| ondansetron / Generic mfg. |
ACTRN12610000173099: Does gabapentin reduce itch in children with acute severe burns? A prospective randomised double blinded controlled study. |
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| Not yet recruiting | 3 | 90 | | | Children's Hospital at Westmead, Children's Hospital at Westmead | Pruritus, Acute burns in children | | | | |
| Not yet recruiting | 3 | 168 | | | University of New South Wales, Sydney, Australia., University of New South Wales | rlL-2 toxicity
, Interleukin-2 therapy, HIV | | | | |
ACTRN12610000151033: A randomized phase III trial with dose-dense sequential chemotherapy with epirubicin/paclitaxel/Cyclophosphamide-Methotrexate-Fluorouracil (CMF) vs epirubicin/CMF/docetaxel or paclitaxel as adjuvant chemotherapy in high-risk patients with operable breast cancer. |
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| Completed | 3 | 1000 | | | Hellenic Cooperative Oncology Group, Hellenic Cooperative Oncology Group | High risk breast cancer patients | | | | |
| Completed | 3 | 233 | US | hydrochlorothiazide, diet, potassium supplementation, diet, magnesium supplementation, triamterene, chlorthalidone | University of California, San Francisco, National Heart, Lung, and Blood Institute (NHLBI) | Cardiovascular Diseases, Death, Sudden, Cardiac, Heart Arrest, Heart Diseases, Hypertension | 09/89 | | | |
NCT00006348: Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment |
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| Completed | 3 | 100 | US | ondansetron, placebo | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI) | Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Nausea and Vomiting, Precancerous Condition, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific | 09/01 | 09/01 | | |
NCT00016380: Ondansetron With/Out Dexamethasone to Prevent Vomiting in Patients Receiving Radiation to the Upper Abdomen |
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| Completed | 3 | 211 | Canada | dexamethasone, ondansetron, quality-of-life assessment | NCIC Clinical Trials Group | Cancer | 04/04 | 02/09 | | |
NCT00642512: Dronabinol Versus Standard Ondansetron Antiemetic Therapy in Preventing Delayed-Onset Chemotherapy-Induced Nausea and Vomiting |
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| Completed | 3 | 64 | US | dronabinol, ondansetron, dronabinol/ondansetron, placebo | Solvay Pharmaceuticals | Chemotherapy Induced Nausea and Vomiting | 07/04 | 07/04 | | |
NCT00020657: Comparison of Antiemetic Drugs in Preventing Delayed Nausea After Chemotherapy in Patients With Cancer |
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| Completed | 3 | | US | dolasetron mesylate, granisetron hydrochloride, ondansetron, prochlorperazine, quality-of-life assessment | Gary Morrow, National Cancer Institute (NCI) | Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific | 10/04 | 10/04 | | |
| Completed | 3 | 482 | US, Canada, Europe, RoW | GW679769 (casopitant) | GlaxoSmithKline | Nausea and Vomiting, Postoperative | 07/06 | 07/06 | | |
| Completed | 3 | 515 | US, Canada, Europe, RoW | casopitant | GlaxoSmithKline | Nausea and Vomiting, Postoperative, Postoperative Nausea and Vomiting | 07/06 | 07/06 | | |
| Completed | 3 | 848 | NA | aprepitant, MK0869, Comparator: ondansetron, Zofran®, Comparator: dexamethasone, DEXAMETHASONE TABLETS USP, Comparator: fosaprepitant dimeglumine, EMEND®, Comparator; Placebo (unspecified) | Merck Sharp & Dohme LLC | Chemotherapy-Induced Nausea and Vomiting | 10/08 | 11/08 | | |
NCT00147355: Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy |
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| Terminated | 3 | 28 | RoW | ondansetron, ibuprofen, paracetamol, Ondansetron, ibuprofen, paracetamol, metoclopramide, ibuprofen, paracetamol, Metoclopramide, codeine phosphate, ibuprofen, paracetamol | Kirby Institute, The University of New South Wales | HIV Infections | 11/08 | 12/08 | | |
| Completed | 3 | 283 | US | Ondansetron + Cognitive Behavioral Therapy, Zofran, Placebo + Cognitive Behavioral Therapy, Sugar Pill | Bankole Johnson, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Dependence | 03/09 | 12/09 | | |
| Completed | 3 | 710 | US, Canada, Europe, RoW | Casopitant, Dexamethasone, Placebo, Ondansetron | GlaxoSmithKline | Nausea and Vomiting, Chemotherapy-Induced | 04/09 | 04/09 | | |
NCT00619359: Evaluation of Fosaprepitant (MK0517) in Single Dose Schedule (0517-017) |
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| Completed | 3 | 2322 | US | Comparator: fosaprepitant dimeglumine, Comparator: Aprepitant, Dexamethasone, Ondansetron | Merck Sharp & Dohme LLC | Chemotherapy-Induced Nausea and Vomiting (CINV) | 06/09 | 06/09 | | |
NCT00645138: Comparison of Paravertebral Block With General Anesthesia in Patients Undergoing Breast Cancer Surgery |
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| Completed | 3 | 40 | US | Paravertebral Block, General Anesthesia | Weill Medical College of Cornell University | Breast Cancer | 03/10 | 03/10 | | |
NCT01052844: Gabapentin in the Prevention of Nausea and Vomiting Induced by Chemotherapy |
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| Completed | 3 | 80 | RoW | Placebo, Gabapentin | Faculdade de Medicina do ABC | Vomiting, Cisplatin Adverse Reaction | 07/10 | 07/10 | | |
NCT00547989: Paravertebral Block, an Adjunct to General Anaesthesia for Breast Surgery? |
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| Completed | 3 | 46 | Europe | standard anaesthesia (bupivacaine), additional pvb (ropivacaine) and elastomeric disposable infusion pump, additional pvb (ropivacaine) | Maastricht University Medical Center | Breast Cancer | 12/10 | 05/11 | | |
NCT00971399: Ramosetron Versus Ondansetron for Radiotherapy Induced Nausea and Vomiting |
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| Completed | 3 | 172 | RoW | ramosetron, ondansetron | Seoul National University Hospital | Radiotherapy Induced Nausea and Vomiting | 02/11 | | | |
NCT01297010: Dexamethasone Compared to Ondansetron and Dexamethasone for Prophylaxis of Postoperative Vomiting in Children |
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| Completed | 3 | 134 | RoW | Dexamethasone and ondasetron, Decadron and nausedron, Dexamethasone, Decadron | Instituto Materno Infantil Prof. Fernando Figueira, Universidade Federal de Pernambuco | Vomiting Postoperative | 07/11 | 07/11 | | |
| Completed | 3 | 72 | Europe | paracetamol /droperidol, paracetamol / ondansetron | University Hospital, Limoges | Pain | 06/12 | 06/12 | | |
| Completed | 3 | 300 | US | Ondansetron 4 ug/kg b.i.d. + Cognitive Behavioral Therapy, Zofran, Naltrexone 50 mg/day + Cognitive Behavioral Therapy, Revia, Ondansetron 4 ug/kg b.i.d.+ Naltrexone 50 mg/day + Cognitive Behavioral Therapy, Zofran and Revia, Placebo + Cognitive Behavioral Therapy, sugar pill | Bankole Johnson, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcoholism | 12/12 | 12/12 | | |
| Completed | 3 | 307 | NA | Aprepitant 125 mg, MK-0869, Emend®, Aprepitant 80 mg, Aprepitant powder for suspension (PFS), Ondansetron, Zofran™, Placebo for Aprepitant 125 mg, Placebo for Aprepitant 80 mg, Placebo for Aprepitant PFS, Emetogenic chemotherapy | Merck Sharp & Dohme LLC | Chemotherapy Induced Nausea and Vomiting | 03/13 | 08/13 | | |
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NCT01402024: Study to Evaluate Anti-emetic Effect of Aprepitant Versus Placebo in Children and Adolescent Receiving Chemotherapy |
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| Completed | 3 | 96 | RoW | Aprepitant, Empov, Placebo, Empov placebo capsules | All India Institute of Medical Sciences, New Delhi, Dr. Reddy's Laboratories Limited | Chemotherapy Induced Nausea and Vomiting | 06/13 | 06/13 | | |
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| Completed | 3 | 356 | Europe | Ondansetron, zofran, Domperidone, Motilium, placebo | IRCCS Burlo Garofolo, Mario Negri Institute for Pharmacological Research, Agenzia Italiana del Farmaco | Gastroenteritis, Vomiting, Acute Gastroenteritis | 11/13 | 11/13 | | |
| Terminated | 3 | 20 | Europe | Ondansetron, Ondansetron hydrochloride dihydrate | Assistance Publique - Hôpitaux de Paris | Vomiting, Gastroenteritis | 10/14 | 10/14 | | |
MK-0517-031, NCT01594749: Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting |
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| Completed | 3 | 1015 | NA | Fosaprepitant dimeglumine, EMEND for Injection, MK-0517, Fosaprepitant Placebo, Dexamethasone, Decadron, Ondansetron, Zofran, Dexamethasone Placebo, Ondansetron Placebo, Rescue Therapy | Merck Sharp & Dohme LLC | Chemotherapy-Induced Nausea and Vomiting (CINV) | 11/14 | 11/14 | | |
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2014-001580-12: Efficacité de l'Ondansétron sur la diminution des hypotensions artérielles induites par la rachianesthésie pour césarienne. |
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| Not yet recruiting | 3 | 126 | Europe | ONDANSETRON, Solution for injection, ONDANSETRON | CHU de DIJON | Césarienne sous rachianesthésie, césarienne sous rachianesthésie, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
NCT02116530: Antiemetic Therapy With or Without Olanzapine in Preventing Chemotherapy-Induced Nausea and Vomiting in Patients With Cancer Receiving Highly Emetogenic Chemotherapy |
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| Completed | 3 | 401 | US | Olanzapine, Chemotherapy (cisplatin or cyclophosphamide and doxorubicin), Antiemetic treatment (ondansetron or granisetron or palonosetron; plus dexamethasone; plus fosaprepitant or aprepitant), Placebo | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI) | Hematopoietic/Lymphoid Cancer, Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific | 04/15 | 11/15 | | |
NCT02106494: A Prospective, Multicenter, Study of APF530 (Granisetron) SC for Prevention of CINV in Patients Receiving HEC |
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| Completed | 3 | 942 | US | APF530, Ondansetron, Ondansetron placebo, APF530 placebo, Fosaprepitant, Dexamethasone | Heron Therapeutics | Chemotherapy-induced Nausea and Vomiting | 05/15 | 05/15 | | |
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2013-000905-22: à compléter ETUDE DE L’EFFET DU DROPERIDOL ET DE L’ONDANSETRON SUR L’INCIDENCE DE L’AKATHISIE POST OPERATOIRE EN CHIRURGIE GYNECOLOGIQUE AMBULATOIRE |
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| Not yet recruiting | 3 | 300 | Europe | droperidol, ondansetron, Solution for injection | Hôpitaux Universitaires de Strasbourg, Ministère de la Santé | akathisia akathisie, unpleasant sensations of inner restlessness impossibilité de s'asseoir ou de rester dans la position assise, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT01942343: Akathisia in Post Operative Outpatients Surgery |
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| Completed | 3 | 300 | Europe | Droperidol 1,25 mg administration, Droperidol 0,625 mg administration, Odansetron 4 mg administration | University Hospital, Strasbourg, France | Akathisia | 10/15 | 10/15 | | |
2006-001761-42: A Randomized, Double-Blind, Active Comparator-Controlled, Parallel-Group StudyConducted Under In-House Blinding Conditions, to Examine the Safety, Tolerability, and Efficacy of Aprepitant for the Prevention of Postoperative Nausea and Vomiting (PONV) |
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| | 3 | 40 | Europe | EMEND, ZOFRAN, MK-0869, ZOFRAN, ZOFRAN | Merck & Co., Inc, Merck Sharp & Dohme GesmbH | Postoperative Nausea and Vomiting | | 04/06 | | |
2007-002819-99: L’administration d’ondansetron dans le cadre d’une prophylaxie des nausées et vomissements postopératoires réduirait-il l’effet analgésique du paracétamol ? |
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| Ongoing | 3 | 50 | Europe | ZOPHREN, ZOPHREN | Centre Hospitalier Universitaire de Nancy | analgésieBut de l\'étude : évaluer cliniquement l’action inhibitrice de l’ondansetron administré en prophylaxie des nausées et vomissements postopératoires sur l’effet analgésique du paracétamol en postopératoire. | | | | |
2007-004043-30: A Phase III, Randomized, Double-Blind, Active-Controlled,Parallel-Group Study, Conducted Under In-House Blinding Conditions,to Examine the Safety, Tolerability, and Efficacy of aSingle Dose of Intravenous MK-0517 for the Prevention ofChemotherapy-Induced Nausea and Vomiting (CINV) AssociatedWith Cisplatin Chemotherapy |
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| | 3 | 120 | Europe | Fosaprepitant dimeglumine, EMEND aprepitant 125mg, EMEND aprepitant 80mg, ondansetron HCl, Dexamethasone, MK-0517, MK-0869, EMEND, Dexamethasone, EMEND, Dexamethasone | Merck Sharp & Dohme (Sweden) AB, Merck Sharp & Dohme de España, S.A., MERCK SHARP DOHME, Merck & Co., Inc., Merck Sharp and Dohme de España, S.A., Merck Sharp & Dohme BV | Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) Associated with Cisplatin Chemotherapy. | | 12/08 | | |
2012-001718-41: Examine the Efficacy and Safety of a Single Dose of Intravenous MK-0517 |
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| | 3 | 50 | Europe, RoW | IVEMEND, Zofran, Dexamethasone, MK-0517, IVEMEND, Zofran, Dexamethasone, IVEMEND, Zofran, Dexamethasone | Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc | chemotherapy induced nausea and vomiting | | 11/14 | | |
NCT04140058: Hemodynamic Protection of Preoperative Ondansetron 15 Minutes Before Spinal Anaesthesia in Caesarean Section |
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| Completed | 3 | 151 | RoW | Ondansetron, Normal saline | University of Jordan | Hypotension, Nausea, Vomiting | 01/17 | 01/17 | | |
| Completed | 3 | 19 | US | Ondansetron, dexamethasone, aprepitant, Aprepitant = Emend, ARM A, Ondansetron, Dexamethasone, placebo, ARM B | University of Oklahoma | Nausea, Vomiting, Childhood Cancer | 06/17 | 06/17 | | |
FOND-O, NCT02635984: Study of FOND Versus FOND+O for the Prevention of CINV in Hematology Patients Receiving Highly Emetogenic Chemotherapy Regimens |
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| Completed | 3 | 108 | US | Olanzapine, Zyprexa, Placebo | Augusta University, University of Georgia | Complications of Bone Marrow Transplant, Hematologic Neoplasms | 12/17 | 12/17 | | |
NCT02979548: Study to Evaluate the Effect of Aprepitant in Children and Adolescents Receiving AML Remission Induction Chemotherapy |
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| Unknown status | 3 | 116 | RoW | Aprepitant, Apretero, Ondansetron, Zofer, Emset, Metoclopramide, Reglan | Dr Atul Sharma | Chemotherapy Induced Vomiting, Acute Myeloid Leukemia | 06/18 | 12/18 | | |
NCT01121042: Double Blind, Placebo-Controlled, Randomised Investigation of Ondansetron in Schizophrenia |
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| Completed | 3 | 85 | RoW | Ondansetron, Placebo | Bayside Health | Schizoaffective and Schizophreniform Disorders, Schizophrenia | 08/18 | 08/18 | | |
ACTRN12616001213437: Ondansetron to reduce vomiting in children receiving intranasal fentanyl and inhaled nitrous oxide for procedural sedation: a double blind, randomised placebo controlled trial |
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| Completed | 3 | 442 | | | Murdoch Children’s Research Institute, Murdoch Children’s Research Institute | vomiting, sedation | | | | |
NCT03219710: "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)" |
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| Completed | 3 | 240 | RoW | Ondansetron, Dexamethasone, Aprepitant, Olanzapine | All India Institute of Medical Sciences, New Delhi | Chemotherapy-induced Nausea and Vomiting | 07/19 | 07/19 | | |
NCT03022240: Neurobiological and Cognitive Changes Following Exposure to Either Sevoflurane- or Propofol-based Anesthesia in Children |
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| Completed | 3 | 50 | Canada | Propofol, Sevoflurane, Ametop, Ondansetron | University of Calgary | Cognitive Change, Behavior | 09/19 | 09/19 | | |
2016-002601-19: ondansetron for dehydratation in children ondansetron para el tratamiento de la deshidratacion en niños |
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| Not yet recruiting | 3 | 220 | Europe | Tablet, Ondansetron Normon | Basque Health Service, Basque Health Service | Vomiting Vómitos, Vomiting Vómitos, Diseases [C] - Digestive System Diseases [C06] | | | | |
NCT02987985: Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy |
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| Completed | 3 | 50 | Canada | Acetaminophen, gabapentin, Opioid-free preoperative medications, Acetaminophen, Opioid-sparing preoperative medications, Ketamine , Lidocaine , Dexmedetomidine, Opioid-free pre-intubation medications, Fentanyl, Dexmedetomidine, Opioid sparing pre-intubation medications, Dexamethasone , Ondansetron, Postoperative nausea and vomiting prophylaxis, Sevoflurane, Opioid-free maintenance medication, Sevoflurane, Fentanyl, Opioid-sparing maintenance medications | University of Saskatchewan | Anesthesia, General Anesthesia, Analgesics, Opioid, Postoperative Complications, Pathologic Processes, Physiologic Effects of Drugs, Narcotics, Analgesics, Sleep Disordered Breathing, Obstructive Sleep Apnea of Child, Tonsillectomy, Respiratory Depression, Dexmedetomidine, Ketamine, Lidocaine, Gabapentin, Pulse Oximetry | 09/19 | 12/20 | | |
NCT01536392: Oral Ondansetron Versus Transdermal Granisetron (Sancuso) for Women With Cervical, Endometrial or Vaginal Cancer Receiving Pelvic Chemoradiation |
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| Completed | 3 | 76 | US | Granisetron, Ondansetron, Zofran, Questionnaires, Surveys, Study Drug Diary | M.D. Anderson Cancer Center, Sancuso | Cancer of the Cervix | 10/19 | 10/19 | | |
NCT02861859: Individualised Versus Standard Care for Breast Cancer Patients at High-risk for Chemotherapy-induced Nausea and Vomiting The ILIAD Study |
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| Completed | 3 | 221 | Canada | Olanzapine, Mylan-Olanzapine, Olanzapine Placebo | Ottawa Hospital Research Institute | Breast Cancer | 12/19 | 12/19 | | |
| Completed | 3 | 30 | Canada | Zyprexa® (OLANZapine 5MG), Zyprexa®, Emend® (Aprepitant), Emend® | CR-CSSS Champlain-Charles-Le Moyne | Chemotherapy-induced Nausea and Vomiting | 12/19 | 12/19 | | |
2017-001651-31: What improves the symptoms of nausea and vomiting in pregnancy better alongside IV rehydration: ondansetron vs placebo or metoclopramide vs placebo? |
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| Not yet recruiting | 3 | 600 | Europe | Metoclopramide MCP-ratiopharm® SF 10 mg / 2 ml injection solution, Metoclopramide 10mg Tablets, Ondansetron 2mg/ml Solution for injection, Ondansetron 4mg Film-Coated Tablets, Solution for injection, Tablet, Metoclopramide MCP-ratiopharm® SF 10 mg / 2 ml injection solution, Metoclopramide 10mg Tablets, Ondansetron 2mg/ml Solution for injection, Ondansetron 4mg Film-Coated Tablets | Newcastle upon Tyne Hospitals NHS Foundation Trust, NIHR: HTA | Nausea and Vomiting in pregnancyHyperemesis gravidarum, Severe nausea and vomiting in pregnancy., Body processes [G] - Reproductive physiologi cal processes [G08] | | | | |
TRITON, NCT03555188: TReatment of Irritable Bowel Syndrome With Diarrhoea Using Titrated ONdansetron Trial |
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| Completed | 3 | 80 | Europe | Ondansetron | University of Leeds, Barnsley Hospital NHS Foundation Trust, Barts & The London NHS Trust, County Durham and Darlington NHS Foundation Trust, Flinders University, The Leeds Teaching Hospitals NHS Trust, London North West Healthcare NHS Trust, NHS Lothian, Queen Mary University of London, Sandwell & West Birmingham Hospitals NHS Trust, Sheffield Teaching Hospitals NHS Foundation Trust, University College London Hospitals, University Hospitals of North Midlands NHS Trust, Manchester University NHS Foundation Trust, University of Manchester, National Institute for Health Research, United Kingdom | IBS - Irritable Bowel Syndrome | 08/20 | 09/20 | | |
2017-000533-31: Ondansetron for the treatment of IBS with diarrhoea: predicting the responder. |
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| Not yet recruiting | 3 | 400 | Europe | Ondansetron, Capsule | Nottingham University Hospitals NHS Trust, NIHR - Efficacy and Mechanism Evaluation Programme | Irritable Bowel Syndrome with Diarrhoea, Irritable Bowel Syndrome with Diarrhoea, Diseases [C] - Digestive System Diseases [C06] | | | | |
NCT03079219: Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Chinese Breast Cancer Patients |
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| Completed | 3 | 120 | RoW | Experimental drug: Aprepitant, Experimental drug: Ondansetron, Experimental drug: Dexamethasone, Experimental drug: Olanzapine, Standard: Aprepitant, Standard: Ondansetron, Standard: Dexamethasone | CCTU | Breast Cancer | 03/21 | 03/21 | | |
A221602, NCT03578081: Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy |
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| Completed | 3 | 690 | US, RoW | Palonosetron Hydrochloride, Ondansetron Hydrochloride, Dexamethasone, Fosaprepitant Dimeglumine, Olanzapine, Placebo | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI) | Malignant Neoplasm | 11/21 | 05/23 | | |
COMBINE, NCT02772965: Low Dose Oral Methotrexate in Pediatric Crohn's Disease Patients Initiating Anti-Tumor Necrosis Factor (Anti-TNF) Therapy |
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| Completed | 3 | 306 | US | Methotrexate, Methotrexate Sodium, Sugar pill (placebo) | University of North Carolina, Chapel Hill, Patient-Centered Outcomes Research Institute, ImproveCareNow (ICN), The Leona M. and Harry B. Helmsley Charitable Trust, Children's Hospital Medical Center, Cincinnati, Grifols Diagnostics Solutions, Inc, National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Pediatric Crohn's Disease | 04/22 | 04/22 | | |
| Enrolling by invitation | 3 | 160 | US | Total Shoulder Arthroplasty, Caffeine Pill, Percocet 10Mg-325Mg Tablet, Zofran 4Mg Tablet | Rothman Institute Orthopaedics | Caffeine, Pain, Joint | 04/22 | 04/22 | | |
NCT03931863: The Effect of Ondansetron on Spinal Anesthesia in Caesarean Section |
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| Recruiting | 3 | 180 | Europe | Ondansetron 4mg, Onda, Ondansetron 8mg, 100ml normal saline 0.9 percent, N/S 0.9 percent | Aretaieion University Hospital, University of Athens | Hypotension | 05/22 | 05/22 | | |
| Completed | 3 | 557 | RoW | Olanzapine+NK-1 RA+5-HT3 RA, Dexamethasone+NK-1 RA+5-HT3 RA, Acidocont, Deronil, Dexacortal, Desameton, Fluprednisolone, (11β，16α）-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione | Fifth Affiliated Hospital, Sun Yat-Sen University | Chemotherapy-induced Nausea and Vomiting | 05/22 | 07/22 | | |
Neo-AEGIS, NCT01726452: NEOadjuvant Trial in Adenocarcinoma of the oEsophagus and oesophagoGastric Junction International Study |
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| Completed | 3 | 377 | Europe | Epirubicin, Cisplatin / Oxaliplatin, 5 Flourouracil/ Capecitabine, (41.4 Gy/23 fractions), Paclitaxel, Carboplatin, Docetaxel, Oxaliplatin, Leucovorin, 5-Fluorouracil | Cancer Trials Ireland, Southampton Clinical Trials Unit, Region H Rigshospitalet, Centre Hospitalier Régional, Universitaire de Lille | Adenocarcinoma of the Oesophagus, Adenocarcinoma of the Oesophago-gastric Junction, Oesophageal Tumours, Junctional Tumours, Oesophageal Cancer | 08/22 | 08/22 | | |
NCT05099055: Dexmedetomine as Adjuvant for Spinal Anesthesia in Elective Cesarian Sections : a Pilot Study |
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| Completed | 3 | 42 | Canada | Dexmedetomidine 0.004 MG/ML [Precedex], Opioids | St. Justine's Hospital | Analgesia, Analgesics, Opioid, Anesthesia, Obstetrical, Anesthesia, Spinal, Analgesics, Non-Narcotic, Dexmedetomidine, Analgesia, Obstetrical | 01/23 | 05/23 | | |
BBPVOMSBAFH, NCT05586763: Comparison of Efficacy of Metoclopramide , Promethazine and Prochloroperazine in the Treatment of Vertigo. |
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| Recruiting | 3 | 90 | RoW | Metoclopramid ( 10mg), IM promethazine (25mg) , IM prochloroperazine( 12.5mg), Metoclopramid ( 10mg), IM phenergan (25mg) , IM stemetil( 12.5mg) | Oman Medical Speciality Board | Peripheral Vertigo | 02/23 | 08/23 | | |
RUMBLE, NCT04144933: Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery |
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| Recruiting | 3 | 60 | Canada | Acetaminophen, Gabapentin, Opioid-free preoperative medications, Opioid-containing preoperative medications, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Opioid-free pre-intubation medications, Dexamethasone, Ondansetron, Postoperative nausea and vomiting prophylaxis, Sevoflurane, Lidocaine 2% Injectable Solution, Ketamine, Dexmedetomidine, Magnesium Sulfate, Opioid-free maintenance medications, Lidocaine 1% Injectable Solution, Sufentanil, Opioid-containing pre-intubation medications, Sevoflurane, Sufentanil, Opioid-containing maintenance medications | University of Saskatchewan | Anesthesia, General Anesthesia, Analgesics, Opioid, Opioid Free Anesthesia, Postoperative Ileus, Colorectal Surgery, Laparoscopic Surgery, Analgesia, Dexmedetomidine, Lidocaine, Ketamine | 07/24 | 08/24 | | |
| Recruiting | 3 | 72 | US | Granisetron, Kytril, Ondansetron, Zofran, Palonosetron, Aloxi | University of Colorado, Denver, Memorial Sloan Kettering Cancer Center, Rutgers University, National Institute of General Medical Sciences (NIGMS) | Nephrotoxicity | 09/25 | 12/26 | | |
NCT05021263: Does IV Magnesium Improve Quality of Recovery With ERAS Protocols in Laparoscopic Colorectal Surgery? |
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| Completed | 3 | 90 | US | IV Medications, placebo | Thomas Jefferson University | Colo-rectal Cancer, Anesthesia | 12/23 | 12/23 | | |
| Recruiting | 3 | 56 | Canada | Ketamine, Ketamine hydrochloride, 0.9% Saline, Normal saline | University Health Network, Toronto, The Canadian Pain Society, Pfizer | Chronic Daily Headache | 10/23 | 02/24 | | |
NCT05876585: Clinical Trial to Investigate the Efficacy and Safety of Ondansetron (Danset - Adwia) Versus Placebo Plus the Standard of Care in the Treatment of Nausea and Vomiting in Adult Patients With Acute Gastroenteritis |
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| Not yet recruiting | 3 | 126 | NA | Ondansetron 8 mg ampoule, Danset ampoule, Metoclopramide 10 mg ampoule, Primperan | Genuine Research Center, Egypt, Adwia Pharma, Egypt | Gastroenteritis | 06/25 | 06/25 | | |
NCT06282211: the Efficacy and Safety of Ondansetron Oral Soluble Pellicles |
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| Recruiting | 3 | 184 | RoW | Ondansetron Oral Soluble Pellicles, Aiqisu | The First Affiliated Hospital of Xinxiang Medical College | Nausea and Vomiting | 03/24 | 12/24 | | |
NCT04503668: Olanzapine for the Prevention of Chemotherapy Induced Nausea and Vomiting in Gynecologic Oncology Patients |
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| Terminated | 3 | 62 | US | Ondansetron, Dexamethasone, Neurokinin-1 Receptor Antagonist (NK1-RA), Fosaprepitant, Olanzapine, Zyprexa, Compazine | University of Michigan Rogel Cancer Center | Gynecologic Cancer | 01/24 | 03/24 | | |
OZONE-V, NCT05346731: Low Dose Olanzapine to the Prophylaxis of Nausea and Vomiting Induced by Chemotherapy in Children and Adolescents |
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| Recruiting | 3 | 210 | RoW | Ondansetron, Dexamethasone, Aprepitant, Olanzapine | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | Chemotherapy-induced Nausea and Vomiting | 03/24 | 08/24 | | |
| Recruiting | 3 | 1030 | Canada | Ondansetron Oral Solution, Zofran, Oral Placebo | University of Calgary, Canadian Institutes of Health Research (CIHR), Women and Children's Health Research Institute (WCHRI), The Hospital for Sick Children, Children's Hospital Research Institute of Manitoba, University of Manitoba, Université de Montréal, University of Ottawa, University of Alberta, Alberta Children's Hospital Research Institute, Western University, Canada | Acute Gastroenteritis, Viral Illness, Vomiting, Diarrhea | 06/24 | 06/24 | | |
NCT06478667: The Role of Levosimendan as Inotropic Agent in Acute Aluminum Phosphide-induced Cardiotoxicity |
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| Recruiting | 3 | 50 | RoW | levosemindan, dobutamine | Ain Shams University | Acute Cardiotoxicity | 12/24 | 01/25 | | |
NCT04606264: Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data |
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| Recruiting | 3 | 2500 | US | Neuraxial Analgesia, Intrathecal morphine/hydromorphone, IT morphine/hydromorphine, Regional Block 1: Paravertebral, Nerve Block, Perphenazine, Aprepitant, Dimenhydrinate, Ondansetron 4 MG, Dexamethasone, Regional Block 2: QL1 | Jennifer Holder-Murray, Berry Consultants | Perioperative Optimization | 12/24 | 12/25 | | |
NCT05872893: Continuous Infusion of First-Generation 5-HT3 Receptor Antagonists in Combination With Dexamethasone |
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| Recruiting | 3 | 40 | RoW | Ondansetron, Dexamethasone | Immune Oncology Research Institute | Pediatric Cancer | 01/25 | 01/25 | | |
POST 9, NCT05657925: Study of Ondansetron in the Prevention of Sleep Syncope: The Nineth Prevention of Syncope Trial (POST9) |
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| Not yet recruiting | 3 | 24 | Canada | ondansetron 8 mg, Matching placebo | University of Calgary | Sleep Syncope | 12/26 | 12/27 | | |
2022-002947-23: A study of intravenous amisulpride as prevention of post-operative nausea and vomiting in children |
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| Not yet recruiting | 2/3 | 410 | Europe | Amisulpride, ondansetron, APD421, Solution for injection | Acacia Pharma Ltd, Acacia Pharma Ltd | post-operative nausea and vomiting in pediatric patients, sickness after an operation in children, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
| Withdrawn | 2/3 | 256 | US | Ondansetron + Brief Behavioral Enhancement Treatment, Zofran, Placebo + Brief Behavioral Enhancement Treatment, Sugar Pill | University of Virginia, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcoholism | 12/17 | 02/18 | | |
| Unknown status | 2/3 | 120 | NA | Normal saline, placebo, Ondansetron 4 MG, low ondansetron, Ondansetron 8mg, high ondansetron | Assiut University | Shivering, Ondansetron | 08/18 | 09/18 | | |
2019-003220-21: Management of diarrhoea in ulcerative colitis: multi-arm multi stage trial of low FODMAP diet, amitriptyline, ondansetron, or loperamide: MODULATE. |
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| Not yet recruiting | 2/3 | 491 | Europe | Amitriptyline, Ondansetron, Loperamide, Film-coated tablet, , Amitriptyline | University of Leeds, NIHR - Health Technology Assessment (HTA) Programme | Diarrhoea in patients with stable ulcerative colitis., Diarrhoea in patients with stable ulcerative colitis ., Diseases [C] - Digestive System Diseases [C06] | | | | |
NCT03052361: Triage Administration of Ondansetron for Gastroenteritis in Children |
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| Terminated | 2/3 | 81 | Canada | Ondansetron, Zofran, Placebos | St. Justine's Hospital | Gastroenteritis | 09/20 | 10/20 | | |
NCT03367988: Opioid Free Anesthesia vs. Opioid Anesthesia Techniques. |
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| Recruiting | 2/3 | 100 | US | Opioid Anesthesia, Opioid-free Anesthesia | University of South Florida | Analgesic Drug Dependence, Colectomy | 01/23 | 08/23 | | |
NCT05504265: Perioperative Analgesia Modes in Minimally Invasive Esophagectomy |
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| Not yet recruiting | 2/3 | 102 | RoW | Preemptive flurbiprofen axetil, Postoperative flurbiprofen axetil, Patient-controlled analgesia pump | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Esophageal Cancer, Perioperative Analgesia, NSAIDs, Opioid, Patient-controlled Analgesia | 05/23 | 05/23 | | |
NCT06390787: The Efficacy of B6 and Metoclopramide Combination in Comparison With the Other Antiemetics |
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| Completed | 2/3 | 250 | RoW | Metoclopramide and Vitamin B6, Vitamin B6 and Metoclopramide combination, Vitamin B6, Pyridoxine, Ondansetron, Zofran, Metoclopramide, Plasil | University of Baghdad | Vomiting | 04/24 | 04/24 | | |
NCT06046105: Efficacy of Adding Dexmedetomidine Versus Ibuprofen as an Adjuvant to Intraperitoneal Bupivacaine for Pain Control After Laparoscopic Gynecological Procedures |
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| Not yet recruiting | 2/3 | 180 | NA | Administering intraperitoneal bupivacaine for pain control after laparoscopic gynecological procedures, Administering intraperitoneal bupivacaine plus Dexmedetomidine for pain control after laparoscopic gynecological procedures, Administering intraperitoneal bupivacaine plus Ibuprofen for pain control after laparoscopic gynecological procedures | Ain Shams University | Postoperative Pain, Acute | 03/24 | 03/24 | | |
NCT05418244: Inhaled Isopropyl Alcohol for Treatment of Nausea |
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| Recruiting | 2/3 | 84 | US | Inhaled Isopropyl Alcohol, Webcol, Oral Ondansetron, Zofran, Inhaled Placebo, Inhaled Normal Saline' | State University of New York at Buffalo | Vomiting, Nausea, Children, Only | 06/24 | 06/24 | | |
