Ongoing

4

25

Europe

Powder for solution for injection, Tablet, Solution for infusion, Solution for injection, Powder for infusion*, Powder and solvent for solution for injection, Concentrate for solution for infusion, ENDOXAN BAXTER*EV 1FL 500MG, DELTACORTENE FORTE*10CPR 25MG, MABTHERA*EV 1FL 50ML 500MG, DECADRON*10CPR 0,5MG, VINCRISTINA TEVA*IV FL 1MG 1ML, HOLOXAN*EV 1FL 1G, METOTRESSATO TEVA*FL 1G 10ML, VEPESID*EV 1FL 100MG/5ML, VUMON*INFUS 1F 50MG/5ML, ELDISINE*INIET EV FL POLV 5MG, ARACYTIN*IV SC 1FL 500MG+F10ML, CAELYX*INFUS 1FL 2MG/ML 25ML

AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI

B-ALL, Burkitt and Burkitt likeand Non-Hodgkinﾒs Lymphoma in Adults

 

 

Completed

4

40

 

MMF 1.0g/bid (<50kg 0.75g bid) ;Intravenous CTX0.5-0.75g/m2 (10-15mg/kg, <1g once)

Shanghai Jiaotong University Affiliated Ruijin Hospital; Level of the institution：, Shanghai Jiaotong University Affiliated Ruijin Hospital

ANCA Associated Systemic Vasculitiswith renal involvement

 

 

Completed

4

60

 

intravenous CTX 0.5-0.75g/m2 Monthly+Oral prednisone (Prednisolone) 0.8mg/kg.d ;Oral FK506 FK506 0.1mg/kg.d+prednisone (Prednisolone) 0.5mg/kg.d

Shanghai Jiaotong University Affiliated Ruijin Hospital; Level of the institution：, Shanghai Jiaotong University Affiliated Ruijin Hospital

primary focal segmental glomerulosclerosis

 

 

Recruiting

4

40

 

hormone, cyclophosphamide, three months ;hormone+CsA, three months

Department of Nephrology, China-Japan Friendship Hospital; Department of Nephrology, China-Japan Friendship Hospital, No

Atypical membranous nephropathy

 

 

Ongoing

4

60

Europe

PACLITAXEL, FLUOROURACIL, CYCLOPHOSPHAMIDE, EPIRUBICIN, TAXOL, FLUOROURACILO FERRER FARMA, GENOXAL, PHARMORUBICIN, TAXOL, FLUOROURACILO FERRER FARMA, GENOXAL, PHARMORUBICIN

GRUPO ESPAÑOL DE INVESTIGACIÓN EN CÁNCER DE MAMA (GEICAM)

Patients with histologically confirmed stage I-III invasive carcinoma of the breastfor whom adjuvant chemotherapy is indicated.

 

 

Ongoing

4

20

Europe

methylprednisolone, cyclophosphamide, cyclophosphamide, Solu-medrone, Solu-medrone

Newcastle upon Tyne NHS Foundation Trust

Systemic Sclerosis associated interstitial lung disease

 

 

Ongoing

4

206

Europe

Rituximab (MabThera), Fludarabine (Fludara Oral), Cyclophosphamide Tablets, Fludarabine (Fludara), Mitoxantrone, Rituximab (MabThera or Rituxan) (Reduced dose), Cyclophosphamide injection, MabThera, Mitoxantrone, MabThera, Mitoxantrone

Leeds Teaching Hospitals NHS Trust

Chronic Lymphocytic Leukaemia

 

 

Ongoing

4

110

Europe

Revlimid, Cyclophosphamide, Bortezomib, Thalidomide, Dexamethasone, PL 00032/0335, EU/1/04/274/001, EU/1/08/443/001, PL0065/5045R, Revlimid, Cyclophosphamide, VELCADE, Thalidomide, Dexamethasone, Revlimid, Cyclophosphamide, VELCADE, Thalidomide, Dexamethasone

Hull and East Yorkshire Hospitals NHS Trust

Chemotherapy related thrombosis in patients treated for multiple myeloma.

 

 

Recruiting

4

60

 

cyclophosphamide ;tacrolimus

Baoji Central Hospital; Baoji Central Hospital, Self-financing

idiopathic membranous nephropathy

 

 

Recruiting

4

45

 

continuous low-dose cyclophosphamide and prednisone

Zhabei district centeral hospital, Shanghai, China; Zhabei district centeral hospital, Shanghai, Shanghai committee of science and technology research plan

Multiple myeloma

 

 

Ongoing

4

800

Europe

Obinutuzumab, Fludarabine, Fludarabine (IV), Cyclophospamide (oral), Cyclophosphamide (IV), Rituximab, Bendamustine, Mitoxantrone, Alemtuzumab, Ofatumumab, Concentrate for solution for infusion, Film-coated tablet, Powder for solution for infusion, Tablet, Powder for concentrate for solution for infusion, Concentrate and solvent for solution for infusion, Obinutuzumab, Fludarabine (oral), Ofatumumab

University of Leeds, Napp Pharmaceuticals

Chronic lymphocytic leukaemia (CLL), Chronic lymphocytic leukaemia (CLL), Diseases [C] - Cancer [C04]

 

 

Recruiting

4

50

 

R-EPOCH regimen treatment ;R-CHOP regimen treatment

Shanghai Public Health Clinical Center; 上海市金山区漕廊公路2901号, Medical Science Support Program by Shanghai Science and Technology Committee

AIDS-associated CD20+ diffuse large B lymphoma

 

 

Recruiting

4

120

 

Cyclophosphamide+methylprednisolone ;Methylprednisolone

Shanghai Changzheng Hospital; Shanghai Changzheng Hospital, Second Military Medical University

thyroid associated ophthalmopathy

 

 

Not yet recruiting

4

100

 

treated with mizoribine and steroid ;treated with cyclophosphamide and steroid

Tianjin First Central Hospital; Tianjin First Central Hospital, self-financing

membranous nephropathy

 

 

Not yet recruiting

4

96

 

The patients distributed in group A was treated with rhTPO immediately at a dose of 300 U.d-1.kg-1, ih. ;The patients distributed in group B continued to observe and check blood every other day. When platelets were found to be less than 75*109/L, rhTPO was administered subcutaneously at a dose of 300 U.d-1.kg-1 once a day.

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Beijing Xisike Clinical Oncology Research Foundation

Osteosarcoma and soft tissue sarcoma

 

 

Not yet recruiting

4

90

 

Tacrolimus 0.05-0.1mg/kg/d ;CTX 750mg/m2 ivgtt q2w for 8 weeks, then q4w for 4 weeks

Sichuan Provincial People's Hospital; Sichuan Provincial People's Hospital, self-financing

primary membranous nephropathy

 

 

Recruiting

4

80

 

Idarubicin, Etoposide, Cytarabine,Cyclophosphamide (IEAC ) Regimen followed by ASCT

The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, research funding

malignant lymphoma

 

 

Recruiting

4

20

 

low dose Dac+R-CHOP ;R-CHOP

Anhui Provincial Cancer Hospital; Anhui Provincial Cancer Hospital, Anhui province department of finance appropriation

Diffuse Large B Cells Lymphoma

 

 

Recruiting

4

120

 

Mycophenolate mofetil dispersible tablets 2 g /d; Steroid 0.75 mg/kg/d ;Tacrolimus capsule, 3mg/d, Steroid 0.75 mg/kg/d ;Cyclophosphamide 1-2mg/kg/d, Steroid 0.75 mg/kg/d ;Steroid from 0.75 mg/kg/d to 15 mg/d.

Peking Union Medical College Hospital; Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd, Hangzhou ZhongMei Huadong Pharmaceutical Co., Ltd.

nonspecific interstitial pneumonia (NSIP)

 

 

Completed

4

92

 

Tacrolimus ;Cyclophosphamide ;Mycophenolate mofetil

Lanzhou University Second Hospital; Lanzhou University Second Hospital, Partial support of Cuiying Science and Technology Innovation Project (CY2017-MS16) and Science and Technology Development Program of Lanzhou University Second Hospital

Allergic purpuric nephritis in children

 

 

Not yet recruiting

4

60

 

Prednisone + cyclophosphamide ;Prednisone + Tacrolimus

The First Affiliated Hospital of Bengbu Medical College; The First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College key project of Translational Medicine

Membranous nephropathy

 

 

Recruiting

4

800

RoW

Busulfan, Bu, Cyclophosphamide, Cy, Fludarabine, Flu, Thymoglobulin, ATG, cyclosporine A, CsA, Mycophenolate mofetil, MMF, Tacrolimus, FK506, Methotrexate, MTX, Basiliximab, Simulect, Ruxolitinib

First Affiliated Hospital of Guangxi Medical University, Peking University People's Hospital, Ruijin Hospital, The 923th Hospital of People's Liberation Army, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou General Hospital, Hainan General Hospital, The Affiliated Hospital Of Guizhou Medical University, The First People's Hospital of Yunnan

Thalassemia Major

05/22

05/23

Recruiting

4

136

 

pomalidomide combined with cyclophosphamide, clarithromycin, dexamethasone ;pomalidomide combined with cyclophosphamide and dexamethasone

Shanghai Changzheng Hospital; Shanghai Changzheng Hospital, Self-funded

Multiple Myeloma

 

 

Completed

4

88

 

prednisone-premedication R-CHOP protocol ;standard R-CHOP regimen

Jiujiang University Affiliated Hospital; Jiujiang University Affiliated Hospital, None

diffuse large B cell lymphoma

 

 

Recruiting

4

49

 

zanubrutinib plus R-CHOP

West China Hospital, Sichuan University; West China Hospital, Baiji Shenzhou Biotechnology Co., Ltd

double expressing diffuse large B-cell lymphoma

 

 

Recruiting

4

50

 

propofol ;cyclophosphamide

Minhang Hospital Affiliated to Fudan University; Minhang Hospital Affiliated to Fudan University, Beijing Kangmeng Charity Foundation

N/A

 

 

Recruiting

4

40

RoW

Cyclophosphamide and glucocorticoids, Glucocorticoids

Peking Union Medical College Hospital

Idiopathic Retroperitoneal Fibrosis

02/23

02/23

Recruiting

4

60

RoW

Baricitinib, Olumiant, Cyclophosphamide, Cytoxan

Tongji Hospital

Systemic Sclerosis

03/23

04/23

Completed

4

418

RoW

ATG/PTCy, standard ATG, ATG, standard PTCy, PTCy

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Myeloid Tumor

08/23

08/23

Not yet recruiting

4

192

 

Short interval cyclophosphamide pulse infusion and oral placebo ;Short interval normal saline pulse infusion and oral methotrexate

Qilu Hospital, Shandong University; Qilu Hospital, Shandong University, Clinical Research Center of Shandong University（No.2020SDUCRCA014）

Idiopathic inflammatory myopathy

 

 

Recruiting

4

284

 

Propofol intravenous anesthesia ;Ciprofol intravenous anesthesia

The General Hospital of the Northern Theater of the Chinese People's Liberation Army; The General Hospital of the Northern Theater of the Chinese People's Liberation Army, self-funded

Biliary obstruction

 

 

Recruiting

4

20

 

R-CHOP/BR+zanubrutinib

The First Affiliated Hospital of Soochow University; The First Affiliated Hospital of Soochow University, Beigene, Ltd.

N/A

 

 

Recruiting

4

30

RoW

Telitacicept, RC18, Hydroxychloroquine, HCQ, Prednisone, PRED, Methylprednisolone, MP, Cyclophosphamide, CTX, Mycophenolate Mofetil, MMF, Tacrolimus, TAC

Fen Li

Systemic Lupus Erythematosus

06/24

06/24

Not yet recruiting

4

172

 

Ixazomib plus Cyclophosphamide and Dexamethasone ;Lenalidomide plus Cyclophosphamide and Dexamethasone

Ruijin Hospital Shanghai Jiaotong University School of Medicine; Ruijin Hospital Shanghai Jiaotong University School of Medicine, raise independently

Multiple myeloma

 

 

Not yet recruiting

4

360

 

The chemotherapy regimen was TC regimen. Docetaxel 75 mg / m2 IV D1, cyclophosphamide 600 mg / m2 IV D1, 21d as one cycle for 4 cycles. ;No chemotherapy was administered postoperatively.

Department of Breast Center, West China Hospital of Sichuan University; West China Hospital of Sichuan University, Clinical Research Program for West China Hospital, Sichuan University

Breast cancer

 

 

Not yet recruiting

4

30

 

Zebutinib + cyclophosphamide + dexamethasone

Beijing Chaoyang Hospital, Capital Medical University; Beijing Chaoyang Hospital, Capital Medical University, Beijing Dengfeng Talent Program

Newly diagnosed and progressed of waldenstrom macroglobulinemia

 

 

Recruiting

4

20

 

anti-PD-1 monoclonal antibody and R-CHOP

Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University; Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Beijing Medical Award Foundation

diffuse large B cell lymphoma

 

 

Not yet recruiting

4

450

 

PLD + cyclophosphamide ;Epirubicin + cyclophosphamide

The Second Affiliated Hospital of Harbin Medical University; The Second Affiliated Hospital of Harbin Medical University, Self-funded

HER2-negative breast cancer

 

 

Not yet recruiting

4

120

 

High-dose glucocorticoid + cyclophosphamide + calcineurin inhibitor ;High-dose glucocorticoid + cyclophosphamide or calcineurin inhibitor

First Affiliated Hospital of Nanjing Medical University; First Affiliated Hospital of Nanjing Medical University, National Natural Science Foundation of China (NSFC): 81971532, 81971533

anti-MDA5 antibody-positive dermatomyositis

 

 

Recruiting

4

224

RoW

Cyclophosphamide, Mycophenolate Mofetil

Second Xiangya Hospital of Central South University, Peking Union Medical College Hospital, Children's Hospital of Chongqing Medical University, Beijing Children's Hospital, Jiangxi Province Children's Hospital, The Affiliated Hospital of Qingdao University, Shenzhen Children's Hospital, The First Affiliated Hospital of Zhengzhou University, The Children's Hospital of Zhejiang University School of Medicine, The Second Hospital of Hebei Medical University

Mycophenolate Mofetil, Cyclophosphamide, Lupus Nephritis

05/25

05/25

Not yet recruiting

4

20

 

Pretreatment scheme for full-sib compatibility: C5 McAb 600 mg for -9 days.Fludarabine (FLU) 30 mg/m2/d x 6 d (-7 to -2D) + CY 50 mg/kg/d x 2D (-4 to -3D) + ATG 2.5mg/kg/d x 5 d (-8 to -4D). ;Alternative donor (unrelated donor, haplotype donor) conditioning regimen: C5 McAb 600 mg for -9 days. Busulfan (BU) 3.2 mg/kg/d (0.8 mg/kg, q6h) x 2D (-7 to -6d) + cyclophosphamide (CY) 50 mg/kg/d x 4D (-5 to -2D) + ATG 2.5 mg/kgd x 4D (-5 to -2D). ;Treatment regimen for GVHD: Grade II treatment, methylprednisolone 1-2 mg/kg, divided into two doses, second-line drugs can be selected as appropriate: FK506, MMF, MTX, ATG, CD25 monoclonal antibody, etc. Hormone reduction as appropriate ;Symptomatic and supportive treatment: Transplant-related complications such as infection, bleeding, hemorrhagic cystitis, epilepsy and mucositis, as well as immunoglobulin and nutritional support were routinely given to the participating units. ;Other concomitant therapy: For hemoglobin < 60 g/L or red blood cell transfusion therapy is allowed in emergency. Hormones are allowed to control acute hemolysis, hematopoietic and erythropoietic drugs are allowed, and G-CSF can be used when neutrophils are less than 1 x 10^9/L. In the case of organ dysfunction, the use of drugs to protect organs is allowed. Anti-infective drugs are permitted in the presence of infection.

Hongci Hematology Branch of the First Affiliated Hospital of Soochow University; Hongci Hematology Branch of the First Affiliated Hospital of Soochow University, Self-funded

Classic PNH and PNH with bone marrow failure

 

 

Recruiting

4

200

RoW

Huaier Granule, Epirubicin, Docetaxel, Cyclophosphamide

Shandong University

Breast Cancer

10/25

10/25

Recruiting

4

240

 

Paclitaxel (Albumin Bound）combined with cisplatin ;Epirubicin combined with cyclophosphamide sequential docetaxel

Jiangxi Cancer Hospital; Jiangxi Cancer Hospital, Jiangsu Hengrui Pharmaceutical Co., Ltd

Breast cancer

 

 

Not yet recruiting

4

152

RoW

palbociclib combined with letrozole, Endocrine group, epirubicin combined with cyclophosphamide and sequential docetaxel, Chemotherapy group

Shengjing Hospital

Breast Cancer

11/25

05/26

Not yet recruiting

4

20

 

Haplotype transplantation pretreatment protocol: Busulfan (BU) 3.2 mg/kg/d (0.8 mg/kg, q6h) × 2D (-7 to - 6d) + cyclophosphamide (CY) 50 mg/kg/d × 4D (-5 to -2D) + ATG 2.5 mg/kgd × 4D (- 5 to -2D). Application of C5 monoclonal antibody: 1 dose (600 mg) on day + 7 after transplantation. Treatment regimen for GVHD: Grade II treatment, methylprednisolone 1 ~ 2mg/kg, divided into two doses, second-line drugs can be selected as appropriate: FK506, MMF, MTX, ATG, CD25 monoclonal antibody, etc.Hormone reduction as appropriate. Symptomatic and supportive treatment: Transplant-related complications such as infection, bleeding, hemorrhagic cystitis, epilepsy and mucositis, as well as immunoglobulin and nutritional support were routinely given to the participating units. Transfusion of red blood cells is allowed for hemoglobin < 60g/L or emergency treatment.Hormones are allowed to control acute hemolysis, hematopoietic and erythropoietic drugs are allowed, and G-CSF can be used when neutrophils are less than 1 × 109/L.When organ function damage occurs, it is allowed to use drugs to protect organs.Anti-infective drugs are permitted in the presence of infection

Hongci Hematology Branch of the First Affiliated Hospital of Soochow University; Hongci Hematology Branch of the First Affiliated Hospital of Soochow University, Self-financing

Haplotype hematopoietic stem cell transplantation for SAA

 

 

Recruiting

4

1576

RoW

Docetaxel, Carboplatin, Trastuzumab, Pertuzumab, Nab paclitaxel, Epirubicin, Cyclophosphamide

Second Affiliated Hospital, School of Medicine, Zhejiang University

Breast Cancer

06/27

12/27

Not yet recruiting

4

450

 

Doxorubicin hydrochioride liposome injection plus cyclophosphamide followed by docetaxel plus trastuzumab and pertuzumab ;Docetaxel plus carboplatin combined with trastuzumab and pertuzumab

Liaoning Cancer Hospital; Liaoning Cancer Hospital, CSPC Ouyi Pharmaceutical Co., Ltd.

Breast cancer