| Palexia RP (tapentadol extended release) / Assertio, J&J, Grunenthal, Collegium Pharma |
| Completed | 4 | 622 | Europe | Tapentadol Prolonged Release, Tapentadol Prolonged Release with Pregabalin, Tapentadol Prolonged Release open label maintenance | Grünenthal GmbH | Low Back Pain, Neuropathic Pain | 01/12 | 01/12 | | |
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NCT01631513: An Open-label Evaluation of Tapentadol Extended Release (ER) in Participants With Moderate to Severe Chronic Pain After Conversion From Hydrocodone, Oxycodone Controlled Release (CR), and/or Morphine Sustained Release (SR) |
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| Withdrawn | 4 | 0 | US | Nucynta ER, Nucynta Extended Release | Janssen Scientific Affairs, LLC | Pain, Chronic Back Pain, Chronic Low Back Pain, Osteoarthritis Pain In The Hip or Knee | 08/12 | 04/13 | | |
NCT01838616 / 2012-002943-11: Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component. |
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| Completed | 4 | 367 | Europe | Tapentadol Prolonged Release, Nucynta, Palexia, Oxycodone/Naloxone Prolonged Release, Targin | Grünenthal GmbH | Back Pain, Low Back Pain, Neuropathic Pain | 01/14 | 01/14 | | |
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2011-003628-11: Tapentadol PR vs Oxycodon CRA pilotstudiy for a mechanism-orientated Therapy of peripheral chronic neuropathic pain syndrom Tapentadol PR vs. Oxycodon CR - Eine Pilotstudie für eine mechanismen-orientierte Therapie bei peripheren chronisch neuropathischen Schmerzsyndromen |
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| | 4 | 48 | Europe | Palexia, Oxygesic, Palexia (R) retard, Oxygesic®, Palexia (R) retard, Oxygesic® | University Hospital Schleswig Holstein Kiel, Clinic of Neurology, Gruenenthal GmbH | Chronical neuropathic pain syndrome | | 11/13 | | |
2011-003238-15: Quality of postoperative pain control and incidence and severity of nausea, vomiting, constipation, sedation, vertigo and somnolence during the treatment of postoperative pain with Palexia® compared to Targin®. Klinischer Vergleich zweier Schmerztherapie- Regimes nach unfallchirurgischen Eingriffen hinsichtlich Qualität der Schmerzerleichterung und Häufigkeit und Schwere von Nebenwirkungen. |
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| Completed | 4 | 266 | Europe | Palexia retard®, Targin retard® prolonged release tablets, Palexia retard, 76262.00.00, Palexia retard®, Targin retard® prolonged release tablets, Palexia retard, Palexia retard®, Targin retard® prolonged release tablets, Palexia retard | KKRN Katholisches Klinikum Ruhrgebiet Nord GmbH, KKRN Katholisches Klinikum Ruhrgebiet Nord GmbH | Management of postoperative pain in trauma surgery patients (adults) requiring postoperative opiates for the management of postoperative pain. Management des postoperativen Schmerzes bei unfallchirurgischen erwachsenen Patienten, welche Opiate zur postoperativen Schmerztherapie benötigen. | | 05/15 | | |
2017-000141-52: The effect of tapentadol and oxycodone on the human pain system Effekten af tapentadol og oxycodon på det humane smertenetværk |
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| Ongoing | 4 | 20 | Europe | Palexia Depot, OxyContin, Modified-release tablet, Palexia Depot, OxyContin | Asbjørn Mohr Drewes, Grünenthal GmBH | Healthy volunteers - pain, Pain, Diseases [C] - Nervous System Diseases [C10] | | | | |
2016-005082-31: Assessment of Tapentadol effects on patients with pain central sensitization using functional MRI Evaluación del efecto de tapentadol en pacientes con dolor por sensibilización central utilizando la resonancia magnética funcional (fMRI) |
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| Ongoing | 4 | 40 | Europe | Palexia Retard, Palexia retard, Prolonged-release tablet, Palexia retard 50 mg, Palexia retard 100 mg, Palexia retard 150 mg, Palexia retard 200 mg, Palexia retard 250 mg | MRI Research Unit, Radiology Department. Hospital del Mar., Grunenthal Pharma S.A. | Patients suffering from pain due to knee osteoarthritis Pacientes con dolor por artrosis de rodilla, Patients suffering from pain due to knee osteoarthritis Pacientes con dolor por artrosis de rodilla, Diseases [C] - Musculoskeletal Diseases [C05] | | | | |
2017-001285-23: A comparison of pain relief and effects on respiration from tapentadol and oxycodone after surgical removal of the uterus. |
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| Not yet recruiting | 4 | 90 | Europe | Tablet, Modified-release tablet, Capsule, hard, Palexia® 50 mg, Palexia depot®, OxyNorm®, OxyContin® | Oslo University Hospital, Oslo University Hospital | Pain after laparoscopic hysterectomy., Pain after surgical removal of the uterus using a minimal invasive surgical technique., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
