| Ozurdex (dexamethasone intravitreal implant) / AbbVie |
2011-000425-72: Treatment of macular edema secondary to central or branch vein occlusion by dexamethazone intravitreal injection |
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| Completed | 4 | 15 | Europe | Ophthalmic insert, OZURDEX | IRCCS- FONDAZIONE G.B. BIETTI PER LO STUDIO E LA RICERCA IN OFTALMOLOGIA-ONLUS | macular edema seconday to central or branch retinal vein occlusion | | | | |
NCT01546402: Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema |
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| Completed | 4 | 20 | RoW | Dexamethasone Drug delivery system (Ozurdex), Ozurdex, Cataract surgery, Phacoemulsification | Postgraduate Institute of Medical Education and Research | Macular Edema, Cystoid, Vision Disorders, Diabetic Macular Edema, Cystoid Macular Edema Following Cataract Surgery, Cataract | 11/12 | 11/12 | | |
NCT01309451: Ozurdex as Adjunct to Avastin Compared to Avastin Alone in Treatment of Patients With Diabetic Macular Edema |
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| Completed | 4 | 40 | US | Bevacizumab, Avastin, dexamethasone intravitreal implant, Ozurdex | Maturi, Raj K., M.D., P.C. | Diabetic Macular Edema | 04/13 | 04/13 | | |
NCT01903720: A Safety and Efficacy Study of OZURDEX® in Macular Edema Associated With Branch Retinal Vein Occlusion |
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| Completed | 4 | 71 | RoW | dexamethasone implant, OZURDEX® | Allergan | Macular Edema, Retinal Vein Occlusion | 09/14 | 03/15 | | |
NCT01580020 / 2011-005045-13: Extension Study to Compare Long-term Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With RVO |
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| Completed | 4 | 175 | Europe | RFB002, Dexamethasone | Novartis Pharmaceuticals | Retinal Vein Occlusion | 10/14 | 10/14 | | |
| Completed | 4 | 307 | Europe, RoW | dexamethasone intravitreal implant, Ozurdex®, ranibizumab, Lucentis® | Allergan | Retinal Vein Occlusion, Macular Edema | 11/14 | 11/14 | | |
NCT01870440: TAHOE: Intravitreal Dexamethasone Implant (Ozurdex) for Uveitic Macular Edema |
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| Completed | 4 | 10 | US | Ozurdex Intravitreal Injection (0.7 mg), Ozurdex (0.7 mg) | Northern California Retina Vitreous Associates, Allergan | Macular Edema, Uveitis | 02/15 | 02/15 | | |
NCT02036424: Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Alone Versus Ozurdex Given Every 3 Months for Treatment of Persistent Diabetic Macular Edema |
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| Completed | 4 | 45 | US | Ozurdex, Dexamethasone Intravitreal Implant, Bevacizumab, Avastin | Raj K. Maturi, MD, Allergan | Diabetic Macular Edema | 08/15 | 08/15 | | |
2014-005700-24: Cytokine Levels within patients with diabetic macular edema. |
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| Completed | 4 | 20 | Europe | Lucentis, Ozurdex, EMEA/H/C/000715, EU/1/10/638/001, Injection, Intravitreal implant in applicator, Lucentis, Ozurdex | Abteilung für Augenheilkunde, AKH Linz, Bayer | Diabetic Retinopathy and diabetic macular edema are leading causes for visual loss and blindness in young adults around the world., Diabetic Macular Edema, Diseases [C] - Eye Diseases [C11] | | | | |
2010-023110-30: An exploratory phase III prospective open-label clinical study on monthly OCT monitoring of the effects of Ozurdex for macular oedema related to retinal vascular diseases |
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| Completed | 4 | 30 | Europe | OZURDEX, Ozurdex, Ozurdex | King\'s College Hospital NHS Foundation Trust | Macular oedema related to retinal vascular diseases | | 12/12 | | |
2011-006063-22: Prevención del edema macular diabético en pacientes con retinopatía diabética tratados con Ozurdex® tras la cirugía de cataratas |
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| Completed | 4 | 40 | Europe | dexametasona, unk, Implant, OZURDEX 700 microgramos implante intravítreo en aplicador | Fundación Oftalmológica del Mediterráneo, Sistema Nacional de Salud.- Minesterio Sanidad | edema macular diabético en pacientes con retinopatía diabética, Edema macular diabético en pacientes con retinopatía diabética, Diseases [C] - Eye Diseases [C11] | | | | |
ORION, NCT01827722: Ozurdex Versus Ranibizumab Versus Combination for Central Retinal Vein Occlusion |
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| Unknown status | 4 | 45 | US | Ozurdex, Dexamethasone, Ranibizumab, Lucentis, Combination Ozurdex with Ranibizumab PRN, Dexamethasone and Lucentis | Valley Retina Institute | Macular Edema, Central Retinal Vein Occlusion | 05/16 | 12/16 | | |
COLLIDE, NCT02684084: Combination OZURDEX® & LUCENTIS® vs. OZURDEX® Monotherapy in Incomplete-Responders With Diabetic Macular Edema |
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| Terminated | 4 | 5 | Canada | Ozurdex, DEX implant, dexamethasone, Lucentis, Ranibizumab | North Toronto Eye Care Laser and Eye Specialists, Allergan | Diabetic Macular Edema | 11/16 | 12/16 | | |
OPERA, NCT01613716: Ozurdex for Diabetic Macular Edema Treated With Pars Plana vitrEctomy and Membrane RemovAl ( Study) |
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| Completed | 4 | 30 | US | Ozurdex, Dexamethasone | The Cleveland Clinic, Allergan | Diabetic Macular Edema, Epiretinal Membrane | 12/16 | 02/17 | | |
NCT02399657: Effect of Dexamethasone Implant in Hard Exudate Complicated With Diabetic Macular Edema |
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| Unknown status | 4 | 48 | RoW | Intravitreal dexamethasone 0.7mg implant, Ozurdex injection | Inje University, Allergan | Diabetes Mellitus, Macular Edema, Retinal Exudates and Deposits | 12/16 | 12/16 | | |
2016-003870-41: Comparison of the efficacy of treatment of retinal macular inflammation due to diabetes with ozurdex or with ozurdex plus laser treatment in the area. Comparación de la eficacia del tratamiento de la inflamación macular retiniana debida a la diabetes con ozurdex o con ozurdex más tratamiento de láser en la zona. |
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| Ongoing | 4 | 30 | Europe | Ozurdex, EMEA/H/C/001140, Intravitreal implant in applicator, Ozurdex | Fundación para la Investigación Biomédica del Hospital Universitario Príncipe de Asturias, Allergan | Diabetic macular edema Edema macular diabético, retinal inflammation due to diabetes Inflamación retiniana debida a la diabetes, Diseases [C] - Eye Diseases [C11] | | | | |
IPACK, NCT03094663: Adductor Canal Block With Periarticular Injection and (ACB/PAI/) Versus Periarticular Injection (PAI) |
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| Completed | 4 | 86 | US | Bupivacaine with epinephrine, Sensorcaine/Epinephrine, Sensorcaine-MPF/Epinephrine, Marcaine-Epinephrine (PF), Methylprednisolone, Depo-Medrol, Solu-Medrol, Medrol, Cefazolin, cephalosporin antibiotics, 8 MHz. Chiba needle, Bupivacaine with Dexamethasone, dexamethasone to non-liposomal bupivacaine, Bupivacaine 25cc, Exparel, Marcaine, Marcaine Spinal (PF), Bupivacaine 20cc, Dexamethasone, Ozurdex, Maxidex, DexPak 6 Day | Hospital for Special Surgery, New York | Knee Arthropathy | 05/18 | 09/18 | | |
NCT03475407: The Effects of Intravitreal Ozurdex Implant in DME |
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| Unknown status | 4 | 20 | RoW | Ozurdex intravitreal injection | Nune Eye Hospital, Seoul, Korea | Diabetic Macular Edema | 06/18 | 12/18 | | |
NCT02049476: Study of the Effectiveness of Ozurdex for the Control of Uveitis |
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| Completed | 4 | 20 | US | Dexamethasone pellet, Ozurdex pellet | Johns Hopkins University, Allergan | Uveitis, Intermediate, Uveitis, Posterior | 06/18 | 06/18 | | |
DIME, NCT02471651: Dexamethasone Intravitreal Implant for the Treatment of Persistent Diabetic Macular Edema |
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| Completed | 4 | 40 | US | Dexamethasone intravitreal implant (0.7 mg), Ozurdex, Intravitreal anti-VEGF injection, ranibizumab, bevacizumab, or aflibercept | California Retina Consultants, Allergan | Diabetic Macular Edema | 10/18 | 10/18 | | |
NCT04089605: Ranibizumab vs Dexamethasone Implant in Vitrectomized Eyes With Diabetic Macular Edema |
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| Completed | 4 | 48 | RoW | dexamethasone implant, Dexamethasone implants (Ozurdex®, Allergan Inc., Irvine, CA, USA), Ranibizumab, (Lucentis®, Ranibizumab (Novartis Pharma AG, Basel, Switzerland, and Genentech Inc., South San Francisco, CA, USA) | Far Eastern Memorial Hospital | Diabetic Macular Edema | 11/18 | 04/19 | | |
NCT05736081: Short-term Effect of Intravitreal Dexamethasone Implant in Refractory Diabetic Macular Edema |
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| Completed | 4 | 15 | RoW | Intravitreal dexamethasone implant, Ozurdex implant | Asociación para Evitar la Ceguera en México | Diabetic Macular Edema | 06/19 | 06/19 | | |
| Completed | 4 | 59 | RoW | Dexamethasone intravitreal implant, Ozurdex, DEX-implant, Bevacizumab Injectable Product, Avastin | Lions Eye Institute, Perth, Western Australia, Lions Outback Vision, Allergan | Diabetic Macular Edema, Diabetic Retinopathy | 02/20 | 02/20 | | |
| Completed | 4 | 50 | US | Ozurdex, dexamethasone implant, Eylea, aflibercept | Texas Retina Associates, The Emmes Company, LLC | Diabetic Macular Edema | 10/22 | 10/22 | | |
ICOD, NCT04038125: Increase in Capillary Plexus Density Level Following the Use of Ozurdex for the Treatment of DME |
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| Unknown status | 4 | 20 | US | Ozurdex Drug Implant Product, Dexamethasone | Retina Macula Specialists of Miami, LLC, Allergan | Diabetic Macular Edema, Diabetic Retinopathy, Retinal Ischemia | 08/20 | 08/21 | | |
NCT03757715: Regional Anesthesia to Reduce Opioid Use Following Functional Endoscopic Sinus Surgery |
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| Completed | 4 | 46 | US | Bupivacaine, Marcaine, Dexamethasone, Ozurdex | University of Alabama at Birmingham | Pain Management | 03/21 | 04/21 | | |
2020-005100-18: Comparaison de 2 traitements de référence sur les œdèmes maculaires diabétiques résistants, persistants malgré un traitement bien conduit depuis plus de 2 ans |
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| Not yet recruiting | 4 | 106 | Europe | Intravitreal implant in applicator, Iluvien, OZURDEX | CHU Dijon Bourgogne | Œdème maculaire diabétique, Œdème maculaire diabétique, Diseases [C] - Eye Diseases [C11] | | | | |
NCT03999125: Anti-VEGF Therapy Versus Dexamethasone Implant for DME |
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| Not yet recruiting | 4 | 150 | Europe | Aflibercept,, Ranibizumab, Dexamethasone Implant, Laser, Ranibizumab Injection, Dexamethasone Implant, Aflibercept, Laser, Ozurdex Drug Implant Product | Sudhalkar Eye Hospital | Clinically Significant Macular Edema Due to Diabetes Mellitus | 06/21 | 06/23 | | |
YANGTZE, NCT03908307: Evaluation of OZURDEX® in Patients With Macular Edema Secondary to Retinal Vein Occlusion in China |
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| Completed | 4 | 150 | RoW | OZURDEX | Allergan | Macular Edema, Retinal Vein Occlusion | 09/21 | 09/21 | | |
DANTE, NCT04448496: Prospective Trial of Dexamethasone implAnt for Treatment Naïve diabeTic Macular Edema |
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| Unknown status | 4 | 49 | RoW | Dexamethasone implant, Ozurdex | Yeungnam University College of Medicine | Diabetic Retinopathy | 12/21 | 12/21 | | |
ChiCTR2100043399: A prospective randomized controlled study of long-acting dexamethasone implant to improve the prognosis of PDR patients after vitrectomy |
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| Recruiting | 4 | 75 | | Ozurdex ;anti-VEGF drugs ;no | Tianjin Medical University Eye Hospital; Tianjin Medical University Eye Hospital, Self-financing | diabetic retinopathy | | | | |
ChiCTR2100044228: A prospective study on the prognosis of idiopathic epimacular membrane after vitrectomy |
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| Recruiting | 4 | 30 | | intravitreal injection of ozurdex ;Nil | Tianjin Medical University Eye Hospital; Tianjin Medical University Eye Hospital, Self-financing | Idiopathic epimacular membrane | | | | |
OPEAXE, ChiCTR2000036080: Evaluation of the efficacy of dexamethasone sustained-release implant (Ozurdex) in patients with proliferative diabetic retinopathy complicated with diabetic macular edema (vitrectomy / silicone oil filling and silicone oil removal) in combination |
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| Not yet recruiting | 4 | 200 | | Intraoperative dexamethasone sustained release implant ;none | Beijing aier intech eye hospital; Beijing aier intech eye hospital, Self-financing | Diabetic retinopathy | | | | |
STAMP, NCT03832179: Steroid vs. Anti-vascular Endothelial Growth Factor for Diabetic Macular Edema Prior to Phacoemulsification |
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| Completed | 4 | 16 | US | Bevacizumab, Avastin, Ranibizumab, Lucentis, Aflibercept, Eylea, Ozurdex, Dexamethasone implant | Bay Area Retina Associates, Allergan | Diabetic Macular Edema, Cataract | 09/23 | 03/24 | | |
2018-004785-33: Study to Evaluate the Efficacy and Safety of OZURDEX® in Treatment Naïve Patients with Diabetic Macular Edema Estudio para evaluar la eficacia y seguridad de OZURDEX® ) en pacientes sin tratamiento previo con edema macular diabetic |
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| Not yet recruiting | 4 | 150 | Europe | OZURDEX®, Intravitreal implant in applicator, OZURDEX® | Allergan Pharmaceuticals International Limited, Allergan Pharmaceuticals International Limited | Diabetic Macular Edema Edema Macular Diabético, Diabetic Macular Edema Edema Macular Diabético, Diseases [C] - Eye Diseases [C11] | | | | |
| Completed | 4 | 82 | Europe | Dexamethasone Intravitreal Implant | Allergan, Allergan Pharmaceuticals International Limited | Diabetic Macular Edema | 07/22 | 07/22 | | |
ChiCTR2100043460: A short-term clinical trial of intravitreal dexamethasone implant (OZURDEX) in treatment of persistent diabetic macular edema |
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| Recruiting | 4 | 30 | | intravitreal dexamethasone implant (OZURDEX) ;intravitreal dexamethasone implant (OZURDEX) combined with laser photocoagulation | Shanghai Tongji Hospital; Shanghai Tongji Hospital, Shanghai Tongji Hospital, clinical research and breeding program | Diabetic Macular Edema | | | | |
NCT03859024: Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty |
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| Completed | 4 | 48 | US | Oxycodone, oxycontin, Acetaminophen, tylenol, Gabapentin, neurontin, celebrex, celecoxib, Bupivacaine, marcaine, exparel, Ibuprofen 800 mg, advil, motrin, Dexamethasone, decadron, ozurdex | University of Alabama at Birmingham | Pain, Postoperative, Urethral Stricture | 04/23 | 06/23 | | |
ChiCTR2200059909: Intervention study of intravitreal injection of conbercept in combination with dexamethasone intravitreal implants (Ozurdex) for the treatment of diabetic macular edema |
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| Recruiting | 4 | 80 | | Conbercept intravitreal injection (3+PRN regimen) ;The first treatment was combined with conbercept intravitreal injection and Ozurdex intravitreal implant, followed by treatment with the control group (3 +PRN regimens). | Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong; Level of the institution：, Chaozhou Science and Technology Program Project (210531174603743) | diabetic macular edema | | | | |
ChiCTR2100046387: efficacy of conbercept combined dexamethasone intravitreal implants for the treatment of cystoid macular edema secondary to retinal vein occlusion |
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| Recruiting | 4 | 80 | | Joint injection ;Anti-VEGF therapy | Tianjin Medical University Eye Hospital; Tianjin Medical University Eye Hospital, Beijing Bethune Public Welfare Foundation | retinal vein occlusion | | | | |
PRECISION, NCT04411693: Comparative Study of Dexamethasone Implant to Intravitreal Aflibercept in Subjects With Diabetic Macular Edema |
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| Completed | 4 | 23 | US | Dexamethasone implant, Ozurdex, Aflibercept, Eylea | The Cleveland Clinic, Allergan | Diabetic Macular Edema | 01/24 | 01/24 | | |
NCT05720949: Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery |
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| Completed | 4 | 192 | US | Genicular Nerve Block with bupivacaine and preservative free dexamethasone, Exparel, Ozurdex | Hospital for Special Surgery, New York | ACL, Anterior Cruciate Ligament Injuries | 11/24 | 12/24 | | |
NCT06268704: Particulate vs. Non-Particulate Steroid for Sacroiliac Joint Injection |
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| Recruiting | 4 | 230 | US | Dexamethasone, Ozurdex, Maxidex, DexPak, Methylprednisolone, Solu-medrol, Depo-Medrol, Medrol, 2% Lidocaine HCl Injection, Lignocaine, Xylocaine | University of New Mexico | Sacroiliac Joint Dysfunction, Sacro-Iliac Spondylosis | 01/27 | 05/27 | | |
ChiCTR2300069732: Study on the pathological mechanism of macular edema caused by retinal vein occlusion and related factors affecting treatment prognosis by MLC combined with aqueous humor cytokine detection |
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| Not yet recruiting | 4 | 60 | | Intravitreal injection of Aflibercept ;Intravitreal injection of Ozurdex | Qingdao Eye Hospital of Shandong First Medical University ; Qingdao Eye Hospital of Shandong First Medical University, Qingdao Eye Hospital introduced doctoral research funds | Retinal vein occlusion | | | | |
NCT05990829: Compare the Efficacy of VItrectomy Combined With DExamethasone Implant Versus With Aflibercept in DME Patients Diagnosed by Intraoperative OCT (the VIDEO Study): Study Protocol for a Randomized Controlled Trial |
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| Recruiting | 4 | 64 | RoW | Ozurdex, Aflibercept | Tianjin Medical University Eye Hospital, Abbvie Pharmaceutical Trading (Shanghai) Co., Ltd. | Diabetic Macular Edema, Pars Plana Vitrectomy, Dexamethasone Intravitreal Implant, Intraoperative Optical Coherence Tomography | 10/24 | 04/25 | | |
| Withdrawn | 4 | 84 | Canada | Ozurdex 0.7mg Ophthalmic Implant, Prednisone | Ottawa Hospital Research Institute | Uveitis, Posterior, Uveitis, Intermediate, Panuveitis | 01/25 | 01/25 | | |
NCT05980546: Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty |
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| Completed | 4 | 244 | US | Bupivacaine Injection, Marcaine, Dexamethasone injection, Ozurdex, Fentanyl, Actiq, Mepivacaine, Carbocaine | Hospital for Special Surgery, New York | Total Knee Replacement, Genicular Nerve Block, Opioid Use | 09/25 | 09/25 | | |
EMMA, NCT04910503: Medico Economic Evaluation of Fluocinolone Acetonide Implant Versus Dexametheasone Implant in Resistant Diabetic Macular Oedema |
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| Recruiting | 4 | 106 | Europe | Dexamethasone intravitreal implant, Fluocinolone Acetonide Intravitreal Implant | Centre Hospitalier Universitaire Dijon | Diabetic Macular Edema | 04/30 | 04/30 | | |
