| Caprelsa (vandetanib) / Sanofi |
| Completed | 1 | 18 | RoW | ZD6474 (vandetanib), ZACTIMA™, 5-Fluorouracil, 5-FU, Leucovorin, Oxaliplatin | Genzyme, a Sanofi Company | Advanced Colorectal Carcinoma | 06/06 | 04/08 | | |
NCT00496509: Phase I Efficacy On Vascular Permeability In Patients With Advanced Colorectal Cancer |
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| Completed | 1 | 24 | Europe | ZD6474 (Zactima) 100mg, Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MR), Biomarker Draws, ZD6474 (Zactima) 300mg | Genzyme, a Sanofi Company | Colorectal Cancer | 10/07 | 10/07 | | |
NCT00681798: Dose Escalation Study With Zactima and Chemotherapy in Metastatic Pancreas Carcinoma |
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| Completed | 1 | 8 | Europe | Vandetanib, Zactima | Sanofi | Pancreatic Cancer | 06/09 | 06/09 | | |
NCT00532909: Phase I Vandetanib Plus Capecitabine, Oxaliplatin and Bevacizumab for Metastatic Colorectal Cancer |
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| Completed | 1 | 13 | US | Vandetanib, Capecitabine, Oxaliplatin, Bevacizumab | Branimir Sikic, AstraZeneca | Anal, Colon, and Rectal Cancers, Colorectal Neoplasms, Colon/Rectal Cancer | 05/10 | 05/10 | | |
NCT00734890: Vandetanib and Bevacizumab in Treating Patients With Advanced Solid Tumors or Lymphoma |
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| Completed | 1 | 18 | US | bevacizumab, vandetanib, laboratory biomarker analysis, pharmacological study | National Institutes of Health Clinical Center (CC), National Cancer Institute (NCI) | Lung Cancer, Lymphoma, Lymphoproliferative Disorder, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific | 06/10 | 02/11 | | |
NCT00436072: ZD6474, Cetuximab, and Irinotecan in Patients With Metastatic Colorectal Cancer |
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| Completed | 1 | 46 | US | ZD6474, Cetuximab, Irinotecan | Dana-Farber Cancer Institute, Massachusetts General Hospital, Beth Israel Deaconess Medical Center, AstraZeneca | Colorectal Cancer | 02/12 | 08/12 | | |
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NCT00551096: Gemcitabine/Capecitabine/ZD6474 in Advanced Solid Tumors |
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| Completed | 1 | 23 | US | Gemcitabine, Gemzar, Capecitabine, Xeloda, ZD6474, Zactima | University of Colorado, Denver, AstraZeneca | Malignant Solid Tumour, Biliary Cancer, Pancreatic Cancer | 05/13 | 05/13 | | |
