| Ozurdex (dexamethasone intravitreal implant) / AbbVie |
| Completed | 3 | 599 | Canada, US, Europe, RoW | 700 µg Dexamethasone, Posurdex®, 350 µg Dexamethasone, Sham Injection | Allergan | Macular Edema, Retinal Vein Occlusion | 03/08 | 10/08 | | |
| Completed | 3 | 668 | Canada, US, Europe, RoW | 700 µg Dexamethasone, Posurdex®, 350 µg Dexamethasone, Sham Injection | Allergan | Macular Edema, Retinal Vein Occlusion | 03/08 | 09/08 | | |
NCT00168337: A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema |
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| Completed | 3 | 554 | US, Canada, Europe, RoW | Dexamethasone, Posurdex®, Ozurdex®, Sham | Allergan | Diabetic Macular Edema | 05/12 | 05/12 | | |
2004-004997-10: A 3-Year, Phase 3, Multicenter, Masked, Randomized, Sham-Controlled Trial to Assess the Safety and Efficacy of 700 µg and 350 µg Dexamethasone Posterior Segment Drug Delivery System (DEX PS DDS) Applicator System in the Treatment of Patients with Diabetic Macular Edema |
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| Completed | 3 | 1050 | Europe | DEX PS DDS Applicator System, 9632X, 9635X, Implant | Allergan Limited, ALLERGAN Limited, Allergan, | Diabetic macular edema, To treat damage (swelling) of the retina (the light sensitive part of the eye) caused by complications of diabetes., Body processes [G] - Ocular Physiological Phenomena [G14] | | | | |
| Completed | 3 | 494 | US, Canada, Europe, RoW | Dexamethasone, Posurdex®, Ozurdex®, Sham | Allergan | Diabetic Macular Edema | 06/12 | 06/12 | | |
NCT01449682: Efficacy of an Intravitreal DEX Implant in Retinal Vein Occlusion Following Treatment With Anti-VEGF Injections. |
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| Completed | 3 | 10 | US | Ozurdex, Dexamethasone implant, DEX implant, dexamethasone implant, DEX implant | Retina Macula Institute, Allergan | Retinal Vein Occlusion, Macular Edema | 07/12 | 02/13 | | |
| Completed | 3 | 244 | Europe | Ranibizumab, Dexamethasone Implant, Sham injection | Novartis Pharmaceuticals | Visual Impairment, Macular Edema, Branch Retinal Vein Occlusion | 06/13 | 06/13 | | |
| Completed | 3 | 243 | Europe | Ranibizumab, Dexamethasone implant and sham injections | Novartis Pharmaceuticals | Visual Impairment, Macular Edema, Central Retinal Vein Occlusion | 01/14 | 01/14 | | |
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NCT01660802: Safety and Efficacy Study of Dexamethasone in the Treatment of Patients With Macular Edema Following Retinal Vein Occlusion (RVO) |
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| Completed | 3 | 262 | RoW | 700 μg Dexamethasone, Ozurdex®, Sham | Allergan | Macular Edema | 03/14 | 05/14 | | |
NCT01892163: Multicentre Randomised Clinical Trial Comparing Fixed vs Pro re Nata (PRN) Dosing of 700 μg Dexamethasone |
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| Completed | 3 | 100 | Europe | Ozurdex, Dexamethasone | Moorfields Eye Hospital NHS Foundation Trust, The Royal Wolverhampton Hospitals NHS Trust, Frimley Park Hospital NHS Trust, Brighton and Sussex University Hospitals NHS Trust, University Hospitals Bristol and Weston NHS Foundation Trust | Diabetic Macular Edema | 12/14 | 12/14 | | |
NCT01748487: The Effect of Intravitreal Ozurdex on DME After Cataract Surgery |
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| Completed | 3 | 24 | Canada | dexamethasone intravitreal implant (OZURDEX), OZURDEX | University Health Network, Toronto | Diabetic Macular Edema | 09/15 | 09/15 | | |
2011-003339-74: A Prospective Randomised Controlled Trial of Intravitreal Ozurdex and Macular Laser Therapy versus Macular Laser Therapy only in Diabetic Macular Oedema (OZLASE study) |
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| Ongoing | 3 | 80 | Europe | OZURDEX, Ozurdex, Ozurdex | Moorfields Eye Hospital R&D Department, Allergan Pharmaceuticals Ltd | Diabetic macular oedema | | | | |
2011-004498-96: Using an anti inflammatory eye implant (Ozurdex) to help improve surgical outcomes in patients with scar tissue (PVR) on the retina |
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| Ongoing | 3 | 140 | Europe | Ozurdex, Ozurdex, Ozurdex | Moorfields Eye Hospital | Proliferative Vitreoretinopathy | | | | |
POINT, NCT02374060: PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial |
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| Completed | 3 | 192 | Canada, US, Europe, RoW | Periocular triamcinolone 40 mg, Kenalog, Intravitreal triamcinolone 4 mg, Triescence (in U.S); Kenalog allowed at non-U.S. clinics, Dexamethasone intravitreal implant, Ozurdex | JHSPH Center for Clinical Trials, National Eye Institute (NEI) | Macular Edema, Uveitis | 08/17 | 01/18 | | |
2017-003243-37: Macular Edema Ranibizumab v. Intravitreal anti-inflammatory Therapy (MERIT) Trial |
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| Suspended | 3 | 240 | Europe | Lucentis, Ozurdex, Methotrexate, EU/1/06/374/001, Injection, Intravitreal implant in applicator, Lucentis, Ozurdex, Methotrexate | MUST Coordinating Centre, John Hopkins Bloomberg School of Public Health | Uveitic macular oedema, Swelling of part of the retina called the macula, which is responsible for fine vision, occuring due to inflammation in the eye (uveitis), Diseases [C] - Eye Diseases [C11] | | | | |
2016-000304-29: Investigation into optimal steroid treatment for subjects with sight threatening uveitis |
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| Terminated | 3 | 267 | Europe | triamcinolone acetonide, Dexamethasone 0.7mg intravitreal implant, Injection, Implant, Kenalog, Ozurdex | MUST Coordinating Centre, John Hopkins Bloomberg School of Public Health | Uveitic macular oedema, Swelling of part of the retina called the macular, which is responsible for fine vision, occuring due to inflammation in the eye (uveitis), Diseases [C] - Eye Diseases [C11] | | | | |
OASIS, ACTRN12618000202268: Comparing the effectiveness and safety of two treatments (OZURDEX® intravitreal implant versus Avastin®) for diabetic eye disease in adult Indigenous patients living in Western Australia.
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| Active, not recruiting | 3 | 50 | | | LIONS EYE INSTITUTE LTD, ALLERGAN AUSTRALIA PTY LTD | Diabetic Macular Oedema | | | | |
NCT02121262: A Safety and Efficacy Study of Dexamethasone Versus Laser Photocoagulation in Participants With Diabetic Macular Edema |
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| Completed | 3 | 284 | RoW | Dexamethasone, OZURDEX®, Laser Photocoagulation | Allergan, Tigermed Consulting Co., Ltd | Macular Edema | 11/19 | 11/19 | | |
NCT03183596: Optimal Injection Site for Serratus Anterior Plane Block in Reconstructive Breast Surgery |
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| Withdrawn | 3 | 0 | US | Bupivacaine, Marcaine, Sensorcaine, Dexamethasone, Ozurdex, Decadron, DexPak, Maxidex, Baycadron | University of Alabama at Birmingham | Pain, Postoperative | 08/20 | 01/24 | | |
TRIOZ, NCT02556424 / 2015-000468-33: Efficacy and Tolerance Comparison Between Subconjunctival Injection of Triamcinolone and Intravitreal Implant of Dexamethasone for the Treatment of Inflammatory Macular Edema |
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| Completed | 3 | 114 | Europe | Dexamethasone, Ozurdex®, Triamcinolone, Kénacort retard® | Nantes University Hospital | Inflammatory Macular Edema | 02/21 | 02/21 | | |
| Completed | 3 | 194 | Europe, Canada, US, RoW | Dexamethasone intravitreal implant 0.7 mg, Ozurdex, Intravitreal Methotrexate 400 µg, Intravitreal Ranibizumab 0.5 mg, Lucentis | JHSPH Center for Clinical Trials, National Eye Institute (NEI) | Uveitis, Macular Edema | 10/21 | 02/22 | | |
NCT04976777: A Study to Evaluate an Updated Dexamethasone Intravitreal (Into the Eye) Applicator in Adult Participants With Macular Edema Due to Diseases of the Retina |
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| Completed | 3 | 54 | US | Updated DEX PS DDS Applicator, Approved DEX PS DDS Applicator, OZURDEX®, Dexamethasone | AbbVie | Macular Edema | 02/22 | 02/22 | | |
ChiCTR2000040087: A 12-month clinical study of conbercept combined with Intravitreal Dexamethasone (DEX) Implant in the treatment of macular edema secondary to central retinal vein occlusion |
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| Recruiting | 3 | 20 | | conbercept combined with Ozurdex ;conbercept | Department of Ophthalmology, Central Theater Command General Hospital,; Central Theater Command General Hospital of PLA, Self-raised funds | Central retinal vein occlusion | | | | |
NCT05138029: Study on Precision Treatment of Diabetic Retinopathy Macular Edema Guided by Real-time OCT During Operation |
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| Recruiting | 3 | 60 | RoW | Ranibizumab Injection [Lucentis], Lucentis, Inner limiting membrane stripping, Dexamethasone intravitreal implant, Dexamethasone Implants | Affiliated Hospital of Nantong University | Diabetic Retinopathy | 12/23 | 05/24 | | |
ACTRN12615000118505: Is it possible to use long acting steroid preparations such as the dexamethasone intravitreal implant Ozurdex to prevent a deterioration in vision in patients with diabetes undergoing cataract surgery in central Australia. |
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| Recruiting | 2/3 | 40 | | | Alice Springs Hospital, ALLERGAN AUSTRALIA PTY. LTD | Diabetic retinopathy, Diabetic macular edema, Cataract | | | | |
| Terminated | 2/3 | 5 | US | Dexamethasone | Allergan | Anterior Uveitis | 03/07 | 03/07 | | |
| Completed | 2/3 | 229 | US, Canada, Europe, RoW | Dexamethasone, Posurdex®, dexamethasone, Sham injection | Allergan | Intermediate Uveitis, Posterior Uveitis | 12/08 | 04/09 | | |
NCT01273727: Ozurdex for Macular Edema Post Membrane Peeling |
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| Completed | 2/3 | 35 | US | Dexamethasone, Ozurdex, dexamethasone, ozurdex | Retina Specialists, PC, Allergan | Epiretinal Membrane, Cellophane Maculopathy, Macular Edema, Retinal Edema | 04/14 | 04/14 | | |
| Completed | 2/3 | 40 | US | dexamethasone implant, Ozurdex | Johns Hopkins University, Allergan | Retinal Vein Occlusion | 12/14 | 12/14 | | |
NCT01295112: Effect of Ozurdex® 0.7 mg on Improvement of Efficacy of Bevacizumab for Central Retinal Vein Occlusion |
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| Completed | 2/3 | 68 | US | Active bevacizumab and Sham dexamethasone, Avastin® (bevacizumab), Ozurdex® (dexamethasone intravitreal implant), Active bevacizumab and Active dexamethasone | Texas Retina Associates | Non-Ischemic Central Retinal Vein Occlusion | 10/15 | 10/15 | | |
