Central Nervous System Diseases  >>  Activase (alteplase)  >>  Phase 3
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5 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
NCT00147316: Japan Alteplase Clinical Trial (J-ACT): Efficacy and Safety Study of Tissue Plasminogen Activator (Alteplase) for Ischemic Stroke

Completed
3
103
Japan
Alteplase
Mitsubishi Tanabe Pharma Corporation, Kyowa Hakko Kogyo Co., Ltd.
Cerebral Infarction, Brain Ischemia
 
09/03
NCT00153036 / 2005-003176-38: Rt-PA in the Treatment of Acute Ischemic Stroke

Completed
3
821
Europe
rt-PA 0.9 mg/kg verum or placebo Intravenous
Boehringer Ingelheim
Cerebrovascular Accident
02/08
 
CERE-LYSE-1, NCT00840671 / 2004-001729-11: Combined Treatment With Alteplase (Rt-PA) and Cerebrolysin® in Acute Ischemic Hemispheric Stroke

Completed
3
119
Europe, RoW
Cerebrolysin, 0.9% Saline Solution, NaCl
Ever Neuro Pharma GmbH, JSW-Research Forschungslabor GmbH, Parkring 12, 8074 Grambach
Stroke
03/08
07/08
CLEAR III, NCT00784134 / 2008-006916-39: Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III

Completed
3
500
Canada, US, Europe, RoW
Alteplase, Cathflo Activase, rt-PA, Normal saline
Johns Hopkins University, National Institute of Neurological Disorders and Stroke (NINDS), Genentech, Inc., Emissary International LLC
Intraventricular Hemorrhage
07/15
01/16
PRISMS, NCT02072226: A Study of the Efficacy and Safety of Alteplase in Participants With Mild Stroke

Terminated
3
313
US
Alteplase, Activase; RO5532960, Alteplase Placebo, Aspirin, Aspirin Placebo
Genentech, Inc.
Stroke
03/17
03/17

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