Completed

4

5

RoW

donor derived cytomegalovirus specific T lymphocytes, cytomegalovirus specific T lymphocytes, Foscarnet, Ganciclovir

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China

Cytomegalovirus Infections, Hematological Disease

12/21

12/21

Not yet recruiting

3

20

RoW

Maribavir, TAK-620

Takeda

Cytomegalovirus (CMV)

02/27

02/27

Ongoing

2

64

Europe

GANCICLOVIR, FOSCARNET, VALGANCICLOVIR, CYMEVENE, FOSCAVIR, VALCYTE, CYMEVENE, FOSCAVIR, VALCYTE

FUNDACION INVESTIGACION HOSPITAL CLINICO DE VALENCIA-INSTITUTO DE INVESTIGACION SANITARIA INCLIVA, Ministerio de Sanidad y Politica Social

Cytomegalovirus infection in patients treated with hematopoietic allogenic transplant INFECCION POR CITOMEGALOVIRUS EN PACIENTES TRATADOS CON TRASPLANTE HEMATOPOYETICO ALOGENICO

 

 

Not yet recruiting

N/A

3650

 

No intervention is taken. ;Induction therapy: fluconazole 800mg/d, PO, for 2 weeks; consolidation therapy: fluconazole 400mg/d, PO, for 8 weeks; maintenance therapy: fluconazole 200mg/day, PO, for 1 year. ;Fluconazole 400mg / day, PO, for 1 year. ;When the initial intracranial pressure≥250mmH2O, according to the patients' will, lumbar puncture and removing CSF should be done by regular. ;When the initial intracranial pressure is ≥ 250 mmH2O, lumbar puncture was given daily to reduce intracranial pressure. The intracranial pressure was measured once every 10ml of released cerebrospinal fluid, until the initial intracranial pressure< 50% of the initial intracranial pressure or the pressure< 200 mmH2 ;When the initial intracranial pressure is ≥250mmH2O, the drainage is given, and the cerebrospinal fluid is continuously drained by the improved drainage device to maintain the daily intracranial pressure <200mmH2O; when the intracranial pressure is <200mmH2O for 2 days or more, Stop drainage. ;Amphotericin B deoxycholate combined with flucytosine. Details: amphotericin B deoxycholate 0.5 - 0.7mg / kg, once a day, intravenous drip; flucytosine, daily 100mg / kg, divided into 4 times, PO. Lumbar puncture, biochemical examination of cerebrospinal fluid, cerebrospinal fluid ink staining and fungal culture were p ;Voriconazole combined with flucytosine. Details: Voriconazole was given orally at the induction dose of 400 mg on the first day, once every 12 hours, 200 mg on the second day, once every 12 hours, and flucytosine at the dose of 100 mg/kg per day, four times a day. Lumbar puncture, biochemical ex ;Amphotericin B deoxycholate combined with fluconazole. Details: Amphotericin B deoxycholate 0.5-0.7 mg/kg, once a day, intravenous drip; fluconazole 800 mg, once a day, intravenous drip. Lumbar puncture, biochemical examination of cerebrospinal fluid, cerebrospinal fluid ink staining and fungal culture were performed according to& ;Amphotericin B deoxycholate combined with voriconazole. Details: Voriconazole was administered orally at the induction dose of 400 mg on the first day, once every 12 hours; the maintenance dose of 200 mg on the next day, once every 12 hours; amphotericin B deoxycholate 0.5-0.7 mg/kg once a day, intravenous& ;Subjects start ART after 2 weeks of treatment for cryptococcosis. ;Subjects start ART after 5 weeks of treatment for cryptococcosis. ;SMZ-TMP 1.44g PO q8h + azithromycin 0.5 g IV qd at least for 6 weeks. ;Sulfamethoxazole,Sulfadiazine and Trimethoprim Tablets 1.44g PO q8h + Clindamycin 600mg IV q8h at least for 6 weeks. ;Subjects start ART within 2 weeks of treatment for Toxoplasma gondii. ;Subjects start ART after 2 weeks of treatment for Toxoplasma gondii. ;TMP-SMZ (TMP 15-20 mg/kg/d, SMX 75-100 mg/kg/d) plus prednisone (40 mg 2 times/day, 5 days; 40 mg 1 times/day, 5 days; 20mg 1 time/day, 11 days), total course of treatment 3-4 weeks ;TMP-SMZ (TMP 15-20mg/kg/d, SMX 75-100 mg/kg/d) plus clindamycin (0.6g clindamycin combine with 100ml saline slow) Instillation, 1 time / 6h) plus prednisone (40mg 2 times / day, 5 days; 40mg 1 time / day, 5 days; 20mg 1 time / day, 11 days), the total course of treatment 3-4 weeks. ;Caspofungin (70 mg once daily, 1 day; 50 mg once daily, 20 days) combine with TMP-SMZ (TMP 15-20 mg/kg/d, SMX 75-100 mg/kg/d) plus prednisone (40 mg twice daily, 5 days; 40 mg once daily, 5 days; 20 mg once daily, 11 days), total course of treatment 3-4 weeks. ;Subjects start ART within 1 weeks of treatment for Pneumocystis jirovecii. ;Subjects start ART after 2 weeks of treatment for Pneumocystis jirovecii. ;Induction therapy: sodium foscarnet 60mg/kg, q8h, infusion time > 2h, 2 weeks of treatment; maintenance treatment: sodium foscarnet 90mg/kg/day, intravenous infusion time > 2 h, treatment for at least 2 weeks. At the same time, dexamethasone 5 mg qd was administered intravenously for 4 weeks. ;induction therapy: sodium foscarnet 60mg/kg, q8h, intravenous infusion time > 2h, 2 weeks of treatment; maintenance treatment: sodium foscarnet 90mg/kg/day, intravenous infusion time > 2 h, treatment for at least 2 weeks . At the same time, combined with ganciclovir 0.2 ~ 0.4mg qw intra-balloon injection for ;induction therapy: sodium foscarnet 60mg/kg, q8h, infusion time > 2h, 2 weeks of treatment; maintenance treatment: sodium foscarnet 90mg/kg/day, intravenous infusion time > 2h, treatment for at least 2 weeks. ;Subjects start ART within 2 weeks of treatment for CMV. ;Subjects start ART after 2 weeks of treatment for CMV. ;The amphotericin B deoxycholate was given intravenously for 2 weeks, the dose was 5 mg on the first day, 15 mg on the second day, and 0.5-0.7 mg/kg/d on the third day and later. Then changed to oral itraconazole capsule 200 mg q12 h for 10 weeks, the total course of treatment for 12 ;Voriconazole 4 mg/kg q12h for 4 days, the first day was given a loading dose (voriconazole 6 mg / kg q12 h). After 4 days, it was changed to oral voriconazole capsule 200 mg q12h. After 2 weeks of voriconazole, it was changed to oral itraconazole 200 mg q12 h for 10 weeks. The total& ;Voriconazole 4 mg/kg q12h for 2 weeks，the first day was given a loading dose (voriconazole 6mg/kg q12h), and then changed to oral voriconazole capsule 200 mg q12h for 10 weeks, the total course of treatment for 12 weeks. ;Subjects start ART within 2 weeks of treatment for Talaromyces marneffei. ;Subjects start ART after 2 weeks of treatment for Talaromyces marneffei.

Chongqing Public health medical center; Chongqing Public health medical center, National Science and Technology Major Project -

AIDS opportunistic infections and refractory AIDS

 

 

Recruiting

N/A

50

 

Foscarnet ( IV.) ;acyclovir（IV.）

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University; School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, National key research and development project

herpes simplex virus keratitis