| ondansetron / Generic mfg. |
| Not yet recruiting | 4 | 75 | | | Dr. Elsa Taylor, Pfizer | The Pharmacokinetic and Pharmacodynamics of Parecoxib.
The perioperative pain relief in children and the effects of parecoxib in children | | | | |
| Not yet recruiting | 4 | 120 | | | A/Prof Gabriel T Lau, Port Macquarie Base Hospital | nausea | | | | |
| Not yet recruiting | 4 | 450 | | | St John Ambulance - Western Australian Ambulance Service, St John Ambulance - Western Australian Ambulance Service | Nausea and vomiting | | | | |
ACTRN12624000303549: Brisbane-based Anti-Emetic Randomised Controlled Trial in the Prehospital Setting |
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| Not yet recruiting | 4 | 1000 | | | Queensland Ambulance Service, Emergency Medicine Foundation | Nausea and vomiting | | | | |
ACTRN12616000900415: Pain treatment after open-chest operations with three possibilities of pain-relief therapy. |
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| Recruiting | 4 | 120 | | | Medical University of Lublin, Medical University of Lublin | Thoracotomy surgery | | | | |
| Recruiting | 4 | 160 | | | St Vincent's Hospital Melbourne, St Vincent's Hospital Melbourne Research Endowment Fund | morbid obesity, Post-operative nausea and vomitting | | | | |
| Recruiting | 4 | 200 | | | Perth Children's Hospital, Perth Children's Hospital, Department of Health | Pain following tonsillectomy surgery | | | | |
NCT00092183: An Investigational Drug for the Prevention of Chemotherapy-Induced Nausea and Vomiting (MK-0869-071) |
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| Completed | 4 | 866 | NA | MK0869, aprepitant / Duration of Treatment: 3 days, Comparator: ondansetron / Duration of Treatment: 3 days | Merck Sharp & Dohme LLC | Nausea, Vomiting, Breast Neoplasms | 12/03 | 02/04 | | |
NCT00090207: Aprepitant for the Prevention of Chemotherapy Induced Nausea and Vomiting (CINV) Associated With Highly Emetogenic Chemotherapy (0869-801)(COMPLETED) |
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| Completed | 4 | 477 | NA | MK0869, aprepitant / Duration of Treatment: 3 days, Comparator: ondansetron / Duration of Treatment: 4 days | Merck Sharp & Dohme LLC | Nausea, Vomiting | 09/04 | 09/04 | | |
NCT00429832: A RCT of Ondansetron and Promethazine in the Treatment of Nausea and Vomiting in the Emergency Department |
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| Completed | 4 | 120 | US | Ondansetron, promethazine | University of New Mexico, GlaxoSmithKline | Nausea, Vomiting | | 11/05 | | |
| Completed | 4 | 140 | Europe | Acupuncture, Ondansetron, Physiological saline solution, Sham acupuncture, Acupuncture at P6 point | Catholic University of the Sacred Heart | Cholelithiasis | 09/07 | 09/07 | | |
NCT00825071: Dexamethasone for Postoperative Nausea and Vomiting |
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| Completed | 4 | 180 | RoW | Dexamethasone, Ondansetron, normal saline | University of Jordan | Postoperative Nausea and Vomiting | 03/08 | 03/08 | | |
NCT00781768: Odansetron and Dexamethasone Alone vs. Odansetron, Dexamethason and Apreptant to Prevent Nausea |
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| Completed | 4 | 181 | NA | Standard PO (Zofran + Dexamethason), Ondansetron (Zofran), Aprepitant (MK-869) + Standard PO, Ondansetron + Dexamethason (Standard PO) | Loyola University, Merck Sharp & Dohme LLC | Nausea, Vomiting | 10/08 | 07/10 | | |
NCT00796497: Ondansetron in Treatment Resistant Obsessive Compulsive Disorder (OCD) |
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| Completed | 4 | 14 | Europe | ondansetron, Zofran | Institute of Neuroscience, Florence, Italy | Obsessive Compulsive Disorder | 11/08 | 12/08 | | |
NCT01165866: Ondansetron Versus Metoclopramide in Treatment of Vomiting in Gastroenteritis |
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| Completed | 4 | 170 | RoW | Treatment 1. Metoclopramide, primpran, Treatment 2 Ondansetron, Zofrane | Hamad Medical Corporation | Gastroenteritis | 12/08 | 12/08 | | |
NCT00734929: Aprepitant With Dexamethasone Versus Ondansetron With Dexamethasone for PONV Prophylaxis in Patients Having Craniotomy |
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| Completed | 4 | 115 | US | Aprepitant + Dexamethasone, Ondansetron + Dexamethasone | Duke University, Merck Sharp & Dohme LLC | Postoperative Nausea and Vomiting | 06/09 | 06/09 | | |
NCT00659945: Aprepitant for PONV Prophylaxis in Outpatient Plastic Surgery |
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| Completed | 4 | 150 | US | Aprepitant plus Ondansetron, Emend, Ondansetron plus placebo, Zofran | University of Pittsburgh, Merck Sharp & Dohme LLC | Postoperative Nausea and Vomiting | 11/09 | 06/10 | | |
| Terminated | 4 | 20 | Europe | aprepitant, Emend, Dexamethasone and Ondansetron during CE-treatment, Decadron, Zofran | Radboud University Medical Center, Merck Sharp & Dohme LLC | Tumor | 01/10 | 01/10 | | |
| Completed | 4 | 150 | Europe | Sevoflurane | San Gerardo Hospital, University of Milano Bicocca | Adenotonsillectomy, Postoperative Pain, Emergence Delirium | 03/10 | 03/10 | | |
NCT01303536: Ondansetron Augmentation in Treatment-resistant OCD |
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| Completed | 4 | 21 | Europe | Ondansetron | Institute of Neuroscience, Florence, Italy | Obsessive Compulsive Disorder | 03/10 | 03/10 | | |
NCT00738621: Combination Antiemetic Regimen for Prevention of PONV in Breast Surgery Patients |
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| Completed | 4 | 100 | US | Aprepitant, Dexamethasone, Ondansetron, Emend=aprepitant, Aprepitant, Dexamethasone, Placebo | Scott and White Hospital & Clinic, Merck Sharp & Dohme LLC | Postoperative Nausea and Vomiting | 08/10 | 08/10 | | |
PAI vs FNB, NCT01335542: Analgesia After Total Knee Arthroplasty: Peri-Articular Injection Versus Epidural + Femoral Nerve Blockade |
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| Completed | 4 | 91 | US | Peri-Articular Injection, Epidural Pathway (PCEA+FNB) | Hospital for Special Surgery, New York | Readiness to Discharge | 03/11 | 09/11 | | |
| Completed | 4 | 220 | Europe | Xenon, LENOXe, Sevoflurane, Sevorane, Dexamethasone, Fortecortin Inject, NaCl, Ondansetron, Zofran | RWTH Aachen University, Air Liquide Santé International | Anaesthetics Gases, Xenon, Anaesthetics Volatile, Sevoflurane, Depth of Anaesthesia, Postoperative Nausea, Postoperative Vomiting | 04/11 | 04/11 | | |
NCT00745004: Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D) |
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| Completed | 4 | 150 | Europe | Ondansetron, Placebo | University of Nottingham, National Institute for Health Research, United Kingdom | Irritable Bowel Syndrome With Diarrhoea | 07/11 | 07/11 | | |
NCT01659775: Phase 4 Trial to Evaluate the Efficacy and Safety of Sancuso Patch in Chemotherapy-induced Nausea and Vomiting Associated With the Administration of Highly Emetogenic Chemotherapy (HEC) |
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| Completed | 4 | 389 | RoW | Sancuso patch, Zofran inj.+Zofran tab. | LG Life Sciences | Chemotherapy-induced Acute or Delayed Nausea and Vomiting (CINV) | 11/12 | 11/12 | | |
| Completed | 4 | 222 | Europe | Ondansetron, CAS number: 99614-02-5, acetylcysteine, cas number: 616-91-1, CAS number: 616-91-1 | University of Edinburgh, NHS Lothian, Chief Scientist Office of the Scottish Government | Overdose | 12/12 | 03/13 | | |
NCT01298193 / 2010-022689-29: Incidence of Chemotherapy-Induced Nausea and Vomiting Associated With Docetaxel-Cyclophosphamide in Early Breast Cancer. |
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| Completed | 4 | 212 | Europe | Aprepitant, Rescue therapy:Patients may be provided with a prescription., - 5-HT3 antagonists, - Phenothiazines., - Butyrophenones (e.g., haloperidol or droperidol), - Benzamides (e.g., metoclopramide or alizapride), - Benzodiazepines, - Corticosteroids, - Domperidone | Spanish Breast Cancer Research Group, Merck Sharp & Dohme LLC | Breast Cancer | 03/13 | 04/14 | | |
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NCT01434017: Comparison of Three Different Prophylactic Treatments of Postoperative Nausea and Vomiting (PONV) in Children |
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| Completed | 4 | 300 | Europe | Dexamethasone, Dexamethasone and droperidol, Dexamethasone and Ondansetron | Centre Hospitalier Universitaire Vaudois | Postoperative Nausea and Vomiting | 06/13 | 06/13 | | |
NCT01897337: The Effect of Combining Aprepitant With Ondansetron in High-risk Patients for Postoperative Nausea and Vomiting |
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| Completed | 4 | 125 | RoW | Aprepitant, Emend, placebo | Yonsei University | Postoperative Nausea and Vomiting | 06/13 | 06/13 | | |
NCT01837394: Ultrasound-guided Blocks for Ambulatory Knee Arthroscopy |
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| Completed | 4 | 60 | Europe | Block of the SN and ONP, Naropin, Placebo block, NaCl, Paracetamol, Acetaminophen, Morphine, Ondansetron, Zofran, Metoclopramide, Emperal, Primperan | Jens Borglum Neimann | Postoperative Pain, Postoperative Nausea and Vomiting, Postoperative Function Level | 06/13 | 09/13 | | |
| Completed | 4 | 75 | Europe | Xomolix 0.625 mg intravenously, Xomolix 1.25 mg, Zofran 8 mg | Medical University of Gdansk | Cardiac Repolarization | 07/13 | 07/13 | | |
NCT01896440: Heart Safety Study of Ondansetron in Children Receiving Chemotherapy |
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| Withdrawn | 4 | 0 | US | Ondansetron, Zofran | University of Oklahoma | Malignant Childhood Neoplasm | 10/13 | 10/13 | | |
NCT01876290: Dexamethasone and Ondansetron Versus Placebo for Postoperative Nausea and Vomiting |
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| Completed | 4 | 122 | Europe | Dexamethasone and Ondansetron, Placebo | Hopital Foch | Postoperative Nausea and Vomiting | 01/14 | 03/15 | | |
ChiCTR-IPR-15006629: Preventive effects of ondansetron on post-anesthesia shivering in children receiving general anesthesia with caudal block |
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| Completed | 4 | 59 | | ondansetron vs control | The Children's Hospital，Zhejiang University School of Medicine; The Children's Hospital, Zhejiang University School of Medicine, by self | POST-ANAESTHESIA SHIVERING | | | | |
ChiCTR-ORC-12002210: The Effects of Different Drugs on Isolated—Uterine Smooth Muscle in Pregnant Women |
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| Completed | 4 | 78 | | salt water ;Ondansetron ;Granisetron ;metoclopramide+oxytocin ;Hemabate ;Hemabate+oxytocin ;methergine ;methergine+oxytocin ;Dexmedetomidine ;Dexmedetomidine+oxytocin ;oxytocin ;tropisetron ;tropisetron | Department of Anesthesiology, West China Second University Hospital, Sichuan University; Level of the institution：, Self-financing | isolated—uterine smooth muscle in pregnant women | | | | |
NCT02110719: Decreasing Narcotics in Advanced Pelvic Surgery |
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| Completed | 4 | 138 | US | Celebrex, Gabapentin, IV acetaminophen, oral acetaminophen, oral ibuprofen, percocet, vicodin, Oxycodone, dilaudid, Dexamethasone, zofran | Hartford Hospital | Narcotic Use, Pain, Constipation, Nausea | 07/15 | 06/16 | | |
| Completed | 4 | 90 | RoW | Aprepitant, Emend | Instituto do Cancer do Estado de São Paulo | Postoperative Nausea and Vomiting | 08/15 | 08/15 | | |
2014-004621-40: The effect of oral ondansetron on referral rate in children aged 6 months to 6 years attending in primary care out of hours service with stomach flu and vomiting. |
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| Ongoing | 4 | 1064 | Europe | Ondansetron, RVG 31839, Coated tablet, Ondansetron | University Medical Center Groningen, University Medical Center Groningen, ZonMW | Gastroenteritis Gastro-enteritis, Stomach flu Buikgriep, Diseases [C] - Digestive System Diseases [C06] | | | | |
ChiCTR-TRC-14004777: Efficacy and safety of dexmedetomidine combined with sufentanil for patient - controlled intravenous analgesia after lower limb fracture surgery:a multicenter study |
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| Completed | 4 | 240 | | Sufentanil 2ug/kg + ondansetron 8mg diluted to 100ml of saline ;Sufentanil 3ug/kg+ ondansetron 8mg diluted to 100ml of saline ;Sufentanil 2ug/kg + dexmedetomidine 1.0ug/kg + ondansetron 8mg diluted to 100ml of saline ;Sufentanil 2ug/kg + dexmedetomidine 2.0ug/kg + ondansetron 8mg diluted to 100ml of saline | Second Affiliated Hospital of Anhui Medical University; Second Affiliated Hospital of Anhui Medical University, Research Fund | Patients with lower limb fracture | | | | |
2006-000526-31: Brush-evoked allodynia in patients with peripheral neuropathy before and following intravenous infusion of ondansetron. A randomised, double-blind, placebo controlled, cross-over study. |
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| Completed | 4 | 15 | Europe | ondansetron, Zofran, Zofran | Section of Clinical Pain Research, Department of Molecular Medicine and Surgery Karolinska Institute | Peripheral neuropathy | | 12/07 | | |
2008-004789-20: ” A comparative double-blind placebo-controlled study between alizapride and ondansetron for the prevention of postoperative nausea and vomiting.” |
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| Ongoing | 4 | 520 | Europe | Litican, Zofran, A03FA05, Litican, Zofran, Litican, Zofran | UZLEUVEN | Prevention of post-operative nausea and vomiting. | | | | |
ChiCTR-TRC-13003280: The study of the optimal dose and effects on maternal and fetal of ondansetron in the prevention of hypotension during spinal anesthesia |
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| Completed | 4 | 150 | | Five min prior to spinal anesthesia, patients were intravenously injected with 5 ml saline ;Five min prior to spinal anesthesia, patients were intravenously injected with2mg ondansetron (diluted in 5 ml physiological saline) ;Five min prior to spinal anesthesia, patients were intravenously injected with4mg ondansetron (diluted in 5 ml physiological saline) ;Five min prior to spinal anesthesia, patients were intravenously injected with6mg ondansetron (diluted in 5 ml physiological saline) ;Five min prior to spinal anesthesia, patients were intravenously injected with8mg ondansetron (diluted in 5 ml physiological saline) | Wuxi Maternity and Child Health Hospital; Wuxi Maternity and Child Health Hospital, Wuxi Municipal Health Bureau | hypotension during cesarean delivery | | | | |
NCT02327923: Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy |
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| Completed | 4 | 90 | RoW | Lidocaine, Lignocaine, Xylocaine, Esmolol, Paracetamol, Xylocaine, Propofol, Fentanyl, Vecuronium, Atropine, Ephedrine, Morphine, Ketorolac, Ondansetron, Bupivacaine, Tramadol, Neostigmine, Glycopyrrolate | B.P. Koirala Institute of Health Sciences | Gall Stone Disease | 02/16 | 04/16 | | |
PEGAZUS, NCT02441894: Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer |
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| Completed | 4 | 21 | Japan | CABAZITAXEL XRP6258, JEVTANA, PEG-G-CSF, G-LASTA, Prednisolone, Dexchlorpheniramine or Diphenhydramine, Ranitidine, Metoclopramide, Granisetron, or Ondansetron, Dexamethasone | Sanofi | Prostate Cancer | 02/16 | 11/16 | | |
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GALOFF, NCT02953210: Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia |
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| Unknown status | 4 | 40 | RoW | dexter ketamine, ketamine plus, Lidocaine Hydrochloride, xylocaine, Fentanyl Hydrochloride, Fentanil, Clonidine Hydrochloride, Catapres, Midazolam Hydrochloride, Isoflurane Volatile Liquid, isoflurane, Rocuronium Injectable Solution, rocuronium, Propofol 1 % Injectable Suspension, propofol, Dexamethasone-21-Sulfobenzoate, Sodium Salt, Ranitidine Hydrochloride, Ondansetron Hydrochloride, ondasetron, Ketorolac Injectable Solution, keterolac, Bupivacaine Hydrochloride, bupivacaine | Federal University of São Paulo, Faculdade de Ciências Médicas da Santa Casa de São Paulo | Pain, Postoperative, Anesthesia Complication, Nausea, Vomiting, Ileus Paralytic, Hemodynamic Instability | 11/16 | 03/17 | | |
OWEP, NCT01870635: Ondansetron Administration to WELL Children With Gastroenteritis Associated Vomiting in EDs in Pakistan |
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| Completed | 4 | 625 | RoW | Ondansetron, Zofran, Placebo, Sugar Pill | Dr. Stephen Freedman, Thrasher Research Fund, Bill and Melinda Gates Foundation, Aga Khan University | Dehydration, Gastroenteritis, Vomiting, Diarrhea | 01/17 | 02/17 | | |
2016-003582-25: The added effect of oral ondansetron to care-as-usual on persistingvomiting in children aged 6 months to 6 years, presenting at primary careout of hours service with stomach flu and concomitant vomiting |
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| Ongoing | 4 | 220 | Europe | Ondansetron, RVG 31839, Syrup, Ondansetron | University Medical Center Groningen, University Medical Center Groningen | Gastroenteritis Gastro-enteritis, Stomach flu Buikgriep, Diseases [C] - Digestive System Diseases [C06] | | | | |
ACTRN12613000806763: A randomized trial of sevoflurane versus desflurane on the quality of recovery following knee arthroscopy |
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| Completed | 4 | 300 | | | The University of Melbourne | recovery following knee arthroscopy | | | | |
PONV, NCT02468323: Prophylactic Antiemetic Efficacy of Palonosetron Versus Ondansetron for Cesarean Sections Under Regional Anesthesia |
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| Completed | 4 | 150 | RoW | Placebo, Saline, Ondansetron, Palonosetron | Hospital de Base | PONV | 02/17 | 02/17 | | |
| Terminated | 4 | 300 | US | Acupressure, Ondansetron, Zofran | University of California, Davis | Vomiting, Nausea | 04/17 | 12/18 | | |
| Unknown status | 4 | 323 | Canada | Dexamethasone, Ondansetron, Aprepitant, Decadron, Zofran, Emend, Arm A: Standard Anti-emetic regimen | Ottawa Hospital Research Institute | Emesis | 08/17 | 12/17 | | |
NCT02760069: Isopropyl Alcohol vs Ondansetron for Nausea in the Emergency Department |
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| Completed | 4 | 122 | US | Inhaled isopropyl alcohol, ISO, Oral ondansetron, Ondansetron, Inhaled normal saline, Inhaled placebo, Oral placebo, Oral sugar water | Brooke Army Medical Center | Nausea | 11/17 | 11/17 | | |
| Withdrawn | 4 | 0 | NA | IONSYS Patch, Patient Controlled Transdermal Fentanyl Patch | Hospital for Special Surgery, New York, The Medicines Company | Spinal Injury | 11/17 | 11/17 | | |
| Completed | 4 | 112 | US | multimodal:acetaminophen, gabapentin, ketamine, bupivacaine, placebo pills and injectables | University of Wisconsin, Madison | Pain | 12/17 | 12/17 | | |
OSEP, NCT01870648: Ondansetron Administration to Children With Gastroenteritis, Vomiting and SOME Dehydration in EDs in Pakistan |
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| Completed | 4 | 918 | RoW | Ondansetron, Zofran, Placebo, Sugar Pill | Dr. Stephen Freedman, Bill and Melinda Gates Foundation, Thrasher Research Fund, Aga Khan University | Dehydration, Gastroenteritis, Vomiting, Diarrhea | 12/17 | 12/17 | | |
EPhON, NCT03421860: Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia |
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| Completed | 4 | 120 | RoW | cardiac output changes with "ephedrine", cardiac output: CO (cm3 / min) = ITV * S * HR . ITV (cm) = integral time velocity is measured by pulsed doppler at the level of the ascending aorta, on apical cut., cardiac output changes with "phenylephrine", cardiac output: CO (cm3 / min) = ITV * S * HR. ITV (cm) = integral time velocity is measured by pulsed doppler at the level of the ascending aorta, on apical cut., cardiac output changes with "ondansetron", cardiac output changes with "nor-epinephrine" | University Tunis El Manar | Cardiac Output, Low | 02/18 | 03/18 | | |
NCT03152955: Postoperative Analgesia in Patients With Microvascular Decompression |
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| Unknown status | 4 | 90 | RoW | Ketamine, scalp nerve block, ondansetron, Sufentanil | Xiangya Hospital of Central South University | Trigeminal Neuralgia | 05/18 | 05/18 | | |
NCT02724033: Comparative Study of Superficial Cervical Plexus Block and Nerve of Arnold Block and Incidence of PONV for Inner Ear Surgery |
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| Terminated | 4 | 37 | US | regional nerve block, Bupivacaine, Antiemetic, Dexamethasone (Decadron), ondansetron (Zofran) | Indiana University | Anesthesia, Pediatrics, Surgery | 09/18 | 09/18 | | |
NCT03035942: Quality of Recovery After Dexamethasone, Ondansetron or Placebo Intrathecal Morphine Administration |
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| Completed | 4 | 135 | RoW | Dexamethasone, D Group, Ondansetron, O Group, Saline, Placebo Group | Pontificia Universidade Catolica de Sao Paulo | Fractures, Bone, Nausea and Vomiting, Postoperative, Pruritus, Morphine Adverse Reaction, Satisfaction, Personal | 10/18 | 11/19 | | |
NCT03297021: Effects of Ondansetron Dose and Timing on Post-operative Nausea and Vomiting |
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| Completed | 4 | 141 | US | Ondansetron 4 MG, Ondansetron 8mg | Icahn School of Medicine at Mount Sinai | Post-operative Nausea and Vomiting | 04/19 | 04/19 | | |
MOLID, NCT03833999: Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea |
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| Completed | 4 | 16 | Europe | Ondansetron 8mg, abdominal MRI, Lactulose, Placebo oral capsule | University of Nottingham | Motility Disorder of Intestine, Ondansetron, Small Bowel Water | 06/19 | 06/19 | | |
| Completed | 4 | 33 | Canada | Ondansetron 8mg, Zofran, Haloperidol 0.05mg/kg, Haldol, Haloperidol 0.1mg/kg | Dr. Marco L.A. Sivilotti | Cannabis Use Disorder | 06/19 | 07/19 | | |
NCT03862391: Does Low Flow Anesthesia Reduce Postanaesthetic Emergence Agitation? |
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| Completed | 4 | 60 | RoW | Analgesics, Antiemetics | Sakarya University | Agitated; State, Acute Reaction to Stress | 11/19 | 11/19 | | |
NCT02202369: Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study |
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| Suspended | 4 | 50 | US | Multimodal Analgesia Treatment, Standard of Care Pain Management Protocol | OrthoCarolina Research Institute, Inc., Charlotte Orthopedic Hospital | Single Level Lumbar Decompression and Fusion Spine Surgery | 02/20 | 12/50 | | |
ChiCTR2000029510: The effect of different time of administration ondansetron on the dose requirement of prophylactic phenylephrine for preventing spinal anesthesia induced in cesarean section |
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| Not yet recruiting | 4 | 75 | | 15 min before spinal injection ;5 min before spinal injection ;saline | Jiaxing University Affiliated Women and Children Hospital; Jiaxing University Affiliated Women and Children Hospital, None | hypotension | | | | |
ChiCTR1900026640: Safety and effectiveness of nalbuphine for postoperative analgesia in ERAS pathway of pancreaticoduodenectomy |
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| Not yet recruiting | 4 | 111 | | PCIA: sufentanil 0.05 mg/kg/h and ondansetron 12 mg diluted with saline to 150 ml ;PCIA: fufentanil 0.025 mg/kg/h, nalbuphine 0.025mg/kg/h and ondansetron 12 mg diluted with saline to 150 ml ;PCIA: nalbuphine 0.05mg/kg/h and ondansetron 12 mg diluted with saline to 150 ml | Lanzhou University; Lanzhou University, CHEN XIAN-PING FOUNDATION FOR THE DEVELOPMENT OF SCIENCE AND TECHENOLOGY OF HUBEI PROVINCE | pancreaticoduodenectomy | | | | |
NCT04576390: Palonosetron Versus Ondansetron for PONV Prevention in Patients Undergoing ERCP |
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| Not yet recruiting | 4 | 90 | NA | Ondansetron 4 mg, Zofran, Palonosetron 75 mcg, Aloxi | Theodor Bilharz Research Institute, Cairo University | Antiemetic, Postoperative Nausea and Vomiting | 04/21 | 05/21 | | |
NCT04870541: Nefopam Versus Ondansteron for Prevention of Post Spinal Shivering. |
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| Recruiting | 4 | 150 | RoW | Ondansetron 8mg, Nefopam Injectable Solution | Saint-Joseph University | Shivering, Adverse Effects in the Therapeutic Use of Anaesthetic | 06/21 | 12/21 | | |
ChiCTR2100042451: Effect of ondansetron on dose effect relationship and hemodynamics of norepinephrine in preventing hypotension after spinal anesthesia in cesarean section |
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| Recruiting | 4 | 80 | | 0.2mcg/kg/min of phenylephrine ;0.3mcg/min of phenylephrine ;0.4mcg/min of phenylephrine ;0.5mcg/min of phenylephrine | Jiaxing University Affiliated Women and Children Hospital; Jiaxing University Affiliated Women and Children Hospital, Supported by our hospital | cesarean section | | | | |
ACTRN12619001205123: Droperidol vs Ondansetron in Nausea Treatment in the Emergency Department (DONuT) |
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| Completed | 4 | 120 | | | A/Prof Gabriel T Lau, Port Macquarie Base Hospital | nausea | | | | |
ChiCTR2100042453: Effect of ondansetron on dose effect relationship and hemodynamics of norepinephrine in preventing hypotension after spinal anesthesia in cesarean section |
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| Recruiting | 4 | 80 | | 0.2mcg/kg/min of phenylephrine ;0.3mcg/kg/min of phenylephrine ;0.4 mcg/kg/min of phenylephrine ;0.5 mcg/kg/min of phenylephrine | Jiaxing University Affiliated Women and Children Hospital; Jiaxing University Affiliated Women and Children Hospital, Supported by our hospital | cesarean section | | | | |
| Unknown status | 4 | 312 | Europe | Methotrexate, Adalimumab, humira, Azathioprine / 6 Mercaptopurine, imurel / purinethol | PIBD-Net, European Commission | Crohn's Disease | 10/21 | 07/22 | | |
NCT04509258: Effectiveness of N-acetyl Cysteine, Acetyl L- Carnitine and Medicated Paraffin Oil in Aluminium Phosphide Poisoning |
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| Not yet recruiting | 4 | 100 | RoW | N-acetyl cysteine, acetyl L-carnitine, medicated paraffin oil, Sodium Bicarbonate Powder and ondansetron | Cairo University, Ain Shams University hospitals | the Study Focus to Improve the Standard of Care Used for Aluminuim Phosphide Poisoning and to Save Patients With the Minimal Organ Damage | 10/21 | 12/21 | | |
| Terminated | 4 | 57 | US | Guided mindfulness exercises, Self-administered aromatherapy, Baby aspirin, Tylenol/Acetaminophen, Pregabalin, Prednisone, Meloxicam, Prilosec, Tramadol, Voltaren, Zofran, Pepcid, Reglan, Versed, Lidocaine, Propofol, Ancef, Tranexamic Acid (TXA), Decadron, Bupivacaine hydrochloride, Toradol | Emory University | Anesthesia, Opioid Use | 12/21 | 12/21 | | |
NCT05221151: Melatonin vs Pregabalin for Anxiolysis and Sedation |
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| Completed | 4 | 78 | RoW | Melatonin, Pregabalin, Ondansetron 4 MG | Menoufia University | Anxiety | 05/22 | 10/22 | | |
NCT03239210: Effects of Ondansetron in Obsessive-compulsive and Tic Disorders |
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| Completed | 4 | 110 | US | Ondansetron, Zofran, Placebo | NYU Langone Health, National Institutes of Health (NIH) | Obsessive-Compulsive Disorder, Tic Disorders, Tourette Syndrome | 05/22 | 05/22 | | |
NCT05772676: The Effect of Aprepitant Reducing Postoperative Nausea and Vomiting |
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| Active, not recruiting | 4 | 400 | RoW | Aprepitant, Placebo | Hospital General Tlahuac | Obesity, Nausea and Vomiting, Postoperative | 01/23 | 04/23 | | |
NCT05458453: An Exploratory Study of Esketamine in Patients After Thoracoscopic Surgery |
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| Completed | 4 | 80 | RoW | Esketamine | The Second Affiliated Hospital of Chongqing Medical University | Esketamine, Thoracoscopic Surgery | 02/23 | 02/23 | | |
NCT04318847: Efficacy and Safety of the Administration of Ondansetron Versus Habitual Clinical Practice for the Treatment of Vomiting in Children With Mild and Moderate Dehydration: Randomized Clinical Trial |
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| Not yet recruiting | 4 | 220 | NA | Ondansetron 4 MG | Lizar Aguirre Pascasio | Vomiting in Infants and/or Children | 04/23 | 04/23 | | |
| Recruiting | 4 | 70 | RoW | Esketamine, patient controlled intravenous analgesia, Sufentanil | The Second Affiliated Hospital of Chongqing Medical University | Hepatocellular Carcinoma, Transarterial Chemoembolization, Hepatic Arterial Infusion Chemotherapy, Pain | 04/23 | 04/23 | | |
NCT05265507: Comparison of Postoperative Anti-nausea and Vomiting Effect Between Glycopyrronium and Ondansetron |
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| Recruiting | 4 | 480 | RoW | Glycopyrronium, Ondansetron | The Second Affiliated Hospital of Chongqing Medical University, Chongqing University Jiangjin Hospital, Chongqing Medical University, The People's Hospital of DAZU ，Chongqing, Xiangya Hospital of Central South University, West China Hospital, The People's Hospital of Tongliang District， Chongqing city, Chongqing Medical Center for Women and Children, Dianjiang People's Hospital of Chongqing, The Ninth People's Hospital of Chongqing, The People's Hospital of Yubei District of Chongqing city, Chongqing Yongchuan District People's Hospital, The First People's Hospital Of Chongqing Liang Jiang New Area, ChongGang General Hospital, The People's Hospital of Nanchuan, People's Hospital of Pengshui County, Yunyang people's Hospital, Chongqing Liangping District People's Hospital, Jiulongpo People's Hospital of chongqing, The People's Hospital of Qijiang District，Chongqing, University-Town Hospital of Chongqing Medical University, Chongqing Public Health Medical Center, CHONGQING BANAN HOSPITAL OF TCM | Postoperative Nausea and Vomiting | 05/23 | 05/23 | | |
NCT05006638: Assessing The Role Of Intravenous Lipid Emulsion As A Life Saving Therapy In Pesticides Toxicity |
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| Recruiting | 4 | 62 | RoW | Lipid Emulsion, Intravenous, Atropine, Toxogonin, Sodium Bicarbonate Powder and ondansetron | Aya Sabry Mohamed Mohamed | Pesticide Poisoning | 06/23 | 12/23 | | |
NCT05670561: Effects of Esketamine on Acute Abdominal Pain After TACE in Patients With Hepatocellular Carcinoma |
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| Recruiting | 4 | 60 | RoW | Esketamine, patient controlled intravenous analgesia, Sufentanil | The Second Affiliated Hospital of Chongqing Medical University | Hepatocellular Carcinoma, Transcatheter Arterial Chemoembolization, Pain | 06/23 | 07/23 | | |
ChiCTR2300070409: Clinical study of lidocaine combined with hydromorphone for hypopiate analgesia after VATS lobectomy: a randomized controlled study |
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| Not yet recruiting | 4 | 135 | | PCIA was used after surgery. The analgesic drug was formulated as hydromorphone 10mg+ Ondansetron 8mg+0.9% normal saline 100ml, background dose 2ml/h, single supplementary dose 2ml, locking time 15min. ;During anesthesia induction, lidocaine was injected 1mg/kg intravenously (slowly within 10 minutes), and then lidocaine was pumped 1.5mg/kg/h until the patient left the room. The postoperative analgesic was formulated as 2% lidocaine (5mg/Kg) + hydromorphone 8mg+ Ondansetron 8mg+0.9% normal saline 100ml, background dose 2ml/h, a single supplementary dose of 2ml, locking time 15min. ;During anesthesia induction, lidocaine was injected 1mg/kg intravenously (slowly within 10 minutes), and then lidocaine was pumped 1.5mg/kg/h until the patient left the room. The postoperative analgesic pump was formulated as 2% lidocaine (dosage calculated as 5mg/Kg) + hydromorphone 6mg+ Ondansetron 8mg +0.9% normal salin 100ml. | Tai 'an Central Hospital; Tai 'an Central Hospital, None | N/A | | | | |
ChiCTR2300072011: Comparison of Analgesic Effect and Inflammatory Factors of Dezocine and Esketamine after Laparoscopic Cholecystectomy |
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| Not yet recruiting | 4 | 58 | | 2ug/kg sufentanil, 1.5mg/kg esketamine, and 0.2mg/kg ondansetron are used for Patient-Controlled Intravenous Analgesia (PCIA), diluted to 100ml with normal saline, and the initial dose is 2ml, with a continuous infusion of 2ml/h and a bolus dose of 0.5ml. ;2ug/kg sufentanil, 0.3mg/kg dezocine, and 0.2mg/kg ondansetron are used for Patient-Controlled Intravenous Analgesia (PCIA), diluted to 100ml with normal saline, and the initial dose is 2ml, with a continuous infusion of 2ml/h and a bolus dose of 0.5ml. | Zigong Hospital of Traditional Chinese Medicine; Zigong Hospital of Traditional Chinese Medicine, none | Pain after laparoscopic cholecystectomy | | | | |
NCT04894864: Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair |
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| Recruiting | 4 | 40 | Europe | Opioid-Based Anesthesia-Analgesia Strategy, Opioid-Based Anesthesia, OBA-A, Opioid-free Anesthesia-Analgesia Strategy, Opioid-Free Anesthesia, OFA-A | University of Crete, University Hospital of Crete | Elective Surgical Procedures, Postoperative Pain, Anesthesia, Opioid Use, Abdominal Aortic Aneurysm Without Rupture, Vascular Surgical Procedure, Interleukin 6, Immunomodulators | 10/25 | 10/27 | | |
ChiCTR2200064860: Prevention and treatment of postpartum depression in cesarean delivery women with esketamine |
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| Recruiting | 4 | 250 | | 5 minutes after delivery, the fetus was given intravenous esticketamine 0.125mg/kg. Postoperative intravenous analgesia pump: butorphenol 0.125mg/kg+ ondansetron 8mg plus normal saline was configured to 100mL ;Esticketamine 0.125mg/kg was given intravenously 5 minutes after delivery. Postoperative analgesia pump: esticketamine 1mg/kg+ Butorphenol 0.125mg/kg+ ondansetron 8mg plus normal saline was configured to 100mL ;5 minutes after delivery, the fetus was given 0.25mg/kg esticketamine intravenously. Postoperative intravenous analgesia pump: butorphenol 0.125mg/kg+ ondansetron 8mg plus normal saline was configured to 100mL ;5 minutes after delivery, the fetus was given 0.25mg/kg esticketamine intravenously. Postoperative analgesia pump: esticketamine 1mg/kg+ butorphanol 0.125mg/kg+ ondansetron 8mg plus normal saline was configured to 100mL ;Esketamine is not used. Postoperative intravenous analgesic pump: Butorphanol 0.125mg/kg+ ondansetron 8mg + normal saline was configured to 100mL | Xi 'an International Medical Center Hospital; Xi 'an International Medical Center Hospital, Provincial Science and Technology Department + self-funded | Postpartum Depression | | | | |
NCT05439772: Examining the Effect of Ondansetron on Bowel Prep Success |
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| Completed | 4 | 41 | US | Ondansetron | State University of New York - Downstate Medical Center | Abdominal Pain, Inflammatory Bowel Diseases, Eosinophilic Gastroenteritis, Diarrhea, Hematochezia, Weight Loss | 07/23 | 07/23 | | |
NCT06225466: Muscle Relaxation for Pediatric Adenotonsillectomy |
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| Recruiting | 4 | 172 | US | Rocuronium, Neuromuscular blocking agent, Paralytic, Zemuron, Esmeron, Neuromuscular blocking drug, Nondepolarizing neuromuscular blocker, Nondepolarizing neuromuscular blocking agent, Nondepolarizing neuromuscular blocking drug, Sugammadex, Bridion, Neuromuscular blocking agent reversal, Neuromuscular blocking drug reversal, Paralytic reversal, Nondepolarizing neuromuscular blocking agent reversal, Nondepolarizing neuromuscular blocking drug reversal, Nondepolarizing neuromuscular blocker reversal, Anesthesia without neuromuscular blockade | University of Texas Southwestern Medical Center, Merck Sharp & Dohme LLC | Tonsillectomy | 05/25 | 08/25 | | |
| Recruiting | 4 | 60 | | Arepidtan injection+Ondansetron tablets ;Ondansetron tablets | Dandong First Hospital; Dandong First Hospital, Guangzhou Life Oasis Public Welfare Service Center | malignancy | | | | |
NCT03467750: Effect of Ketorolac on Post Adenotonsillectomy Pain |
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| Completed | 4 | 63 | US | Ketorolac, Toradol, Standard of Care, Sojourn, Ultane, Diprivan, Decadron, Precedex, Zofran, Morphine | Emory University | Obstructive Sleep Apnea | 08/23 | 08/23 | | |
ChiCTR2300075028: Aprepitant, the NK1 Antagonist, Versus Ondansetron for the Prevention of Postoperative Nausea and Vomiting After Minimally Invasive Wedge Resection (AKSO)----A Multicentric, Randomized-Controlled, Double-Blind, Prospective Clinical Trial |
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| Not yet recruiting | 4 | 964 | | One hour before anesthesia induction, intravenous bolus injection of 32mg Aprepitant, equivalent to 4.4ml of Aprepitant, mixed with 5.6ml of 0.9% Sodium Chloride Solution, for a total volume of 10ml injection. ;One hour before anesthesia induction, intravenous bolus injection of 4mg Ondansetron, equivalent to 2ml of Ondansetron, mixed with 8ml of 0.9% Sodium Chloride Solution, for a total volume of 10ml injection. | Shanghai Chest Hospital; Shanghai Chest Hospital, Qilu pharmaceutical co.,ltd. | Postoperative Nausea and Vomiting After Minimally Invasive Wedge Resection of the lung | | | | |
NCT04240626: Multimodal Analgesia Effect on Post Surgical Patient |
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| Recruiting | 4 | 60 | US | Neurontin, Gabapentin, Dilaudid Injectable Product, Hydromorphone, Marcaine Injectable Product, Oxycodone Hydrochloride, Hycet 7.5Mg-325Mg/15Ml Solution, Hydrocodone, Zofran Injection, Odanesetron, Scopolamine patch, Scopolamine, Ativan, Flexeril Oral Product, Cyclobenziparin, Tylenol Suspension, Acetaminophen | University of California, Davis | Obesity, Morbid, Surgery, Bariatric Surgery Candidate | 12/24 | 12/25 | | |
DDA-PONV, NCT05189756: Dual-dose Aprepitant to Reduce Postoperative Nausea and Vomiting After Laparoscopic Bariatric Surgery. |
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| Recruiting | 4 | 224 | Europe | Aprepitant 80 mg, Aprepitant Zentiva 80mg, Placebo, Placebo Capsules | University Hospital Inselspital, Berne | Postoperative Nausea and Vomiting, Bariatric Surgery | 03/25 | 04/25 | | |
NCT05172739: Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC |
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| Recruiting | 4 | 70 | Europe | Opioid-Based Anesthesia-Analgesia Strategy, Opioid-Based Anesthesia, OBA-A, Opioid-free Anesthesia-Analgesia Strategy, Opioid-Free Anesthesia, OFA-A | University of Crete | Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic, Infections Postoperative, Opioid Use, Anesthesia, Non-small Cell Lung Cancer | 11/25 | 11/26 | | |
NCT05844501: Ondansetron for the Management of Atrial Fibrillation |
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| Recruiting | 4 | 80 | US | Ondansetron 8mg, Placebo | Indiana University, American Heart Association, Purdue University | Atrial Fibrillation | 12/27 | 12/27 | | |
ACTRN12613000036718: the effect of ondansetron on hypotension due to spinal anesthesia for caesarean section. |
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| Completed | 3/4 | 80 | | | Tunisian Military Hospital, Tunisian Military Hospital | hypotension induced by spinal anesthesia for caeserean section | | | | |
