Carcinoma  >>  Mekinist (trametinib)  >>  Phase 1
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4 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Mekinist (trametinib) / Novartis, BeiGene
NCT02258607: Efficacy and Safety of Momelotinib Combined With Trametinib in Adults With Metastatic KRAS-mutated Non-Small Cell Lung Cancer (NSCLC) Who Have Failed Platinum-Based Chemotherapy Preceded by a Dose-finding Lead-in Phase

Terminated
1b
21
US
Momelotinib (MMB), GS-0387, CYT387, Trametinib
Sierra Oncology, Inc.
Relapsed Metastatic KRAS-Mutated Non-Small Cell Lung Cancer
07/16
02/17
NCT01938456: Safety and Tolerability of Trametinib in Combination With Docetaxel in Japanese Subjects With Non-small Cell Lung Cancer

Withdrawn
1
0
Japan
Trametinib, Docetaxel, Filgrastim
GlaxoSmithKline
Lung Cancer, Non-Small Cell
07/14
07/14
NCT01438554: Phase 1 Study of Pazopanib With GSK1120212 in Advanced Solid Tumors, Enriched With Patients With Differentiated Thyroid Cancer, Soft-tissue Sarcoma, and Cholangiocarcinoma

Checkmark ASCO 2015
May 2015 - May 2015: ASCO 2015
Checkmark AACR-NCI-EORTC 2013
Oct 2013 - Oct 2013: AACR-NCI-EORTC 2013
Checkmark P1 data-ASCO
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Completed
1
89
US
Pazopanib, Votrient, GSK1120212, Trametinib, Mekinist
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Comprehensive Cancer Network, Novartis
Solid Tumors, Thyroid Cancer, Soft-tissue Sarcoma, Cholangiocarcinoma
04/16
08/18
NCT02538627: Phase 1 Combination Study of MM-151 With MM-121, MM-141, or Trametinib

Terminated
1
5
US
MM-151, MM-121, MM-141, trametinib, MEKINIST
Merrimack Pharmaceuticals
Colorectal Cancer, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck
10/16
10/16

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