2011-003466-33: Memantine as an adjunctive therapy to ongoing clozapine treatment: a proof-of-concept study Memantine toevoeging bij voortgezette behandeling met clozapine: een studie om het concept te bewijzen |
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| Completed | 2 | 52 | Europe | Memantine hydrochloride, EU/1/02/219/023, Film-coated tablet, Ebixa | Mental Health Services North Holland North, Mental Health Services North Holland North | Cognitive functioning, severity of psychopathology and treatment response (positive symptoms and negative symptoms of schizophrenia), depressive symptoms, social cognition, obsessive-compulsive symptoms, psychosocial functioning, quality of life and adverse effects in outpatients with refractory schizophrenia and a nonsatisfactory response to clozapine (duration of adequate clozapine treatment at least six months). Cognitief functioneren, ernst van psychopathologie en behandelrespons (positieve symptomen en negatieve symptomen van schizofrenie), depressieve symptomen, sociale cognitie, obsessief-compulsieve symptomen, psychosociaal functioneren, kwaliteit van leven en bijwerkingen bij ambulante patiënten met therapieresistente schizofrenie en onvoldoende respons na minimaal 6 maanden adquate behandeling met clozapine., Cognitive function, severity of psychopathology, depressive symptoms, obsessive-compulsive symptoms, social outcome and adverse effects in ambulatory patients with clozapine-resistant schizophrenia. Cognitieve functie, ernst van psychopathologie, depressieve symptomen, obsessief-compulsieve symptomen, sociale uitkomst en bijwerkingen bij ambulante patiënten met clozapineresistente schizofrenie., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2014-003080-38: GOAT - Glutamatergic medication in the treatment of Obsessive Compulsive Disorder (OCD) and Autism Spectrum Disorder (ASD) |
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| Completed | 2 | 100 | Europe, RoW | Ebixa 5 mg film-coated tablets, Ebixa 10 mg film-coated tablets, Film-coated tablet, Ebixa 5 mg film-coated tablets, Ebixa 10 mg film-coated tablets | Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, European Union, Framework Programme 7 (FP7) European Union/European Commission | Obsessive Compulsive Disorders (OCD) Autism Spectrum Disorders (ASD), OCD: repetitive thoughts/impulses/images and behaviours/mental actsASD: deficits in social interaction/communication, and restricted, repetitive and stereotyped patterns of behaviour/interests/activ, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Completed | 2 | 160 | US, RoW | Memantine, Namenda, Placebo, Inactive Capsules | University Hospitals Cleveland Medical Center, Alana USA Foundation | Down Syndrome, Intellectual Disability | 07/20 | 07/20 | | |
