Sarcoma  >>  ifosfamide  >>  Phase 3
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44 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
ifosfamide / Generic mfg.
NACLESS, jRCTs031220446: JCOG2102: Randomized phase III trial of Neo-adjuvant and adjuvant chemotherapy vs Adjuvant Chemotherapy alone for LocalizEd Soft tissue Sarcoma

Recruiting
3
224
Japan
doxorubicin hydrochloride - Generic mfg., ifosfamide - Generic mfg.
Oita University Hospital, National Cancer Center Japan
Resectable high grade non-round cell soft tissue sarcoma
 
 
SWOG-EORTC-62933, NCT00002764: Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma

Completed
3
340
Europe
filgrastim, doxorubicin hydrochloride, ifosfamide, conventional surgery
European Organisation for Research and Treatment of Cancer - EORTC, Eastern Cooperative Oncology Group, Scandinavian Sarcoma Group, Southwest Oncology Group
Endometrial Cancer, Kidney Cancer, Metastatic Cancer, Ovarian Cancer, Pheochromocytoma, Sarcoma
11/00
 
NCT00001300: A Randomized Study of the Effect of Adjuvant Chemotherapy With Doxorubicin and Ifosfamide With Mesna in the Treatment of High-Grade Adult Extremity Soft Tissue Sarcoma

Completed
3
150
US
doxorubicin, ifosfamide, mesna
National Cancer Institute (NCI)
Sarcoma
 
03/01
NCT00003212: Ifosfamide or Doxorubicin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma

Completed
3
780
Europe
doxorubicin hydrochloride, ifosfamide
European Organisation for Research and Treatment of Cancer - EORTC
Sarcoma
11/01
 
NCT00038311: Safety and Efficacy of (PN-152,243)/PN-196,444 in the Prevention of Thrombocytopenia

Completed
3
120
US
PN-152,243)/PN-196,444
Pfizer
Sarcoma
 
03/03
NCT00003937: Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma

Completed
3
253
US, Canada, Europe, RoW
cisplatin, Cis-diamminedichloroplatinum II, CDDP, Platinol, NSC #119875, dexrazoxane hydrochloride, ADR-529, ZINECARD, ICRF-187, NSC #169780, doxorubicin hydrochloride, Adriamycin, NSC #123127, etoposide, VP-16, VePesid, NSC #141540, ifosfamide, IFX, IFOS, NSC #109724, methotrexate, MTX, amethopterin, NSC #000740, conventional surgery
Children's Oncology Group, National Cancer Institute (NCI)
Cardiac Toxicity, Sarcoma
03/04
06/08
NCT00162695: Rhabdomyosarcoma and Malignant Soft Tissue Tumours of Childhood

Terminated
3
400
Europe
Ifosfamide, oncovin, actinomycine D, epirubicine, carboplatinum, etoposide
Gustave Roussy, Cancer Campus, Grand Paris
Rhabdomyosarcoma, Malignant Soft Tissue
 
 
NCT00180908: Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children

Completed
3
226
Europe
Etoposide, Ifosfamide, Methotrexate, Doxorubicin, Methotrexate
Gustave Roussy, Cancer Campus, Grand Paris
Osteosarcoma, Localised High Grade Osteosarcoma of the Limbs
 
 
NCT00334867: Combination Chemotherapy With or Without Topotecan in Treating Patients With Newly Diagnosed Localized Ewing's Sarcoma

Withdrawn
3
0
RoW
cyclophosphamide, dexrazoxane hydrochloride, doxorubicin hydrochloride, etoposide, ifosfamide, topotecan hydrochloride, vincristine sulfate, conventional surgery, radiation therapy
Children's Oncology Group, National Cancer Institute (NCI)
Sarcoma
01/06
 
EORTC-STBSG 62931, NCT00002641: Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma

Completed
3
350
Canada, Europe
filgrastim, doxorubicin hydrochloride, ifosfamide, isolated perfusion, adjuvant therapy, conventional surgery, radiation therapy
European Organisation for Research and Treatment of Cancer - EORTC, NCIC Clinical Trials Group
Endometrial Cancer, Kidney Cancer, Ovarian Cancer, Pheochromocytoma, Sarcoma
02/06
06/12
COG-AEWS0031, NCT00006734: Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor

Completed
3
587
Europe, Canada, US, RoW
filgrastim, GRANULOCYTE COLONY-STIMULATING FACTOR, r-metHuG-CSF, G-CSF, Neupogen, NSC 614629, cyclophosphamide, CTX, Cytoxan, NSC #026271, doxorubicin hydrochloride, Adriamycin, NSC #123127, IND #7038, etoposide, VP-16, VePesid, Etopophos, NSC #141540, ifosfamide, Ifex, NSC #109724, vincristine sulfate, Oncovin, NSC #067574, adjuvant therapy, conventional surgery, neoadjuvant therapy, brachytherapy, radiation therapy
Children's Oncology Group, National Cancer Institute (NCI), SWOG Cancer Research Network
Sarcoma
08/06
06/23
NCT00003128: Ifosfamide With or Without Paclitaxel in Treating Patients With Advanced, Refractory, or Recurrent Cancer of the Uterus

Completed
3
166
US
filgrastim, ifosfamide, paclitaxel
Gynecologic Oncology Group, National Cancer Institute (NCI), Eastern Cooperative Oncology Group
Sarcoma
02/07
 
NCT00162721: The Addition of Polychemotherapy to Adjuvant Radiotherapy in the Treatment of Non-Metastatic Uterine Sarcomas

Unknown status
3
270
Europe
doxorubicin, ifosfamide, cisplatin
Gustave Roussy, Cancer Campus, Grand Paris
Uterine Sarcoma
 
 
NCT00002546: Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Cancer of the Uterus

Completed
3
216
US, RoW
cisplatin, ifosfamide, adjuvant therapy, radiation therapy
Gynecologic Oncology Group, National Cancer Institute (NCI), Eastern Cooperative Oncology Group
Sarcoma
09/07
 
NCT00002898: Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma

Completed
3
400
Europe
dactinomycin, carboplatin, cyclophosphamide, epirubicin hydrochloride, etoposide, ifosfamide, vincristine sulfate, adjuvant therapy, conventional surgery, neoadjuvant therapy, brachytherapy, radiation therapy
Societe Internationale d'Oncologie Pediatrique
Childhood Malignant Fibrous Histiocytoma of Bone, Sarcoma
 
12/09
NCT00354744: High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma

Completed
3
109
Europe, Canada, US, RoW
dactinomycin, Actinomycin-D, Cosmegen, NSC #3053, cyclophosphamide, Cytoxan, NSC #26271, doxorubicin hydrochloride, Adriamycin, NSC #123127, etoposide, VePesid, Etopophos, VP-16, NSC #141540, ifosfamide, Isophosphamide, Iphosphamide, Z4942, Ifex, NSC #109724, irinotecan hydrochloride, CPT-11, Camptothecin-11, 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin, Camptosar, NSC #616348, vincristine sulfate, Oncovin, VCR, LCR, NSC #67574, conventional surgery, radiation therapy, filgrastim, Granulocyte Colony-Stimulating Factor, r-metHuG-CSF, G-CSF, Neupogen, NSC #614629
Children's Oncology Group, National Cancer Institute (NCI)
Sarcoma
01/10
06/19
NCT00061984: Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma

Completed
3
455
Canada, Europe
pegfilgrastim, doxorubicin hydrochloride, ifosfamide, multimodality therapy
European Organisation for Research and Treatment of Cancer - EORTC
Sarcoma
05/10
07/12
NCT00334854 / 2005-001139-31: Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma

Unknown status
3
250
Europe
doxorubicin hydrochloride, ifosfamide, adjuvant therapy, conventional surgery, neoadjuvant therapy, radiation therapy
European Paediatric Soft Tissue Sarcoma Study Group, Italian Association for Pediatric Hematology Oncology, Cooperative Weichteilsarkom Studie, Children's Cancer and Leukaemia Group, Dutch Childhood Oncology Group
Childhood Malignant Fibrous Histiocytoma of Bone, Sarcoma
05/10
 
NCT00003052: Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma

Completed
3
340
Europe
doxorubicin hydrochloride, etoposide, ifosfamide, conventional surgery, hyperthermia treatment, radiation therapy
European Organisation for Research and Treatment of Cancer - EORTC, The European Society for Hyperthermic Oncology
Sarcoma
 
06/10
NCT00379457 / 2005-000217-35: Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma

Unknown status
3
600
Europe
dactinomycin, carboplatin, cyclophosphamide, doxorubicin hydrochloride, etoposide, ifosfamide, topotecan hydrochloride, vincristine sulfate, vinorelbine tartrate, conventional surgery, radiation therapy
European Paediatric Soft Tissue Sarcoma Study Group, Italian Association for Pediatric Hematology Oncology, Children's Cancer and Leukaemia Group, Dutch Childhood Oncology Group
Sarcoma
05/11
 
EURO-E.W.I.N.G.99, NCT00020566: Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma

Unknown status
3
1200
Canada, US, RoW
dactinomycin, busulfan, doxorubicin hydrochloride, etoposide, ifosfamide, melphalan, vincristine sulfate, autologous hematopoietic stem cell transplantation, conventional surgery, radiation therapy
University of Leicester, National Cancer Institute (NCI), Children's Cancer and Leukaemia Group, Societe Francaise Oncologie Pediatrique, European Organisation for Research and Treatment of Cancer - EORTC, Gesellschaft fur Padiatrische Onkologie und Hamatologie - Germany, Gesellschaft fur Padiatrische Onkologie und Hamatologie - Austria, Swiss Group for Clinical Cancer Research, EBMT Solid Tumors Working Party, Children's Oncology Group
Sarcoma
12/11
 
2004-002113-36: Randomised trial of single agent doxorubicin versus doxorubicin plus ifosfamide in the first line treatment of advanced or metastatic soft tissue sarcoma

Completed
3
450
Europe
doxorubicin, ifosfamide, Solution for injection, Powder for injection*
European Organisation for the Research and Treatment of Cancer
Locally advanced or metastatic soft tissue sarcoma
 
 
NCT00796120 / 2008-002326-11: An Efficacy and Safety Study of Trabectedin Versus Doxorubicin-Based Chemotherapy in Participants With Translocation-Related Sarcomas (TRS)

Completed
3
121
US, Europe
Trabectedin, Doxorubicin, Ifosfamide
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., PharmaMar
Sarcoma
08/12
08/14
NCT00699517 / 2007-003592-39: A Study of AVE8062 in Advanced-stage Soft Tissue Sarcoma After Failure of Anthracycline and Ifosfamide Chemotherapies

Completed
3
355
US, Europe, RoW
OMBRABULIN (AVE8062), Placebo
Sanofi
Sarcoma
04/13
04/13
NCT00002516: Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma

Unknown status
3
Europe
dactinomycin, cyclophosphamide, doxorubicin hydrochloride, etoposide, ifosfamide, mesna, vincristine sulfate, conventional surgery, low-LET cobalt-60 gamma ray therapy, low-LET photon therapy
University Hospital Muenster, Medical Research Council
Sarcoma
 
 
ARST0332, NCT00346164: Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma

Completed
3
588
Canada, US, RoW
doxorubicin hydrochloride, ADM, ADR, Adria, Adriamycin PFS, Adriamycin RDF, clinical observation, observation, therapeutic conventional surgery, 3-dimensional conformal radiation therapy, 3D conformal radiation therapy, 3D-CRT, ifosfamide, Cyfos, Holoxan, IFF, IFX, IPP
Children's Oncology Group, National Cancer Institute (NCI)
Adult Alveolar Soft-part Sarcoma, Adult Angiosarcoma, Adult Epithelioid Sarcoma, Adult Extraskeletal Chondrosarcoma, Adult Extraskeletal Osteosarcoma, Adult Fibrosarcoma, Adult Leiomyosarcoma, Adult Liposarcoma, Adult Malignant Fibrous Histiocytoma, Adult Malignant Hemangiopericytoma, Adult Malignant Mesenchymoma, Adult Neurofibrosarcoma, Adult Synovial Sarcoma, Childhood Alveolar Soft-part Sarcoma, Childhood Angiosarcoma, Childhood Epithelioid Sarcoma, Childhood Fibrosarcoma, Childhood Leiomyosarcoma, Childhood Liposarcoma, Childhood Malignant Mesenchymoma, Childhood Neurofibrosarcoma, Childhood Synovial Sarcoma, Dermatofibrosarcoma Protuberans, Metastatic Childhood Soft Tissue Sarcoma, Nonmetastatic Childhood Soft Tissue Sarcoma, Stage I Adult Soft Tissue Sarcoma, Stage II Adult Soft Tissue Sarcoma, Stage III Adult Soft Tissue Sarcoma, Stage IV Adult Soft Tissue Sarcoma
09/14
03/22
EURAMOS-1, NCT00134030 / 2004-000242-20: Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma

Completed
3
1334
Europe, Canada, US, RoW
Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone''s Chloride, Peyrone''s Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP-16, VP-16-213, VP16, Ifosfamide, Asta Z 4942, Asta Z-4942, Cyfos, Holoxan, Holoxane, Ifex, IFO, IFO-Cell, Ifolem, Ifomida, Ifomide, Ifosfamidum, Ifoxan, IFX, Iphosphamid, Iphosphamide, Iso-Endoxan, Isoendoxan, Isophosphamide, Mitoxana, MJF 9325, MJF-9325, Naxamide, Seromida, Tronoxal, Z 4942, Z-4942, Methotrexate, Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, CL 14377, CL-14377, Emtexate, Emthexat, Emthexate, Farmitrexat, Fauldexato, Folex, Folex PFS, Lantarel, Ledertrexate, Lumexon, Maxtrex, Medsatrexate, Metex, Methoblastin, Methotrexate LPF, Methotrexate Methylaminopterin, Methotrexatum, Metotrexato, Metrotex, Mexate, Mexate-AQ, MTX, Novatrex, Rheumatrex, Texate, Tremetex, Trexeron, Trixilem, WR-19039, Peginterferon Alfa-2b, PEG Interferon Alpha-2b, PEG Intron, PEG-IFN Alfa-2b, PEG-IFN-a 2b, PEG-Interferon Alfa-2b, PEG-Intron, Pegylated Interferon Alpha-2b, Polyethylene Glycol IFN-A2b, Polyethylene Glycol Interferon Alfa-2b, SCH 54031, Sylatron, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Therapeutic Conventional Surgery
Children's Oncology Group, National Cancer Institute (NCI), University College, London, Medical Research Council
Localized Osteosarcoma, Metastatic Osteosarcoma
01/15
09/22
OS2006, NCT00470223 / 2006-003377-27: Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma

Active, not recruiting
3
318
Europe
cisplatin, doxorubicin hydrochloride, etoposide, ifosfamide, methotrexate, zoledronic acid, conventional surgery
UNICANCER, Novartis, Chugai Pharmaceutical, National Cancer Institute, France, SFCE, Ligue contre le cancer, France
Sarcoma
12/15
12/26
2010-023484-17: Sarcomas de partes blandas localizados de alto riesgo de extremidades y pared de tronco en adultos: un enfoque integrador que incluye tratamiento con medicamentos antitumorales estándar comparado con tratamientos específicos para las diferentes variedades histológicas como primer tratamiento.

Ongoing
3
250
Europe
epirrubicina, ifosfamida, Gemcitabina, Docetaxel, Etoposido, FARMIBLASTINA, Dacarbazina, epirubicin, ifosfamide, gemcitabine, docetaksel, etoposide, dacarbazine, epirubicin, ifosfamide, gemcitabine, docetaksel, etoposide, dacarbazine
ITALIAN SARCOMA GROUP, Grupo Español de Investigación en Sarcomas, Italian Sarcoma Group, , Grupo Español de Investigación en Sarcomas, NHS (diagnostic and therapeutic procedures), Eurosarc, funded by project/grant FP7
High risk localized soft tissue sarcomas typical of the adult
 
 
2012-002107-17: International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing\'s Sarcoma Family of Tumours

Ongoing
3
300
Europe
Vincristine, Ifosfamide, Doxorubicin, Etoposide, Actinomycin D, Cyclophosphamide, Zoledronic acid, Vincristine Sulphate, Ifosfamide, Doxorubicin hydrochloride, Eposin, Cosmegen Lyovac, Cyclophosphamide, Zometa, Vincristine Sulphate, Ifosfamide, Doxorubicin hydrochloride, Eposin, Cosmegen Lyovac, Cyclophosphamide, Zometa
University of Birmingham, CTAAC, FP7
Ewing\'s Sarcoma Family of Tumours
 
 
NCT02049905 / 2013-004103-40: Phase 3 Study to Treat Patients With Soft Tissue Sarcomas

Completed
3
433
Europe, Canada, US, RoW
Aldoxorubicin, INNO-206, Investigator's Choice Treatment (Darcabazine, Pazopanib, Gemcitabine + Docetaxel, Doxorubicin, Ifosfamide), Darcabazine, Pazopanib, Gemcitabine + Docetaxel, Doxorubicin, Ifosfamide
ImmunityBio, Inc.
Metastatic, Locally Advanced or Unresectable Soft Tissue Sarcoma
05/17
05/17
2018-000186-36: Phase III trial investigating the potential benefit of intensified peri-operative Chemotherapy in patients with in high-risk CINSARC patients with resectable soft-tissue SARComas

Not yet recruiting
3
334
Europe
Solution for injection, Solution for infusion, DOXORUBICINE, IFOSFAMIDE
Institut Bergonié, Programme Hospitalier de Recherche Clinique en Cancérologie 2016 - DGOS
Resectable, non-metastatic soft-tissue sarcoma (STS), Resectable, non-metastatic soft-tissue sarcoma (STS), Diseases [C] - Cancer [C04]
 
 
NCT00954174: Paclitaxel and Carboplatin or Ifosfamide in Treating Patients With Newly Diagnosed, Persistent or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Cavity Cancer

Active, not recruiting
3
637
US, RoW
Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Ifosfamide, Asta Z 4942, Asta Z-4942, Cyfos, Holoxan, Holoxane, Ifex, IFO, IFO-Cell, Ifolem, Ifomida, Ifomide, Ifosfamidum, Ifoxan, IFX, Iphosphamid, Iphosphamide, Iso-Endoxan, Isoendoxan, Isophosphamide, Mitoxana, MJF 9325, MJF-9325, Naxamide, Seromida, Tronoxal, Z 4942, Z-4942, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Quality-of-Life Assessment, Quality of Life Assessment
GOG Foundation, National Cancer Institute (NCI)
Mixed Mesodermal (Mullerian) Tumor, Ovarian Carcinosarcoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Stage I Ovarian Cancer AJCC v6 and v7, Stage IA Fallopian Tube Cancer AJCC v6 and v7, Stage IA Ovarian Cancer AJCC v6 and v7, Stage IA Uterine Sarcoma AJCC v7, Stage IB Fallopian Tube Cancer AJCC v6 and v7, Stage IB Ovarian Cancer AJCC v6 and v7, Stage IB Uterine Sarcoma AJCC v7, Stage IC Fallopian Tube Cancer AJCC v6 and v7, Stage IC Ovarian Cancer AJCC v6 and v7, Stage IC Uterine Sarcoma AJCC v7, Stage II Ovarian Cancer AJCC v6 and v7, Stage IIA Fallopian Tube Cancer AJCC v6 and v7, Stage IIA Ovarian Cancer AJCC V6 and v7, Stage IIA Uterine Sarcoma AJCC v7, Stage IIB Fallopian Tube Cancer AJCC v6 and v7, Stage IIB Ovarian Cancer AJCC v6 and v7, Stage IIB Uterine Sarcoma AJCC v7, Stage IIC Fallopian Tube Cancer AJCC v6 and v7, Stage IIC Ovarian Cancer AJCC v6 and v7, Stage IIIA Fallopian Tube Cancer AJCC v7, Stage IIIA Ovarian Cancer AJCC v6 and v7, Stage IIIA Primary Peritoneal Cancer AJCC v7, Stage IIIA Uterine Sarcoma AJCC v7, Stage IIIB Fallopian Tube Cancer AJCC v7, Stage IIIB Ovarian Cancer AJCC v6 and v7, Stage IIIB Primary Peritoneal Cancer AJCC v7, Stage IIIB Uterine Sarcoma AJCC v7, Stage IIIC Fallopian Tube Cancer AJCC v7, Stage IIIC Ovarian Cancer AJCC v6 and v7, Stage IIIC Primary Peritoneal Cancer AJCC v7, Stage IIIC Uterine Sarcoma AJCC v7, Stage IV Fallopian Tube Cancer AJCC v6 and v7, Stage IV Ovarian Cancer AJCC v6 and v7, Stage IV Primary Peritoneal Cancer AJCC v7, Stage IVA Uterine Sarcoma AJCC v7, Stage IVB Uterine Sarcoma AJCC v7, Uterine Carcinosarcoma
03/19
 
2019-003014-13: Interest of peri operative CHemotherapy In patients with CINSARC high-risk localized grade 1 or 2 Soft Tissue Sarcoma. Intérêt de la chimiothérapie péri-opératoire chez les patients porteurs de sarcomes des tissus mous localisés de grade 1 ou 2, définis à HAUT RISQUE par la signature CINSARC.

Not yet recruiting
3
600
Europe
DOXORUBICIN, IFOSFAMIDE, DACARBAZINE, Solution for infusion, Powder for solution for injection, Powder for solution for infusion
INSTITUT CLAUDIUS REGAUD, Direction Générale de l’Offre de Soins (DGOS)
Soft Tissue Sarcoma Sarcome des tissus mous, Soft Tissue Sarcoma Sarcome des tissus mous, Diseases [C] - Cancer [C04]
 
 
AEWS1031, NCT01231906: Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma

Active, not recruiting
3
642
Canada, US, RoW
Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Dexrazoxane, 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)- (8CI), 2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)- (9CI), ADR 529, ADR-529, ADR529, ICRF 187, ICRF-187, ICRF187, Razoxane (+)-form, Soluble ICRF (L-isomer), Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, FI106, hydroxydaunorubicin, Rubex, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213, Ifosfamide, Asta Z 4942, Asta Z-4942, Cyfos, Holoxan, Holoxane, Ifex, IFO, IFO-Cell, Ifolem, Ifomida, Ifomide, Ifosfamidum, Ifoxan, IFX, Iphosphamid, Iphosphamide, Iso-Endoxan, Isoendoxan, Isophosphamide, Mitoxana, MJF 9325, MJF-9325, Naxamide, Seromida, Tronoxal, Z 4942, Z-4942, Laboratory Biomarker Analysis, Topotecan Hydrochloride, Evotopin, Hycamptamine, Hycamtin, Nogitecan Hydrochloride, Potactasol, SKF S 104864 A, SKF S-104864-A, SKF S104864A, Topotec, Topotecan HCl, topotecan hydrochloride (oral), Vincristine Sulfate, Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate
Children's Oncology Group, National Cancer Institute (NCI)
Localized Extraskeletal Ewing Sarcoma, Peripheral Primitive Neuroectodermal Tumor of Bone, Peripheral Primitive Neuroectodermal Tumor of Soft Tissues
03/20
 
2019-003543-30: A study to test the effect of chemotherapy before surgery compared to surgery alone in patients with high risk retroperitoneal sarcoma

Ongoing
3
250
Europe
Doxorubicin, Epirubicin, Dacarbazin, Ifosfamide, [Doxorubicin], [Epirubicin], [Dacarbazin], [Ifosfamide], Solution for infusion, Solution for injection/infusion, Powder for solution for injection/infusion
European Organisation for Research and Treatment of Cancer, EORTC AISBL/IVZW, European Organisation for the Research and Treatment of Cancer, Anticancer fund
Primary high risk leiomyosarcoma or Liposarcoma of retroperitoneal space or infra-peritoneal spaces of pelvis, Retroperitoneal sarcoma: a sarcoma developed in the back of the belly, next to the kidneys, in a relatively “hidden” location known as the retroperitoneum., Diseases [C] - Cancer [C04]
 
 
AEWS1221, NCT02306161: Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma

Active, not recruiting
3
312
Canada, US
Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, FI106, hydroxydaunorubicin, Rubex, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213, Etoposide Phosphate, Etopophos, External Beam Radiation Therapy, Definitive Radiation Therapy, EBRT, External Beam Radiation, External Beam Radiotherapy, External Beam Radiotherapy (conventional), External Beam RT, external radiation, External Radiation Therapy, external-beam radiation, Radiation, External Beam, Teleradiotherapy, Teletherapy, Teletherapy Radiation, Ganitumab, AMG 479, AMG-479, AMG479, Anti-IGF-1R Human Monoclonal Antibody AMG-479, Ifosfamide, Asta Z 4942, Asta Z-4942, Cyfos, Holoxan, Holoxane, Ifex, IFO, IFO-Cell, Ifolem, Ifomida, Ifomide, Ifosfamidum, Ifoxan, IFX, Iphosphamid, Iphosphamide, Iso-Endoxan, Isoendoxan, Isophosphamide, Mitoxana, MJF 9325, MJF-9325, Naxamide, Seromida, Tronoxal, Z 4942, Z-4942, Stereotactic Radiosurgery, SRS, Stereotactic External Beam Irradiation, stereotactic external-beam radiation therapy, Stereotactic Radiation Therapy, Stereotactic Radiotherapy, stereotaxic radiation therapy, stereotaxic radiosurgery, Therapeutic Surgical Procedure, Vincristine, LCR, Leurocristine, VCR, Vincrystine, Vincristine Sulfate, Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate
National Cancer Institute (NCI)
Metastatic Ewing Sarcoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Bone Marrow, Metastatic Malignant Neoplasm in the Lung, Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone, Peripheral Primitive Neuroectodermal Tumor of Soft Tissues
03/21
09/24
ISG/AIEOP EW-1, NCT02063022 / 2008-008361-35: Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma

Completed
3
278
Europe
Standard treatment (as per protocol ISG SSG III), Vincristine, Dactinomycin, Doxorubicin, Ifosfamide, Cyclophosphamide, Etoposide, Busulfan, Melphalan, Intensified chemotherapy, Vincristine,
Italian Sarcoma Group
Ewing's Sarcoma
04/22
04/22
ISG-STS-1001, NCT01710176: Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy

Active, not recruiting
3
550
Europe
epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3), gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8), trabectedin 1.3 mg/m2, high-dose ifosfamide 14 g/m2, given in in 14 days, etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3), gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)
Italian Sarcoma Group, French Sarcoma Group, Grupo Espanol de Investigacion en Sarcomas
Localized High-risk Soft Tissue Sarcomas of the Extremities and Trunk Wall in Adults
06/24
06/24
CIRSARC, NCT03805022: Benefit of Intensified Peri-operative Chemotherapy Within High-risk CINSARC Patients With Resectable Soft-tissue Sarcomas

Recruiting
3
351
Europe
Doxorubicin, Ifosfamide or dacarbazine, At the discretion of the investigator
Institut Bergonié, Novartis, Chugai Pharma France
Non-metastatic Soft-tissue Sarcoma, Resectable
02/25
02/25
JCOG1306, jRCTs031180003: Randomized phase II/III study of adjuvant chemotherapy with Adriamycin+Ifosfamide vs Gemcitabine+Docetaxel for high-grade soft tissue sarcoma ( AI vs GD for STS RPII/III )

Completed
2/3
140
Japan
ifosfamide - Generic mfg., gemcitabine - Generic mfg., docetaxel - Generic mfg.
Okayama University Hospital
Soft tissue sarcoma
 
 
2014-000259-99: A comparison of four widely used chemotherapy regimens for the treatment of Ewing sarcoma, a type of bone cancer, to see which is most effective and/or has the fewest side effects.

Ongoing
2/3
400
Europe
Cyclophosphamide, Topotecan, Irinotecan, Temozolomide, Gemcitabine, Docetaxel, Ifosfamide, Cyclophosphamide, Topotecan, Irinotecan, Temozolomide, Gemcitabine, Docetaxel, Ifosfamide, Infusion, Capsule, hard, , Cyclophosphamide, HYCAMTIN, CAMPTO, Temodal, GEMZAR, TAXOTERE, Ifosfamide
University of Birmingham, UNIVERSITY OF BIRMINGHAM, European Commission, German Cancer Aid
Recurrent and refractory Ewing sarcoma, Ewing sarcoma, a type of bone cancer, that has either grown during initial treatment or has grown after the end of treatment., Diseases [C] - Cancer [C04]
 
 
ARST1321, NCT02180867: Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

Checkmark Data from ARST1321 trial in unresected intermediate-grade or high-grade soft tissue sarcoma
Jul 2020 - Jul 2020: Data from ARST1321 trial in unresected intermediate-grade or high-grade soft tissue sarcoma
Active, not recruiting
2/3
140
Canada, US
Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, FI106, hydroxydaunorubicin, Rubex, Ifosfamide, Asta Z 4942, Asta Z-4942, Cyfos, Holoxan, Holoxane, Ifex, IFO, IFO-Cell, Ifolem, Ifomida, Ifomide, Ifosfamidum, Ifoxan, IFX, Iphosphamid, Iphosphamide, Iso-Endoxan, Isoendoxan, Isophosphamide, Mitoxana, MJF 9325, MJF-9325, Naxamide, Seromida, Tronoxal, Z 4942, Z-4942, Pazopanib, GW786034, Pazopanib Hydrochloride, GW 786034B, GW-786034B, GW786034B, Pazopater, Votrient, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Therapeutic Conventional Surgery
National Cancer Institute (NCI)
Alveolar Soft Part Sarcoma, Angiomatoid Fibrous Histiocytoma, Atypical Fibroxanthoma, Clear Cell Sarcoma of Soft Tissue, Epithelioid Malignant Peripheral Nerve Sheath Tumor, Epithelioid Sarcoma, Extraskeletal Myxoid Chondrosarcoma, Extraskeletal Osteosarcoma, Fibrohistiocytic Neoplasm, Fibrosarcoma, Inflammatory Myofibroblastic Tumor, Intimal Sarcoma, Leiomyosarcoma, Liposarcoma, Liver Embryonal Sarcoma, Low Grade Fibromyxoid Sarcoma, Low Grade Myofibroblastic Sarcoma, Malignant Peripheral Nerve Sheath Tumor, Malignant Skin Granular Cell Tumor, Malignant Triton Tumor, Mesenchymal Chondrosarcoma, Myxofibrosarcoma, Myxoid Chondrosarcoma, Myxoinflammatory Fibroblastic Sarcoma, Nerve Sheath Neoplasm, PEComa, Pericytic Neoplasm, Plexiform Fibrohistiocytic Tumor, Sclerosing Epithelioid Fibrosarcoma, Skin Glomus Tumor, Stage IB Soft Tissue Sarcoma AJCC v7, Stage IIB Soft Tissue Sarcoma AJCC v7, Stage III Soft Tissue Sarcoma AJCC v7, Stage IV Soft Tissue Sarcoma AJCC v7, Synovial Sarcoma, Undifferentiated High Grade Pleomorphic Sarcoma of Bone
06/19
12/24
PDVPSTS, NCT03342300: Pegylated Liposomal Doxorubicin Versus Pirarubicin Plus Ifosfamide, Dacarbazine in Locally Advanced, Unresectable or Metastatic Soft-tissue Sarcoma

Withdrawn
2/3
0
RoW
pegylated liposomal doxorubicin, pirarubicin
Peking University People's Hospital, Peking University Shougang Hospital, Chinese PLA General Hospital, Beijing Jishuitan Hospital, Xijing Hospital, Peking Union Medical College Hospital
Progression-free Survival, Overall Survival, Toxicity
11/20
12/20

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