AiRuiKa (camrelizumab) / HLB Bio Group |
Icemelting, NCT04393506: Inductive Camrelizumab and Apatinib for Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma |
|
|
| Completed | 1 | 21 | RoW | Camrelizumab, Humanized anti-PD-1 inhibitor, Apatinib, VEGFR2 inhibitor, Radical surgery, Post-operative radiotherapy/chemoradiotherapy | Shanghai Jiao Tong University School of Medicine | Oral Cancer, VEGFR2 Inhibitor, Programmed Cell Death 1 Inhibitor, Inductive Therapy | 11/20 | 11/23 | | |
ChiCTR2100046181: A phase IB clinical study of camrelizumab intratumoral injection combined with apatinib in the treatment of malignant ascites in advanced gastric cancer |
|
|
| Recruiting | 1 | 6 | | PD-1 antibody intratumoral injection combined with apatinib | Union Hospital Tongji Medical College Huazhong University of Science and Technology; Union Hospital Tongji Medical College Huazhong University of Science and Technology, The company sponsored the PD-1 drug | Malignant ascites of Gastric cancer | | | | |
ChiCTR1900026236: A phase 1b study for fuzuoparib in combination with Albumin Palitaxel and Camrelizumab in the treatment of patients with advanced solid cancer |
|
|
| Not yet recruiting | 1 | 38 | | fuzuoparib (PARP inhibitor) in combination with Albumin Palitaxel and Camrelizumab (PD-1 inhibitor) | The General Hospital of the People's Liberation Army (PLAGH); The General Hospital of the People's Liberation Army (PLAGH), scientific research project | advanced solid cancer | | | | |
NCT04665362: IIT Study of M1-c6v1 Combined With SHR-1210 and Apatinib in Patients With HCC |
|
|
| Not yet recruiting | 1 | 10 | NA | Recombinant oncolytic virus M1, anti PD-1 antibody, Apatinib | Liang Peng, Guangzhou Virotech Pharmaceutical Co., Ltd. | Advanced/Metastatic Hepatocellular Carcinoma | 06/22 | 10/22 | | |
ChiCTR2000033727: SHR-1210 combined with apatinib for patients failed with one line therapy of advanced Intrahepatic Cholangiocarcinoma |
|
|
| Not yet recruiting | 1 | 30 | | SHR-1210+apatinib | Third Affiliated Hospital of the Second Military Medical University; Third Affiliated Hospital of the Second Military Medical University, Jiangsu Hengrui Pharmaceutical Co. LTD | Intrahepatic Cholangiocarcinoma | | | | |
NCT04508686: Combination of Metronomic Capecitabine With Camrelizumab for Treatment of Refractory Solid Tumor Trial (Cohort 1) |
|
|
| Recruiting | 1 | 20 | RoW | Capecitabine, camrelizumab | Ruijin Hospital | Advanced Cervical Cancer | 08/22 | 08/24 | | |
McCrest-2, NCT04510818: Combination of Metronomic Capecitabine With Camrelizumab for Treatment of Refractory Solid Tumor Trial (Cohort 2) |
|
|
| Recruiting | 1 | 20 | RoW | Capecitabine, Camrelizumab | Ruijin Hospital | Head and Neck Cancer, Esophageal Squamous Cancer | 08/22 | 08/24 | | |
NCT05019534: Tolerability and Safety of Vemurafenib, Cetuximab Combined With Camrelizumab for BRAF V600E-mutated /MSS Metastatic Colorectal Cancer |
|
|
| Recruiting | 1 | 12 | RoW | Vemurafenib Oral Tablet [Zelboraf], Zelboraf, Cetuximab Injection [Erbitux], Erbitux, Camrelizumab | West China Hospital | BRAF V600E-mutated /MSS Metastatic Colorectal Cancer, Vemurafenib (BRAFi) Plus Cetuximab (EGFRi) Combined With PD-1 Monoclonal Antibody | 08/22 | 12/22 | | |
NCT04564313: Safety and Efficacy of Camrelizumab (Anti-PD-1 Antibody) in Recurrent HCC After Liver Transplantation |
|
|
| Recruiting | 1 | 20 | RoW | Camrelizumab treatment | Third Affiliated Hospital, Sun Yat-Sen University | Hepatocellular Carcinoma, Liver Transplantation | 09/22 | 07/23 | | |
NCT04625894: The Combination of Immunotherapy and Stereotactic Ablative Radiotherapy in Oligometastatic Gastrointestinal Cancer |
|
|
| Not yet recruiting | 1 | 21 | RoW | Stereotactic Ablative Radiotherapy (SABR), Camrelizumab for injection (200 mg, iv), D1, Q2W, 14-day cycle | Fudan University | Oligometastatic Gastrointestinal Cancer | 12/22 | 06/23 | | |
NCT05008861: Gut Microbiota Reconstruction for NSCLC Immunotherapy |
|
|
| Not yet recruiting | 1 | 20 | RoW | Capsulized Fecal Microbiota Transplant, Capsulized FMT, Anti-programmed cell death protein 1/programmed death-ligand 1 monoclonal antibody, Anti-PD-1/PD-L1 mAb, Anti-PD-1/PD-L1, Pembrolizumab, Nivolumab, Durvalumab, Sintilimab, Tislelizumab, Camrelizumab, Platinum based chemotherapy, Platinum based Chemotherapy drugs | Shanghai Zhongshan Hospital | Non-Small Cell Lung Cancer | 12/22 | 12/22 | | |
NCT05001412: Chemotherapy Combined With Camrelizumab and Apatinib in First-line Treatment of ES-SCLC |
|
|
| Recruiting | 1 | 36 | RoW | Camrelizumab; apatinib; carboplatin; etoposide | Zhou Chengzhi, Jiangsu Hengrui Pharmaceutical Co., Ltd. | Extensive Stage Small Cell Lung Cancer | 01/23 | 01/24 | | |
NCT05198817: A Trial of SHR-2002 Injection or Combined With Other Anti-cancer Medication in Advanced Malignant Tumors of Patients |
|
|
| Enrolling by invitation | 1 | 240 | RoW | SHR-2002 injection、Camrelizumab for Injection, SHR-1316 injection, SHR-1701 injection | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | Advanced Malignant Tumors | 01/23 | 06/23 | | |
PIANO, NCT03491631: Phase I Study of SHR9146 + SHR-1210 +/- Apatinib in Patients With Advanced Solid Tumors |
|
|
| Active, not recruiting | 1 | 23 | RoW | SHR9146+SHR-1210, SHR9146+SHR-1210+Apatinib | Jiangsu HengRui Medicine Co., Ltd. | Tumor, Solid, Cancer, Metastatic, Neoplasm Malignant | 06/23 | 09/23 | | |
McCrest-3, NCT04932187: Combination of Metronomic Capecitabine With Camrelizumab for Treatment of Refractory Solid Tumor Trial (Cohort 3) |
|
|
| Recruiting | 1 | 20 | RoW | Capecitabine, Camrelizumab | Ruijin Hospital | Hepatobiliary, Pancreatic and Other Gastrointestinal Carcinoma (Non-stomach, Non-esophagi) | 07/23 | 07/25 | | |
NCT05429398: A Study of Linperlisib Combination With Camrelizumab in Patients With Solid Tumor |
|
|
| Not yet recruiting | 1 | 118 | NA | Linperlisib Tablet, Camrelizumab for Injection | Shanghai YingLi Pharmaceutical Co. Ltd. | Advanced Solid Tumor | 08/23 | 05/24 | | |
NCT05643417: Camrelizumab Combined With Bevacizumab and HAIC in Patients With Metastatic Liver Cancer Who Failed Standard Therapy |
|
|
| Not yet recruiting | 1 | 80 | RoW | HAIC、Bevacizumab、Camrelizumab, Camrelizumab brand name: ai rui ka; Bevacizumab brand name: ai rui tuo | Fudan University | Metastatic Liver Cancer | 10/23 | 10/24 | | |
| Recruiting | 1 | 118 | RoW | SHR-1210 | Jiangsu HengRui Medicine Co., Ltd. | Advanced Tumors | 10/23 | 11/23 | | |
ChiCTR2200060165: Clinical study of camrelizumab combined with nabTC in the long-term neoadjuvant treatment of patients with stage II-III operable lung adenocarcinoma |
|
|
| Not yet recruiting | 1 | 30 | | Carrilizumab + albumin-paclitaxel + carboplatin was given. After 2 weeks of treatment, the drug was stopped and lung cancer resection was performed | First Affiliated Hospital of Anhui Medical University; First Affiliated Hospital of Anhui Medical University, None | non-small cell lung cancer (NSCLC) | | | | |
NCT06326736: Study of Neoantigen mRNA Vaccines in Patients With Resectable Pancreatic Cancer |
|
|
| Recruiting | 1 | 12 | RoW | Surgery, Surgical resection, Camrelizumab, PD-1 inhibitor, SJ-Neo006, Neoantigen mRNA Vaccines, Gemcitabine+Abraxane, chemotherapy | Jinling Hospital, China, Jiangsu Synthgene Biotechnology Co.Ltd. | Pancreatic Cancer | 12/25 | 12/26 | | |
NCT06356701: Tumor Nutritional Therapy in the First-line Treatment of Stage IV NSCLC |
|
|
| Recruiting | 1 | 120 | RoW | Cancer nutritional treatment regimen (Spirulina Bifidobacterium Capsules, Fish Oil Grape Seed Blueberry Soft Capsules, Ganoderma Spore Oil Soft Capsules) | The First Affiliated Hospital of Dalian Medical University | Long-Term Effects Secondary to Cancer Therapy | 12/24 | 12/25 | | |
NCT06346808: Oncolytic Virus Plus Anti-PD1 and Chemotherapy as Preoperative Therapy for Patients With BRPC/LAPC |
|
|
| Not yet recruiting | 1 | 20 | RoW | Oncolytic virus Plus Anti-PD1 and Chemotherapy | Sichuan University | Pancreatic Cancer | 05/26 | 05/27 | | |
NCT04074564: MASCT-I Combined With Apatinib and/or Camrelizumab in the Treatment of Bone and Soft Tissue Sarcoma |
|
|
| Recruiting | 1 | 60 | RoW | MASCT-I, Camrelizumab,Apatinib | HRYZ Biotech Co. | Sarcoma | 08/24 | 12/24 | | |
NCT06109207: Neoadjuvant Camrelizumab With Dalpiciclib for Resectable Esophageal or Head and Neck Squamous Cell Carcinomas |
|
|
| Recruiting | 1 | 12 | RoW | Camrelizumab, Dalpiciclib 100mg, Dalpiciclib 150mg | West China Hospital | Esophageal Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma | 10/24 | 10/25 | | |
ChiCTR2200060742: Effects of thalidomide combined with Camrelizumab on the incidence and efficacy of RCCEP in patients with non-small cell lung cancer |
|
|
| Not yet recruiting | 1 | 100 | | Thalidomide combined with carrilizhu | The Third Affiliated Hospital of Shandong First Medical University; The Third Affiliated Hospital of Shandong First Medical University, self-funded | reactive cutaneous capillary endothelial proliferation | | | | |
CCGLC-003, NCT05031949: Hyperbaric Oxygen Therapy Combined Camrelizumab in Patients With Advanced/Metastatic Hepatocellular Carcinoma |
|
|
| Recruiting | 1 | 20 | RoW | hyperbaric oxygen therapy plus Camrelizumab | Zhang Bi Xiang, MD | Combinational Immunotherapy, Hepatocellular Carcinoma Non-Resectable, Hyperbaric Oxygen Therapy | 12/24 | 06/25 | | |
ChiCTR2000040646: Camrelizumab and apatinib combined with chemotherapy (mFOLFOX6) in neoadjuvant therapy for locally advanced right-sided colon cancer |
|
|
| Not yet recruiting | 1 | 64 | | PD-1+Apatinib+Chemotherapy | The First Affiliated Hospital, Zhejiang University School of Medicine; The First Affiliated Hospital, Zhejiang University School of Medicine, Third Party Funded Drugs | colon cancer | | | | |
ChiCTR2300069990: Carrilizumab combined with Apatinib in the treatment of RCC with inferior vena cava cancer thrombus: a single-arm multicenter exploratory clinical study |
|
|
| Not yet recruiting | 1 | 48 | | Carrilizumab combined with Apatinib neoadjuvant therapy | Peking University Third Hospital; Peking University Third Hospital, National Nature Science Foundation of China /Wu Jieping Medical Foundation/Innovative Transformation Project of Haidian District | Renal Cell Carcinoma | | | | |
ChiCTR2300073069: Multicenter, single-dose, randomized, open, parallel-designed bioequivalence study of carrilizumab for injection with old and new processes in healthy male subjects |
|
|
| Not yet recruiting | 1 | 118 | | A single intravenous administration of 20 mg was performed, and 12 subjects were randomly divided into 1:1 groups to receive carrilizumab (old process) and carrilizumab (new process) at random. The pre-trial study procedure was the same as the formal trial. ;A single intravenous administration of 20 mg was performed, and 12 subjects were randomly divided into 1:1 groups to receive carrilizumab (old process) and carrilizumab (new process) at random. The pre-trial study procedure was the same as the formal trial. ;Test preparation (T) was a new process of carrilizumab; The reference preparation (R) was the old process carrilizumab. Using a single intravenous administration of 20 mg, 106 healthy male subjects were randomly divided into 1:1 groups to receive carrilizumab (old process) and carrilizumab (new process), and the formal trial study process was the same as the preliminary trial. ;Test preparation (T) was a new process of carrilizumab; The reference preparation (R) was the old process carrilizumab. Using a single intravenous administration of 20 mg, 106 healthy male subjects were randomly divided into 1:1 groups to receive carrilizumab (old process) and carrilizumab (new process), and the formal trial study process was the same as the preliminary trial. | Clinical Trial Center of Third Xiangya Hospital of Central South University; Third Xiangya Hospital, Central South University, Suzhou Shengdia Biomedicine Co., LTD | Malignant tumor | | | | |
NCT06121557: Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast Cancer |
|
|
| Recruiting | 1 | 24 | RoW | Surgery for harvesting tumor-draining lymph nodes, Cyclophosphamide, Fludarabine, Tumor-draining lymph node-derived lymphocyte (LNL), LNL, Interleukin-2, IL-2, Camrelizumab, SHR-1210, Chemotherapeutic drug, ADC or PARP inhibitor | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Breast Neoplasms | 12/26 | 12/31 | | |