Health Research, United Kingdom, MS Society, University of Edinburgh, Queen Mary University of London, Keele University, University of Sheffield, University of Leeds, University of Warwick | Secondary Progressive Multiple Sclerosis | 06/18 | 07/18 | | |
NCT01671124: The Study of Antidepressant Properties and Safety of Fer-01(Soline®) on the Patients With Depression |
|
|
| Unknown status | 2a | 1 | RoW | Soline capsule, prozac | Taipei Medical University Hospital, Taipei Medical University Shuang Ho Hospital | Major Depressive Disorder | 07/13 | 11/13 | | |
| Completed | 2 | 0 | US | Fluoxetine | New York State Psychiatric Institute, National Institute on Drug Abuse (NIDA), Columbia University | Cocaine-Related Disorders | 04/91 | 04/91 | | |
NCT00005850: Combination Chemotherapy Plus Fluoxetine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer |
|
|
| Completed | 2 | 21 | US | cisplatin, fluoxetine, gemcitabine hydrochloride | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI) | Anxiety Disorder, Depression, Fatigue, Lung Cancer | 09/03 | 09/03 | | |
| Completed | 2 | 130 | US | Desipramine, Anafranil, Fluoxetine, Prozac, Benztropine, Cogentin | US Department of Veterans Affairs | Back Pain, Sciatica | 12/03 | 03/04 | | |
NCT00497562: Growth Hormone as Add-on Treatment in Severe Fibromyalgia With Low IGF-1 Serum Levels (56 Characters) |
|
|
| Completed | 2 | | Europe | sc recombinant growth hormone + amitriptyline, fluoxetine and tramadol (treated group), amitriptyline, fluoxetine and tramadol alone (control group) | Centro Medico Teknon | Fibromyalgia, Growth Hormone Deficiency | | 11/05 | | |
NCT00265291: Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group |
|
|
| Completed | 2 | 700 | US | fluoxetine or desipramine, Prozac | National Institute of General Medical Sciences (NIGMS) | Major Depressive Disorder, Major Depression, Unipolar Depression | 05/06 | 10/08 | | |
NCT00338767: Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy |
|
|
| Completed | 2 | 150 | US | Directly Observed Therapy (DOT), Fluoxetine | Massachusetts General Hospital, National Institute of Mental Health (NIMH) | HIV Infections, Depression | 08/06 | 08/06 | | |
NCT00011765: Effect of Fluoxetine (Prozac) on Domestic Violence |
|
|
| Completed | 2 | 104 | US | Fluoxetine | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Domestic Violence | 02/07 | 02/07 | | |
| Completed | 2 | 50 | US | fluoxetine (Prozac), Placebo plus Treatment As Usual | University of Pittsburgh, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcoholism, Depression | 06/07 | 06/08 | | |
NCT01119430: Fluoxetine Versus Fluoxetine Plus DU125530 in Major Depressive Disorder |
|
|
| Terminated | 2 | 50 | Europe | DU125530, Fluoxetine+DU, Placebo, Fluoxetine+placebo | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | Major Depression | 11/07 | 11/07 | | |
| Completed | 2 | 18 | US | Fluoxetine, Prozac, Placebo | University of North Carolina, Chapel Hill, National Institute of Mental Health (NIMH) | Autistic Disorder | 02/08 | 02/08 | | |
NCT00078754: A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder |
|
|
| Completed | 2 | 90 | US | Fluoxetine, Divalproex, Placebo | University of Chicago, National Institute of Mental Health (NIMH) | Intermittent Explosive Disorder | 10/08 | 10/08 | | |
NCT00758966: Naltrexone SR and Fluoxetine Combination Therapy in Subjects With Obsessive-Compulsive Disorder |
|
|
| Terminated | 2 | 8 | US | Fluoxetine 60 mg, Naltrexone 32 mg and fluoxetine 60 mg, Naltrexone SR 32 mg | Orexigen Therapeutics, Inc | Obsessive-Compulsive Disorder | 12/08 | 12/08 | | |
CADY, NCT00149643: Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence |
|
|
| Completed | 2 | 70 | US | Fluoxetine, Prozac, Placebo | University of Pittsburgh, National Institute on Drug Abuse (NIDA) | Depressive Disorder, Major, Cannabis Abuse | 08/09 | 12/12 | | |
NCT00797966: Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder |
|
|
| Completed | 2 | 850 | US | OPC-34712, Generic Name: Brexpiprazole, Placebo, ADT, Each individual will receive one of the following 6 ADTs:, Escitalopram (Lexapro), Fluoxetine (Prozac), Paroxetine CR (Paxil CR), Sertraline (Zoloft), Desvenlafaxine (Pristiq), Venalfaxine XR (Effexor XR) | Otsuka Pharmaceutical Development & Commercialization, Inc. | Major Depressive Disorder | 06/10 | 07/10 | | |
| Withdrawn | 2 | 0 | Europe | fluoxetine, SSRI compared to placebo, placebo, Placebo and drug packaging applied | Assistance Publique - Hôpitaux de Paris | Autism | 11/10 | 11/11 | | |
| Completed | 2 | 100 | Europe | fluoxetine, PROZAC, placebo | University Hospital, Toulouse | Ischemic Stroke, Motor Impairment | 12/10 | 12/10 | | |
| Completed | 2 | 87 | Europe | FLUOXETINE, PROZAC® | University Hospital, Toulouse, Clinical Research Center, Toulouse | Multiple System Atrophy | 06/11 | 09/11 | | |
NCT00942708: Safety and Efficacy of Fluoxetine in Pulmonary Arterial Hypertension |
|
|
| Completed | 2 | 6 | US | Fluoxetine, Total dose How to take:, Week 1-2 20 mg daily, Week 3-4 40 mg daily, Week 5-6 40 mg BID, Week 7-12 40mg BID | University of Texas Southwestern Medical Center, National Center for Research Resources (NCRR) | Pulmonary Arterial Hypertension | 06/11 | 08/11 | | |
NCT01254305: Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Adults With Fatigue Associated With Major Depressive Disorder |
|
|
| Completed | 2 | 262 | US | Levomilnacipran ER, Paroxetine, Sertraline, Citalopram or Fluoxetine., Placebo | Forest Laboratories | Major Depressive Disorder | 07/12 | 07/12 | | |
NCT01545843: Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression |
|
|
| Completed | 2 | 68 | US | Sleep scheduling, Fluoxetine, Prozac | University of Michigan | Depression | 12/12 | 12/12 | | |
NCT00851006: Creatine Treatment for Female Adolescents With Depression Who Are Non-Responders to Fluoxetine or Escitalopram |
|
|
| Completed | 2 | 13 | US | Creatine Monohydrate, Creapure | University of Utah, AlzChem, LLC | Major Depressive Disorder | 12/12 | 12/12 | | |
NCT01447576: Study of Safety & Tolerability of OPC-34712 as Adjunctive Therapy in Treatment of Adult Patients With Major Depressive Disorder |
|
|
| Completed | 2 | 1036 | US | ADT, Anti-depressant Drug Therapy, OPC-34712 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Major Depressive Disorder | 12/12 | 12/12 | | |
2010-023216-14: Combination treatment of antidepressant medication with eye training program to treat lazy eye in adults. |
|
|
| Completed | 2 | 34 | Europe | Capsule, hard, Seronil 20 mg hard capsule | Hermo Pharma Ltd, Hermo Pharma Ltd. | treatment of adult amblyopia - amblyopia due to myopic or hyperopic anisometropia, or, congenital esotropia., Lazy eye, Diseases [C] - Eye Diseases [C11] | | | | |
| Completed | 2 | 133 | RoW | Individualized homeopathic treatment, Homeopathic remedies, Homeopathic medicines, Fluoxetine, Prozac, Placebo, Fluoxetine placebo, Individualized homeopathic placebo | Hospital Juarez de Mexico | Moderate Depression, Menopausal and Postmenopausal Disorders | 02/14 | 03/14 | | |
NCT05378711: Evaluating the Results of Physician and Parent Decisions to Treat Selective Mutism With Fluoxetine |
|
|
| Completed | 2 | 6 | US | Fluoxetine, Prozac | Michigan State University | Selective Mutism, Social Anxiety | 05/15 | 05/15 | | |
2014-005088-34: A clinical trial investigating the effect of the anti-depressant fluoxetine on learning and memory in people with epilepsy. |
|
|
| Ongoing | 2 | 60 | Europe | Fluoxetine, Capsule, fluoxetine | Cardiff University, Epilepsy Research UK | Mesial Temporal Lobe Epilepsy, Epilepsy, Diseases [C] - Nervous System Diseases [C10] | | | | |
2006-005044-86: Influence of long-term administration of fluoxetine on cerebral threshold and muscle activity patterns in chronic stroke patients. |
|
|
| Ongoing | 2 | 30 | Europe | fluoxetine, | Roessingh Research and Development | The effect of fluoxetine on brain excitability and muscle activation will be measured in chronic stroke patients (> 6 months after stroke). As secondary measures, also brain activation, phase-synchronization in the brain, and motor function will be studied. | | | | |
2008-000787-16: Etude pilote ouverte de l\'effet de la fluoxetine chez des patientes agées de 8 à 28 ans atteintes du Syndrôme de Rett Typique |
|
|
| Ongoing | 2 | 30 | Europe | Prozac, Prozac | Inserm | Sydrome de Rett typique | | | | |
2008-003349-97: Influence of a single dose of fluoxetine on brain activity during movement observation and execution, muscle activity and motor function in chronic stroke patients |
|
|
| Ongoing | 2 | 20 | Europe | fluoxetine, | Roessingh Research&Development | The objective of this study is to examine the effect of a single dose of fluoxetine and of movement observation on cortical activity in chronic stroke patients (>6 months after stroke). As secondary objectives, the effect of fluoxetine on motor function and muscle activity will be measured. | | | | |
NCT01714310: Characterization and Sequential Pharmacotherapy of Severe Mood Dysregulation |
|
|
| Completed | 2 | 34 | US | lisdexamfetamine, Vyvanse, Placebo, fluoxetine, Prozac | University of California, Los Angeles, National Institute of Mental Health (NIMH), Shire | Severe Mood Dysregulation | 06/16 | 06/16 | | |
ACTRN12608000173392: Fluoxetine for the treatment of repetitive behaviours in children and adolescents with autism: A randomised double-blind placebo-controlled trial. |
|
|
| Completed | 2 | 146 | | | Victorian Medical Insurance Agency, Department of Developmental Medicine, Royal Chidlren's Hospital | Repetitve behaviours in autism. | | | | |
NCT03638908: Fluoxetine in Pulmonary Arterial Hypertension (PAH) Trial |
|
|
| Completed | 2 | 8 | US | Fluoxetine | University of Texas Southwestern Medical Center | Pulmonary Arterial Hypertension | 05/17 | 12/18 | | |
NCT02929667: Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI |
|
|
| Completed | 2 | 30 | US | Fluoxetine, Prozac, Placebo | Rup Kamal Sainju | Epilepsy, SUDEP | 03/19 | 03/19 | | |
NCT03138681: Rapid Antidepressant Effects of ATP and Phosphocreatine |
|
|
| Unknown status | 2 | 42 | RoW | Placebo, ATP, Phosphocreatine | Zhujiang Hospital | Major Depressive Disorder | 04/19 | 04/19 | | |
NCT02208466: Effects rTMS Combined With Fluoxetine on Motor Recovery in Stroke Patients |
|
|
| Completed | 2 | 44 | US | Active Repetitive Transcranial Magnetic Stimulation (rTMS), magnetic stimulation, Magstim, Fluoxetine, Prozac, Sarafem, Ladose, Fontex, Sham repetitive transcranial magnetic stimulation (rTMS), Magstim, magnetic stimulation, Placebo Fluoxetine | Spaulding Rehabilitation Hospital | Stroke, Motor Function | 06/19 | 06/19 | | |
ACUfNIRS, NCT04272476: The Activation on Prefrontal Cortex With Acupuncture and Moxibustion for Major Depressive Disorder: A Study of Functional Near Infrared Spectroscopy |
|
|
| Completed | 2 | 20 | RoW | acupuncture and moxibustion, Fluoxetine, Prozac | Chengdu University of Traditional Chinese Medicine, Massachusetts General Hospital | Depressive Disorder, Major | 12/19 | 12/19 | | |
| Terminated | 2 | 17 | US | Fluoxetine, Prozac, Sarafem, Placebo | Bogachan Sahin | Acute Stroke, Visual Field Loss | 08/20 | 08/20 | | |
2019-004255-36: Cesar - an open, randomized controlled phase II study, comparing Naltrexon and Fluoxetin treating Compulsive Sexual Behavior Disorder. Cesar - en öppen randomiserad kontrollerad fas II-studie som jämför Naltrexon med Fluoxetin vid behandling av tvångsmässig sexuell beteendestörning. |
|
|
| Not yet recruiting | 2 | 80 | Europe | Fluoxetine Orion, Tablet, Capsule, hard, Naltrexon Vitaflo 50 mg, tablets for oral treatment., Fluoxetine Orion | Karolinska Universitetssjukhuset, SLSO, Region Västerbotten | Compulsive Sexual Behavior Disorder Tvångsmässig sexualitet/sexuell störning., Compulsive Sexual Behavior Disorder Tvångsmässig sexualitet/sexuell störning., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT01963832: RCT of a Neuroplasticity Agent and CI Therapy for Severe Arm Paresis After Stroke |
|
|
| Withdrawn | 2 | 0 | US | Fluoxetine, Placebo, eCMIT, Usual Care | University of Alabama at Birmingham | Severe Stroke With Affected Arm Motor Function | 11/20 | 11/21 | | |
MAMBO, NCT03728153: Measuring Ambulation, Motor, and Behavioral Outcomes With Post-Stroke Fluoxetine in Tanzania |
|
|
| Completed | 2 | 34 | RoW | Fluoxetine 20 MG Oral Tablet, Prozac 20 MG Oral Tablet | Massachusetts General Hospital, Muhimbili University of Health and Allied Sciences | Acute Stroke, Stroke, Ischemic | 01/21 | 01/21 | | |
| Not yet recruiting | 2 | 111 | Europe | Fluoxetin, Capsule, Fluoxetine | Karolinska Universitetssjukhuset, SLSO Stockholm | Pedophilic Disorder, Pedofil störning, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Completed | 2 | 52 | Canada | Fluoxetine Hydrochloride, Prozac, Placebo, "Sugar" Pill, Exercise Program | University Health Network, Toronto, University of British Columbia, Sunnybrook Health Sciences Centre, University of Calgary, Dalhousie University, Parkwood Hospital, London, Ontario, Riverview Health Centre Foundation, Memorial University of Newfoundland, Applied Health Research Centre, Brain Canada, Heart and Stroke Foundation Canadian Partnership for Stroke Recovery | Stroke, Cerebrovascular Accident, Cerebral Infarction, Brain Infarction, Brain Ischemia, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Vascular Diseases | 09/22 | 09/22 | | |
ChiCTR2100053508: A multi-center, randomized, double-blind, double-dummy, dose-finding, placebo- and active-drug parallel-controlled clinical trial to evaluate the efficacy and safety of Yi'nao Jieyu Granules in the treatment of depression due to kidney deficiency and liver stagnation |
|
|
| Recruiting | 2 | 240 | | 3 bags of Yi'nao Jieyu Granules, 2 times a day, take it with warm water in the morning and after dinner. One fluoxetine hydrochloride capsule simulation capsule, once a day, orally in the morning. ;2 bags of Yi'nao Jieyu Granules + 1 bag of Yi'nao Jieyu Granules Simulator, twice a day, take it with warm water in the morning and after dinner. One fluoxetine hydrochloride capsule simulation capsule, once a day, orally in the morning. ;3 bags of Yi'nao Jieyu Granule Simulator, twice a day, take it with warm water in the morning and after dinner. One fluoxetine hydrochloride capsule simulation capsule, once a day, orally in the morning. ;3 bags of Yi'nao Jieyu Granule Simulator, twice a day, take it with warm water in the morning and after dinner. 1 fluoxetine hydrochloride capsule, once a day, orally in the morning. | Beijing Anding Hospital Affiliated to Capital Medical University; Zhongjing Wanxi Pharmaceutical Co., Ltd., Own expense | Depression with kidney deficiency and liver depression | | | | |
NCT05431413: Rapid Improvement of Depression of Fluoxetine Combined With ATP |
|
|
| Recruiting | 2 | 195 | RoW | Control group: Fluoxetine and Placebo, Experimental group: Fluoxetine and ATP, Control group: Fluoxetine and Phosphocreatine | Nanfang Hospital, Southern Medical University | Depression | 12/25 | 12/25 | | |
NCT05725837: Effects of Paroxetine on Cardiovascular Function in Septic Patients |
|
|
| Recruiting | 2 | 92 | RoW | Paroxetine | Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude | Septic Shock, Sepsis | 07/24 | 07/24 | | |
| Recruiting | 2 | 224 | US | Fluoxetine, Prozac, Placebo | University of Washington | Stroke Hemorrhagic, Depression | 02/24 | 11/24 | | |
NCT05792540: Clinical Study to Evaluate the Possible Efficacy of Dapagliflozin and Atorvastatin in Patients With Major Depressive Disorders |
|
|
| Recruiting | 2 | 75 | RoW | Fluoxetine 20 mg, Dapagliflozin 10mg Tab, Atorvastatin 80mg | Tanta University, Eman Ibrahim Elberri, Faculty of Pharmacy, Tanta University, Fedaa Abd El-monem Kamal El-deen Kotkata Faculty of Pharmacy, Tanta University, Manal Ali Mahrous Hamouda Faculty of Pharmacy, Menufia University | Depressive Disorder | 11/24 | 03/25 | | |
PLATCOV, NCT05041907: Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 |
|
|
| Recruiting | 2 | 3000 | RoW | Nirmatrelvir/ritonavir (e.g. PAXLOVID™), Nitazoxanide, Molnupiravir and nirmatrelvir/ritonavir (e.g. PAXLOVID™), Hydroxychloroquine, No treatment, Monoclonal antibodies, Fluoxetine, Molnupiravir, Sotrovimab, Ensitrelvir, Favipiravir, Ivermectin, Remdesivir | University of Oxford | COVID-19 | 01/27 | 01/27 | | |
NCT04899687: Study of Dextromethorphan in OCD and Related Disorders |
|
|
| Recruiting | 2 | 60 | US | Fluoxetine, Prozac, Dextromethorphan | Stanford University, Avy L. & Roberta L. Miller Foundation | Obsessive-Compulsive Disorder, Illness Anxiety Disorder, Body Dysmorphic Disorders, Somatic Symptom Disorder | 04/25 | 12/25 | | |
NCT05948553: Department of Defense PTSD Adaptive Platform Trial Intervention A - Fluoxetine |
|
|
| Recruiting | 2 | 200 | US | Intervention A Fluoxetine Hydrochloride (HCl), Intervention A Placebo | U.S. Army Medical Research and Development Command, PPD, Berry Consultants, Idorsia Pharmaceuticals Ltd., Cambridge Cognition Ltd, Citeline | Post Traumatic Stress Disorder | 03/26 | 09/26 | | |
NCT05422612: Department of Defense PTSD Adaptive Platform Trial - Master Protocol |
|
|
| Recruiting | 2 | 600 | US | Intervention A Fluoxetine Hydrochloride (HCl), Intervention A Placebo, Intervention B Vilazodone Hydrochloride (HCl), Intervention B Placebo, Intervention C Daridorexant, Intervention C Placebo | U.S. Army Medical Research and Development Command, PPD, Berry Consultants, Idorsia Pharmaceuticals Ltd., Cambridge Cognition Ltd, Citeline | Post Traumatic Stress Disorder | 03/26 | 09/26 | | |
NCT00018057: Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders |
|
|
| Recruiting | 2 | 2530 | US | Attention Bias Modification Training, Fluoxetine | National Institute of Mental Health (NIMH), University of Minnesota, University of Oregon, University of Maryland | Anxiety Disorders, Major Depressive Disorder | 01/29 | 01/29 | | |
| Withdrawn | 1/2 | 54 | | | The University of Auckland, Neurological Foundation of New Zealand | Stroke | | | | |
NCT00339079: Treatment of Hypochondriasis With CBT and/or SSRI |
|
|
| Completed | 1/2 | 195 | US | Fluoxetine, Prozac, Prodep, Sarafem, Lovan, Symbyax, Fluctin, Cognitive Behavioral Therapy (CBT), Supportive Therapy, Placebo | Brigham and Women's Hospital, National Institute of Mental Health (NIMH) | Hypochondriasis | 05/11 | 12/11 | | |
NCT00296725: Dichotic Listening as a Predictor of Medication Response in Depression |
|
|
| Completed | 1/2 | 25 | US | Fluoxetine, Prozac, Imipramine, Tofranil | New York State Psychiatric Institute | Major Depression, Dysthymia, Depressive Disorder Not Otherwise Specified | 06/11 | 06/11 | | |
| Completed | 1/2 | 40 | US | Fluoxetine, Prozac, Increased Dose of Interpersonal Psychotherapy, Continue to Receive Initial Dose of Interpersonal Psychotherapy | University of Minnesota | Adolescent Depression | 06/16 | 06/16 | | |
| Completed | 1/2 | 15 | US | Fluoxetine, Prozac, Interpersonal Psychotherapy, IPT | University of Minnesota | Adolescent Depression | 10/18 | 10/18 | | |
NCT02723903: Hierarchical Treatment Based on Somatization Symptom Checklist |
|
|
| Unknown status | 1/2 | 200 | RoW | Deanxit, Deanxit as anti-anxiety treatment, Prozac, Prozac as anti-depression treatment, coronary artery disease treatment, re-vascularization | RenJi Hospital | Syndrome X | 12/20 | 12/21 | | |
NCT04131829: Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD |
|
|
| Recruiting | 1/2 | 100 | US | Fluoxetine - immediate treatment, fluoxetine, prozac, Fluoxetine - delayed treatment | Yale University, National Institute of Mental Health (NIMH) | Obsessive-Compulsive Disorder | 07/24 | 07/24 | | |
STAMD, NCT05814640: Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD) |
|
|
| Recruiting | 1/2 | 520 | RoW | Fluoxetine, Sertraline, Vortioxetine, Duloxetine, Aripiprazole, Lithium Carbonate, Olanzapine, GCBT | First Affiliated Hospital of Chongqing Medical University, The Second Affiliated Hospital of Chongqing Medical University, Children's Hospital of Chongqing Medical University, Southwest Hospital, China, Central South University | Depression, Sequestra | 12/25 | 07/27 | | |
