methylprednisolone sodium succinate / Generic mfg. |
ACTRN12622001186741: Autologous Stem Cell Transplant in Neuro-Inflammatory diseases other than multiple sclerosis |
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| Not yet recruiting | N/A | 5 | | | The Alfred- Melbourne, The Alfred-Melbourne | Neuro-Inflammatory disease | | | | |
ACTRN12623000321640: Chest hyperinflation and response to steroids and inhaled adrenaline in children with bronchiolitis admitted to intensive care |
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| Not yet recruiting | N/A | 211 | | | Royal Children's Hospital, Royal Children's Hospital | Bronchiolitis | | | | |
ChiCTR-TRC-12002662: Effect of epidural dexamethasone or methylprednisolone on post combined spinal-epidural anesthesia lumbar pain |
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| Completed | N/A | 200 | | epidural dexamethasone injection ;epidural methylprednisolone injection | Department of ICU, The third affiliated Hospital of Harbin Medical University; Level of the institution:, None | lumbar pain postoperative | | | | |
ChiCTR-ONC-13003666: Long-term Effects of High-dose Intravenous Methylprednisolone Pulse Therapy on Thyroid-associated Ophthalmopathy |
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| Completed | N/A | 58 | | high-dose intravenous methylprednisolone pulse (IVMP) therapy | First Affiliated Hospital of Xi’an Jiaotong University School of Medicine; First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Self-financing | Thyroid-associated ophthalmopathy | | | | |
ChiCTR-TRC-12002058: Randomized controlled clinical study of inhale budesonide and inject methylprednisolone in AECOPD patients |
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| Completed | N/A | 400 | | inhale budesonide suspension ;inject methylprednisolone sodium succinate | the 3rd affiliated hospital of Anhui Medical University (The 1st hospital of Hefei); the 3rd affiliated hospital of Anhui Medical University, self-raised funds about 60%, about 40% raised by Hefei Medical Association | chronic obstructive pulmonary disease | | | | |
ChiCTR-IOR-15005906: Methylprednisolone decreases the duration of rocuronium-induced neuromuscular block |
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| Not yet recruiting | N/A | 105 | | Patients received methylprednisolone 40mg intravenously 0.5h prior to surgery ;Patients received methylprednisolone 40mg after induction of anaesthesia ;Patients received normal saline 2ml | Obstetrics and Gynecology Hospital of Fudan University; Obstetrics and Gynecology Hospital of Fudan University, no | anaesthesia | | | | |
ChiCTR-BOC-16008999: The role and molecular mechanism of HDAC2 on glucocorticoid resistance formation in sudden sensorineural hearing loss |
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| Recruiting | N/A | 125 | | intratympanic methylprednisolone perfusion (0.5ml/day,40mg/ml) ;intravenous methylprednisolone 80mg/day×4day, 40mg/day×3day, 20mg/day×3day ;Not treatment | Nanjing Drum Tower Hosipital, Nanjing University Medical School; Nanjing Drum Tower Hosipital, Nanjing University Medical School, National Science Funds of China | Sudden Sensorineural Hearing Loss | | | | |
| Recruiting | N/A | 50 | | high-dose intravenous methylprednisolone pulse (IVMP) therapy | Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology; Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Self-financing | Thyroid-associated ophthalmopathy | | | | |
ChiCTR2000029656: A randomized, open-label study to evaluate the efficacy and safety of low-dose corticosteroids in hospitalized patients with novel coronavirus pneumonia (COVID-19) |
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| Not yet recruiting | N/A | 100 | | Standard treatment ;Standard treatment and methylprednisolone for injection | Wuhan Pulmonary Hosptial; Wuhan Pulmonary Hosptial, Emergency Project for 2019-nCoV of Ministry of Science and Technology | novel coronavirus pneumonia (COVID-19) | | | | |
| Recruiting | N/A | 200 | RoW | Methylprednisolone Injectable Product, solu madrol | Lahore General Hospital | SARS-CoV Infection, SARS (Severe Acute Respiratory Syndrome) | 12/20 | 12/20 | | |
ChiCTR-OOC-17013257: Efficacy evaluation of systemic glucocorticoids in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease in different phenotypes |
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| Not yet recruiting | N/A | 1044 | | intravenous use methylprednisolone 40mg qd for 5 days ;observation | West China Hospital, Sichuan University; West China Hospital, Sichuan University, National key research project of China during the 13th five-year plan period | Chronic Obstructive Pulmonary Disease | | | | |
ChiCTR2000029386: Effectiveness of glucocorticoid therapy in patients with severe novel coronavirus pneumonia: a randomized controlled trial |
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| Recruiting | N/A | 48 | | Methylprednisolone, intravenous injection, 1-2mg/kg·d for 3 days. ;Without any glucocorticoid therapy | Chongqing Public Health Medical Center; Chongqing Public Health Medical Center, Chongqing Science and Technology of Bureau | Novel Coronavirus Pneumonia (COVID-19) | | | | |
NCT05793359: Comparison of the Effectiveness of Two Glucocorticoid Regimens for Treatment of Graves' Orbitopathy |
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| Completed | N/A | 62 | Europe | Methylprednisolone, Urbason | Medical University of Sofia | Graves Ophthalmopathy | 02/21 | 02/21 | | |
ChiCTR2100043498: Effect of combined treatment with volatile anesthetics, dexmedetomidine, and methylprednisolone on prognosis in patients undergoing heart valve surgery |
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| Recruiting | N/A | 246 | | Intravenous methylprednisolone 120mg at anesthetic induction; Dexmedetomidine infusion at a rate of 0.4ug/kg/h after induction until the end of surgery; Volatile anesthetic to maintain anesthesia. ;Use the same technique to give the same amount or rate of normal saline at the same time point mentioned above, and use total intravenous anesthesia (propofol) throughout the surgery to maintain anesthesia | West China Hospital, Sichuan University; West China Hospital, Sichuan University, self-raised | postoperative recovery and perioperative organ protection | | | | |
ChiCTR1800019155: Multi-center clinical study for vestibular conversion and rehabilitation training effect of the idiopathic sudden deafness with vertigo |
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| Not yet recruiting | N/A | 180 | | Intravenous methylprednisolone andintratympanic injection ;Intravenous methylprednisolone +intratympanic injection+intravenous of Ginaton ;shock dose hormone group | Eye & ENT Hospital of Fudan University; Eye &ENT Hospital of Fudan University, The 2018 annual science and technology innovation action plan project of Shanghai municipal science and technology commission | the idiopathic sudden deafness with vertigo | | | | |
| Not yet recruiting | N/A | 100 | RoW | Paravertebral block+Anterior serratus plane block, nerve block, opioid free anesthesia, OFA, opioid based anesthesia, Standard anesthesia | Peking University People's Hospital | Opioid Free Anesthesia | 07/21 | 07/22 | | |
SUCCES, NCT03942861: Sonographic Assessment in Severe Ulcerative Colitis Patients Admitted for Intravenous Corticosteroids and Eligible for Infliximab Rescue Therapy; a Prospective Clinician-blinded Observational Study Protocol. |
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| Recruiting | N/A | 50 | Europe | Solu-Medrol | Copenhagen University Hospital at Herlev | Ulcerative Colitis, Ultrasound Therapy; Complications | 09/21 | 02/22 | | |
NCT06189586: Comparison of Aerosol Inhalation and Intravenous Glucocorticoid in the Treatment of Severe AECOPD |
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| Enrolling by invitation | N/A | 100 | RoW | aerosol inhalation of glucocorticoids, intravenous injection of glucocorticoids | Dong Yang, Jilin University | Acute Exacerbation of Chronic Obstructive Pulmonary Disease | 12/24 | 07/25 | | |
NCT04810819: Clinical Study of the Effect of Methylprednisolone Combined |
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| Not yet recruiting | N/A | 110 | NA | Methylprednisolone 40 MG Injection;Dihydroxypropyltheophylline;, Placebo | Qianfoshan Hospital | Methylprednisolone;Dihydroxypropyltheophylline;One Lung Ventilation;Respiratory Dynamics | 10/21 | 12/21 | | |
NCT03586557: Effectiveness of Plasma Exchange in Treating With Severe Acute AQP4-Ab Positive Optic Neuritis |
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| Recruiting | N/A | 142 | RoW | Corticosteroid & Plasma exchange, CS+PE, Corticosteroid, CS | Chinese PLA General Hospital | Optic Neuritis | 12/21 | 12/21 | | |
ChiCTR1800020060: A prospective, randomized, multicenter, controlled trial for the use of glucocorticoids in the treatment of AECOPD through different routes and courses |
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| Not yet recruiting | N/A | 480 | | 6ml (3mg) Budesonide aerosol inhalation for Bid*5 days ;6ml (3mg) Budesonide aerosol inhalation for Bid*9-14 days ;Methylprednisolone 40 mg intravenous drip or oral prednisolone 40 mg, Qd*5 days ;Methylprednisolone 40 mg intravenous drip or oral prednisolone 40 mg, Qd*9-14 days | Hefei First People's Hospital; Hefei First People's Hospital, Anhui Key Research and Development Plan | Chronic obstructive pulmonary disease | | | | |
ChiCTR1900025244: The efficacy and safety of immunomodulatory treatment in HBV-related ACLF |
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| Not yet recruiting | N/A | 135 | | common medical treatment, combined with methylprednisolone 40mg intravenously once a day, discontinued after 5 days ;common medical treatment, combined with the Zidaxian 1.6mg subcutaneous injection once a day, discontinued after 5 days. ;Routine medical treatment. | Zhejiang University; The Third Affiliated Hospital, SUN YAT-SEN University, Ministry of Finance,China | HBV-ACLF | | | | |
NCT05990894: Steroid for Treatment of Acute/Subacute Severe Cerebral Venous Thrombosis. |
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| Completed | N/A | 170 | RoW | Methylprednisolone | Xuanwu Hospital, Beijing | Cerebral Venous Thrombosis | 07/24 | 07/24 | | |
NCT04808856: Treatment of Refractory Gout With ACTH or Methylprednisolone |
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| Recruiting | N/A | 60 | RoW | Adrenocorticotropic Hormone, Methylprednisolone Injection | Shanghai 10th People's Hospital | Gout | 04/22 | 04/22 | | |
NCT03122847: Glucocorticoids and Bone in Graves' Ophthalmopathy |
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| Active, not recruiting | N/A | 30 | Europe | Methylprednisolone | Torben Harsløf, Odense University Hospital | Graves Ophthalmopathy | 07/22 | 07/23 | | |
ChiCTR1900027528: Prospective observational cohort study on the efficacy of different treatment methods for severe neuroimmune diseases |
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| Not yet recruiting | N/A | 390 | | plasma exchange ;Lymphatic plasma exchange ;Intravenous immunoglobulin ;plasma exchange ;Lymphatic plasma exchange ;Intravenous immunoglobulin ;plasma exchange ;Lymphatic plasma exchange ;Methylprednisolone Intravenous Shock ;plasma exchange ;Lymphatic plasma exchange ;Methylprednisolone Intravenous Shock ;Intravenous immunoglobulin | Department of Neurology, Xiangya Hospital, Central South University; Xiangya Hospital, Central South University, Self-raised | Severe Neuroimmune Disease | | | | |
ChiCTR2000038871: Clinical study of batroxobin injection in the treatment of sudden deafness |
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| Recruiting | N/A | 210 | | Batroxobin + methylprednisolone intravenous injection ;Methylprednisolone intravenous injection + dexamethasone injection ;Batroxobin + methylprednisolone intravenous injection + dexamethasone tympanic injection | The First Affiliated Hospital of Guangzhou Medical University; The First Affiliated Hospital of Guangzhou Medical University, Tinnitus stimulation non-invasive neuromodulation therapy | Sudden deafness | | | | |
NCT05455398: Establishment of a Trans-round Window Inner Ear Continuous Drug Delivery System for the Treatment of Severe-to-profound Sudden Sensorineural Hearing Loss |
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| Recruiting | N/A | 218 | RoW | Surgical treatment of round window niche enlargement via round window for inner ear drug delivery, Drum chamber drug injection | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Hearing Loss, Sudden | 11/23 | 03/24 | | |
| Completed | N/A | 104 | Europe | leg fracture | University Hospital, Clermont-Ferrand | Leg Injuries, Fracture, Edema | 12/23 | 05/24 | | |
REVIVES, NCT06203847: The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA |
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| Not yet recruiting | N/A | 1200 | RoW | Combination group, Standard group | National Taiwan University Hospital | Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Emergency Medical Services | 06/26 | 12/26 | | |
NCT05842681: Azithromycin in the Management of Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
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| Not yet recruiting | N/A | 30 | RoW | Azithromycin, azithromycin 500 mg oral tablet, Methylprednisolone, methylprednisolone 500 mg | Assiut University | Idiopathic Pulmonary Fibrosis | 03/24 | 06/24 | | |
ChiCTR2100047811: The relationship between FeNO50 +CANO combined detection and treatment response in patients with acute exacerbation of COPD |
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| Not yet recruiting | N/A | 103 | | Intravenous methylprednisolone (40mg/ day) was used for 1-3 days during hospitalization; Intravenous methylprednisolone (40mg/ day) was used for 4-7 days during hospitalization ;No systemic hormones were used during hospitalization | Shenzhen Second People's Hospital; Shenzhen Second People's Hospital, Funding from hospital-level clinical research projects in 2021 | chronic obstructive pulmonary disease | | | | |
NCT06068829: Inebilizumab and Rituximab in Neuromyelitis Optica Spectrum Disorders |
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| Not yet recruiting | N/A | 80 | NA | Inebilizumab, Rituximab(RTX) | Feng Jinzhou | Neuromyelitis Optica Spectrum Disorders | 06/24 | 06/25 | | |
NCT05964725: The Study on Effect and Neural Network Mechanism of Transcranial Direct Current Stimulation for Sudden Deafness With Tinnitus |
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| Recruiting | N/A | 86 | RoW | Receive traditional medical therapy and transcranial direct current stimulation, Receive traditional medical therapy and sham stimulation | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Tinnitus, Subjective, Sudden Deafness, Transcranial Direct Current Stimulation, Double-Blind Method, Female, Male, Human, Treatment Outcome | 08/24 | 08/24 | | |
NCT06118398: Efgartigimod in Acute Neuromyelitis Optica Spectrum Disorders |
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| Not yet recruiting | N/A | 24 | NA | Intravenous methylprednisolone (IVMP) and Efgartigimod, IVMP | Feng Jinzhou | Neuromyelitis Optica, Efgartigimod | 11/24 | 05/25 | | |
ChiCTR2400080486: Effect of high-dose methylprednisolone on the early postoperative quality of recovery in patients undergoing minimally invasive esophagectomy: a randomized controlled trial |
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| Not yet recruiting | N/A | 218 | | Intravenous methylprednisolone 120 mg before skin incision; An equal volume of saline was administered intravenously prior to skin incision | West China Hospital, Sichuan University; West China Hospital, Sichuan University, None | Esophageal cancer | | | | |
ChiCTR2300071734: Effectiveness and safety evaluation of Chinese medicine in the treatment of patients with PPF with phlegm heat-blood stasis obstructing in the lung: a randomized controlled, open-label clinical trial |
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| Not yet recruiting | N/A | 50 | | Mahuang, Kuxingren, Gancao, Fengfang, Dilong, Chishao, Jiezi, Laifuzi, Zisuzi, Huangqi, Huangqin, Qinghao ;1. All patients will take pulmonary rehabilitation therapy; 2. Patients with hypoxia at rest, will take long-term oxygen therapy; 3. Patients with pulmonary infection will take empirical anti-infective treatment, and targeted anti-infective treatment will be given after obtaining the results of drug sensitivity test. For the dosage of hormones and immunomodulators, our recommendations are summarised below: (1) Glucocorticoid: the initial dose of glucocorticoid can range from oral prednisone (1mg·kg-1·d-1) to intravenous methylprednisolone (500-1000 mg/d) for 3 days, then reduced to prednisone or equivalent dose, gradually reduced to maintenance dose in 4-8 weeks according to the patient's condition and treatment response, and maintained close follow-up; (2) Cyclophosphamide: adhere to the daily use of 2mg, the initial dose is prescribed daily oral 25mg-50mg, and increase 25mg every other week to two weeks, according to this cycle until the maximum dose reaches the daily 150mg; (3) Azathioprine: administered at 2-3 mg·kg-1·d-1. The initial dose is 25-30mg/d, and then 25mg will be increased every 7 to 14 days until the maximum amount of 150mg/d is reached; In addition, if the subjects had taken oral corticosteroids for more than one month before entering the trial, and the hormone had reached the maintenance dose, or if they had taken oral immunomodulators for more than one month before entering the trial, the original drug treatment regimen should not be changed during the clinical observation, the investigators should record it completely and truthfully. | Hospital of Chengdu University of Traditional Chinese Medicine; Beijing University of Chinese Medicine, National Natural Science Foundation of China (No.81973713) | progressive pulmonary fibrosis(PPF) | | | | |
NCT01630850: Islet Transplantation in Patients With "Brittle" Type I Diabetes |
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| Recruiting | N/A | 20 | US | Allogenic islet cells (human, U. Chicago), Intraportal infusion of islet cells | University of Chicago | Diabetes Mellitus, Type 1 | 05/25 | 06/30 | | |
ChiCTR2000034214: A multicenter, prospective, cohort study for the efficacy and adverse reactions of ANCA associated glomerulonephritis based on ARRS score |
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| Not yet recruiting | N/A | 106 | | Induction remission stage: Glucocorticoid + cyclophosphamide; Maintain remission stage: Hormone + azathioprine / methotrexate / mycophenolate mofetil ;Induction remission stage: Methylprednisolone + intravenous cyclophosphamide or rituximab; Maintain remission stage: Hormone + azathioprine / mycophenolate mofetil / rituximab ;Induction: Methylprednisolone + cyclophosphamide + rituximab + plasma exchange; Maintain: Hormone + azathioprine / mycophenolate mofetil / rituximab ;Induction: Methylprednisolone + intravenous cyclophosphamide; Maintain: Hormone + azathioprine / methotrexate / mycophenolate mofetil | Children's Hospital Affiliated to Chongqing Medical University; Children's Hospital Affiliated to Chongqing Medical University, self-financing | ANCA associated glomerulonephritis | | | | |
ChiCTR2200058688: A prospective, single-center, randomized controlled trial of glucocorticoid impulse therapy for acute exacerbation of idiopathic pulmonary fibrosis |
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| Not yet recruiting | N/A | 60 | | Methylprednisolone 500mg/qd intravenous for 3 days ;Methylprednisolone 160mg/qd intravenous for 3 days,then taped gradually. | Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School; Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Self-finance | Acute exacerbation of idiopathic pulmonary fibrosis | | | | |
NCT05891379: Inebilizumab in Acute Neuromyelitis Optica Spectrum Disorders |
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| Recruiting | N/A | 50 | RoW | Inebilizumab, oral immunosuppressant | Xuanwu Hospital, Beijing, Jiangsu Hansoh Pharmaceutical Co., Ltd. | Neuromyelitis Optica Spectrum Disorder | 07/25 | 07/25 | | |
| Active, not recruiting | N/A | 249 | Europe | Cyclosporine, Sandimmun Neural, Mycophenolate mofetil (MMF), Cellcept, Rabbit Anti thymocyte globulin, Thymoglobulin®, Corticosteroids, Methylprednisolon, Tacrolimus, Advagraf® | Vastra Gotaland Region, Oslo University Hospital, Helsinki University Central Hospital, Skane University Hospital, Copenhagen University Hospital, Denmark | Lung Transplantation, Allografts | 10/25 | 10/26 | | |
| Recruiting | N/A | 142 | Europe | Lidocaine, Methylprednisolone Acetate, Depo-Medrol, Dexamethasone | C.L.A.Vleggeert-Lankamp, Spaarne Gasthuis, Stichting Achmea Gezondheidszor, Posthumus Meyjes Fonds | Sciatica, Sciatica Due to Intervertebral Disc Disorder, Sciatic Radiculopathy | 12/25 | 07/26 | | |
ChiCTR2400079564: Evaluation of the clinical effectiveness of hormone therapy alone versus IVIG combined with hormone therapy for second dose IVIG unresponsive Kawasaki disease ---- a multicenter randomized controlled t |
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| Not yet recruiting | N/A | 100 | | IVIG+solu-medrol 2mg/kg; solu-medrol 2mg/kg | Shenzhen Children’s Hospital; Shenzhen Children’s Hospital, Special clinical research project of Shenzhen Children's Hospital | Kawasaki Disease | | | | |