| Isentress (raltegravir) / Merck (MSD) |
NCT01061957: Raltegravir Treatment in Patients Failing Highly Active Antiretroviral Therapy (HAART) in Denmark |
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| Completed | N/A | 96 | Europe | | Rigshospitalet, Denmark, Merck Sharp & Dohme LLC | HIV Infections | 07/09 | 12/09 | | |
NCT00858962: Buprenorphine/Raltegravir Pharmacokinetic Interaction Study |
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| Completed | N/A | 12 | US | Raltegravir, Isentress | Yale University, National Institute on Drug Abuse (NIDA), Merck Sharp & Dohme LLC | HIV Infection, HIV Infections | 12/09 | 12/09 | | |
NCT00961272: Evaluating the Pharmacokinetics of 400 mg Oral Dose of Raltegravir in HIV-Infected Pre-Menopausal Women |
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| Completed | N/A | 6 | US | | Kristine Patterson, MD, Merck Sharp & Dohme LLC | HIV Infections | 02/10 | 02/10 | | |
| Withdrawn | N/A | 0 | US | Efavirenz + Tenofovir DF/Emtricitabine, Sustiva, EFV, Tenofovir, Tenofovir Disoproxil Fumarate, TDF, Emtriva, FTC, Truvada, Atripla, Nucleoside Reverse Transcriptase Inhibitor, NRTI, Non-Nucleoside Reverse Transcriptase Inhibitor, NNRTI, Raltegravir + Tenofovir DF/Emtricitabine, Isentress, MK-0518, Integrase Inhibitor, Colonoscopy with biopsies, Colonoscopy, Biopsy, Secondary, Lymphatic, Tissue, Gastrointestinal, GALT, Peyers, Patch, Lamina, Propria, Inguinal Lymph Node Excision, Inguinal, Lymph, Node, LN, Excision | University of Minnesota, Merck Sharp & Dohme LLC | HIV Infection, HIV Infections | 03/10 | 03/11 | | |
| Completed | N/A | 200 | Europe | Raltegravir, Isentress | University of Zurich, Swiss HIV Cohort Study, Merck Sharp & Dohme LLC | HIV Infection | 04/10 | 12/11 | | |
NCT01190124: Raltegravir With Optimized Background Therapy (OBT) in Multiple Experienced HIV-infected Patients |
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| Completed | N/A | 151 | Europe | | Doroana, Maria Manuela, M.D., Merck Sharp & Dohme LLC, Eurotrials Brasil Consultores Cientificos Ltda | HIV Infections | 07/10 | 07/10 | | |
NCT00672932: Raltegravir Augmentation on Persistent Central Nervous System (CNS) Immunoactivation in Treated HIV-1 Patients |
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| Completed | N/A | 18 | US | raltegravir, Isentress | University of California, San Francisco, National Institute of Mental Health (NIMH), Merck Sharp & Dohme LLC | HIV Infections | 10/10 | 02/11 | | |
| Completed | N/A | 20 | US | change from tenofovir to raltegravir, Isentress | Metropolis Medical, Merck Sharp & Dohme LLC | HIV Infections, Proteinuria | 12/10 | 06/11 | | |
PINT, NCT00641641: The Effect of Raltegravir on HIV Decay During Primary and Chronic Infection |
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| Completed | N/A | 16 | RoW | Tenofovir + emtricitabine + raltegravir., TDF, FTC, RAL | Kirby Institute, Merck Sharp & Dohme LLC | HIV Infection | 03/11 | 06/11 | | |
NCT00745368: Comparing Raltegravir Genital Tract Distribution in HIV-infected Men and Women |
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| Completed | N/A | 28 | US | Raltegravir | University of Rochester, Merck Sharp & Dohme LLC | HIV Infections | 06/11 | 06/11 | | |
NCT00689910: Pharmacokinetics of Raltegravir During Third Trimester Pregnancy and Post-Partum |
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| Withdrawn | N/A | 0 | US | | University of California, San Francisco, Merck Sharp & Dohme LLC | HIV Infections | | | | |
NCT00734344: Pilot Study of Raltegravir/Truvada Versus Efavirenz/Truvada for Adults With Acute IV-1 Infection |
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| Completed | N/A | 18 | US | Raltegravir, Efavirenz, Emtricitibine, Tenofovir disoproxil once daily, Tenofovir disoproxil twice daily | University of Alabama at Birmingham, Merck Sharp & Dohme LLC | Acute HIV Infection | 08/12 | 09/12 | | |
RACING, NCT01048671: Management of Human Immunodeficiency Virus 1 (HIV-1) Participants Treated With Antiretroviral (ARV) Combination Therapy Including Raltegravir (MK-0518-138) |
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| Completed | N/A | 482 | Europe | Raltegravir, Isentress, ARV (non-raltegravir) | Merck Sharp & Dohme LLC | HIV Infections | 12/12 | 12/12 | | |
NCT00814879: Pilot Study of a Raltegravir Based NRTI Sparing Regimen |
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| Completed | N/A | 60 | US | Raltegravir, Isentress, Atazanavir, Reyataz, Standard treatment regimen | Yale University, Bristol-Myers Squibb, Merck Sharp & Dohme LLC | Acquired Immune Deficiency Syndrome, AIDS, Human Immunodeficiency Virus, HIV Infections | 05/13 | 11/13 | | |
NCT01814722: Quality of Life of HIV-infected Participants Switched to Raltegravir Versus Other Antiretroviral Regimens (MK-0518-266) |
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| Terminated | N/A | 63 | NA | | Merck Sharp & Dohme LLC | Human Immunodeficiency Virus | 10/13 | 10/13 | | |
| Completed | N/A | 996 | RoW | | Merck Sharp & Dohme LLC | HIV Infection, HIV Infections | 05/14 | 05/14 | | |
NCT01213316: A Study to Assess the Efficacy of Raltegravir (Isentress®), Administered in Combination With Other Antiretroviral Drugs as Treatment for Adults and Older Adults Infected With the Human Immunodeficiency Virus 1 (HIV-1)(MK-0518-145) (Wirksamkeit Von Isentress® Unter Praxisbedingungen) |
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| Completed | N/A | 451 | Europe | Raltegravir, ISENTRESS® | Merck Sharp & Dohme LLC | HIV-1 Infection | 04/15 | 04/15 | | |
NCT02218320: Comparison of Virologic and Immunologic Responses to Raltegravir and Dolutegravir in the Gastrointestinal Tract of HIV-Positive Adults |
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| Completed | N/A | 20 | US | Raltegravir, Isentress ®, Dolutegravir, Tivicay ®, Colonoscopy with biopsy | University of North Carolina, Chapel Hill, Merck Sharp & Dohme LLC | Human Immunodeficiency Virus | 10/15 | 10/15 | | |
NCT00377065: Early Access of MK0518 in Combination With an Optimized Background Antiretroviral Therapy (0518-023) |
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| Approved for marketing | N/A | | US | raltegravir, MK0518, ISENTRESS™ | Merck Sharp & Dohme LLC | HIV Infections | | | | |
NCT01793467: Transplantation and the Use of Raltegravir in HIV-Infected Patients |
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| Completed | N/A | 17 | US | | Duke University, Merck Sharp & Dohme LLC | HIV Positive, Organ Transplant Recipient, Active Wait Listing for Organ Transplant | 06/17 | 06/17 | | |
