oxaliplatin / Generic mfg. |
ChiCTR-TRC-12002393: Preoperative Concurrent Chemoradiotherapy for Potentially Resectable Adenocarcinoma of the Esophagogastric Junction |
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| Completed | N/A | 450 | | preoperative radiochemotherapy+surgeron+adjuvantchemotherapy ;surgeron+adjuvant chemotherapy | Hebei Medical University affiliated Fourth Hospital; Level of the institution:, self-raise | Adenocarcinoma of the Esophagogastric Junction | | | | |
ChiCTR-IPR-14005415: Phase II Randomised Control Study of Neoadjuvant Docetaxel/Oxaliplatin/Xelode (DOX) in Locally Advanced Gastric Cancer |
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| Recruiting | N/A | 100 | | neoadjuvant Docetaxel/Oxaliplatin/Xelode (DOX) ;Neoadjuvant Docetaxel/Oxaliplatin/Xelode (DOX) three weeks and eight weeks courses | the First Affiliated Hospital of Nanjing Medical University; the First Affiliated Hospital of Nanjing Medical University, research fund from department of gastric surgery | gastric cancer | | | | |
ChiCTR-OPC-15006819: S-1 and raltitrexed for patients with metastatic colorectal cancer after failure to fluoropyrimidine, irinotecan and oxaliplatin. |
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| Completed | N/A | 30 | | S-1 and raltitrexed | Department of Medical Oncology, Cancer Center, The State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University.; Department of Medical Oncology, Cancer Center, The State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University., Research Fund of West China Hospital | colorectal cancer | | | | |
ChiCTR-ONC-12002258: Effects of Gemcitabine, oxaliplatin and dexamethasone (GOD) as salvage treatment for elderly patients with refractory and relapsed peripheral T-cell lymphoma |
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| Completed | N/A | 30 | | Treated with Gemcitabine, oxaliplatin and dexamethasone (GOD) regimen | Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Level of the institution:, Scientific Research Program from Health Bureau of Shanghai (grant no.2010101). | relapsed or refractory peripheral T-cell lymphoma | | | | |
ChiCTR-TRC-11001361: A clinical trial on efficacy and safety of intra-arterial chemotherapy and systemic venous chemotherapy for locally advanced gastric cancer |
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| Completed | N/A | 818 | | (m)Folfox6 chemo-regimen, repeated every 2 week ;(m)Folfox6 chemo-regimen, repeated every 2 week | Xijing Hospital of Digestive Diseases. The Fourth Military Medical University; Xijing Hospital of Digestive Diseases. The Fourth Military Medical University, self-financed | locally advanced gastric cancer | | | | |
ChiCTR-ONC-14005147: Multicenter and prospective study of chemotherapy associated myelotoxicity among Chinese gastric cancer population receiving cytotoxic conventional regimens |
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| Completed | N/A | 1285 | | six commonly used regimens (i.e. CF/XP; EC(O)F/EC(O)X; DC(O)F/DC(O)X; PC(O)F/PC(O)X; FOLFOX4; mFOLFOX7/XELOX) | Gastrointestinal Oncology Department, Affiliated Cancer Center of Academy of Military Medical Sciences; Gastrointestinal Oncology Department, Affiliated Cancer Center of Academy of Military Medical Sciences, SHENYANG SUNSHINE PHARMACEUTICAL CO., LTD, Shenyang, China; Affiliated hospital of Academy of Military Medical Sciences | Gastric Cancer | | | | |
ChiCTR-TRC-14004765: Clinical observation on the efficacy of Huangqi guizhi wuwu decoction granules for oxaliplatin-induced peripheral neuropathy |
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| Completed | N/A | 82 | | Placebo ;Huangqi guizhi wuwu decoction granules | Jiangsu Province Hospital on Integration of Chinese and Western Medicine; Level of the institution:, Supported by the Fundamental Research Funds for the Central public welfare research institutes | Tumor | | | | |
| Active, not recruiting | N/A | 57 | NA | RAPIDO TNT, LCRT | Sengkang General Hospital | Rectal Cancer | 05/22 | 06/24 | | |
NCT02836977: Maintenance Tegafur-uracil Versus Observation Following Adjuvant Oxaliplatin-based Regimen in Patients With Stage III Colon Cancer After Radical Resection |
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| Active, not recruiting | N/A | 400 | RoW | tegafur-uracil, UFUR | Kaohsiung Medical University Chung-Ho Memorial Hospital | Stage III Colon Cancer | 03/17 | 02/24 | | |
ChiCTR-TRC-14004983: Phase III Trial of neoadjuvant chemotherapy with Three drugs for advanced gastric cancer: a multicenter, open, randomized, controlled clinical study |
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| Recruiting | N/A | 300 | | Preoperative chemotherapy of DOX for 4 cycles, capecitabine 1000mg/m2, bid, p.o, 1 to 14 days; oxaliplatin 130mg/m2, ivgtt, 2h, d1, docetaxel 60mg/m2, ivgtt, d1, 21 day/cycle, operation after 2~4 weeks, and postoperative chemotherapy of XP for 4cycles after surgery ;Preoperative chemotherapy of XP for 4 cycles, capecitabine 1000mg/m2, bid, p.o, 1 to 14 days; oxaliplatin 130mg/m2, ivgtt, 2h, d1, 21 day/cycle, operation after 2~4 weeks, and postoperative chemotherapy of XP for 4cycles after surgery ;Operation after 2~4 weeks, and postoperative chemotherapy of XP for 8cycles after surgery, capecitabine 1000mg/m2, bid p.o, 1 to 14 days; oxaliplatin 130mg/m2, ivgtt, 2h, d1 | Hebei Medical University affiliated Fourth Hospital; Hebei Medical University affiliated Fourth Hospital, self-raise | Advanced gastric cancer | | | | |
PIPAC/PITAC, NCT02720835: Efficacy and Safety of in Gastric,Ovarian, Colorectal Cancer and Mesothelioma With Pleural Carcinomatosis. |
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| Recruiting | N/A | 200 | Europe | pressurized intraperitoneal/intrathoracal aerosol chemoTx, PIPAC/PITAC | Othmar Schoeb | Colorectal Cancer, Ovarian Cancer, Gastric Cancer, Mesothelioma | 02/18 | 02/18 | | |
PROOF, ChiCTR-OPC-15005865: Prospective, Multicenter, Registry study of Oxaliplatin (Eloxatin)/Fluorouracil based regimen for Chinese Local Advanced or Metastatic Hepatocellular Carcinoma patients ineligible for curative resection and local treatment |
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| Recruiting | N/A | 500 | | NA | 81 Hospital of Chinese PLA; Level of the institution:, Sanofi (Hangzhou) Pharmaceuticals Co., Ltd | Hepatocellular Carcinoma | | | | |
ChiCTR-OOC-16009575: Molecular characteristics of refractory gastric adenocarcinoma highly sensitive to trastuzumab: A study based on phosphorylated proteomics |
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| Recruiting | N/A | 76 | | Trastuzumab plus XELOX protocol | Shanghai General Hospital; Shanghai General Hospital, Clinical Research Plan of SHDC | Gastric adenocarcinoma | | | | |
ChiCTR1800014296: Neoadjuvant Therapy of Locally Advanced Gastric Carcinoma by Green Tea Extract and XELOX: a prospective randomized controlled trial |
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| Recruiting | N/A | 80 | | EGCG(epigallocatechin gallate) + chemotherapy ;chemotherapy | Cancer Hospital of Shantou University Medical College; Cancer Hospital of Shantou University Medical College, Scientific research project of traditional Chinese Medicine Bureau of Guangdong Provincial | Gastric Cancer | | | | |
NCT06235164: The Safety and Efficacy of Neoadjuvant Immunochemotherapy Followed by Laparoscopic Gastrectomy for Gastric Cancer |
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| Active, not recruiting | N/A | 585 | RoW | immune checkpoint inhibitors: sintilimab, nivolumab, and camrelizumab | Fujian Medical University | Locally Advanced Gastric Cancer | 12/22 | 12/25 | | |
RECOMMEND, NCT03413514: Real World Evidence for the Cycle of Neoadjuvant Chemotherapy in Gastric Cancer With Shared Decision Making |
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| Recruiting | N/A | 100 | RoW | NACT, SDM, Surgery, ACT, Questionnaire | Peking University | Gastric Cancer | 01/19 | 01/23 | | |
| Completed | N/A | 279 | RoW | Transarterial chemoembolization, TACE, Systemic treatment | Zhejiang University | Hepatocellular Carcinoma | 03/23 | 10/23 | | |
NCT03122886: Fat Emulsion in Preventing Hypersensitivity Reactions in Patients With Cancer Receiving Carboplatin or Oxaliplatin |
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| Active, not recruiting | N/A | 19 | US | Fat Emulsion, FAT EMULSION, INTRAVENOUS, Intralipid, Intravenous Fat Emulsion, Placebo, placebo therapy, PLCB, sham therapy | Mayo Clinic, National Cancer Institute (NCI) | Advanced Malignant Neoplasm | 07/19 | 12/24 | | |
ChiCTR-INR-17010977: A multicenter prospective randomized controlled trial of Folfox6 regimen in the treatment of intrahepatic cholangiocarcinoma at different stages of hepatic arterial infusion chemotherapy |
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| Recruiting | N/A | 480 | | The hepatic artery catheter Folfox6 chemotherapy ;Transcatheter arterial infusion chemotherapy after radical resection of ICC (Folfox 6 regimen) ;Whole-body (gemcitabine-based regimen) in the treatment of patients with unresectable middle and late ICC | The First Affiliated Hospital of Xi'an Jiaotong University,; The First Affiliated Hospital of Xi'an Jiaotong University, , National Scientific Foundation Grand | intrahepatic cholangiocarcinomas, ICC | | | | |
CLASS-03a, NCT03468712: Laparoscopic D2 Distal Gastrectomy Following Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancers |
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| Recruiting | N/A | 166 | RoW | Laparoscopic D2 distal gastrectomy | West China Hospital, Peking University Cancer Hospital & Institute, Southern Medical University, China, Shanghai Zhongshan Hospital, Chinese PLA General Hospital, Fujian Medical University Union Hospital, Ruijin Hospital, Southwest Hospital, China, RenJi Hospital, The First Affiliated Hospital with Nanjing Medical University, Fudan University, Tang-Du Hospital, Harbin Medical University, The First Hospital of Jilin University, Guangdong Provincial People's Hospital, Sir Run Run Shaw Hospital | Complications, Postoperative, Surgery--Complications, Cancer of Stomach, Chemotherapy Effect | 04/20 | 04/23 | | |
TransValid-A, NCT03034473: Translational Validation Study to Examine KFO179-1 Biomarker Scores for the Prediction and Prognosis of Advanced Primary Resectable Rectal Cancer Stages UICC-II-IV, With a 5-Fluorouracil-based Standard Radiochemotherapy Followed by Total Mesorectal Excision. |
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| Active, not recruiting | N/A | 200 | Europe | Translational Research and multimodal treatment | University Medical Center Goettingen, German Research Foundation | Locally Advanced Rectal Cancer | 08/24 | 08/24 | | |
ChiCTR1800014815: Concurrent Neoadjuvant Chemoradiotherapy Plus Trastuzumab in the Treatment of Siewert II, III of HER-2 Positive Gastroesophageal Junction Adenocarcinoma: A Randomized, Controlled trial |
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| Recruiting | N/A | 48 | | Trastuzumab XELOX and radiotherapy ;XELOX and radiotherapy | Fourth Hospital of Hebei Medical University; Fourth Hospital of Hebei Medical University, self-raised | adenocarcinoma at gastroesophageal junction | | | | |
NCT06205173: Explored About Temperature Packing Care to Improve the Quality of Life for Chemotherapy Induced Peripheral Neuropathy (CIPN) in Colorectal Cancer and Gastric Cancer Patient |
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| Completed | N/A | 18 | RoW | Hot compressing, Cold compressing | National Taiwan University Hospital | Colorectal Cancer, Gastric Cancer, Chemotherapy-induced Peripheral Neuropathy | 08/21 | 08/21 | | |
IMMUNOPAC, NCT04122885: Study of Plasma Tumor-promoting Factors and Immune Function After Laparotomy, Cytoreductive Surgery and HIPEC vs. PIPAC in Patients With Peritoneal Metastasis |
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| Recruiting | N/A | 60 | Europe | PIPAC with oxaliplatin, Cytoreductive surgery and Hyperthermic IntraPeritoneal Chemotherapy, CRS and HIPEC | University Hospital Tuebingen, Icahn School of Medicine at Mount Sinai | Peritoneal Cancer, Chemotherapy-Induced Change | 09/20 | 09/22 | | |
ChiCTR1800019445: Efficacy of Adjuvant Chemotherapy in Patients with Clinical T3b/T4, N+ Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy: A Pathology-oriented, Prospective, Multicenter, Randomized, Open-label, Parallel Group Clinical Trial |
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| Recruiting | N/A | 764 | | 5-fluorouracil ;oxaliplatin combined with 5-fluorouracil ;Observation ;5-fluorouracil alone | Fudan University Shanghai Cancer Center; Fudan University Shanghai Cancer Center, Shanghai Anticancer Association | Rectal cancer | | | | |
NCT04305288: Chemotherapy mFOLFIRINOX in Locally Advanced or Metastatic Cholangiocarcinoma |
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| Recruiting | N/A | 100 | RoW | | Shanghai Jiao Tong University School of Medicine | Cholangiocarcinoma of the Bile Duct | 12/20 | 12/21 | | |
| Recruiting | N/A | 196 | RoW | CRT, concurrent chemoradiotherapy, surgery, esophagectomy | The First Affiliated Hospital of Henan University of Science and Technology, Jiangsu HengRui Medicine Co., Ltd., Anyang Tumor Hospital, 150th Hospital of PLA | Esophagus Cancer | 12/20 | 06/21 | | |
ChiCTR-OOC-17014182: Prospective study of oxaliplatin combined with retitrexed continuous hepatic artery infusion in the treatment of advanced primary liver cancer |
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| Recruiting | N/A | 50 | | continuous hepatic artery infusion of oxaliplatin combined with retitrexide | Fujian Cancer Hospital; Fujian Cancer Hospital, institution funding | Hepatocellular Carcinoma | | | | |
ChiCTR-IOR-16008729: A multicentre, open-label, randomised, controlled study of molecularly precision target therapy based on tumor molecular profiling with gemcitabine and oxaliplatin in advanced or recurrent extrahepatic cholangiocarcinoma and gallbladder carcinoma |
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| Recruiting | N/A | 152 | | GEMOX ;molecularly precision target therapy with GEMOX | Xinhua Hospital affiliated to Shanghai Jiaotong University, School of Medicine; Xinhua Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Xinhua Hospital affiliated to Shanghai Jiaotong University, School of Medicine | extrahepatic cholangiocarcinoma and gallbladder carcinoma | | | | |
ChiCTR1800016946: Efficacy and safety of combination chemotherapy with LBP or oxaliplatin plus capecitabine in locally advanced or metastatic gastric cancer: a randomized, controlled, multicenter clinical trial |
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| Recruiting | N/A | 348 | | LBP combined with capecitabine ;Oxaliplatin combined with capecitabine | The first hospital of China medical university; Anhui provincial hospital, Hainan Changan International Pharmaceutical Co., Ltd. | Stomach cancer | | | | |
NCT06323382: Locoregional Therapy Combined With Bevacizumab and PD1/L1 Inhibitor in Advanced Hepatocellular Carcinoma |
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| Recruiting | N/A | 240 | RoW | Locoregional therapy, TACE/HAIC, Bevacizumab, Atezolizumab, Tislelizumab, Toripalimab, Sintilimab, Camrelizumab | Sun Yat-sen University | Advanced Hepatocellular Carcinoma, Anti-PD1/PDL1 Antibody, Bevacizumab | 12/24 | 12/24 | | |
NCT06333561: HAIC Combined With Lenvatinib and PD-1 Inhibitor in Infiltrative Hepatocellular Carcinoma |
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| Recruiting | N/A | 300 | RoW | Hepatic arterial infusion chemotherapy, Lenvatinib, Tislelizumab, Toripalimab, Sintilimab, Camrelizumab | Sun Yat-sen University | Hepatocellular Carcinoma, Lenvatinib, PD-1 Inhibitor, Hepatic Arterial Infusion Chemotherapy | 12/24 | 12/24 | | |
ChiCTR2000029201: A medical records based study for selection of medicine depends on clinical characteristics between fluorouracil combined with oxaliplatin and irinotecan regimens and their effects on patients' life quality |
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| Recruiting | N/A | 1400 | | mFOLFOX6 ;FOLFIRI | The First Affiliated Hospital of College of Medicine, Zhejiang University; The First Affiliated Hospital of College of Medicine, Zhejiang University, Raise Independently | Tumour | | | | |
NCT06199297: Atezolizumab Plus Bevacizumab Versus Sintilimab Plus Bevacizumab With TACE and HAIC in Unresectable Hepatocellular Carcinoma |
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| Completed | N/A | 188 | RoW | Atezolizumab combined with Bevacizumab, Sintilimab combined with Bevacizumab, Transcatheter arterial chemoembolization and hepatic arterial infusion chemotherapy | Sun Yat-sen University | Hepatocellular Carcinoma | 07/23 | 07/23 | | |
ChiCTR-OOC-16008241: The predictive value of XRCC1, ERCC1, GSTP1, XPD and TS detection in the efficacy and toxicty of XELOX chemotherapy for colorectal cancer |
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| Recruiting | N/A | 854 | | XELOX protocol | Shanghai ChangZheng Hospital; Shanghai ChangZheng Hospital, self-collected funds | Colorectal cancer | | | | |
NCT03777475: the Effect of Different Oxaliplatin Dose in Transarterial Infusion (TAI) in Unresectable Hepatocellular Carcinoma |
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| Recruiting | N/A | 350 | RoW | transarterial infusion | Sun Yat-sen University | Hepatocellular Carcinoma | 06/21 | 12/22 | | |
NCT04751513: Auricular Acupressure : Improves Oxaliplatin-induced Peripheral Neuropathy |
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| Recruiting | N/A | 76 | RoW | auricular acupressure | Chang Gung Memorial Hospital | Oxaliplatin-induced Peripheral Neuropathy, Chemotherapy | 08/21 | 08/21 | | |
GASPACCO, NCT04595929: Oncological Benefits of Pressured Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients With T3-4 Gastric Cancer Cyt- |
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| Recruiting | N/A | 304 | RoW | Staging laparoscopy, 5-Fluorouracil, 5-FU, Leucovorin, Calciumfolinat, Oxaliplatin, Docetaxel, Radical surgery, PIPAC, Adjuvant chemotherapy | St. Petersburg State Pavlov Medical University | Peritoneal Carcinomatosis, Gastric Cancer | 10/21 | 01/29 | | |
| Not yet recruiting | N/A | 25 | RoW | Individualized Treatment | Shanghai Zhongshan Hospital | Gastroesophageal Varices Hemorrhage, Colorectal Cancer, Received Oxaliplatin-based Chemotherapy | 10/21 | 09/22 | | |
| Not yet recruiting | N/A | 370 | RoW | the level of vWF | Shanghai Zhongshan Hospital | Gastroesophageal Varices, Colorectal Cancer, Received Oxaliplatin-based Chemotherapy | 10/21 | 09/22 | | |
| Recruiting | N/A | 20 | | treprilumab and sox regime | Renji Hospital, School of Medicine, Shanghai Jiaotong University; Renji Hospital, School of Medicine, Shanghai Jiaotong University, self-raised | gastric cancer | | | | |
ChiCTR1900024867: Efficacy observation for sequential first-line treatment of advanced metastatic pancreatic cancer with albumin combined with paclitaxel + teggio/gemcitabine + oxaliplatin: a single-arm prospective study |
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| Recruiting | N/A | 30 | | The albumin binding paclitaxel + teggio/gemcitabine + oxaliplatin regimen was sequential and alternating | Affiliated Cancer Hospital of Harbin Medical University; Affiliated Cancer Hospital of Harbin Medical University, By oneself | Locally advanced and metastatic pancreatic cancer | | | | |
NCT04669977: Effects of a Glucoside- and Rutinoside-rich Material in Chemotherapy-induced Peripheral Neuropathy and Related Symptoms |
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| Recruiting | N/A | 246 | RoW | Mulberry juice | Taipei Medical University | Chemotherapy-induced Peripheral Neuropathy | 12/21 | 12/23 | | |
NCT04618367: HAIC Combined With Lenvatinib and Sintilimab for Hepatocellular Carcinoma With PVTT |
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| Completed | N/A | 30 | RoW | Hepatic arterial infusion chemotherapy, Lenvatinib, TKI inhibits, Sintilimab, programmed cell death protein-1 (PD-1) antibody | Sun Yat-sen University, Second Affiliated Hospital of Guangzhou Medical University | Carcinoma, Hepatocellular, Liver Neoplasms, Sintilimab, Portal Vein Tumor Thrombus | 12/21 | 12/22 | | |
ChiCTR1900023191: A clinical study for TAE in combination with anlotinib, oxaliplatin and raltitrexed in the sequential treatment of middle or advanced primary liver cancer (PLC) |
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| Recruiting | N/A | 80 | | TAE in combination with anlotinib, oxaliplatin and raltitrexed ;Symptomatic treatment | Center Hospital of Liutie; Center Hospital of Liutie, CHIA TAI TIANQING (CTTQ) Pharmaceutical Co., Ltd. | Heaptocellular Carcinoma,HCC | | | | |
| Recruiting | N/A | 66 | Europe | Hilotherapy | Universitaire Ziekenhuizen Leuven | Quality of Life, Chemotherapy-induced Peripheral Neuropathy | 12/21 | 05/22 | | |
NCT02135887: A Trial of MB-6 for Reduction of Neutropenia Induced by Chemotherapy in Patients With Stage III Colorectal Cancer. |
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| Recruiting | N/A | 184 | RoW | MB-6, Folinic acid; Fluorouracil ; Oxaliplatin, Placebo | Microbio Co Ltd | Stage III Colorectal Cancer, Neutropenia | 03/22 | 12/22 | | |
NCT04886193: FLOT Combined With PD-1 in the First-line Treatment of Patients With Advanced Gastric Cancer and Peritoneal Metastasis |
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| Recruiting | N/A | 20 | RoW | FLOT(Docetaxel+oxaliplatin+leucovorin+5-FU), Treprizumab, Tiggio capsule (S-1) | Guangdong Provincial Hospital of Traditional Chinese Medicine, Shanghai Junshi Bioscience Co., Ltd. | Chemotherapy, Gastric Cancer | 05/22 | 05/23 | | |
NCT04996355: Organoids-on-a-chip for Colorectal Cancer and in Vitro Screening of Chemotherapeutic Drugs |
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| Recruiting | N/A | 52 | RoW | comprehensive treatment after MDT discussion | Peking University People's Hospital, Peking University | Colorectal Neoplasms, Organoids | 05/22 | 05/24 | | |
ChiCTR2000032996: Effects of External Application of Traditional Chinese Medicine Hexue Tongbi Powder on Oxaliplatin-Induced Peripheral Neuropathy Among Patients With Colorectal Cancer: an Open-Label, Randomized Controlled Trial |
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| Not yet recruiting | N/A | 100 | | Oxaliplatin-based chemotherapy, education disease related knowledge and He-Xue Tong-Bi Powder will be used ;Oxaliplatin-based chemotherapy and education disease related knowledge will be used | The First Affiliated Hospital of Guangzhou University of Chinese Medicine; The First Affiliated Hospital of Guangzhou University of Chinese Medicine, 'Dengfeng hospital' plan of the First Affiliated Hospital of Guangzhou University of traditional Chinese Medicine | Colorectal cancer | | | | |
NCT03001726: To Observe the Efficacy and Safety by Comparing Chemotherapy(Docetaxel, Oxaliplatin Plus S1 ) Followed With Radical Resection Versus Chemotherapy Alone in Advanced Gastric Cancer With Single Non-curable Factor. |
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| Enrolling by invitation | N/A | 228 | RoW | Gastrectomy, oxaliplatin, Eloxatin, S1, tegafur, Docetaxel, Taxotere | Shanghai Zhongshan Hospital | Gastric Cancer | 06/22 | 12/23 | | |
ChiCTR1900021862: A randomized controlled trial for irinotecan-eluting beads transarterial chemoembolization with systemic GEMOX (gemcitabine plus oxaliplatin) versus GEMOX in patients with unresectable, local advanced or metastatic intrahepatic cholangiocarcinoma |
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| Not yet recruiting | N/A | 150 | | irinotecan DEB-TACE with GEMOX ;GEMOX treatment | Zhongshan Hospital of Fudan University; Zhongshan Hospital of Fudan University, Fund for Clinical Research, Zhongshan Hospital of Fudan University | intrahepatic cholangiocarcinoma | | | | |
NCT06202781: Tumor Microenvironment in Gastric Cancer Patients Treated With Combined Immunotherapy and Chemotherapy |
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| Recruiting | N/A | 28 | RoW | SOX plus PD-1 inhibitor, Gastroscopic biopsy | Chinese PLA General Hospital | Gastric Cancer, Tumor Microenvironment, Immunotherapy, Chemotherapy | 06/24 | 07/24 | | |
NCT06378580: The Prognostic Impact of Surufatinib for the Treatment of Advanced Pancreatic Ductal Adenocarcinoma |
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| Completed | N/A | 72 | RoW | Surufatinib combine immune checkpoint inhibitor, AG/FOLFIRINOX | Luo Cong | Pancreatic Cancer | 07/23 | 04/24 | | |
NCT00430313: Effects of Acupoint Electro-stimulation on Preventing Nausea and Vomiting Induced by Cisplatin or Oxaliplatin |
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| Withdrawn | N/A | 100 | NA | Electro-Stimulation of Yongquan (K1) Acupoint, ES | M.D. Anderson Cancer Center, National Cancer Institute (NCI) | Liver Cancer, Liver Metastasis | 08/22 | 08/22 | | |
COBRA, NCT03451370: First-line Combination of Capecitabine and Oxaliplatin Plus Bevacizumab in Elderly Patients With Metastatic Colorectal Cancer |
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| Active, not recruiting | N/A | 121 | Europe | Capecitabine, Oxaliplatin, Bevacizumab | Istituto Oncologico Veneto IRCCS | Elderly Metastatic Colorectal Cancer Patients | 07/24 | 12/24 | | |
NCT05544812: A Small-sample, Real-world Study of Sintilimab Plus Bevacizumab/Cetuximab Plus XELOX Regimen for Conversion Therapy in Patients With Advanced Colorectal Cancer |
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| Recruiting | N/A | 10 | RoW | Sintilimab ,bevcizumab/cetuximab,XELOX | Xijing Hospital | Colorectal Cancer | 09/22 | 06/23 | | |
ChiCTR2000037568: A multicenter study on the efficacy and influencing factors of Insect Compound Particle in the treatment of MMR related stage III colorectal cancer |
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| Not yet recruiting | N/A | 262 | | Insect compound Particels combined with mfolfox6 ;Placebo of Insect compound Particles combined with mfolfox6 | Shanghai Municipal Hospital of Traditional Chinese Medicine; Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai Shenkang Hospital Development Center | colorectal cancer | | | | |
ChiCTR2000036864: A multicenter study on the efficacy and influencing factors of Insect Compound Particle in the treatment of MMR related stage III colorectal cancer |
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| Not yet recruiting | N/A | 490 | | Insect Compound Particle combine with mFOLFOX6 ;placebo of Insect Compound Particle combine with mFOLFOX6 | Shanghai Municipal Hospital of Traditional Chinese Medicine; Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai Shenkang Hospital Development Center | colorectal cancer | | | | |
ChiCTR2000036228: Clinical study of Hongai Tongluo decoction combined with Du moxibustion in the treatment of Oxaliplatin Neurotoxicity |
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| Not yet recruiting | N/A | 300 | | Hongai Tongluo decoction combined with Du moxibustion and chemotherapy ;Chemotherapy | Shanghai Longhua University Hospital of traditional Chinese Medicine; Shanghai Longhua University Hospital of traditional Chinese Medicine, Special funds | Digestive tract tumor | | | | |
ChiCTR-ONC-17010430: A single-arm exploratory clinical research of S1/ oxaliplatin chemotherapy plus Apatinib in the conversion therapy of metastatic gastric cancer. |
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| Recruiting | N/A | 30 | | S1/ oxaliplatin chemotherapy plus Apatinib | Fujian Cancer Hospital; Fujian Cancer Hospital, Hengrui Company, Jiangsu, China | Gastric cancer | | | | |
ChiCTR2000038884: Clinical study on acupuncture in the treatment of oxaliplatin-induced peripheral neurotoxicity |
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| Recruiting | N/A | 84 | | acupuncture ;sham acupuncture | Hospital of Chengdu University of Traditional Chinese Medicine; Hospital of Chengdu University of Traditional Chinese Medicine, Special funds | Oxaliplatin-induced peripheral neurotoxicity | | | | |
ChiCTR2100046237: Effect of prebiotics in regulating gut microbiota of patients with colorectal cancer on the prognosis of fluorouracil treatment |
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| Recruiting | N/A | 60 | | Volunteers in Xylooligosaccharide group received Xylooligosaccharide 3 g/d in addition to standard capecitabine combined with oxaliplatin adjuvant chemotherapy. ;The blank control group received no additional nutritional intervention on the basis of standard capecitabine combined with oxaliplatin adjuvant chemotherapy. | The Affiliated Hospital of Jiangnan University; The Affiliated Hospital, Jiangnan University, Self-raised | Colorectal cancer | | | | |
ChiCTR1900027023: A non-inferiority study of apatinib versus bevacizumab combined with XELOX regimen in the treatment of metastatic colorectal cancer |
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| Recruiting | N/A | 120 | | Apatinib 250mg po, qd, continuous taken; XELOX: Oxaliplatin 135 mg/m2 Ivgtt d1, Capecitabine 1000mg/m2 d1-14, q3w ;Bevacizumab 7.5mg/kg, q3w; XELOX: Oxaliplatin 135 mg/m2 Ivgtt d1, Capecitabine 1000mg/m2 d1-14, q3w | Tangshan People's Hospital; Tangshan people's Hospital, self-raise | colorectal cancer | | | | |
ChiCTR1900028417: First-Line XELOX Plus Anlotinib Followed by Single-Agent Anlotinib as Maintenance Therapy in mCRC Patients |
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| Recruiting | N/A | 29 | | Anlotinib+XELOX | Sichuan Cancer Hospital and Research Institute; Sichuan Cancer Hospital and Research Institute, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Colorectal Carcinoma | | | | |
NCT04432402: Lenalidomide in Combination With R-GemOx in First-line Treatment of Elderly Diffuse Large B Cell Lymphoma |
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| Recruiting | N/A | 124 | RoW | Lenalidomide, Rituximab, Gemcitabine, oxaliplatin | The First Affiliated Hospital with Nanjing Medical University | Diffuse Large B Cell Lymphoma | 12/22 | 12/24 | | |
ChiCTR2000036551: Establishment and validation of therapeutic effect prediction model of first line treatment of bevacizumab combined with mFOLFOX6 in Ras mutant colorectal cancer patients with liver metastasis |
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| Not yet recruiting | N/A | | | | Zhongshan Hospital, Fudan University; Zhongshan Hospital, Fudan University, Shanghai Shenkang Hospital Development Center | colorectal cancer | | | | |
NCT04521491: A Trial of Adjuvant Therapy After Hepatocarcinoma Resection Based on Folate Receptor-positive Circulating Tumor Cells |
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| Not yet recruiting | N/A | 184 | RoW | FOLFOX4(infusional fluorouracil [FU], leucovorin [LV], and oxaliplatin [OXA]). | Eastern Hepatobiliary Surgery Hospital | Hepatocellular Carcinoma | 12/22 | 12/23 | | |
ChiCTR2200055659: A prospective clinical study of PD-1 inhibitor combined with albumin-paclitaxel + oxaliplatin + S-1 chemotherapy for perioperative treatment of locally advanced gastric cancer |
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| Recruiting | N/A | 30 | | | Cangzhou Central Hospital; Cangzhou Central Hospital, Wu Jieping Medical Foundation | Gastric Cancer | | | | |
NCT05247996: TACE Combined With "Target Immune" Therapy for First-line Treatment in the Treatment of Intrahepatic Cholangiocarcinoma |
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| Not yet recruiting | N/A | 98 | NA | Transcatheter arterial chemoembolization, TACE Thrapy, Multi-target Drug Therapy, Target Therapy, Immunocheckpoint Inhibitor Therapy, Immune Therapy, Systemic Intravenous Chemotherapy, Traditional Chemotherapy | The Central Hospital of Lishui City | Intrahepatic Cholangiocarcinoma | 12/22 | 12/23 | | |
ChiCTR2000029082: Apatinib combined with continuous hepatic arterial infusion of oxaliplatin and raltitrexed in hepatocellular carcinoma with extrahepatic spread: a prospective study |
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| Recruiting | N/A | 30 | | Oral apatinib combined with continuous hepatic arterial infusion of oxaliplatin and raltitrexed | Fujian Cancer Hospital; Fujian Cancer Hospital, Hospital funding | Hepatocellular Carcinoma | | | | |
NCT05233358: HAIC Combined With Second-line "Target Immunity" for HCC With TACE Standard Treatment Low Response or Failure |
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| Not yet recruiting | N/A | 176 | NA | Hepatic Artery Infusion Chemotherapy, HAIC, Transarterial Chemoembolization, TACE, Regorafenib, second-line target drug, Immune Checkpoint Inhibitors, Camrelizumab, Sintilimab, Nivolumab, Pembrolizumab, Toripalimab | The Central Hospital of Lishui City | Hepatocellular Carcinoma | 02/23 | 02/25 | | |
NCT05262452: Concurrent FOLFIRINOX Plus High Intensity Focused Ultrasound for Pancreatic Cancer |
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| Recruiting | N/A | 60 | RoW | ALPIUS 900, an ultrasound-guided high intensity focused ultrasound system, FOLFIRINOX regimen | Seoul National University Hospital, Focused Ultrasound Foundation, Synex Consulting Ltd | Pancreatic Cancer Non-resectable, Chemotherapy Effect, Ultrasound Therapy | 03/23 | 12/24 | | |
NCT05178745: A Prospective Observational Cohort Study Evaluating Resection Rate in Patients With Metastatic Colorectal Cancer Treated With Aflibercept in Combination With FOLFIRI - Observatoire résection |
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| Completed | N/A | 140 | NA | Fluorouracil, Aflibercept, ZALTRAP®, Irinotecan, CAMPTOSAR® | Sanofi | Metastatic Colorectal Cancer, Colorectal Neoplasms | 05/22 | 05/22 | | |
ChiCTR2100045907: Prevention effects of Methylcobalamin on peripheral neuropathy induced by XELOX regimen: a single-center, double-blind, placebo-controlled randomized study |
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| Recruiting | N/A | 70 | | All patients should not use drugs that may affect neurological symptoms during chemotherapy and ask for strict cold avoidance. ;From the first cycle of chemotherapy, oral methylcobalamin tablets (Mikobao)500 ug , orally, tid, 1 to 14 days and 21 days for 1 cycle. | Guangzhou Zengcheng District People's Hospital; Guangzhou Zengcheng District People's Hospital, Guangzhou Science and Technology Bureau | Oncology | | | | |
ChiCTR2100046429: Clinical study of camrelizumab combined with apatinib and SOX regimen in first-line treatment of advanced gastric cancer |
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| Recruiting | N/A | 30 | | Camrelizumab + apatinib + ticgio + oxaliplatin | The Second Affiliated Hospital of Anhui Medical University; The Second Affiliated Hospital of Anhui Medical University, Jiangsu Hengrui Pharmaceutical Co., Ltd | gastric cancer | | | | |
NCT06196554: Gastric Cancer Organoids in the Screening of Neoadjuvant Drugs |
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| Recruiting | N/A | 40 | RoW | Oxaliplatin, Irinotecan (SN-38), 5-Fluorouracil, Paclitaxel, Pembrolizumab, Nivolumab | Dong Bing Zhao | Gastric Cancer, Organoid, Neoadjuvant Therapy | 06/24 | 06/24 | | |
FIRENOX, NCT06251297: Feasibility and Benefits of Reflexology in the Prevention of Neuropathy Induced by Oxaliplatin in Colorectal Cancer |
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| Active, not recruiting | N/A | 40 | Europe | Foot reflexology | University Hospital, Toulouse | Colorectal Cancer | 12/24 | 12/25 | | |
ChiCTR2000035682: Effectiveness and safety of Fruquintinib combined SOX for conversion therapy of unresectable advanced gastric cancer (stage IV A): a single-arm, single-center, prospective clinical trial |
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| Not yet recruiting | N/A | 35 | | Fruquintinib combined with S-1 and oxaliplatin | Shanghai Tenth People's Hospital; Shanghai Tenth People's Hospital, self-finacing | Gastric Cancer | | | | |
NCT06199115: Prevention of Neuropathic Pain From Oxaliplatin by Photobiomodulation |
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| Recruiting | N/A | 70 | Europe | Photobiomodulation | Saint-Gregoire Private Hospital Center | Cancer of the Gastrointestinal Tract | 03/25 | 04/25 | | |
NCT04923620: Neoadjuvant Cetuximab + Chemotherapy Combined With Short-course Radiotherapy |
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| Recruiting | N/A | 51 | RoW | cetuximab+mFOLFOX6, short-course radiotherapy | Shanghai Minimally Invasive Surgery Center | Neoadjuvant Treatment, Rectal Cancer, Cetuximab, Radiotherapy | 08/24 | 06/25 | | |
NCT06322147: Chemotherapy With Cetuximab as Conversion Therapy in RAS/BRAF WT Unresectable Liver Metastasis Right-sided Colon Cancer |
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| Recruiting | N/A | 50 | RoW | Doublet or triplet chemotherapy combined with cetuximab | Qilu Hospital of Shandong University | Colon Cancer | 12/24 | 12/25 | | |
ChiCTR2200055514: Effect of half-dose BYVASDA versus standard dose Avastin combined with mFOLFOX6 chemotherapy on metastatic colorectal cancer : A multicenter, open-label, parallel, randomized controlled clinical study |
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| Recruiting | N/A | 571 | | mFOLFOX6 +half-dose Bevacizumab (BYVASDA) ;mFOLFOX6 + half-dose Bevacizumab (Avastin) | Sichuan Cancer Hospital; Sichuan Cancer Hospital, self-financing and corporate sponsorship | metastatic colorectal cancer | | | | |
ICTCPTLAGC, NCT05385900: Immune Combined Targeted and Chemotherapy in Perioperative Treatment of Locally Advanced Gastric Cancer |
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| Not yet recruiting | N/A | 57 | NA | Penpulimab combination with anlotinib and chemotherapy, Teggio, Oxaliplatin | Xijing Hospital | Gastric Cancer | 06/23 | 06/24 | | |
| Recruiting | N/A | 478 | Europe | XELOX regimen according to standard procedures, FOLFOX regimen according to standard procedures, Surgery, radiofrequency ablation (RFA), transarterial chemo-embolization using irinotecan drug-eluted beads ((DEBIRI-)TACE), stereotactic body radiation therapy (SBRT), Bevacizumab, tumor biopsy | Radboud University Medical Center, Erasmus Medical Center | Multi-organ Metastatic Colorectal Cancer | 07/23 | 07/25 | | |
| Recruiting | N/A | 349 | RoW | CAPEOX adjuvant therapy, deferred CAPEOX adjuvant therapy, mFOLFOXIRI intensive adjuvant therapy | Sun Yat-sen University, Guangzhou Burning Rock Dx Co., Ltd. | Colorectal Cancer | 07/28 | 07/28 | | |
ESCORT, NCT03676517: Evaluation of Efficacy, Quality of Life and Cost Effectiveness of Short-course Radiotherapy Followed by Capecitabine Plus Oxaliplatin chemotheRapy and TME for High-risk Rectal Cancer ( Trial) |
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| Not yet recruiting | N/A | 31 | RoW | preoperative short-course radiotherapy | Yonsei University | Locally Advanced Rectal Cancer | 08/23 | 08/23 | | |
ChiCTR2000034829: Camrelizumab Plus Apatinib Versus Chemotherapy for Initial Primary Unresectable Hepatic Carcinoma: a Randomized, Controlled, Single-Center, Phase II Study |
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| Not yet recruiting | N/A | 60 | | Camrelizumab Plus Apatinib ;Fluorouracil combined with oxaliplatin chemotherapy | Shengjing Hospital Affiliated to China Medical University; Shengjing Hospital Affiliated to China Medical University, Independent project | Hepatic Carcinoma | | | | |
ChiCTR2000035210: Clinical study on the adjuvant treatment of postoperative cholangjocinoma with duvalizumab combined with GEMOX (gemcitabine+oxaliplatin) |
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| Recruiting | N/A | 40 | | duvalizumab combined with GEMOX (gemcitabine+oxaliplatin) | Chinese PLA General Hospital (the 301st Hospital); Chinese PLA General Hospital (the 301st Hospital), self-funding | cholangiocarcinoma | | | | |
ChiCTR2200062090: Safety and efficacy analysis of apatinib combined with oxaliplatin and capecitabine in neoadjuvant chemotherapy for locally advanced gastric cancer |
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| Recruiting | N/A | 30 | | neoadjuvant chemotherapy | The First Affiliated Hospital of USTC WEST district; The First Affiliated Hospital of USTC WEST district, self-raised | gastric | | | | |
| Recruiting | N/A | 240 | Europe | Cinnamaldehyde and capsaicin | Universitaire Ziekenhuizen Leuven | Chemotherapy-induced Peripheral Neuropathy | 09/23 | 09/23 | | |
NCT06430515: The Clinical Efficacy and Safety of Intratumoral Injection of Chemotherapy for Advanced Solid Tumors |
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| Recruiting | N/A | 200 | RoW | Intratumoral Injection of Chemotherapy | Wuxi People's Hospital | Intratumoral Injection, Cancer | 12/27 | 12/28 | | |
| Available | N/A | | Europe, US | zolbetuximab, IMAB362 | Astellas Pharma Global Development, Inc. | Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma Cancer, Metastatic Gastric Adenocarcinoma Cancer, Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma | | | | |
ChiCTR2200063922: Capecitabine enhances sensitivity to oxaliplatin in advanced gastric cancer and the effects on patients' FOXP1 and GGT levels |
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| Not yet recruiting | N/A | 152 | | Capecitabine + oxaliplatin ;Oxaliplatin | Fuwai Central China Cardiovascular Hospital; Fuwai Central China Cardiovascular Hospital, Fuwai Central China Cardiovascular Hospital | gastric cancer | | | | |
NCT06389552: Long-term Observational Study to Evaluate the DFS and OS of Adjuvant FOLFIRINOX Regimen in Pancreatic Cancer Patients |
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| Recruiting | N/A | 36 | RoW | | HK inno.N Corporation | Adjuvant Chemotherapy | 12/26 | 12/27 | | |
ChiCTR2200064999: A single-arm, single-center clinical study on the safety, tolerability and anti-tumor effect of BM601 for TACE in the treatment of hepatocellular carcinoma |
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| Recruiting | N/A | 8 | | Oxaliplatin + adriamycin (at least 2 mL) + BM601 lipiodol suspension (3 ml) hepatic artery embolization | Lishui Central Hospital; Suzhou Baimai Biomaterials & Pharmaceutics CO., LTD, Self-raised | Tumor | | | | |
ChiCTR2000038494: Hepatic arterial infusion chemotherapy (HAIC) versus transcatheter arterial chemoembolization (TACE) for unresectable hepatocellular carcinoma: a multicenter randomized controlled trial |
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| Recruiting | N/A | 380 | | high-dose chemotherapy (oxaliplatin, leucovorin, and fluorouracil) was continuously perfused through the hepatic artery ;A mixture of iodized oil and chemotherapeutic agents was injected through the hepatic artery | Sun Yat-Sen University Cancer Center; Sun Yat-Sen University Cancer Center, none | Hepatocellular Carcinoma | | | | |
NCT02428101: Oxaliplatin - Induced Peripheral Neuropathy in Patients With Gastrointestinal Tract Cancer |
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| Enrolling by invitation | N/A | 80 | RoW | polymorphism analysis | Ain Shams University | Gastrointestinal Tract Cancer, Peripheral Neuropathy | 02/24 | 04/24 | | |
NCT06128252: Clinical Study of Taurine Combined With Neoadjuvant Chemo-Immunotherapy for Treatment of Locally Advanced Gastric Cancer |
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| Recruiting | N/A | 48 | RoW | Taurine, Serplulimab, XELOX regimen, FLOT regimen | Tang-Du Hospital | Gastric Cancer | 12/24 | 12/24 | | |
NCT06157216: Minimal Residual Disease-guided Adjuvant Therapy for Gastric Cancer |
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| Recruiting | N/A | 85 | RoW | MRD-guided therapy | Qilu Hospital of Shandong University, Shandong Provincial Hospital, Jinan Central Hospital, Yantai Yuhuangding Hospital, The Affiliated Hospital of Qingdao University | Stage II-III Gastric Cancer | 04/27 | 04/29 | | |