| bupropion sustained-release / Generic mfg. |
NCT00709371: Zonisamide SR Plus Bupropion SR Combination Therapy in Subjects With Obesity |
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| Completed | 2b | 729 | US | Zonisamide SR placebo/ bupropion SR placebo, Zonisamide SR placebo/ bupropion SR 360 mg/day, Zonisamide SR 120 mg/day/ bupropion SR placebo, Zonisamide SR 360 mg/day/ bupropion SR placebo, Zonisamide SR 120 mg/day/ bupropion SR 360 mg/day, Zonisamide SR 360 mg/day/ bupropion SR 360 mg/day | Orexigen Therapeutics, Inc | Obesity | 04/09 | 07/09 | | |
NCT00150241: A Seven-Week Dose-Ranging Study of CP-526,555 Compared With Placebo and Zyban for Smoking Cessation |
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| Completed | 2 | 625 | US | CP-526,555 (varenicline) | Pfizer | Smoking Cessation | | 01/02 | | |
NCT00000457: Pharmacologic Relapse Prevention for Alcoholic Smokers |
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| Completed | 2 | 195 | US | bupropion (Wellbutrin), bupropion, zyban, wellbutrin, Placebo | Mayo Clinic, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcoholism, Smoking | 04/02 | 08/07 | | |
NCT00060814: Combination Pharmacotherapy for Smoking Cessation Among Methadone Patients |
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| Completed | 2 | 28 | US | Combined intervention | National Institute on Drug Abuse (NIDA) | Tobacco Use Disorder | 09/02 | 12/02 | | |
| Completed | 2 | 135 | US | Bupropion SR, Wellbutrin SR, Zyban SR, placebo, smoking cessation counseling | Watching Over Mothers & Babies Foundation, University of Arizona | Smoking Cessation, Pregnancy | 01/04 | 01/04 | | |
NCT00087880: Maintaining Abstinence in Chronic Cigarette Smokers - 1 |
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| Completed | 2 | 407 | US | Bupropion and NRT, Zyban | National Institute on Drug Abuse (NIDA) | Tobacco Use Disorder | 01/05 | 09/09 | | |
NCT00142870: Effectiveness of Bupropion in Treating Marijuana Dependent Individuals |
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| Completed | 2 | 30 | US | Bupropion, Zyban | National Institute on Drug Abuse (NIDA) | Marijuana Abuse, Substance-Related Disorders | 05/06 | 05/06 | | |
NCT00218231: Effect of Bupropion on Smoking Behavior in Smokers With Schizophrenia |
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| Completed | 2 | 48 | US | 300 mg/day bupropion-sr, zyban, wellbutrin, 0 mg/day bupropion-sr, placebo | National Institute on Drug Abuse (NIDA) | Schizophrenia, Tobacco Use Disorder | 08/06 | 08/06 | | |
NCT00135512: Study Of 323U66 SR In Major Depressive Disorder |
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| Completed | 2 | 234 | Japan, RoW | bupropion hydrochloride | GlaxoSmithKline | Depressive Disorder | 05/07 | 05/07 | | |
NCT00339014: Safety and Efficacy of Different Combinations of Zonisamide-CR Plus Bupropion-SR to Treat Uncomplicated Obesity |
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| Completed | 2 | 611 | US | Zonisamide CR and Bupropion SR, Placebo | Orexigen Therapeutics, Inc | Obesity | 08/07 | 08/07 | | |
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NCT00330616: Study Of Bupropion SR (323U66) In Patients With Major Depressive Disorder In Japan |
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| Completed | 2 | 35 | Japan | 323U66 SR | GlaxoSmithKline | Major Depressive Disorder (MDD) | 11/07 | 11/07 | | |
NCT00086411: Comparing Smoking Treatment Programs for Lighter Smokers - 1 |
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| Completed | 2 | 260 | US | nicotine transdermal system, Nicoderm, bupropion, Zyban, Medication Management, Mayo Counseling, placebo patch, placebo bupropion | University of Pennsylvania, National Institute on Drug Abuse (NIDA) | Tobacco Use Disorder | 04/08 | 06/09 | | |
NCT00136760: Contingent Incentives Plus Bupropion for Smoking in People With Schizophrenia |
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| Completed | 2 | 57 | US | Bupropion, zyban, wellbutrin, Contingent reinforcement plus placebo, non-contingent reinforcement plus bupropion, Non-contingent reinforcement plus placebo | Brown University, National Institute on Drug Abuse (NIDA) | Schizophrenia and Disorders With Psychotic Features, Tobacco Use Disorder | 03/09 | 03/09 | | |
NCT00330187: Combined Pharmaco/Behavior Therapy in Adolescent Smokers |
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| Completed | 2 | 134 | US | Bupropion SR, Contingency Management, Placebo | Medical University of South Carolina, National Institute on Drug Abuse (NIDA) | Nicotine Dependence, Nicotine Use Disorder | 07/09 | 07/09 | | |
| Completed | 2 | 24 | US | Sugar Pill, Varenicline, Chantix, Bupropion HCl, Wellbutrin, Zyban | University of Minnesota, National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA) | Schizophrenia, Smoking Cessation | 08/12 | 08/12 | | |
NCT01286402: Double-blind, Placebo-Controlled Pilot Study of Bupropion to Promote Smoking Cessation During Pregnancy |
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| Completed | 2 | 11 | US | Bupropion SR, Zyban, Wellbutrin, Placebo | The University of Texas Health Science Center, Houston, M.D. Anderson Cancer Center, Gilstrap, Larry C, M.D., The Center for Clinical and Translational Sciences (CCTS) Clinical Research Unit at The University of Texas Health Science Center at Houston | Smoking Cessation | 10/12 | 05/13 | | |
| Completed | 2 | 84 | US | Bupropion, Zyban, Wellbutrin | University of California, Los Angeles, National Institute on Drug Abuse (NIDA) | Methamphetamine, Amphetamine Dependence, Pharmacogenetics, Methamphetamine Dependence, Substance Abuse | 12/12 | 07/13 | | |
| Completed | 2 | 63 | US | Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral, Nicotine replacement therapy - nicotine gum, Nicotine replacement therapy - nicotine lozenge, Bupropion Sustained Release, Zyban, Varenicline, Chantix, Combination pharmacotherapy - transdermal nicotine patch + nicotine gum, Combination pharmacotherapy - transdermal nicotine patch + nicotine lozenge, Combination pharmacotherapy - transdermal nicotine patch + bupropion, Alcohol use risk reduction, Risky alcohol use, Harm reduction, Behavioral activation for the treatment of depression, Depression, Behavioral management of post-cessation weight gain, Weight management | Iowa City Veterans Affairs Medical Center, US Department of Veterans Affairs | Cigarette Smoking | 06/13 | 06/13 | | |
NCT00580853: The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior |
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| Completed | 2 | 62 | US | varenicline, Chantix, bupropion, Zyban, Placebo | Yale University, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Smoking Lapse Behavior | 10/16 | 10/16 | | |
NCT02593396: Bupropion in Sexual Dysfunction Among Methadone Maintenance Treatment Men |
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| Completed | 2 | 80 | RoW | Bupropion hydrochloride sustained-release, wellbutrin SR, placebo | University of Malaya | Sexual Dysfunctions, Psychological, Hypoactive Sexual Desire Disorder, Erectile Dysfunctions | 12/17 | 12/17 | | |
| Not yet recruiting | 2 | 60 | US | AXS-05, Bupropion/dextromethorphan, Bupropion SR, Wellbutrin SR, Zyban SR | James Davis, Axsome Therapeutics, Inc. | Smoking Cessation, Smoking, Cigarette, Nicotine Dependence | 12/18 | 01/19 | | |
| Completed | 2 | 58 | US | AXS-05, Bupropion/dextromethorphan, Bupropion SR, Wellbutrin SR, Zyban SR | James Davis, Axsome Therapeutics, Inc. | Smoking Cessation, Smoking, Cigarette, Nicotine Dependence | 03/19 | 03/19 | | |
TARGET, NCT04971291: An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent Patients |
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| Enrolling by invitation | 2 | 312 | US | AXS-05, Bupropion SR | Axsome Therapeutics, Inc. | Major Depressive Disorder, Treatment Resistant Depression | 07/21 | 07/21 | | |
| Completed | 2 | 388 | Europe | Varenicline Tartrate 1 mg b.i.d, Champix, Bupropion Hydrochloride 150 mg b.i.d, Bupropion Sandoz, Placebo for varenicline, Placebo for bupropion | Vastra Gotaland Region | Alcohol Use Disorder, Alcoholism, Alcohol Dependence | 12/22 | 12/22 | | |
NCT00593099: A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder |
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| Completed | 1/2 | 5 | US | Bupropion, Zyban, Placebo | National Institute on Drug Abuse (NIDA) | Bipolar Disorder | 06/06 | 06/06 | | |
| Terminated | 1/2 | 1 | US | Placebo, Armodafinil, Nuvigil, Minocycline, Dynacin, Minocin, Minocin PAC, Myrac, Solodyn, Bupropion, Wellbutrin, Wellbutrin SR, Zyban | M.D. Anderson Cancer Center, National Cancer Institute (NCI) | Head And Neck Cancer | 01/14 | 01/14 | | |
NCT01048983: Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC) |
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| Withdrawn | 1/2 | 0 | US | Armodafinil, Nuvigil, Modafinil, Bupropion, Wellbutrin, Wellbutrin SR, Zyban, Minocycline, Dynacin, Minocin, Minocin PAC, Myrac, Solodyn, Curcumin, Telephone Questionnaire, Survey | M.D. Anderson Cancer Center, National Cancer Institute (NCI) | Non Small Cell Lung Cancer | | | | |
