| bupropion sustained-release / Generic mfg. |
| Completed | 4 | 32 | US | Bupropion Sustained Release (SR), Wellbutrin SR | National Institute on Drug Abuse (NIDA) | Attention-Deficit/Hyperactivity Disorder, Substance Use Disorders | 08/01 | 08/01 | | |
| Completed | 4 | 555 | US | zyban | National Institutes of Health (NIH) | Smoking Cessation | | 03/02 | | |
NCT01621009: Bupropion SR Plus Counseling for Smoking Cessation |
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| Completed | 4 | 463 | US | Active bupropion + counseling, Active bupropion, No counseling, Placebo medication + counseling, Placebo medication, No counseling | University of Wisconsin, Madison, National Cancer Institute (NCI), National Institute on Drug Abuse (NIDA) | Tobacco Dependence, Smoking | 10/02 | 10/03 | | |
| Completed | 4 | 667 | Europe | Counseling and Nicotine replacement (CN), Counseling, Nicotine replacement and Bupropion (CNB), Bupropion-SR (Zyban) | ZonMw: The Netherlands Organisation for Health Research and Development, The Netherlands Asthma Foundation, Pharmacia, GlaxoSmithKline | Chronic Obstructive Pulmonary Disease (COPD) | 12/02 | 12/03 | | |
NCT00181818: Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease |
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| Completed | 4 | 248 | US | bupropion SR (sustained-release) | Massachusetts General Hospital, National Heart, Lung, and Blood Institute (NHLBI), GlaxoSmithKline | Smoking, Myocardial Infarction, Unstable Angina, Cardiovascular Disease | | 12/03 | | |
NCT00307203: Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke |
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| Completed | 4 | 51 | US | bupropion SR, Zyban, Wellbutrin, Cognitive Behavioral Group Therapy, CBT, nicotine replacement therapy, nicotine patch; nicotine gum | National Institute on Drug Abuse (NIDA) | Tobacco-Use Disorder, Schizophrenia, Psychotic Disorders | 02/04 | 02/04 | | |
NCT00176449: A Comparison of Bupropion SR and Placebo for Smoking Cessation |
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| Completed | 4 | 52 | US | Bupropion SR, Placebo Oral Tablet | University of Maryland, Baltimore, US Department of Veterans Affairs | Tobacco Use Disorder | 12/05 | 12/05 | | |
NCT00119210: Pilot Study of Bupropion for Smoking Cessation in Postpartum Non-breastfeeding Women |
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| Terminated | 4 | 40 | US | Bupropion SR, placebo | Massachusetts General Hospital, Robert Wood Johnson Foundation | Tobacco Use Disorder | | 03/06 | | |
NCT00142831: Bupropion as an Adjunct to the Nicotine Patch Plus CBT |
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| Completed | 4 | 293 | US | Pharmacotherapies for Smoking Cessation | National Institute on Drug Abuse (NIDA) | Tobacco Use Disorder | 08/06 | 08/06 | | |
| Completed | 4 | 779 | Europe | sustained-release bupropion (Zyban(R)), Psychodynamic Model Training (R) = PDM(R) | Medical University Innsbruck | Nicotine Dependence, Substance Abuse, Substance Dependence, Tobacco Dependence | | 01/07 | | |
NCT00181896: Bupropion SR for Major Depression and Depression NOS in Children and Adolescents With Bipolar Disorder |
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| Terminated | 4 | 1 | US | bupropion SR | Massachusetts General Hospital | Depression, Bipolar Disorder | 02/07 | | | |
NCT01576640: Extended Duration Nicotine Replacement Therapy and Bupropion in Smokers With Schizophrenia |
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| Terminated | 4 | 17 | US | NRT, Bupropion SR 150mg bid, Relapse Prevention-Oriented Cognitive Behavioral Therapy | Massachusetts General Hospital | Nicotine Dependence, Schizophrenia | 10/07 | 10/07 | | |
NCT00611975: Effect of Antidepressants on Sex Hormone Levels and Sexual Functioning |
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| Completed | 4 | 83 | NA | Fluoxetine, Prozac, Sarafem, Bupropion, Wellbutrin, Zyban | Weill Medical College of Cornell University, National Institute of Mental Health (NIMH) | Healthy | 05/08 | 09/08 | | |
NCT00511134: Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban |
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| Terminated | 4 | 4 | US | Eszopiclone, Lunesta, Bupropion, Zyban | Yale University, Sunovion | Insomnia, Nicotine Dependence | 12/08 | 12/08 | | |
| Completed | 4 | 59 | US | Bupropion, Zyban, Transdermal Nicotine Patch, Placebo Bupropion, Placebo transdermal nicotine patch | National Institute on Drug Abuse (NIDA) | Tobacco Use Cessation, Sleep Disorders | 05/09 | 05/09 | | |
| Completed | 4 | 665 | US | SSRI + placebo, escitalopram, placebo, Escitalopram + Bupropion SR, bupropion-SR, Venlafaxine XR + Mirtazapine, venlafaxine-XR, mirtazapine | National Institute of Mental Health (NIMH) | Major Depressive Disorder | 09/09 | 09/09 | | |
NCT00006170: Bupropion and Weight Control for Smoking Cessation - 1 |
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| Completed | 4 | 349 | US | Bupropion, zyban, Placebo, weight concerns intervention, smoking cessation intervention | University of Pittsburgh, National Institute on Drug Abuse (NIDA) | Tobacco Use Disorder | 12/09 | 09/10 | | |
NCT00991081: Behaviorally Enhanced Counseling on Nicotine Dependence (BEACON) Trial. |
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| Completed | 4 | 36 | US | Counseling, Motivational interviewing, Motivational enhancement, Self-help guide, Support Materials, Clearing the Air, Pharmacotherapy, NRT, Nicotine Replacement Therapy, The Patch, Bupropion, Zyban, Aplenzin, Wellbutrin, Genetic feedback, verbal, Pharmacogenetics, Pharmacogenetic counseling, Genetic feedback, printed, Pharmacogenetic Feedback | Stanford University, SRI International, Johns Hopkins University, University of Bristol, National Institute on Drug Abuse (NIDA) | Smoking | 03/11 | 03/11 | | |
NCT01023659: Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts |
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| Completed | 4 | 893 | Canada | bupropion, Zyban, varenicline, Champix, motivational emails | Centre for Addiction and Mental Health, Ontario Ministry of Health and Long Term Care | Tobacco Use Disorder, Smoking, Smoking Cessation | 12/11 | 12/11 | | |
NCT01048944: Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers |
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| Completed | 4 | 197 | US | Bupropion SR, ZybanSR, Nicotine Patch, NicodermCQ, Placebo Patch and Placebo Pill, Placebo | Southern Illinois University Carbondale, National Institute on Drug Abuse (NIDA) | Nicotine Dependence | 01/13 | 01/13 | | |
NCT02173886: A Comparison of Sustained and Extended Release Bupropion Following Bariatric Surgery |
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| Completed | 4 | 20 | US | Bupropion SR and XL | North Dakota State University, Neuropsychiatric Research Institute, Fargo, North Dakota | Roux en Y Gastric Bypass | 02/15 | 02/15 | | |
| Completed | 4 | 223 | US | Bupropion, Zyban, Nicotine patch, NRT, Varenicline, Chantix | Stanford University, National Institute on Drug Abuse (NIDA) | Smoking Cessation | 03/15 | 03/15 | | |
NCT01574703 / 2011-005513-37: Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders. |
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| Completed | 4 | 4595 | US, Canada, Europe, RoW | placebo, varenicline tartrate, Chantix; Champix, bupropion hydrochloride, Zyban, Nicotine Replacement Therapy Patch, NRT | Pfizer | Smoking Cessation | 07/15 | 07/15 | | |
| Completed | 4 | 454 | Canada | bupropion HCl, Zyban | Centre for Addiction and Mental Health, Ontario Ministry of Health and Long Term Care | Cigarette Smoking, Nicotine Addiction, Smoking Cessation | 10/15 | 10/15 | | |
2004-002903-34: Phänotypisierung und Genotypisierung von Cytochrom P450-Enzymen |
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| Ongoing | 4 | 50 | Europe | Codeintropfen von ct, Hustenstiller-ratiopharm Kapseln, Lorzaar 12,5mg Start Filmtabletten, Coffeinum purum Tabletten, Antra Mups, Zyban 150mg Redardtabletten, Codeintropfen von ct, Hustenstiller-ratiopharm Kapseln, Lorzaar 12,5mg Start Filmtabletten, Coffeinum purum Tabletten, Antra Mups, Zyban 150mg Redardtabletten | University of Frankfurt, Institute of Clinical Pharmacology | Healthy volunteers | | | | |
NCT02162862: Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease |
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| Completed | 4 | 99 | US | Behavioral Counseling, bupropion-SR, Wellbutrin | Eva Szigethy, Crohn's and Colitis Foundation | Sleep Disturbance, Fatigue, Inflammatory Bowel Disease | 06/16 | 06/16 | | |
NCT01390246: Bupropion for Smoking Cessation During Pregnancy |
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| Completed | 4 | 65 | US | Bupropion SR, Zyban, buproban, Smoking Cessation Counseling, Behavioral counseling, Placebo, Control | The University of Texas Medical Branch, Galveston, National Institute on Drug Abuse (NIDA), UConn Health | Pregnancy Related, Tobacco Use Disorder | 12/16 | 12/16 | | |
NCT02238977: Bupropion for Depression in ESRD Patients on Hemodialysis |
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| Terminated | 4 | 1 | US | Fluoxetine, Prozac, Bupropion, Wellbutrin SR | University of Arkansas, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Major Depression, End Stage Renal Disease | 03/18 | 03/18 | | |
NCT02245308: Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers |
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| Completed | 4 | 133 | US | Nicotine Patches, Nicoderm, mobile contingency management (mCM), Smoking cessation counseling, Nicotine rescue method, Nicorette, Bupropion, Zyban, Wellbutrin | VA Office of Research and Development | Tobacco Use Disorder, Homelessness | 03/18 | 09/18 | | |
NCT03126682: Effect of Bupropion on Seizure Threshold in Depressed Patients |
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| Completed | 4 | 10 | US | Wellbutrin SR 300Mg Extended-Release Tablet, Bupropion sustained release formulation | Duke University | MDD | 05/18 | 05/18 | | |
NCT02420015: Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia |
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| Completed | 4 | 35 | US | Nicotine replacement therapy, nicotine gum, patch, inhaler, and/or lozenge, Bupropion, Zyban, cognitive-behavioral smoking cessation counseling, Mobile Contingency Management, mCM, Stay Quit Coach, SMS text messaging, texting | Duke University | Schizophrenia, Cigarette Smoking | 01/19 | 01/19 | | |
NCT02291666: Evaluation of CYP450 Activities in Diabetic Patients vs. Non-diabetic Subjects |
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| Completed | 4 | 73 | Canada | CRCHUM-MT cocktail, omeprazole, Losec, caffeine, Wake-up, bupropion, Wellbutrin, Zyban, dextromethorphan, midazolam, tolbutamide, chlorzoxazone, Acetazone | Centre hospitalier de l'Université de Montréal (CHUM), Canadian Institutes of Health Research (CIHR) | Type 2 Diabetes | 07/19 | 07/19 | | |
NCT02995915: Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking |
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| Completed | 4 | 45 | US | Nicotine Replacement Therapy, nicotine gum, patch, inhaler, and/or lozenge, Bupropion, Zyban, Cognitive Behavioral Treatment, CBT, Mobile Contingency Management, mobile CM, mCM, Mobile Monitoring | Duke University | Smoking Cessation, Alcohol Drinking | 03/20 | 03/20 | | |
| Completed | 4 | 12 | US | Bupropion, Wellbutrin, Zyban, Varenicline, Chantix, Cognitive Behavioral Therapy, CBT, Nicotine Replacement Therapy, NRT; nicotine patch; nicotine rescue method, Relapse Prevention Text Messaging, SmokefreeVET | VA Office of Research and Development | Human Immunodeficiency Virus, Smoking | 07/21 | 11/21 | | |
| Recruiting | 4 | 120 | US | Smoking Cessation Cognitive Behavioral Therapy (CBT), CBT, Bupropion, Zyban, Cognitive Processing Therapy, CPT, Smoking Abstinence Reinforcement Therapy, SMART, Yoked Contingency Management, Control CM | VA Office of Research and Development | Smoking, Stress Disorders, Post-Traumatic | 09/24 | 09/24 | | |
NCT05351606: Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, Kenya |
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| Recruiting | 4 | 580 | RoW | Tobacco Use Cessation Counselling Sessions, Bupropion, Wellbutrin, Zyban, Nicotine patch, Nicotine Replacement Therapy (NRT), Nicotine lozenge, Nicotine lozenge product, NRT | University of California, San Francisco, Kenya Medical Research Institute, National Cancer Institute (NCI) | Tobacco Use Cessation, Tobacco Use | 11/24 | 11/24 | | |
NCT03950427: PARQuit Smoking Cessation Intervention for Adults With Serious Mental Illness |
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| Recruiting | 4 | 120 | US | Videogame-based physical activity, sedentary videogame, Bupropion, Wellbutrin, Zyban, Counseling | University of California, San Francisco, Tobacco Related Disease Research Program | Smoking Cessation, Smoking, Tobacco, Mental Illness, Tobacco Use Disorder | 07/25 | 07/25 | | |
NCT05737511: Efficacy of Hydroxyzine for Patients With Panic Disorder |
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| Not yet recruiting | 4 | 80 | NA | Hydroxyzine, Atarax, Vistaril, Escitalopram Oxalate, citalopram, fluoxetine, fluvoxamine, paroxetine, paroxetine CR, sertraline, venlafaxine XR,, Alprazolam, clomipramine, clonazepam, diazepam, imipramine, lorazepam, mirtazapine, reboxetine, Bupropion SR, divalproex, duloxetine, gabapentin, levetiracetam, milnacipran, moclobemide, olanzapine, phenelzine, quetiapine, risperidone, tranylcypromine | Sultan Qaboos University | Panic Disorder | 12/26 | 12/26 | | |
