Delirium, Dementia, Amnestic, Cognitive Disorders  >>  avagacestat (BMS-708163)  >>  Phase 1
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10 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
avagacestat (BMS-708163) / BMS
NCT00726726: Drug Interaction Study With a Potential Alzheimer's Disease Compound

Completed
1
22
US
Interacting drugs - Cooperstown Cocktail (midazolam, warfarin, (+ vitamin K), caffeine, omeprazole and dextromethorphan), BMS-708163, BMS-708163 + Cooperstown Cocktail
Bristol-Myers Squibb
Alzheimer Disease
10/08
10/08
NCT01454115: Study to Evaluate the Safety, Pharmacokinetics and Tolerability of BMS-708163

Checkmark P1 data
Mar 2012 - Mar 2012: P1 data
Completed
1
116
US
BMS-708163 (Gamma-Secretase Inhibitor), Placebo matching BMS-708163
Bristol-Myers Squibb
Alzheimer's Disease
03/09
03/09
NCT00860275: Drug-Drug Interaction (DDI) w/Ketoconazole or Fluconazole

Completed
1
30
US
BMS-708163, BMS-708163 + Ketoconazole, Ketoconazole, Fluconazole, BMS-708163 + Fluconazole
Bristol-Myers Squibb
Alzheimer Disease
06/09
06/09
NCT00901498: Relative Bioavailability Study of Four Experimental Formulations for Alzheimer's Disease

Completed
1
36
US
BMS-708163
Bristol-Myers Squibb
Alzheimer's Disease, Healthy
07/09
07/09
NCT00979316: Effect on the Electrocardiographic QT Interval Corrected for Heart Rate (QTc) in Healthy Subjects

Completed
1
62
US
BMS-708163, Placebo, Moxifloxacin, Avelox
Bristol-Myers Squibb
Alzheimer Disease
02/10
02/10
NCT01039194: Drug-Drug Interaction to Study the Effect of BMS-708163 on Pharmacokinetics (PK) of Galantamine Extended Release (ER)

Checkmark P1 data (AAICAD 2012)
Jul 2012 - Jul 2012: P1 data (AAICAD 2012)
Completed
1
18
US
galantamine, Razadyne ER ™, BMS-708163
Bristol-Myers Squibb
Alzheimer Disease
04/10
04/10
NCT01042314: Drug-Drug Interaction Study With Aricept® (Donepezil)

Checkmark P1 data (AAICAD 2012)
Jul 2012 - Jul 2012: P1 data (AAICAD 2012)
Completed
1
18
US
Donepezil, Aricept®, BMS-708163
Bristol-Myers Squibb
Alzheimer Disease
04/10
04/10
NCT01057030: Multiple Dose Japanese Bridging Study

Checkmark P1 data (AAICAD 2012)
Jul 2012 - Jul 2012: P1 data (AAICAD 2012)
Completed
1
22
US
BMS-708163, (GAMMA SECRETASE inhibitor), Placebo
Bristol-Myers Squibb
Alzheimer Disease
06/10
06/10
NCT01002079: Drug-Drug Interaction Study With Rifampin

Completed
1
20
RoW
BMS-708163, Rifampin
Bristol-Myers Squibb, PRA Health Sciences
Alzheimer Disease
10/10
10/10
NCT01079819: Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of BMS-708163

Checkmark P1 data (AAICAD 2012)
Jul 2012 - Jul 2012: P1 data (AAICAD 2012)
Completed
1
32
US
BMS-708163, Placebo
Bristol-Myers Squibb
Alzheimer's Disease
12/10
12/10

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