| Completed | 4 | 667 | Europe | Counseling and Nicotine replacement (CN), Counseling, Nicotine replacement and Bupropion (CNB), Bupropion-SR (Zyban) | ZonMw: The Netherlands Organisation for Health Research and Development, The Netherlands Asthma Foundation, Pharmacia, GlaxoSmithKline | Chronic Obstructive Pulmonary Disease (COPD) | 12/02 | 12/03 | | |