| doxycycline / Generic mfg. |
ACTRN12623001164684: Assessing treatment effectiveness of the 'Repurposing-Drugs-in-Oncology' (ReDO) protocol for cancer: The ReDO cancer treatment study |
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| Not yet recruiting | N/A | 50 | | | Dr Taufiq Binjemain, Patients at the Willow Vale Clinic | Cancer | | | | |
ACTRN12622001340729: Doxy Decay: The impact of doxycycline on the organism load and viability of urethral Mycoplasma genitalium and Chlamydia trachomatis |
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| Not yet recruiting | N/A | 214 | | | Monash University, Australian Research Council | Urethral Mycoplasma genitalium, Urethral Chlamydia trachomatis, Nongonococcal urethritis | | | | |
ChiCTR-OPB-15007284: Characterization of linkage between symbiotic gut microbes and fatty acid metabolism in rheumatoid arthritis patients |
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| Recruiting | N/A | 40 | | Doxycycline ;Placebo | Hong Kong Baptist University; Guang Hua Hosptial, Hong Kong Baptist University | Rheumatoid Arthritis | | | | |
ChiCTR-INR-17011339: Protective effect of matrix metalloproteinase inhibitor in extracorporeal circulation |
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| Recruiting | N/A | 36 | | Oral doxycycline | Department of Anesthesiology of The First Affiliated Hospital of Wenzhou Medical University; The First Affiliated Hospital of Wenzhou Medical University, At my own expense | heart disease | | | | |
ChiCTR1800018914: Treatment effectiveness of urogenital Chlamydia trachomatis infection: a randomized controlled noninferiority trial |
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| Not yet recruiting | N/A | 446 | | Extended azithromycin regimen：1000 mg orally on the first day and 500 mg orally on the following 2 days ;Conventional doxycycline regimen：100 mg orally twice daily for 7 days | Shenzhen Nanshan Center for Chronic Disease Control; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen Nanshan Bureau of Health and Family Planning | Genital Chlamydia trachomatis infections | | | | |
ChiCTR1900024026: A randomized controlled trial for efficacy of 2 g azithromycin dose versus doxycycline 100 mg daily for 7 days in the treatment of urethral and rectal chlamydia infection among Men who have sex with Men |
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| Not yet recruiting | N/A | 120 | | Extended azithromycin regimen：1000 mg orally on the first day and 500 mg orally on the following 2 days ;Doxycycline regimen: 100 mg orally twice a day for 7 days | Dermatology Hospital of Southern Medical University; Dermatology Hospital of Southern Medical University, The Bureau of Science and Information Technology of Guangzhou Municipality (201704020219） | Urethral and rectal chlamydia trachomatis infections | | | | |
ChiCTR1900024009: Study for efficacy of 2 g azithromycin dose versus moxifloxacin 400 mg daily for 7 days in the treatment of urethral and rectal mycoplasma genitalium infection among Men who have sex with Men |
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| Not yet recruiting | N/A | 120 | | Extended azithromycin regimen: 1000 mg orally on the first day and 500 mg orally on the following 2 days. ;Moxifloxacin regimen: 400 mg orally once a day for 7 days | Dermatology Hospital, Sourthern Medical University; Dermatology Hospital, Sourthern Medical University, the Bureau of Science and Information Technology of Guangzhou Municipality (201704020219） | Mycoplasma genitalium infection | | | | |
Bio-MDT, NCT04082559: Biomarker-based Multidisciplinary Team () Approach to Personalized Microbial-targeted Treatment of Pouchitis and Crohn's Disease |
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| Recruiting | N/A | 170 | RoW | Arm 1- Antibiotics treatment, Ciprofloxacin 500 mg 2/d + metronidazole 500 mg 2/d for two weeks, Arm 2- Antibiotics treatment, Doxycycline 100 mg 2/d + metronidazole 500 mg 2/d for two weeks, Arm 1- Combination therapy (Antibiotics + diet), Favorable antibiotics (according to aim 1) for two weeks + Mediterranean diet (MED) for 8 weeks., Arm 2- Combination therapy (Antibiotics + diet), Favorable antibiotics (according to aim 1) for two weeks + specific carbohydrate diet (SCD) for 8 weeks., Arm 1- Nutritional prevention, Mediterranean diet, Arm 2- Nutritional prevention, Control- based on the American Dietetic Association recommendations for patients with IBD, Arm 3- Nutritional prevention, Personalized nutrition group- based on prior results from study- NCT02858557 | Rabin Medical Center, The Leona M. and Harry B. Helmsley Charitable Trust, Tel Aviv University | Inflammatory Bowel Diseases | 06/21 | 06/23 | | |
NCT03530319: Treatment of Macrolide-resistant Mycoplasma Pneumoniae |
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| Recruiting | N/A | 100 | RoW | Doxycycline, Azithromycin | National Taiwan University Hospital | Pneumonia, Mycoplasma | 12/21 | 12/21 | | |
NCT05097846: Differences in the Eradication of Helicobacter Pylori by Different Therapies |
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| Recruiting | N/A | 100 | RoW | Group1 Vonoprazan Fumarate + amoxicillin + doxycycline, Group2 Vonoprazan Fumarate + furazolidone + doxycycline, Group3 esomeprazole + colloidal bismuth tartrate + amoxicillin + doxycycline, Group4 esomeprazole + colloidal bismuth tartrate + furazolidone + doxycycline | wang xiaoyan | Helicobacter Pylori Infection | 06/22 | 10/22 | | |
NCT06570863: To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics as an Adjuvant to NSPT |
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| Active, not recruiting | N/A | 120 | RoW | Antibiotics(doxycycline), Probiotics, Metronidazole gel 25% | Dr fizza khalid | Periodontitis, Adult | 02/24 | 12/24 | | |
ChiCTR2000035120: A Multi-Center, Randomized, Open-Label, Positive Parallel Controlled Clinical Study on the Efficacy and Safety of Pi-Yan-Ning Decotion in the Treatment of Grade II Acneiform Rash Induced by Anti-tumor Targeted Drugs |
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| Recruiting | N/A | 40 | | Pi-Yan-Ning for external use ;Local steroid hormone combined with oral doxycycline | The First Affiliated Hospital of Zhejiang Chinese Medical University; The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Traditional Chinese Medicine of Science and Technology Program (2020ZA053) | Acneiform Rash Induced by Anti-tumor Targeted Drugs | | | | |
| Not yet recruiting | N/A | 45 | NA | treatment | Cairo University | Rosacea | 09/22 | 09/22 | | |
ChiCTR2000036155: A prospective randomized controlled clinical trial of 5-aminolevulinic acid photodynamic therapy for papularpustular rosacea. |
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| Not yet recruiting | N/A | 70 | | ALA-PDT ;Oral doxycycline | Shanghai Dermatology Hospital; Shanghai Dermatology Hospital, Self raised by researchers | Papulopustular rosacea | | | | |
NCT04234945: Effect of Prophylactic Antibiotics for Hysterosalpingography on Post Procedure Morbidity |
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| Recruiting | N/A | 78 | RoW | Doxycycline Capsule, Doxycap. Registration No: MAL 19921000A, Multivitamins W/Iron Tab, Haemaron | Ahmadu Bello University Teaching Hospital | Infertility, Female, Pelvic Inflammatory Disease | 10/22 | 12/22 | | |
NCT04153604: Doxycycline for the Prevention of Spontaneous Bacterial Peritonitis |
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| Completed | N/A | 841 | US | doxycycline | Methodist Health System | Cirrhosis, Spontaneous Bacterial Peritonitis | 08/20 | 08/20 | | |
| Completed | N/A | 60 | RoW | cardiac surgery | Petrovsky National Research Centre of Surgery, Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology | Multiple Organ Dysfunction | 07/23 | 07/23 | | |
NCT05410223: Efficacy and Safety Study of Egg Yolk Antibody in Adjuvant Treatment of Helicobacter Pylori Infection |
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| Recruiting | N/A | 100 | RoW | Yolk antibody and IIaprazole, Amoxicillin/ Clarithromycin/Furazolidone, Doxycycline, Bismuth, IIaprazole, Amoxicillin/Clarithromycin/Furazolidone, Doxycycline, Bismuth, Yolk antibody and IIaprazole, Amoxicillin/ Clarithromycin/Furazolidone, Doxycycline, IIaprazole, Amoxicillin/ Clarithromycin/Furazolidone, Doxycycline, Bismuth | The Third Xiangya Hospital of Central South University | Helicobacter Pylori Infection | 12/22 | 12/22 | | |
| Recruiting | N/A | 310 | Europe | The proposed study is not interventional. | Göteborg University, Sahlgrenska University Hospital, Sweden, Vastra Gotaland Region | Tick-Bite; Fever, Tick Fever, Tick-Borne Diseases, Encephalitis, Tick-Borne, Tick Bites | 12/22 | 02/23 | | |
NCT03911440: Treatment and Vaccine Development of Mycoplasma Pneumoniae |
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| Recruiting | N/A | 100 | RoW | Doxycycline, Azithromycin | National Taiwan University Hospital | Atypical Pneumonia | 12/22 | 12/22 | | |
NCT06179056: Anti-microbial Role of Non-antibiotic Agents Against Cutibacterium Acnes in Patients With Acne Vulgaris |
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| Completed | N/A | 48 | RoW | assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the susceptibility of C. acne for Azithromycin and Doxycycline. | Zagazig University | Acne Vulgaris | 02/24 | 02/24 | | |
NCT06520007: Comparison Between Continuous and Pulsed Oral Doxycycline Treatment Protocols for Refractory Meibomian Gland Dysfunction |
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| Completed | N/A | 65 | Europe | Doxycyclin | University of Milan | Meibomian Gland Dysfunction, Blepharitis, Doxycycline Adverse Reaction | 05/24 | 05/24 | | |
NCT05291468: the PHENOSAR Trial: Use of Antibiotics in Treatment of Sarcoidosis |
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| Not yet recruiting | N/A | 40 | Europe | FDG-PET/CT, serum biomarkers, additional skin biopsy | St. Antonius Hospital, ZonMw: The Netherlands Organisation for Health Research and Development | Sarcoidosis, Pulmonary, Sarcoidosis Skin | 04/23 | 06/23 | | |
NCT05827211: The Usefulness of Antibiotics in Smokers Receiving Dental Implants |
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| Completed | N/A | 80 | RoW | Antibiotic group, Dental implant insertion + Antibiotics, Non-Antibiotic group, Dental implant insertion + Placebo | Arab American University (Palestine) | Dental Implant Therapy | 04/23 | 06/23 | | |
NCT03462329: Patient's Pretreatment Expectations About Post-Lyme Symptoms |
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| Recruiting | N/A | 200 | Europe | Antibiotics (preferentially oral doxycycline 100 mg bid) | University Medical Centre Ljubljana | Erythema Migrans | 12/24 | 12/24 | | |
QoLyme, NCT05742139: Impact on the Quality of Life and Persistent Symptoms of Patients Away From Diagnosed and Treated Neuroborreliosis |
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| Completed | N/A | 159 | Europe | Non intervention | Hopital Nord Franche-Comte | Neuroborreliosis, Lyme, Quality of Life | 08/23 | 10/23 | | |
NCT05878353: Influence of Local Doxycycline on the Outcomes of Periodontal Regeneration |
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| Completed | N/A | 60 | Europe | Decontamination of the pocket with local doxycycline, Decontamination of the pocket with mechanical instrumentation | University of Turin, Italy | Periodontal Diseases | 07/24 | 07/24 | | |
DOXY-MEN, NCT06242730: Doxycycline PEP and 4CMenB as a Comprehensive Prevention Strategy in MSM and TGW at High Risk for Bacterial STIs Within the Swiss HIV Cohort Study |
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| Recruiting | N/A | 400 | Europe | | University of Zurich, Swiss HIV Cohort Study | Doxycycline STI PEP | 10/24 | 10/25 | | |
| Recruiting | N/A | 20 | RoW | Doxycycline Hyclate | Sun Yat-sen University | Thyroid Associated Ophthalmopathy | 12/25 | 12/26 | | |
NCT03956446: Tick-borne Encephalitis and Borrelial Antibodies in Serum |
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| Recruiting | N/A | 80 | Europe | Doxycycline, Symptomatic therapy, Questionnaire | University Medical Centre Ljubljana, University of Ljubljana School of Medicine, Slovenia | Tick Borne Encephalitis | 12/24 | 12/24 | | |
NCT03337932: Duration of Doxycycline Treatment in MEM Patients |
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| Recruiting | N/A | 200 | Europe | Doxycycline 100 milligram Oral Tablet bid, 7 days, Doxycycline 100 milligram Oral Tablet bid, 14 days, Controls without a history of lyme disease. | University Medical Centre Ljubljana | Erythema Chronicum Migrans | 12/24 | 12/24 | | |
| Active, not recruiting | N/A | 30 | US | | The Cleveland Clinic | Amyloidosis, Amyloid, Amyloid Neuropathies, Familial, Amyloid Cardiomyopathy, Amyloid - Primary, Transthyretin Amyloidosis, AL Amyloidosis | 09/26 | 12/26 | | |
| Recruiting | N/A | 211 | Europe | doxycycline 200 mg q.d. - rifampicin 600mg b.i.d., trimethoprim 200mg b.i.d. - rifampicin 600mg b.i.d. | Leiden University Medical Center | MRSA | 04/24 | 04/24 | | |
ChiCTR2200057877: A control study on oral Doxycycline approach to prevent syphilis infection among MSM in China |
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| Not yet recruiting | N/A | 100 | | Take 200mg of doxycycline within 24 hours of high-risk behavior.After a cumulative weekly dose of 600mg, they stopped taking the drug this week. Have syphilis/HIV test every two months ;Have syphilis/HIV test every two months | Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College; Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Health Commission funds for STD prevention and treatment | syphilis | | | | |
NCT06412588: Dual Therapy With Vonoprazan Plus Amoxicillin or Doxycycline Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication:A Prospective, Multicenter, Open-label Randomized Controlled Study. |
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| Not yet recruiting | N/A | 810 | NA | Vonoprazan+amoxicillin+doxycycline+bismuth for 14 days, Doxycycline-based Bismuth Quadruple Therapy, Vonoprazan+Amoxicillin, Vonoprazan+Amoxicillin Dual therapy, Vonoprazan+doxycycline, Vonoprazan+doxycycline Dual therapy | Nanjing First Hospital, Nanjing Medical University | Helicobacter Pylori Infection | 10/24 | 12/24 | | |
NCT03709459: Impact of the Daily Doxycycline Pre-exposure Prophylaxis (PrEP) on the Incidence of Syphilis, Gonorrhoea and Chlamydia |
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| Active, not recruiting | N/A | 100 | RoW | Doxycycline | Kirby Institute, South Australian Health and Medical Research Institute, Monash University | STIs Prevention | 07/24 | 12/24 | | |
NCT03511118: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants |
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| Recruiting | N/A | 1600 | Canada, US | Tranexamic acid (TXA), labetalol, metformin, nifedipine, clindamycin, oxycodone, azithromycin, escitalopram, sertraline, ondansetron, Ciprofloxacin, Doxycycline, Levofloxacin, Methylphenidate, Sumatriptan, Citalopram, Cyclobenzaprine, Furosemide, Gabapentin, Hydrochlorothiazide, Hydroxyurea, Rosuvastatin, Topiramate, Trazodone, Valganciclovir, Venlafaxine, Verapamil, Remdesivir, Anakinra, Tocilizumab, Fluvoxamine, Amoxicillin, Bupropion, Duloxetine, Hydrocodone, Levetiracetam, Paroxetine, Buprenorphine | Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI | 09/24 | 07/26 | | |
PNLABXPART2, NCT02829060: Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2 |
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| Recruiting | N/A | 330 | US | Nitrofurantoin 100 MG, 7d, Macrobid, Gentamicin, 5mg/kg, Gentamicin, Ampicillin 2g, Nitrofurantoin 100 mg, 48 hrs, Gentamicin, 80 mg, 7d, Gentamicin, 80 mg, 48hr | University of California, San Diego | Nephrolithiasis, Urinary Tract Infection (UTI), Sepsis | 01/25 | 01/25 | | |
DOXY-PK, NCT06007534: Pharmacokinetic Characterization of a Single 200 mg Dose of Doxycycline in Post-exposure Prophylaxis (PEP) of Sexually Transmitted Infections in Different Biological Compartments |
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| Recruiting | N/A | 25 | Europe | Samples | Assistance Publique - Hôpitaux de Paris | Post-exposure Prophylaxis, Sexually Transmitted Diseases, Doxycycline | 04/25 | 04/25 | | |
| Recruiting | N/A | 208 | US | Doxycycline, Doxycycline Monohydrate, Indwelling Catheter, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Survey Administration | M.D. Anderson Cancer Center, National Cancer Institute (NCI) | Pleural Neoplasm | 04/25 | 04/25 | | |
ChiCTR2400080564: Study on the efficacy and safety of a chlorin e6 derivative mediated photodynamic therapy for rosacea |
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| Not yet recruiting | N/A | 76 | | 0.5mg/ml STBF solution was evenly applied to the subject's facial treatment area, shielded from light for 0.5h, and illuminated by a LED instrument with a wavelength of 630nm and an energy density of 90J /cm2.; Doxycycline, orally given once a day, 100mg, for 8 weeks | Shanghai Skin Disease Hospital; Shanghai Skin Disease Hospital, A prospective randomized controlled clinical study on the treatment of rosacea by novel porphin derivatives and photodynamic sub-surface type | rosacea | | | | |
NCT06069141: Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline |
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| Recruiting | N/A | 688 | RoW | Benzathine Penicillin G, Doxycycline Capsule | National Taiwan University Hospital, National Taiwan University Hospital Hsin-Chu Branch, Far Eastern Memorial Hospital, Taipei Veterans General Hospital, Taiwan, Taoyuan General Hospital, National Cheng-Kung University Hospital, Chi Mei Medical Hospital, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Veterans General Hospital. | Early Syphilis, Latent, Serological Relapse After Treatment | 12/25 | 12/26 | | |
NCT06045481: Postexposure Prophylaxis With Single Dose Doxycycline for the Prevention of Tick-borne Relapsing Fever |
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| Not yet recruiting | N/A | 526 | NA | administration of single dose of doxycycline | Medical Corps, Israel Defense Force | Relapsing Fever, Tick-Borne | 10/26 | 10/27 | | |
NCT04762134: Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO) |
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| Recruiting | N/A | 560 | Canada | Doxycycline Hyclate | Jonathan Troy Grennan, Canadian Institutes of Health Research (CIHR) | Bacterial Sexually Transmitted Diseases | 12/26 | 06/27 | | |
