| pioglitazone / Generic mfg. |
2006-001398-44: The use of Peroxisome Proliferator Activator Receptor Agonists in the management of Androgen Independent Prostate Cancer |
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| Ongoing | 2 | 80 | Europe | Lipantil Micro, ROCALTROL, Pioglitazone, LIPANTIL, ROCALTROL, LIPANTIL, ROCALTROL | Barts and The London NHS Trust | The use of Peroxisome Proliferator Activator Receptor Agonists in the management of Androgen Independent Prostate Cancer. Open-labeled, non-randomised clinical trial in patients with androgen independent prostate cancer | | | | |
2009-011675-79: A PHASE II STUDY TO ASSESS EFFICACY AND SAFETY OF PIOGLITAZONE (ACTOS®) AS ADD-ON THERAPY TO IMATINIB MESYLATE (GLEEVEC®) IN CHRONIC PHASE CHRONIC MYELOGENOUS LEUKAEMIA (CP-CML) PATIENTS IN MAJOR MOLECULAR RESPONSE (MMR). |
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| Ongoing | 2 | 50 | Europe | PIOGLITAZONE HYDROCHLORIDE, ACTOS 15 mg, ACTOS 15 mg | CH-Versailles | chronic phase chronic myelogenous leukaemia (CP-CML) patients in major molecular response. | | | | |
2009-012226-37: Ensayo clínico piloto de tratamiento con Pioglitazona+Flutamida+Metformina a Dosis Bajas versus Etinil-Estradiol + Acetato de Ciproterona como control, en Adolescentes con Hiperandrogenismo Ovárico e Hiperinsulinismo: Efectos sobre Parámetros de Inflamación Crónica, Diabetes Tipo 2 y Riesgo Cardiovacular |
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| Ongoing | 2 | 48 | Europe | DIANE 35, METFORMINA SANDOZ 850 mg comprimidos recubiertos con película, FLUTAMIDA CINFA 250 mg comprimidos, ACTOS 15 mg comprimdos, DIANE 35, METFORMINA SANDOZ 850 mg comprimidos recubiertos con película, FLUTAMIDA CINFA 250 mg comprimidos, ACTOS 15 mg comprimdos | HOSPITAL SANT JOAN DE DÉU | Hiperandrogenismo ovárico asociado a hiperinsulinismo. | | | | |
2018-003817-16: A 52 weeks double blind, randomized and placebo controlled trial evaluating the effect of oral KIN001 150 mg plus pioglitazone 10 mg daily on injection frequency of Standard of Care in patients with diagnosed unilateral wet AMD undergoing a treat and extend regimen Eine 52-wöchige, doppelblinde, randomisierte und placebokontrollierte Studie zur Bewertung der Wirkung der täglichen oralen Gabe von KIN001 150 mg plus Pioglitazon 10 mg auf das Behandlungsintervall in der Standardtherapie bei Patienten mit diagnostizierter einseitiger feuchter altersbedingter Makuladegeneration (AMD) |
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| Not yet recruiting | 2 | 100 | Europe | Pioglitazone, KIN001, Prolonged-release tablet, Film-coated tablet | Kinarus AG, Kinarus AG | wet age-related macular degeneration feuchte altersbedingte Makuladegeneration, wet age-related macular degeneration feuchte altersbedingte Makuladegeneration, Diseases [C] - Eye Diseases [C11] | | | | |
2020-005626-29: A PHASE II CLINICAL STUDY, ON TRABECTEDIN IN COMBINATION WITH PPARg AGONIST PIOGLITAZONE IN PATIENTS WITH ROUND CELL MYXOID LIPOSARCOMAS OR DEDIFFERENTIATED G1 OR G2 LIPOSARCOMAS WITH STABLE DISEASE IN TREATMENT WITH TRABECTEDIN ALONE. STUDIO CLINICO DI FASE II, VOLTO A VALUTARE L'ASSOCIAZIONE DEL FARMACO TRABECTEDINA E DEL FARMACO PIOGLITAZONE PPARPg AGONISTA, IN PAZIENTI CON LIPOSARCOMA DI TIPO MIXOIDE/ A CELLULE ROTONDE O LIPOSARCOMA DEDIFFERENZIATO G1 E G2, CON MALATTIA STABILE E IN TRATTAMENTO CON IL FARMACO TRABECTEDINA. |
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| Not yet recruiting | 2 | 10 | Europe | Pioglitazone, Trabectedina, [Pioglitazone], [Trabectedina], Tablet, Powder for concentrate for solution for infusion, Pioglitazone, Yondelis | IRCCS- ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI, AIRC (bandi per la ricerca indipendente) | Patients with myxoid/round cell liposarcoma treated with at least 4 cycle of T alone with a stable disease at the last tumor evaluation Pazienti con diagnosi di liposarcoma mixoide/a cellule rotonde trattati per almeno 4 cicli con trabectedina da sola e con malattia stabile in base all’ultima valutazione di malattia., Patients who have been diagnosed with round cell myxoid liposarcoma and who have been treated with only trabectedin and who according to the latest assessment have stable disease. Pazienti con diagnosi di liposarcoma di tipo mixoide/ a cellule rotonde che sono stati trattati negli ultimi 4 cicli con solo il farmaco trabectedina e con malattia stabile all'ultima valutazione., Diseases [C] - Cancer [C04] | | | | |
2021-001442-35: A PHASE 2 MONOCENTRIC PILOT STUDY TO EVALUATE THE EFFICACY AND SAFETY PROFILE OF PIOGLITAZONE IN SUBJECTS WITH VITILIGO STUDIO PILOTA DI FASE 2 PER LA VALUTAZIONE DELL’EFFICACIA E DEL PROFILO DI SICUREZZA DEL PIOGLITAZONE IN SOGGETTI CON VITILIGINE |
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| Ongoing | 2 | 20 | Europe | Pioglitazone, [PTZ], Tablet | ISTITUTI FISIOTERAPICI OSPITALIERI | NON SEGMENTAL VITILIGO WITH BSA BETWEEN 2% AND 50% AND A NON-SATISFACTORY RESPONSE (LESS THAN 10%) TO A PREVIOUS PHOTOTHERAPY CYCLE VITILIGINE NON SEGMENTALE CON ESTENSIONE (BSA) COMPRESO TRA 2% E 50% E CON UNA SCARSA RISPOSTA (INFERIORE AL 10%) AD UN PRECEDENTE TRATTAMENTO FOTOTERAPICO, DIFFUSE VITILIGO WITH A NON-SATISFACTORY RESPONSE TO PHOTOTHERAPY VITILIGINE DIFFUSA SCARSAMENTE RESPONSIVA ALLA FOTOTERAPIA, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2021-002367-21: Fettvävens sammansättning och dess koppling till typ 2 diabetes: En studie som jämför behandling med Empagliflozin, Pioglitazon och Semaglutide |
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| Not yet recruiting | 2 | 60 | Europe | Film-coated tablet, Tablet, Jardiance 25 mg filmdragerade tabletter, Actos 15 mg tabletter, Actos 45 mg tabletter, Rybelsus 3 mg tabletter, Rybelsus 7 mg tabletter, Rybelsus 14 mg tabletter | Karolinska Universitetssjukhuset, Vetenskapsrådet, Diabetesfonden, SRP Diabetes | Diabetes typ 2, Diabetes typ 2, Diseases [C] - Nutritional and Metabolic Diseases [C18] | | | | |
2020-005849-16: An 8-week double-blind, randomized, placebo-controlled, phase II study evaluating the effects of oral pamapimod 150 mg with pioglitazone 10 mg daily on COVID-19 development in hospitalized patients infected with SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) |
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| Not yet recruiting | 2 | 432 | Europe, RoW | Pioglitazone, KIN001, Prolonged-release tablet, Film-coated tablet | Kinarus AG, Kinarus AG | COVID-19 development in hospitalized patients infected with SARS-CoV-2, Hospitalized patients suffering from COVID-19, Diseases [C] - Virus Diseases [C02] | | | | |
DIASA3, NCT04662866: Effects of Glucose Lowering Agents in South Asian Women With Impaired Glucose Tolerance or Impaired Fasting Glucose |
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| Recruiting | 2 | 64 | Europe | Metformin capsule 500 mg, Empagliflozin encapsulated tablet 10 mg, Pioglitazone encapsulated tablet 30 mg, Linagliptin encapsulated tablet 5 mg, biguanide, glitazone, sodium glucose transport inhibitor, dipeptidyl peptidase inhibitor | Oslo University Hospital, The Research Council of Norway, Norwegian Diabetes Association, South-Eastern Norway Regional Health Authority, University of Oslo, University Hospital, Akershus, Vestre Viken Hospital Trust, University of Glasgow | Impaired Glucose Tolerance, Insulin Sensitivity, Glucose Metabolism Disorders | 12/22 | 10/23 | | |
NCT04995978: Insulin Resistance and Androgen Deprivation Therapy |
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| Withdrawn | 2 | 44 | US | Pioglitazone 30 mg, placebo tablet | St. Louis University | Prostate Cancer, Insulin Resistance | 01/23 | 01/23 | | |
NCT05013255: Pioglitazone Therapy Targeting Fatigue in Breast Cancer |
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| Recruiting | 2 | 30 | US | Pioglitazone 15mg, Actos, Pioglitazone 30 mg | West Virginia University | Breast Cancer, Muscle Fatigue | 04/23 | 04/23 | | |
| Recruiting | 2 | 200 | RoW | Metformin plus Pioglitazone plus an SGLT2 inhibitor | Chang Gung Memorial Hospital, National Taiwan University Hospital, Chiayi Christian Hospital, Tainan Sin-lau Hospital | Diabetes Mellitus, Stroke | 07/23 | 01/24 | | |
NCT05254626: Efficacy and Safety of Dapagliflozin in Patients With Non-alcoholic Steatohepatitis |
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| Active, not recruiting | 2 | 100 | RoW | Dapagliflozin 10Mg Tab, Pioglitazone 30 mg | Cairo University | Non-alcoholic Steatohepatitis | 01/24 | 09/24 | | |
EDI-PIO, NCT02852486: Study of Imatinib Discontinuation in Chronic Myeloid Leukemia With Deep Molecular Response |
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| Active, not recruiting | 2 | 31 | RoW | Pioglitazone 30 Mg Oral Tablet, cloridrato de pioglitazona 30mg EMS S/A, Brasil, imatinib discontinuation | University of Campinas, Brazil | Leukemia, Chronic Myeloid | 02/24 | 02/24 | | |
TRABEPIO, NCT04794127: Study on Trabectedin in Combination With Pioglitazone in Patients Myxoid Liposarcomas With Stable Disease After T Alone. |
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| Recruiting | 2 | 10 | Europe | Trabectedin, Trabectedine, Pioglitazone Oral Product, Pioglitazone | Mario Negri Institute for Pharmacological Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Humanitas Hospital, Italy | Liposarcoma, Myxoid, Liposarcoma, Dedifferentiated, Liposarcoma, Round Cell | 12/24 | 02/25 | | |
| Not yet recruiting | 2 | 20 | NA | Pioglitazone 30mg, Actos, Placebo, Labs, Diagnostic labs | Emory University, National Heart, Lung, and Blood Institute (NHLBI) | Pulmonary Hypertension, Pulmonary Hypertension Due to Lung Diseases | 08/28 | 08/28 | | |
SPIOMET4HEALTH, NCT05394142 / 2021-003177-58: A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS) |
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| Recruiting | 2 | 364 | Europe, RoW | Placebo, Pioglitazone, PIO, Spironolactone, S, Metformin, MET | Fundació Sant Joan de Déu | Polycystic Ovary Syndrome (PCOS) | 04/25 | 04/25 | | |
KIN-FAST, NCT05659459: The Trial (KIN001 For Accelerated Symptoms Termination) in Non Hospitalized Patients Infected With SARS-CoV-2 |
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| Suspended | 2 | 400 | Europe | KIN001, Combination Pamapimod 75mg with Pioglitazone 5mg, KIN001-Placebo | Kinarus AG | COVID-19 | 05/25 | 10/25 | | |
| Recruiting | 2 | 24 | US | Pioglitazone 45 mg, Placebo | Pennington Biomedical Research Center | Lung Cancer | 06/25 | 06/26 | | |
| Recruiting | 2 | 20 | US | Pioglitazone 15mg | University of Maryland, Baltimore, Nico Corporation | Intracerebral Haemorrhage, Intraventricular | 07/25 | 07/26 | | |
NCT05875675: Effects of Pioglitazone in Calcific Aortic Valve Disease |
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| Not yet recruiting | 2 | 100 | NA | Drug: Pioglitazone Oral Tablet, Placebo | Wuhan Union Hospital, China | Calcification of Aortic Valve, Aortic Valve Stenosis | 07/25 | 07/28 | | |
NCT04843046: Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention |
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| Recruiting | 2 | 60 | US | Cognitive Behavioral Therapy (CBT), CBT, Pioglitazone, Actos, Placebo, Corn Starch | The University of Texas Health Science Center, Houston, National Institute on Drug Abuse (NIDA) | Cocaine Use Disorder | 08/25 | 08/25 | | |
NCT04501406: Low-Dose Pioglitazone in Patients With NASH (AIM 2) |
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| Recruiting | 2 | 166 | US | Pioglitazone, Actos, Placebo | University of Florida, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type 2 Diabetes Mellitus (T2DM), Nonalcoholic Steatohepatitis | 08/27 | 08/27 | | |
ACTIW, NCT02767063: Therapies in Combination or Sequentially With Tyrosine Kinase Inhibitors (TKIs) in Chronic Phase Chronic Myelogenous Leukemia Patients in CCR |
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| Recruiting | 1/2 | 100 | Europe | Pioglitazone, Avelumab | Versailles Hospital | Leukemia, Myeloid, Chronic-Phase | 11/22 | 06/23 | | |
NCT05107765: Effects of Pioglitazone on Stress Reactivity and Alcohol Craving |
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| Recruiting | 1/2 | 60 | US | Pioglitazone, Placebo | The University of Texas Health Science Center, Houston, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Use Disorder | 08/24 | 08/24 | | |
NCT03109288: Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS) |
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| Recruiting | 1/2 | 250 | US | Pioglitazone, clemastine fumarate, Dantrolene, Pirfenidone | National Institute of Allergy and Infectious Diseases (NIAID) | Multiple Sclerosis | 01/25 | 01/29 | | |
