Rectal Diseases  >>  oxaliplatin  >>  Phase 1
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34 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
oxaliplatin / Generic mfg.
NCT01286818: A Study of Irinotecan, Levofolinate, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab (IMC-1121B)

Checkmark ASCO-GI 2013
Jan 2013 - Jan 2013: ASCO-GI 2013
Completed
1b
6
Japan
Ramucirumab (IMC-1121B), IMC-1121B, Ramucirumab, LY3009806, Irinotecan, levofolinate, 5-Fluorouracil (5-FU)
Eli Lilly and Company
Colorectal Carcinoma
02/12
03/12
NCT00660153: Study of Tivozanib (AV-951) Plus FOLFOX6 in Subjects With Advanced Colorectal Cancer and Other Gastrointestinal Cancers

Checkmark P1 data-ASCO
Jun 2012 - Jun 2012: P1 data-ASCO
Completed
1b
30
Europe
Tivozanib (AV-951) plus FOLFOX6
AVEO Pharmaceuticals, Inc.
Colorectal Cancer, Gastrointestinal Cancer
06/12
06/12
NCT00003427: Oxaliplatin Plus Irinotecan in Treating Patients With Metastatic Gastrointestinal Cancer

Completed
1
36
US
irinotecan hydrochloride, oxaliplatin
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Anal Cancer, Colorectal Cancer, Esophageal Cancer, Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Gastric Cancer, Gastrointestinal Carcinoid Tumor, Liver Cancer, Pancreatic Cancer, Small Intestine Cancer
04/02
04/02
NCT00003799: Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Rectal Cancer

Completed
1
20
US
fluorouracil, 5-fluorouracil, 5-Fluracil, 5-FU, oxaliplatin, 1-OHP, Dacotin, Dacplat, Eloxatin, L-OHP, radiation therapy, irradiation, radiotherapy, therapy, radiation, leucovorin calcium, CF, CFR, LV, therapeutic conventional surgery
National Cancer Institute (NCI)
Adenocarcinoma of the Rectum, Mucinous Adenocarcinoma of the Rectum, Signet Ring Adenocarcinoma of the Rectum, Stage IIA Rectal Cancer, Stage IIB Rectal Cancer, Stage IIC Rectal Cancer, Stage IIIA Rectal Cancer, Stage IIIB Rectal Cancer, Stage IIIC Rectal Cancer
09/03
 
NCT00081237: OSI-7904L and Oxaliplatin in Treating Patients With Refractory or Recurrent Advanced Colorectal Cancer

Completed
1
15
Europe
OSI-7904L, oxaliplatin
European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Cancer
08/05
 
NCT00008294: Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer

Completed
1
US
FOLFOX regimen, dexamethasone, floxuridine, fluorouracil, leucovorin calcium, oxaliplatin
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Colorectal Cancer, Metastatic Cancer
05/06
 
NCT00499850: Phase I FOLFOX Combination

Completed
1
18
RoW
ZD6474 (vandetanib), ZACTIMA™, 5-Fluorouracil, 5-FU, Leucovorin, Oxaliplatin
Genzyme, a Sanofi Company
Advanced Colorectal Carcinoma
06/06
04/08
NCT00353262: A Study of Xeloda (Capecitabine) in Combination With Oxaliplatin in Patients With Metastatic Colorectal Cancer.

Completed
1
36
Canada
Avastin, Oxaliplatin, capecitabine [Xeloda]
Hoffmann-La Roche
Colorectal Cancer
09/06
04/08
NCT00098982: Bortezomib, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Advanced or Metastatic Colorectal Cancer

Completed
1
16
Europe
bortezomib, fluorouracil, leucovorin calcium, oxaliplatin
European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Cancer
01/07
 
NCT00060411: A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer

Completed
1
24
US
erlotinib hydrochloride, CP-358,774, erlotinib, OSI-774, fluorouracil, 5-fluorouracil, 5-Fluracil, 5-FU, leucovorin calcium, CF, CFR, LV, oxaliplatin, 1-OHP, Dacotin, Dacplat, Eloxatin, L-OHP, bevacizumab, anti-VEGF humanized monoclonal antibody, anti-VEGF monoclonal antibody, Avastin, rhuMAb VEGF
National Cancer Institute (NCI)
Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer, Signet Ring Adenocarcinoma of the Colon, Signet Ring Adenocarcinoma of the Rectum, Stage IIIA Colon Cancer, Stage IIIA Rectal Cancer, Stage IIIB Colon Cancer, Stage IIIB Rectal Cancer, Stage IIIC Colon Cancer, Stage IIIC Rectal Cancer, Stage IVA Colon Cancer, Stage IVA Rectal Cancer, Stage IVB Colon Cancer, Stage IVB Rectal Cancer
07/07
 
NCT00458809: Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer

Completed
1
16
US
oxaliplatin
Wake Forest University Health Sciences, National Cancer Institute (NCI)
Carcinoma of the Appendix, Colorectal Cancer, Primary Peritoneal Cavity Cancer
11/07
11/07
NCT00403052: A Study of 1018 Immunostimulatory Sequence (ISS) Administered With Irinotecan and Cetuximab to Treat Patients With Previously Treated Metastatic Colorectal Cancer

Terminated
1
14
US
1018 ISS immunostimulatory oligonucleotide
Dynavax Technologies Corporation
Colorectal Neoplasms
12/07
12/07
NCT00084643: GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors

Completed
1
20
US
GTI-2040, oxaliplatin, 1-OHP, Dacotin, Dacplat, Eloxatin, L-OHP, capecitabine, CAPE, Ro 09-1978/000, Xeloda, pharmacological study, pharmacological studies, laboratory biomarker analysis
National Cancer Institute (NCI)
Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IIIC Colon Cancer, Stage IIIC Rectal Cancer, Stage IVA Colon Cancer, Stage IVA Rectal Cancer, Stage IVB Colon Cancer, Stage IVB Rectal Cancer, Unspecified Adult Solid Tumor, Protocol Specific
04/08
 
NCT00599924: Study Of Sunitinib Plus FOLFOX In Patients With Solid Tumors

Checkmark P1 data (Solid tumor)
May 2012 - May 2012: P1 data (Solid tumor)
Completed
1
53
US
sunitinib + FOLFOX, Sunitinib malate, SUTENT, mFOLFOX6
Pfizer
Colorectal Neoplasms, Neoplasms
11/08
11/08
NCT00631410: Study Of Sunitinib In Combination With Folfox In Patients With Colorectal Cancer

Checkmark P1 data
Mar 2012 - Mar 2012: P1 data
Completed
1
12
Japan
sunitinib + mFOLFOX6
Pfizer
Colorectal Neoplasms
07/09
03/10
NCT01271166: Glivec® Plus m-FOLFOX Avastin® in Advanced Colorectal Cancer

Terminated
1
10
RoW
Imatinib, Fluorouracil, Oxaliplatin, Leucovorin and Bevacizumab
Novartis Pharmaceuticals
Advanced Colorectal Cancer
08/09
 
NCT00387387: Study On Pazopanib When Given With FOLFOX6 (Fluorouracil, Oxaliplatin, Leucovorin) Or CapeOx (Capecitabine, Oxaliplatin)

Completed
1
50
Europe, RoW
Pazopanib, FOLFOX 6, CapeOx
GlaxoSmithKline
Neoplasms, Colorectal
08/09
08/09
NCT00478634: A Phase 1 Study Investigating the Combination of RAD001, Cetuximab and Irinotecan as Second-line Therapy After FOLFOX (or XELOX) Plus Bevacizumab in Patients With Metastatic Colorectal Cancer

Completed
1
19
US
RAD001, Cetuximab, Irinotecan
Novartis Pharmaceuticals
Colorectal Cancer, Colorectal Carcinoma, Colorectal Tumors, Neoplasms, Colorectal
09/09
09/09
NCT00101894: Safety of AMG 706 Plus Panitumumab Plus Chemotherapy in the Treatment of Subjects With Metastatic Colorectal Cancer

Checkmark P2 data - ESMO 2012
Sep 2012 - Sep 2012: P2 data - ESMO 2012
Completed
1
119
US
FOLFOX-4, AMG 706, Panitumumab (Part 1a only), FOLFIRI
Amgen
Rectal Cancer, Colon Cancer
04/10
12/11
NCT00532909: Phase I Vandetanib Plus Capecitabine, Oxaliplatin and Bevacizumab for Metastatic Colorectal Cancer

Completed
1
13
US
Vandetanib, Capecitabine, Oxaliplatin, Bevacizumab
Branimir Sikic, AstraZeneca
Anal, Colon, and Rectal Cancers, Colorectal Neoplasms, Colon/Rectal Cancer
05/10
05/10
NCT00920868: XAD - Xelox (Capecitabine + Oxaliplatin) + Bevacizumab + Dasatinib

Completed
1
22
US
dasatinib, Sprycel, bevacizumab, Avastin, Oxaliplatin, Eloxatin, Capecitabine, Xeloda
Herbert Hurwitz, MD, Bristol-Myers Squibb
Solid Tumor, Metastatic Colorectal Cancer
05/10
08/14
NCT00118261: Erlotinib, Modified FOLFOX6, and Bevacizumab as First-Line Therapy Metastatic Colorectal Cancer

Completed
1
17
US
bevacizumab, erlotinib hydrochloride, fluorouracil, leucovorin calcium, oxaliplatin
Case Comprehensive Cancer Center, National Cancer Institute (NCI)
Colorectal Cancer
01/11
01/11
NCT00779311: A Phase I Trial Evaluating mFOLFOX6 and Avastin With Nexavar as First-Line Treatment for Metastatic Colorectal Cancer

Terminated
1
8
US
sorafenib, Nexavar, bevacizumab, Avastin, mFOLFOX6 regimen
Accelerated Community Oncology Research Network, Bayer
Metastatic Colorectal Cancer
03/11
03/11
NCT00138177: Suberoylanilide Hydroxamic Acid, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Progressive Metastatic or Unresectable Colorectal Cancer or Other Solid Tumors

Completed
1
54
US
oxaliplatin, 1-OHP, Dacotin, Dacplat, Eloxatin, L-OHP, leucovorin calcium, CF, CFR, LV, vorinostat, L-001079038, SAHA, suberoylanilide hydroxamic acid, Zolinza, fluorouracil, 5-fluorouracil, 5-Fluracil, 5-FU
National Cancer Institute (NCI)
Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage III Colon Cancer, Stage III Rectal Cancer, Stage IV Colon Cancer, Stage IV Rectal Cancer, Unspecified Adult Solid Tumor, Protocol Specific
08/11
 
NCT00934882: Study to Determine Safety, Pharmacokinetics, Pharmacodynamics of BAY73-4506 in Combination With mFOLFOX6 or FOLFIRI

Checkmark Combination with FOLFOX or FOLFIRI as first- or second-line treatment of colorectal cancer
Mar 2013 - Mar 2013: Combination with FOLFOX or FOLFIRI as first- or second-line treatment of colorectal cancer
Checkmark P1 data (CRC)
May 2012 - May 2012: P1 data (CRC)
Completed
1
45
Europe
Regorafenib (BAY73-4506)
Bayer
Colorectal Neoplasms
04/12
04/12
NCT00940758: Phase I and Pharmacokinetic Study of Biweekly PEP02 in mCRC Refractory to 1st-line Oxaliplatin Base Therapy

Completed
1
18
RoW
PEP02
PharmaEngine
Metastatic Colorectal Cancer
05/12
06/14
NCT01164215: Biomarker-Guided Fluorouracil in Treating Patients With Colorectal Cancer Receiving Combination Chemotherapy

Completed
1
76
US
fluorouracil, 5FU, leucovorin, leucovorin calcium, oxaliplatin, Eloxatin
UNC Lineberger Comprehensive Cancer Center, National Cancer Institute (NCI)
Colorectal Cancer, Diarrhea, Neutropenia
11/12
09/13
NCT00879385: KRAS Wild-type Metastatic Colorectal Cancer Trial

Checkmark +decitabine
Mar 2013 - Mar 2013: +decitabine
Completed
1
21
US
Dacogen™ (decitabine), Vectibix® (panitumumab)
University of Utah, Amgen, Eisai Inc.
Colorectal Cancer
01/13
01/13
NCT01233505: Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors

Terminated
1
16
US
veliparib, ABT-888, capecitabine, CAPE, Ro 09-1978/000, Xeloda, oxaliplatin, 1-OHP, Dacotin, Dacplat, Eloxatin, L-OHP, pharmacological study, pharmacological studies, laboratory biomarker analysis
National Cancer Institute (NCI)
Adenocarcinoma of the Pancreas, Adenocarcinoma of the Stomach, BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Ovarian Mucinous Cystadenocarcinoma, Recurrent Breast Cancer, Recurrent Colon Cancer, Recurrent Gastric Cancer, Recurrent Ovarian Epithelial Cancer, Recurrent Ovarian Germ Cell Tumor, Recurrent Pancreatic Cancer, Recurrent Rectal Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer, Stage IV Colon Cancer, Stage IV Gastric Cancer, Stage IV Ovarian Epithelial Cancer, Stage IV Ovarian Germ Cell Tumor, Stage IV Pancreatic Cancer, Stage IV Rectal Cancer, Unspecified Adult Solid Tumor, Protocol Specific
10/13
 
NCT00019773: Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer

Completed
1
US
capecitabine, oxaliplatin
National Cancer Institute (NCI)
Carcinoma of the Appendix, Colorectal Cancer, Small Intestine Cancer
 
 
NCT01571024: BKM120 + mFOLFOX6 in Advanced Solid Tumors With Expansion Cohort Pancreatic Cancer

Completed
1
17
US
BKM120, buparlisib, mFOLFOX6, Folinic acid (leucovorin), Fluorouracil (5-FU), Oxaliplatin (Eloxatin)
UNC Lineberger Comprehensive Cancer Center
Advanced Solid Tumors, Metastatic Colorectal Cancer, Metastatic Pancreatic Cancer
05/15
03/16
PIFA, NCT01719926: Phase I Platinum Based Chemotherapy Plus Indomethacin

Completed
1
13
Europe
Indomethacin
UMC Utrecht
Colorectal Neoplasms, Esophageal Neoplasms, Ovarian Neoplasms
08/17
08/17
NCT02041481: MEK Inhibitor MEK162 in Combination With Leucovorin Calcium, Fluorouracil, and Oxaliplatin in Treating Patients With Advanced Metastatic Colorectal Cancer

Checkmark In combination with FOLFOX for colorectal cancer at ASCO GI 2016
Jan 2016 - Jan 2016: In combination with FOLFOX for colorectal cancer at ASCO GI 2016
Completed
1
26
US
MEK inhibitor MEK162, ARRY-162, ARRY-438162, Binimetinib, MEK inhibitor ARRY-438162, MEK162, leucovorin calcium, CF, CFR, LV, fluorouracil, 5-fluorouracil, 5-Fluracil, 5-FU, oxaliplatin, 1-OHP, Dacotin, Dacplat, Eloxatin, L-OHP, pharmacological study, pharmacological studies, Laboratory Biomarker Analysis
City of Hope Medical Center, National Cancer Institute (NCI), Array BioPharma
Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IVA Colon Cancer, Stage IVA Rectal Cancer, Stage IVB Colon Cancer, Stage IVB Rectal Cancer
01/18
01/18
NCT02062749: Escalating Doses of Oxaliplatin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Children and Adolescents With Extensive Colon Carcinoma

Completed
1
1
US
Oxaliplatin, Eloxatin
M.D. Anderson Cancer Center
Colorectal Cancer
06/18
06/18

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