| memantine / Generic mfg. |
2005-004498-31: Behaviour and cognition in Alzheimer s disease patients treated with the NMDA receptor antagonist memantine collelation with the apoptotic mechanisms. |
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| Ongoing | 4 | 40 | Europe | EBIXA 10MG 56 CPR RIV, EBIXA 10MG 56 CPR RIV | FONDAZIONE SANTA LUCIA | Treatment of patients with Alzheimer s Disease | | | | |
2007-004897-26: Memantine for the Long Term Management of Neuropsychiatric Symptoms in Alzheimer\'s disease - MAIN-AD |
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| Ongoing | 4 | 300 | Europe | Memantine, Risperidone, Ebixa, Risperdal, Zyprexa, Seroquel, Haloperidol (proprietary), Ebixa, Risperdal, Zyprexa, Seroquel, Haloperidol (proprietary) | King\'s College London, North Essex Partnership NHS Foundation Trust | Alzheimer\'s disease | | | | |
| Ongoing | 4 | 20 | Europe | Ebixa, Depolan, Ebixa, Depolan | Aalto-yliopiston Kylmälaboratorion Aivotutkimusyksikkö | Complex regional pain syndrome tyyppi 1 eli CRPS-I -potilaita | | | | |
2011-005151-13: Pilot Study of Memantine in Chronic Cough Patients Attending a Specialist Clinic |
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| Ongoing | 4 | 15 | Europe | Memantine, Axura, Axura | University of Manchester, University Hospital of South Manchester, Medical Research Council | Idiopathic and treatment resistant Chronic Cough | | | | |
ChiCTR2400085793: The efficacy of Memantine combined with Speech language therapy for post stroke non-fluent aphasia rehabilitation |
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| Completed | 4 | 60 | | Only receive SLT treatment; Receive memantine + SLT | Beijing Boai Hospital, China Rehabilitation Research Center; Beijing Boai Hospital, Self-financing | post stroke aphasia | | | | |
NCT03954613: Evaluation of the Contribution of Regular Cognitive Exercises to Treatment in Patients With Alzheimer's Disease |
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| Recruiting | 4 | 198 | RoW | Ebicomb, Donepezil-Memantine | Neutec Ar-Ge San ve Tic A.Åž | Alzheimer Disease, Cognitive Change | 03/23 | 03/24 | | |
ChiCTR2000035209: Effects of Memantine on glutamate metabolism in patients with moderate to severe depression: a randomized controlled trial. |
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| Not yet recruiting | 4 | 60 | | combination therapy ;Anti-5-ht antidepressant should be administered alone | The Second Affiliated Hospital of Xinxiang Medical University; The Second Affiliated Hospital of Xinxiang Medica University, Henan Provincial Clinical Research Center for Mental and Psychological Diseases opens the project | depression | | | | |
NCT03703856: Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease |
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| Recruiting | 4 | 32 | US | Memantine, Placebo | University of California, San Diego | Alzheimer Disease | 06/24 | 06/24 | | |
NCT05430867: Efficacy and Safety of Memantine and Sodium Oligomannate in Patients With Moderate to Severe Alzheimer's Disease |
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| Not yet recruiting | 4 | 150 | NA | Memantine Oral Tablet, Memantine, GV-971 capsule, GV-971 | First Affiliated Hospital Xi'an Jiaotong University | Treatment, Efficacy, Safety, Alzheimer Disease | 07/24 | 12/24 | | |
ChiCTR2300071719: Evaluation of the efficacy and safety of Memantine hydrochloride oral membranes in the treatment of moderate-to-severe and severe senile dementia patients in real-world settings: a multicenter registry study |
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| Not yet recruiting | 4 | 2000 | | N/A | The Second Hospital, Cheeloo College of Medicine, Shandong University; The Second Hospital, Cheeloo College of Medicine, Shandong University, enterprise | Senile dementia | | | | |
ChiCTR2300068027: A controlled study of memantine versus propafenone in patients with paroxysmal atrial fibrillation: a multicenter, randomized, open, noninferiority study (MVP-AF) |
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| Not yet recruiting | 4 | 1570 | | Memantine treatment ;Propafenone treatment | East Hospital, Tongji University School of Medicine; Army Specialty Medical Center; East Hospital, Tongji University School of Medicine, Shanghai Cardiovascular Disease Clinical Medical Center project; Personalized training program for key supported objects of Outstanding Talent Pool of Army Medical University | paroxysmal atrial fibrillation | | | | |
ACTRN12621000175875: MEMOIR: a clinical trial of memantine and Graded Motor Imagery for Complex Regional Pain Syndrome |
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| Recruiting | 3 | 160 | | | Neuroscience Research Australia, National Health and Medical Research Council | Complex Regional Pain Syndrome | | | | |
2013-002055-15: CONTROLLED MULTICENTER STUDY ON THE MOOD-STABILIZING EFFECT OF MEMANTINE IN BIPOLAR I DISORDERS STUDIO MULTICENTRICO CONTROLLATO SULL'EFFETTO PROFILATTICO DELLA MEMANTINA NEL DISTURBO BIPOLARE DI TIPO I |
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| Ongoing | 3 | 106 | Europe | Coated tablet, EBIXA, LAMOTRIGINE DOC -GENERIC | UNIVERSITY OF SASSARI, UNIVERSITY OF SASSARI | BIPOLAR I MOOD DISORDERS DISTURBO DELL'UMORE DI TIPO I, MANIC-DEPRESSIVE ILLNESS MALATTIA MANIACO-DEPRESSIVA, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2005-005859-18: EFFECT OF MEMANTINE TREATMENT ON BRAIN FUNCTION AND MORPHOLOGICAL STRUCTURE IN PATIENTS WITH MODERATE TO SEVERE PATIENTS WITH ALZHEIMER S DISEASE A STRUCTURAL MR AND FMRI STUDY |
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| Ongoing | 3 | 30 | Europe | EBIXA*56CPR RIV 10MG, EBIXA*56CPR RIV 10MG | FONDAZIONE SANTA LUCIA | Moderate to severe Alzheimer s disease | | | | |
2006-000860-10: An Open-Label Study Investigating the Specific Effects of Memantine in Institutionalised Patients with Alzheimer’s Disease |
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| | 3 | 40 | Europe | Ebixa, Lu 00-800, Ebixa 10 mg film-coated tablets, Ebixa 10 mg film-coated tablets | H. Lundbeck A/S | Effects of memantine treatment in institutionalised patients with Alzheimer\'s Disease. | | 09/06 | | |
2007-004297-40: Pharmacological treatment of nystagmus: A randomised double masked placebo controlled crossover study using gabapentin and memantine. |
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| Ongoing | 3 | 180 | Europe | Memantine, Gabapentin, N/A, Neurontin, N/A, Neurontin | University Hospitals of Leicester NHS Trust | Nystagmus | | | | |
2009-016751-22: A double blind, placebo controlled study of memantine in patients with obsessive-compulsive disorder. |
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| Ongoing | 3 | 50 | Europe | memantine, Ebixa, Ebixa | AMC, divisie Psychiatrie | Obsessive-compulsive disorder (OCD) | | | | |
2019-002778-30: Double-blind, randomised, multicenter study to evaluate the efficacy and safety of memantine in adolescents with Bipolar Disorder Studio multicentrico randomizzato in doppio cieco per valutare l'efficacia e la sicurezza della memantina negli adolescenti con Disturbo Bipolare |
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| Not yet recruiting | 3 | 68 | Europe | MEMANTINA ACCORD, [NA], Film-coated tablet, MEMANTINA ACCORD - 10 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/PE/PVDC/ALLUMINIO) - 56 COMPRESSE | IRCCS, OSPEDALE PEDIATRICO BAMBINO GESÙ DI ROMA, Ministero della Salute | Bipolar Disorder Disturbo Bipolare, Bipolar Disorder in adolescents Disturbo bipolare negli adolescenti, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT03858270: Inhibition of α-synuclein Cell-cell Transmission by NMDAR Blocker, Memantine |
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| Recruiting | 3 | 50 | US | Memantine, Namenda, Placebo | Wayne State University | Parkinson Disease | 04/22 | 07/23 | | |
2021-002179-21: A phase 3 study to evaluate the safety and efficacy of masitinib as add-on therapy in patients with mild to moderate Alzheimer's disease treated with standard of care: cholinesterase inhibitors, memantine |
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| Not yet recruiting | 3 | 600 | Europe | Masitinib, AB1010, Film-coated tablet | AB Science, ABScience, AB Science, ABScience | Alzheimer's disease, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Not yet recruiting | 3 | 20 | NA | Memantine Oral Tablet, Placebo | University of Roma La Sapienza | Obsessive-Compulsive Disorder | 10/22 | 12/22 | | |
NCT03550391: Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases |
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| Recruiting | 3 | 206 | Canada, US | Memantine, Hippocampal-avoidant (HA-WBRT) Radiotherapy, Stereotactic Radiosurgery (SRS) | Canadian Cancer Trials Group, Alliance for Clinical Trials in Oncology, NRG Oncology | Brain Metastases | 06/27 | 12/27 | | |
NCT06337994: Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury |
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| Completed | 3 | 60 | RoW | Memantine Hydrochloride, Active arm | Assiut University | Treatment of Cognitive Deficits After Traumatic Brain Injury | 06/24 | 08/24 | | |
MEMENTO, NCT06275035: Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI |
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| Recruiting | 3 | 101 | RoW | Memantine Oral Tablet, Memantine | Tata Memorial Centre | Neurocognitive Dysfunction | 01/26 | 01/31 | | |
NCT03553875: Memantine for the Treatment of Social Deficits in Youth with Disorders of Impaired Social Interactions |
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| Suspended | 3 | 100 | US | Memantine Hydrochloride, Placebo | Massachusetts General Hospital | Autism, Autism Spectrum Disorder, Nonverbal Learning Disability | 06/25 | 06/25 | | |
NRG-BN009, NCT04588246: Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery |
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| Terminated | 3 | 19 | US | Memantine, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Stereotactic Radiosurgery, Stereotactic External Beam Irradiation, stereotactic external-beam radiation therapy, Stereotactic Radiation Therapy, Stereotactic Radiotherapy, stereotaxic radiation therapy, stereotaxic radiosurgery, Whole-Brain Radiotherapy, WBRT, whole-brain radiation therapy | NRG Oncology, National Cancer Institute (NCI) | Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Digestive System Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Metastatic Renal Cell Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8, Recurrent Brain Neoplasm, Stage IV Lung Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8 | 08/24 | 08/24 | | |
NRG-CC009, NCT04804644: Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability |
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| Recruiting | 3 | 200 | Canada, US | Memantine Hydrochloride, Ebixia, Namenda, Neurocognitive Assessment, Stereotactic Radiosurgery, Stereotactic External Beam Irradiation, stereotactic external-beam radiation therapy, Stereotactic Radiation Therapy, Stereotactic Radiotherapy, stereotaxic radiation therapy, stereotaxic radiosurgery, Whole-Brain Radiotherapy, WBRT, whole-brain radiation therapy | NRG Oncology, National Cancer Institute (NCI) | Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Recurrent Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8 | 07/28 | 07/30 | | |
NCT04939597: A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for Primary Central Nervous System Tumors |
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| Recruiting | 3 | 192 | US | Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cognitive Assessment, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Memantine Hydrochloride, Ebixia, Namenda, Placebo Administration, Questionnaire Administration | Children's Oncology Group | Central Nervous System Carcinoma | 09/27 | 09/27 | | |
ACTRN12607000181404: Efficacy of Memantine [N- Methyl- D- Aspartate (NMDA) receptor antagonist] versus placebo in acute non arteritic anterior ischemic optic neuropathy (NAION) |
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| Active, not recruiting | 2/3 | 44 | | | Tehran University of Medical sciences, Ophthalmology department/ school of medicine/ Medical Sciences/ Tehran University | Non arteritic anterior ischemic optic neuropathy (NAION) | | | | |
ACTRN12609000111279: The effects of memantine versus placebo on visual functions after scleral buckling for regmatogenous retinal detachment (RRD) |
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| Active, not recruiting | 2/3 | 60 | | | Tehran University of Medical sciences, Ophthalmology department/ school of medicine/ Medical Sciences/ Tehran University | patients with rhegmatogenus retinal detachment undergoing scleral buckeling surgery | | | | |
ACTRN12611000350921: The effects of memantine versus placebo on visual functions of patient with optic neuritis |
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| Active, not recruiting | 2/3 | 60 | | | Tehran University of Medical sciences, Tehran University, Ophthalmology department/ School of medicine/ Medical Sciences | isolated optic neuritis, optic neuritis | | | | |
| Not yet recruiting | 2/3 | 750 | Europe | Memantine, Trazodone, Oral solution, Oral liquid, Trazodone Hydrochloride 100mg/5ml Oral Solution | University of Edinburgh, NHS Lothian, Euan MacDonald Centre, University of Edinburgh, MND Scotland, My Name'5 Doddie Foundation, | Motor Neurone Disease, Motor Neurone Disease, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT04035798: add-on Low Dose Memantine in Middle-to-old Aged Bipolar II Disorder Patients |
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| Recruiting | 2/3 | 120 | RoW | Memantine or placebo | National Cheng-Kung University Hospital, Ministry of Science and Technology, Taiwan | Bipolar II Disorder | 07/21 | 07/22 | | |
NCT04737967: The Potential Protective Role of Venlafaxine Versus Memantine in Paclitaxel Induced Peripheral Neuropathy |
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| Recruiting | 2/3 | 60 | RoW | Venlafaxine, Memantine | Mendel AI, Cairo University | Oncology Pain, Chemotherapy-induced Peripheral Neuropathy | 08/21 | 10/21 | | |
NCT04857983: Memantine Augmentation of Targeted Cognitive Training in Schizophrenia |
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| Recruiting | 2/3 | 69 | US | Memantine, targeted cognitive training (TCT), Placebo | University of California, San Diego | Schizophrenia, Schizoaffective Disorder | 09/24 | 12/24 | | |
NCT05796752: Behavioral Treatment and Memantine in Body Focused Repetitive Behaviors |
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| Recruiting | 2/3 | 28 | US | Memantine, Namenda, ComB Behavioral Therapy | University of Chicago | Skin-Picking, Trichotillomania (Hair-Pulling Disorder) | 12/24 | 12/24 | | |
NCT04687566: Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction |
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| Recruiting | 2/3 | 120 | RoW | Dextromethorphan, Memantine, Dextromethorphan and memantine, Placebo | National Cheng-Kung University Hospital, Ministry of Science and Technology, Taiwan | Amphetamine Addiction, Pharmacotherapy | 07/24 | 07/24 | | |
NCT06007846: A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer |
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| Recruiting | 2/3 | 12 | US | Namenda, Memantine | Inova Health Care Services | Hepatocellular Carcinoma, Cirrhosis | 07/25 | 08/25 | | |
NCT03342443: Effect of Memantine on Radiotherapy-related Cognitive Impairment |
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| Recruiting | 2/3 | 240 | RoW | Memantine, Arm I, Placebo, Arm II | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Cognitive Impairment | 10/24 | 12/24 | | |
| Recruiting | 2/3 | 800 | Europe | Memantine Hydrochloride Oral Solution, Trazodone Hydrochloride oral solution, Placebo oral solution, Amantadine Hydrochloride Oral Solution | University of Edinburgh, University College, London, University of Warwick, NHS Lothian | Motor Neuron Disease, Amyotrophic Lateral Sclerosis | 09/26 | 12/26 | | |
ACTRN12614000619640: The effect of Memantine on cognition disorders induced by Electroconvulsive therapy (ECT) |
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| Recruiting | 2 | 40 | | | Mohammad Abbasinazari, Shahid Beheshti University of Medical Sciences | Post ECT cognition disorders | | | | |
| Ongoing | 2 | 80 | Europe | Dextromethorphan, Memantine, Capsule, Pulmodexane, Ebixa | CHU de Clermont-Ferrand, CHU de Clermont-Ferrand, Ministère du travail, de l'Emploi et de la Santé | Douleurs neuropathiques, Douleurs neuropathiques, Diseases [C] - Nervous System Diseases [C10] | | | | |
2005-004109-27: A double-blind, placebo-controlled multi-centre trial of memantine in patients with Parkinsons’ disease dementia or dementia with Lewy bodies |
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| Ongoing | 2 | 20 | Europe | Ebixa, Ebixa, Ebixa | Neuropsychiatric clinic | Parkinsons disease (PD)and dementia with Lewy bodies (DLB) are both common disease of the elderly. The majority of patients who survive for more than 10 years with PD eventually develope dementia (PDD). The brain changes and clinical presentations of PDD and DLB are similar. The clinical characteristics are cognitive impairment with pronounced visuospatial and executive impairment, visual hallucinations, parkinsonism, fluctuations in cognition and REM sleep disorder. | | | | |
2007-000503-15: Experimental clinical open study, randomized, experimental group vs control group, for the evaluation of tolerability and the effects on magnetic resonance parameters and cognitive functions of memantine in patients at early stage of relapsing- remitting multiple sclerosis treated with interferon-beta. |
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| Ongoing | 2 | 120 | Europe | EBIXA, EBIXA | AZ. OSPEDALIERA GARIBALDI, S.LUIGI CURRO , ASCOLI TOMASELLI | patients at early stage of relapsing- remitting multiple sclerosis treated with interferon-beta. | | | | |
2007-002117-39: MEMANTINA (Ebixa X) PARA LA DISCAPACIDAD FUNCIONAL EN LA ESCLEROSIS LATERAL AMIOTRÓFICAMEMANTINE (Ebixa R) FOR FUNCTIONAL DISABILITY IN AMYOTROPHIC LATERAL SCLEROSIS . |
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| Ongoing | 2 | 80 | Europe | EBIXA, EBIXA | Jorge Matias-Guiu Guia | Esclerosis Lateral AmiotroficaAmyotrophic lateral Sclerosis | | | | |
2011-000802-23: Study of the efficacy of the drug memantine in the treatment of fibromialgia Estudio que evalua la eficacia del medicamento memantina en el tratamiento de la fibromialgia |
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| Ongoing | 2 | 10 | Europe | EBIXA 5mg+10 mg+15 mg+20 mg comprimidos recubiertos con película, EBIXA 20 mg comprimidos recubiertos con película, EBIXA 5mg+10 mg+15 mg+20 mg comprimidos recubiertos con película, EBIXA 20 mg comprimidos recubiertos con película | Javier García Campayo, Lundbeck España S.A. | Fibromialgia Fibromialgia | | | | |
2017-004125-32: A randomised, double blind, placebo controlled trial to evaluate the safety, efficacy and pharmakokinetics of Pleconaril as an add on to AchEI/memantine for treatment of patients with Alzheimer’s disease |
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| Ongoing | 2 | 120 | Europe | pleconaril, Capsule, hard | Apodemus Aktiebolag, Apodemus AB | Alzheimer's disease, Alzheimer's disease, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT04538066: Bryostatin Treatment of Moderately Severe Alzheimer's Disease |
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| Completed | 2 | 122 | US | Bryostatin 1, Placebo | Neurotrope Bioscience, Inc., National Institutes of Health (NIH), National Institute on Aging (NIA) | Alzheimer Disease | 11/22 | 11/22 | | |
NCT03194906: Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors |
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| Completed | 2 | 34 | US | Memantine, Memantine hydrochloride, Namenda®, Placebo, Look-alike drug, Cognitive Assessment, Cognitive and neurologic examinations | St. Jude Children's Research Hospital, National Cancer Institute (NCI) | Glioma of Brain, Craniopharyngioma, Ependymoma, Germ Cell Tumor | 06/23 | 06/23 | | |
NCT04801342: Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases |
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| Recruiting | 2 | 72 | RoW | Conformal Whole Brain Radiotherapy with Unilateral Hippocampal Avoidance, Unilateral HA-WBRT, Conformal Whole Brain Radiotherapy with Bilateral Hippocampal Avoidance, Bilateral HA-WBRT, Memantine Hydrochloride, Memantine | National Taiwan University Hospital | Metastatic Malignant Neoplasm to Brain | 01/24 | 02/25 | | |
NCT05045950: Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique |
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| Recruiting | 2 | 53 | US | Memantine -Twice Daily or Extended Release, Namenda, WBRT utilizing the PRDR technique | Medical College of Wisconsin | Brain Metastases | 05/25 | 05/26 | | |
NCT05538507: Efficacy of Chinese Traditional Medicine "Smart Soup" in Cognition and Behavior Regulation in Alzheimer's Disease |
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| Recruiting | 2 | 180 | RoW | smart soup, traditional chinese medicine, Donepezil, donepezil pill, Memantine, Memantine Pill, Placebo | Peking Union Medical College Hospital, Tongji University | Alzheimer Disease, Mild Cognitive Impairment | 06/24 | 06/24 | | |
NCT04539951: Pragmatic Trial of Obsessive-compulsive Disorder |
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| Recruiting | 2 | 1600 | RoW | Sertraline 200 milligram(mg), Sertraline 300 milligram(mg), Fluvoxamine, Venlafaxine, Augment with Memantine, Augment with Aripiprazole | Shanghai Mental Health Center, The first specialized hospital of harbin, Guizhou Provincial People's Hospital, First Affiliated Hospital of Jinan University, West China Hospital, Suzhou Psychiatric Hospital, Nanjing Medical University, Wuhan Mental Health Centre, Seventh People's Hospital of Hangzhou, The First Affiliated Hospital of Kunming Medical College, General Hospital of Ningxia Medical University, The First Affiliated Hospital of Nanchang University, The Second Affiliated Hospital of Xinxiang Medical University | Obsessive-Compulsive Disorder | 06/24 | 12/24 | | |
NCT05063851: The Use of Memantine for Prevention of Alzheimer's Disease |
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| Recruiting | 2 | 32 | US | Memantine Hydrochloride Tablets, Placebo | University of Virginia | Alzheimer Disease | 12/25 | 12/25 | | |
NCT06594172: Early Application of Memantine and Pioglitazone to Protect Cognitive Function After Radiotherapy |
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| Not yet recruiting | 2 | 67 | NA | Memantine Oral Tablet, pioglitazone, hippocampal avoidance whole-brain radiotherapy (HA-WBRT), Pioglitazone 15mg, Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) | Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangdong Provincial People's Hospital, Fujian Medical University Union Hospital, Southern Medical University, China, The Affiliated Panyu Center Hospital of Guangzhou Medical University, The Central Hospital of Shaoyang City | Radiation Disease, Cognitive Impairment, Drug Effect | 12/25 | 06/27 | | |
| Recruiting | 2 | 80 | US | Memantine, Namenda, Placebo | Vanderbilt University Medical Center, Evergreen Therapeutics, Inc., The University of Texas Health Science Center, Houston, The Cleveland Clinic | Lupus Erythematosus, Systemic | 06/26 | 12/26 | | |
NCT05418049: Evaluating the Neurophysiologic and Clinical Effects of Single Dose Drug Challenge |
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| Recruiting | 2 | 45 | US | Baclofen, Memantine, NAMENDA, Roflumilast, DAILIRESP, Placebo | Children's Hospital Medical Center, Cincinnati, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Fragile X Syndrome | 06/25 | 06/25 | | |
NCT05807165: HF-SRT vs. HS-WBRT in Treating Patients With Brain Oligometastases |
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| Not yet recruiting | 2 | 115 | RoW | Hypofractionated Stereotactic Radiotherapy (HF-SRT), Hippocampus-Sparing Whole-Brain Radiotherapy (HS-WBRT) plus memantine | Chang Gung Memorial Hospital | Brain Oligometastases | 07/26 | 07/26 | | |
NCT05834231: Efficacy of Memantine in Prevention of Oxaliplatin-induced Peripheral Neurotoxicity |
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| Not yet recruiting | 1/2 | 60 | NA | Memantine, Placebo | Mansoura University | Cancer | 03/24 | 10/24 | | |
| Active, not recruiting | 1/2 | 150 | US | Acetazolamide, Diamox, Atomoxetine, Strattera, NO Drug, Clonidine, Catapres, Entacapone, Comtan, Entacapone & Propranolol, Inderal, Atomoxetine & Propranolol, Indomethacin, Indocin, Mecamylamine, inversine, Isosorbide Dinitrate, Isordil, Melatonin, Midodrine, pro-amatine, Modafinil, provigil, Octreotide, sandostatin, Placebo, Propranolol, Modafinil & Propranolol, Provigil, Sertraline, Zoloft, IV Saline, NaCl solution (0.9%), Drinking Water, Breathing Device, memantine, Namenda, Abdominal binder | Satish R. Raj, National Center for Advancing Translational Sciences (NCATS) | Tachycardia, Chronic Orthostatic Intolerance | 12/25 | 12/25 | | |
| Recruiting | 1/2 | 120 | Europe | Gabapentin, Sulfasalazine, Memantine, Temozolomide, Radiotherapy | University of Zurich, Swiss National Science Foundation | Glioblastoma | 06/26 | 12/26 | | |
NCT01430351: Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy |
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| Active, not recruiting | 1 | 144 | US | Mefloquine, Memantine Hydrochloride, Ebixia, Namenda, Metformin Hydrochloride, APO-Metformin, Cidophage, Dimefor, Glifage, Glucoformin, Glucophage, Glucophage ER, Metformin HCl, Riomet, Siofor, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac | M.D. Anderson Cancer Center, National Cancer Institute (NCI) | Glioblastoma, Gliosarcoma, Supratentorial Glioblastoma | 09/25 | 09/25 | | |
NCT04217694: Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors |
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| Active, not recruiting | 1 | 18 | US | Cogstate Assessment Battery, Memantine, Memantine Hydrochloride, Ebixia, Namenda | Mayo Clinic, National Cancer Institute (NCI) | Malignant Central Nervous System Neoplasm, Primary Central Nervous System Neoplasm | 09/22 | 08/24 | | |
AMEND, NCT04789915: Add-on MEmaNtine to Dopamine Modulation to Improve Negative Symptoms at First Psychosis |
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| Recruiting | 1 | 46 | Europe | Memantine, Placebo | Bjorn H. Ebdrup, Lundbeck Foundation, Danish Research Centre for Magnetic Resonance, University of Copenhagen | Psychosis, Negative Symptoms With Primary Psychotic Disorder | 05/25 | 12/26 | | |
TASD, NCT04966546: Targeting Spreading Depolarization After Chronic Subdural Hematoma Surgery |
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| Withdrawn | 1 | 20 | US | Memantine Hydrochloride, Placebo | University of New Mexico | Chronic Subdural Hematoma | 12/25 | 12/25 | | |
ChiCTR-IPR-16008425: Efficacy of quetiapine in behavioral and psychological symptoms of Alzheimer's disease patients |
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| Not yet recruiting | N/A | 120 | | Quetiapine ;Memantine | Changning Mental Health Center; Changning Mental Health Center, Key program of the Changning Science and Technology Committee | Alzheimer's disease | | | | |
NCT05531383: Effect of Early Memantine Administration on Outcome of Patients With Moderate to Severe Traumatic Brain Injury |
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| Active, not recruiting | N/A | 70 | RoW | Memantine Hydrochloride, Namenda | Minia University | Traumatic Brain Injury | 11/23 | 07/24 | | |
| Recruiting | N/A | 60 | RoW | AChE inhibitor monotherapy, Donepezil, AChE inhibitor and NMDA receptor antagonist combination therapy, Donepezil and Memantine combination therapy | University of the Philippines | Alzheimer Disease | 12/23 | 02/25 | | |
STOP-AP, NCT06501638: Efficacy and Safety of memanTine in the Treatment Of Frequently symPtomatic Atrial Premature Beats |
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| Not yet recruiting | N/A | 256 | RoW | Memantine Hydrochloride 10 MG, Placebo | Shanghai East Hospital | Atrial Premature Beats, Contractions, or Systoles | 07/25 | 12/25 | | |
FOCI, ChiCTR2200062493: A real-world study of factors related to disease outcome in patients with various types of subjective cognitive impairment, mild cognitive impairment, and dementia |
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| Not yet recruiting | N/A | 500 | | Donepezil ;Memantine ;Sodium oligomannate ;Other medicine | The First Affiliated Hospital of Kunming Medical University; The First Affiliated Hospital of Kunming Medical University, Science and Technology Innovation Team Construction Project of Kunming Medical University (Project No. CXTD202104) | Subjective cognitive impairment, mild cognitive impairment, and dementia | | | | |