| sildenafil / Generic mfg. |
ACTRN12610001017011: Investigation Into The Efficacy And Safety Of Sildenafil Versus Natural Progesterone For prevention Of Preterm Labour
A randomized controlled study |
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| Recruiting | 4 | 60 | | | waleed elkhayat, waleed elkhayat | prevention Of Preterm Labour, preterm labour | | | | |
ChiCTR-TRC-13003938: Efficacy of daily low-dose sildenafil for treating interstitial cystitis: results of randomized, double-blind, placebo-controlled trial |
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| Completed | 4 | 48 | | oral sildenafil ;oral placebo | The First Af?liated Hospital of Wenzhou Medical College; The First Affiliated Hospital of Wenzhou Medical College, self-raised | interstitial cystitis | | | | |
2011-004811-21: The effect of Sildenafil citrate (Viagra ®) on stomach motility, gastric emptying and food intake in healthy volunteers |
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| Ongoing | 4 | 20 | Europe | Viagra, Film-coated tablet, Viagra | UZLeuven, UZLeuven | study is conducted on healthy volunteers, no medical condition is investigated, study is conducted on healthy volunteers, no medical condition is investigated, Body processes [G] - Physiological processes [G07] | | | | |
2005-000660-74: Tamsulosiinin ja sildenafiilin sydän- ja verenkiertoelinvaikutukset BPH-potilailla |
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| Ongoing | 4 | 20 | Europe | Omnic, Viagra, Omnic, Viagra, Omnic, Viagra | Tuomo Nieminen | Eturauhasen hyvänlaatuinen liikakasvu, BPH | | | | |
2005-001004-39: Investigation of combined phosphodiesterase 5 inhibitor and isosorbide mononitrate for the treatment ofresistant hypertension |
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| Ongoing | 4 | 40 | Europe | Viagra, Isosorbide mononitrate, Viagra, Angeze 10 Isosorbide mononitrate 10 mg Kentipine 10 Cibral tablets 10, Angeze 20 mg Isosorbide mononitrate 20 mg Cibral tablets 20 mg, Viagra, Angeze 10 Isosorbide mononitrate 10 mg Kentipine 10 Cibral tablets 10, Angeze 20 mg Isosorbide mononitrate 20 mg Cibral tablets 20 mg | University of Edinburgh | Hypertension | | | | |
2005-001034-32: Does pre-operative Sildenafil protect against pulmonary related complications following cardiopulmonary bypass? A randomised trial in children undergoing cardiac surgical repair |
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| Ongoing | 4 | 24 | Europe | Sildenafil Citrate, N/A, Sildenafil Citrate, Sildenafil Citrate | NHS Greater Glasgow, Yorkhill | Congenital Heart Disease | | | | |
2005-004171-37: Oxidative Stress in children undergoing cardiopulmonary bypass: A trial of Sildenafil therapy |
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| Ongoing | 4 | 60 | Europe | Sildenafil, Viagra, Viagra | United Bristol Healthcare Trust | Congenital Heart Disease | | | | |
2006-005239-32: Fosfodiesterashämmares akuta hemodynamiska effekter vid pulmonell hypertension och utvärdering av kväveoxid mätningar som icke-invasiv diagnostisk metod |
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| Ongoing | 4 | 50 | Europe | Revatio Cialis Levitra, Revatio Cialis Levitra | Medical Sciences, Akademiska sjukhuset | Pulmonell hypertension med kvarstående förhöjt medeltryck i arteria pulmonalis överstigande 25 mmHg i vila eller >30 mmHg under ansträngning vid hjärtkateterisering definierad av National Institute of Health (NIH). Patienten skriver på för skriftligt samtycke (Informed Consent) Patienten över 18 år | | | | |
2006-004705-26: Safety and Tolerability of Sildenafil in Patients with Eisenmenger Physiology |
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| Ongoing | 4 | 12 | Europe | Sildenafil, Revatio ® 20 mg film-coated tablets, Revatio ® 20 mg film-coated tablets | Imperial College London | Eisenmenger Syndrome (pulmonary hypertension due to congenital heart disease) | | | | |
2007-006040-21: Estudio de los efectos de sildenafilo en combinación con rehabilitación pulmonar sobre la tolerancia al esfuerzo en pacientes con enfermedad pulmonar obstructiva crónica e hipertensión pulmonar |
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| Ongoing | 4 | 60 | Europe | Revatio, Revatio | Dr. J.A. Barberà. Servicio de Neumología. Hospital Clínic de Barcelona | EPOC e hipertensión pulmonar asociada | | | | |
| Ongoing | 4 | 30 | Europe | Sildenafil, Metformine, Simvastatine, G04BE03, A10BA02, C10AA01, Tablet, Sildenafil, Metformine, Simvastatine | Radboud University Medical Center, Radboud University Medical Center | healthy volunteers; the information of this pilot study will be used in the care of patients with diabetes insipidus, diabetes insipidus: conditions leading to the inability of the kidney to concentrate te urine, Body processes [G] - Physiological processes [G07] | | | | |
ChiCTR1900023019: Therapeutic effect of sildenafil on patients with pulmonary hypertension induced by peritoneal dialysis |
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| Not yet recruiting | 4 | 50 | | Sildenafil | Xiangya Hospital, Central South University; Xiangya Hospital, Xiangya Hospital, Department of Nephrology, construction funding | peritoneal dialysis | | | | |
ChiCTR1900022659: Clinical study for phosphodiesterase 5 inhibitor (PDE5i) on endothelial function improvement in cardiovascular patients: a randomized controlled trial |
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| Not yet recruiting | 4 | 200 | | sildenafil ;Tadalafil ;sildenafil ;Tadalafil ;None sildenafil or tadalafil | Xiangya Hospital, Central South University; Xiangya Hospital, Central South University, none | Coronary heart disease and erectile dysfunction | | | | |
NCT05558176: Intrapartum Sildenafil Citrate to Prevent Non Reassuring Foetal Status Among Parturients Delivering at Term |
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| Recruiting | 4 | 176 | RoW | Sildenafil citrate, Viagra | Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso | Foetal Hypoxia | 10/22 | 10/22 | | |
NCT06064448: Clinical Observation of Ningmitai Capsule in Treating Chronic Pelvic Pain Syndrome With Erectile Dysfunction |
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| Completed | 4 | 254 | RoW | Sildenafil, Western Medicine Section, Ningmitai capsule, Traditional Chinese medicine group, Ningbitai capsule + sildenafil, Combined group | Xintian Pharmaceutical | Chronic Prostatitis With Chronic Pelvic Pain Syndrome, Erectile Dysfunction | 12/22 | 12/22 | | |
NCT05183334: Combined On-demand Sildenafil Citrate and Tramadol Hydrochloride for Treatment of Premature Ejaculation |
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| Not yet recruiting | 4 | 160 | NA | Sildenafil 50 mg, sildanafil, Placebo, no drug, Tramadol Hydrochloride 100 MG, tamol | Assiut University | Premature Ejaculation | 12/22 | 12/22 | | |
NCT05753098: Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained Infertility |
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| Completed | 4 | 148 | RoW | estrogen therapy, white tablet of cycloprogynova, Sildenafil, Respatio, Clomiphene Citrate 50mg, Technovula | Beni-Suef University | Subfertility, Female | 01/23 | 01/23 | | |
NCT04908657: Sildenafil for Liver Fibrosis in Adolescents and Adults After Fontan Operation |
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| Recruiting | 4 | 40 | RoW | Sildenafil 20 MG | National Taiwan University Hospital | Liver Fibrosis | 07/23 | 12/23 | | |
| Recruiting | 4 | 2 | Europe | Sildenafil, Vizarsin | Chronic Obstructive Pulmonary Disease Trial Network, Denmark | Acute Exacerbation of COPD | 10/23 | 10/25 | | |
NCT03402191: L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension |
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| Recruiting | 4 | 60 | RoW | L-arginine, Sildenafil, Viagra | Sherief Abd-Elsalam | Thalassemia | 12/23 | 12/23 | | |
NCT02682147: Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema |
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| Recruiting | 4 | 80 | US | Hypoxia administration study group, Oxygen, Hyperoxia administration study group, Sildenafil, Revatio | Eric A. Hoffman, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) | Emphysema | 12/24 | 12/24 | | |
| Recruiting | 4 | 280 | US | Sildenafil 20 MG, Experimental: Smoking Cessation Group 1, Experimental: Non-Smokers Group 1, Placebo Oral Tablet, No Intervention: Smoking Cessation Group 2, Pulse wave velocity, Carotid artery compliance and stiffness, Pressure wave reflection | Eric A. Hoffman, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) | Emphysema | 12/24 | 12/24 | | |
NCT06178523: Cost-effective Treatment of Unexplained Infertility |
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| Not yet recruiting | 4 | 900 | RoW | Clomiphene Citrate., Clomid®, Sildenafil Citrate, Viagra®, Intrauterine Insemination, IUI | Batterjee Medical College | Unexplained Infertility | 09/25 | 09/25 | | |
2017-000421-13: Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil. |
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| Ongoing | 3/4 | 330 | Europe | Solution for injection/infusion, Medicinal gas, compressed, revatio 0.8mg/ml solution for injection, INOmax 800ppm mol/mol inhalatiegas, Neophyr 1000ppm mol/mol | Erasmus MC, SSWO, CDH UK Sparks | Congenital diaphragmatic hernia with pulmonary hypertension Hernia diafragmatica met pulmonale hypertensie, Defect in diaphragm resulting in high blood pressure in the lungs Defect in het middenrif resulterend in hoge bloeddruk in de longen, Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | | | | |
ACTRN12606000116527: Randomised double-blind controlled trial of the use of daily sildenafil (Viagra) in men with early prostate cancer treated with radiation, for the prevention of subsequent erectile dysfunction. |
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| Active, not recruiting | 3 | 80 | | | William Buckland Radiotherapy Centre, Pfizer Australia, William Buckland Radiotherapy Centre, N/A | Prostate cancer | | | | |
ACTRN12621000231842: Can Intrapartum SildEnafil safely Avert the Risks of Contraction-induced Hypoxia? |
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| Recruiting | 3 | 3200 | | | The University of Sydney, NHMRC | Contraction-induced hypoxia in labour | | | | |
2012-004112-63: Sildenafil for early severe fetal growth restriction Sildenafil voor vroege ernstige foetale groeivertraging |
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| Ongoing | 3 | 354 | Europe | Viagra, Viagra | Academic Medical Center, ZonMw, Pfizer | Fetal growth restriction foetale groeivertraging | | | | |
2012-004583-22: Verification of the effectiveness of intravenous sildenafil compared to other pulmonary vasodilators used in the test vessel reactivity of pulmonary Verifica dell’efficacia del sildenafil per via endovenosa rispetto agli altri agenti vasodilatatori polmonari utilizzati nel test di vaso reattività polmonare |
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| Ongoing | 3 | 15 | Europe | REVATIO*EV 1FL 20ML 0,8MG/ML, REVATIO*EV 1FL 20ML 0,8MG/ML | OSPEDALE PEDIATRICO BAMBINO GESU\' DI ROMA, Ospedale Pediatrico Bambino Gesù | Subjects in children with congenital heart disease surgery or not, with echocardiographic signs of pulmonary hypertension followed at the Pediatric Cardiology Centre of the Mediterranean or reported by other centers I and Level II. Soggetti in età pediatrica affetti da cardiopatia congenita operata e non, con segni ecocardiografici di ipertensione polmonare seguiti presso il Centro Cardiologico Pediatrico del Mediterraneo o riferiti da altri centri di I e II livello. | | | | |
REVAD, NCT03356353: Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation |
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| Recruiting | 3 | 24 | Canada | Sildenafil Citrate, Revatio | University of Calgary, Pfizer | End Stage Heart Failure | 09/21 | 01/22 | | |
VIRTUOSE, NCT03686306: : Efficiency of Sildenafil on the Absolute Claudication Distance of Peripheral Arterial Disease Patients With Intermittent Claudication. |
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| Recruiting | 3 | 220 | Europe | Sildenafil, Placebo | Rennes University Hospital | Peripheral Artery Disease | 11/24 | 06/25 | | |
NCT05584956: Clinical Study to Evaluate the Possible Efficacy and Safety of L- Carnitine and Sildenafil in Children Having Beta Thalassemia With Increased Tricuspid Regurgitant Jet Velocity |
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| Recruiting | 3 | 44 | RoW | L_carnitine, Sildenafil | Tanta University | Beta Thalassemia With Increased Tricuspid Regurgitant Jet Velocity | 07/23 | 07/24 | | |
SV-INHIB, NCT03997097: Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart Disease |
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| Withdrawn | 3 | 50 | NA | Sildenafil, sildenafil group, Placebos, placebo group | University Hospital, Montpellier | Single-ventricle, Pulmonary Hypertension, Univentricular Heart | 06/26 | 06/28 | | |
MoD, NCT04039464: Mono vs. Dual Therapy for Pediatric Pulmonary Arterial Hypertension |
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| Recruiting | 3 | 100 | Canada, US | Mono-Therapy with Sildenafil, Revatio monotherapy, Duo-Therapy with Sildenafil + Bosentan, Dual therapy with Revatio and Tracleer | Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), National Center for Advancing Translational Sciences (NCATS) | Pediatric Pulmonary Hypertension | 09/26 | 09/26 | | |
RECTIL, NCT06123156: Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer |
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| Not yet recruiting | 3 | 188 | NA | Sildenafil, Arm I, Placebo, Arm II | University Hospital, Rouen | Rectal Cancer | 05/28 | 05/28 | | |
NCT05846906: Effect of Oral Sildenafil Citrate on Improvement of Endometrial Thickness |
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| Completed | 2/3 | 130 | RoW | Sildenafil Citrate, respatio, Clomiphene Citrate 50mg, technovula | Beni-Suef University | Infertility, Female | 04/22 | 04/22 | | |
| Recruiting | 2/3 | 40 | US | Sildenafil 40mg oral capsule, sildenafil, revatio, Placebo Oral capsule, placebo | National Jewish Health, Augusta University, Cystic Fibrosis Foundation | Cystic Fibrosis | 06/23 | 06/24 | | |
NCT05951413: The Effect of Sildenafil Citrate on Frozen Embryo Transfer Cycles |
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| Recruiting | 2/3 | 110 | RoW | Sildenafil Citrate, respatio, Viagra, estradiol, Cycloprogynova | Beni-Suef University | IVF | 09/23 | 09/23 | | |
NCT05971667: Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes |
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| Not yet recruiting | 2/3 | 200 | RoW | tadalafil, cialong, Sildenafil, Respatio, pentoxifylline, trental | Beni-Suef University | IVF | 10/23 | 10/23 | | |
2007-005513-18: Double blind randomized controlled study on the benefit-risk profile of in the treatment of at term or late preterm newborn infants with severe respiratory disorders and pulmonary hypertension |
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| Ongoing | 2 | 100 | Europe | Oral solution, REVATIO | OSPEDALE PEDIATRICO BAMBINO GESU' DI ROMA | treatment of at term or late preterm newborn infants with severe respiratory disorders and pulmonary hypertension | | | | |
| Ongoing | 2 | 60 | Europe | VIAGRA, Noxap 800 ppm mol/mol, not applicable, Tablet, Medicinal gas, compressed, VIAGRA, Noxap 800ppm mol/mol | UZLeuven, UZLeuven | To investigate acute effects of sildenafil on cardiac hemodynamics, right ventricle performance and cGMP concentrations in heart failure patients with preserved ejection fraction and patients after heart transplantation, Immediatly effects on lowering bloodpressure in the lung arteries after administration of oral sildenafil, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2015-003259-24: The Effect of Sildenafil (Revatio®) on Post Cardiac Surgery Acute Kidney Injury (AKI): A Randomised, Placebo-controlled Clinical Trial: "REVAKI 2 Trial" |
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| Ongoing | 2 | 126 | Europe | Sildenafil, Solution for injection/infusion, Revatio (Sildenafil) | University of Leicester, British Heart Foundation | Post cardiac surgery acute kidney injury, Kidney damage following cardiac surgery, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2007-000257-56: Neural correlates of sexual arousal during treatment of testosterone combined with sildenafil in healthy female subjects with FSD. Effects of differing levels of attentional engagement on neural correlates of sexual arousal induced by an erotic film. |
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| Ongoing | 2 | 30 | Europe | Lybrido, Lybrido, | Emotional Brain BV | Hypoactive sexual desire disorder and female sexual arousal disorder | | | | |
2007-002688-28: Pilot study on the short-term effects of Sildenafil on hemodynamic response to exercise and exercise capacity in Fontan patients |
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| Ongoing | 2 | 16 | Europe | sildenafil, VIAGRA*4CPR 50MG, VIAGRA*4CPR 50MG | AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI | congenital heart disease | | | | |
2012-003921-13: Racecadotril used in combination with sildenafil to reduce blood pressure in the lungs. |
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| Ongoing | 2 | 24 | Europe | Racecadotril, Tiorfan, Tiorfan | University College London, British Heart Foundation, UCLH/UCL Biomedical Research Centre and UCLH/UCL Clinical Research Development Committee | Pulmonary hypertension | | | | |
2011-002707-16: sildenafil in the postoperative period of cardiac surgery in children. sildenafilo en el postoperatorio de cirugia cardiaca en niños. |
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| Ongoing | 2 | 32 | Europe | revatio oral, Revatio inyectable, revatio oral, Revatio inyectable | Fundacion para la investigación Biomédica del hospital Gregorio Marañón, Instituto de salud Carlos III | Postoperative pulmonary artery hypertension hipertension arterial pulmonar postoperatoria | | | | |
2010-023375-26: Effects of Sildenafil on Signs and SYmptoms of Ischemia, Myocardial BlooD Flow, and Markers of ANgiogenesis in Patients with REfractory CoronarY Artery Disease |
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| Ongoing | 2 | 60 | Europe | Revatio, G04BE03, Revatio, Revatio | Medizinische Universität Wien, Klinik für Innere Medizin II, Abteilung für Kardiologie, Medizinische Universität Wien | Patients with coronary artery disease who suffer from myocardial malperfusion and continue to experience angina despite maximal medical and revascularization therapy are called \"no-option\" patients. | | | | |
2016-001591-30: Treatment of congenital nephrogenic diabetes insipidus with riociguat or sildenafil Behandling af medfødt nefrogen diabetes insipidus med riociguat eller sildenafil |
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| Ongoing | 2 | 2 | Europe | Adempas, Viagra, Tablet, Adempas, Viagra | Odense University Hospital, funding | Nephrogenic diabetes insipidus because of AVP2R-mutation Diabetes insipidus på baggrund af mutation i AVP2-receptoren, Nephrogenic diabetes insipidus because of AVP2R-mutation Diabetes insipidus på baggrund af mutation i AVP2-receptoren, Diseases [C] - Hormonal diseases [C19] | | | | |
2017-001878-42: Sildenafil effect in placental vessels. Efecto del Sildenafilo en los vasos de la placenta. |
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| Ongoing | 2 | 60 | Europe | Capsule | CONSORCIO HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA, FUNDACIÓN DE INVESTIGACIÓN HOSPITAL GENERAL DE VALENCIA | This is a placebo – controlled longitudinal study to determine whether maternal administration of an unique oral dose of sildenafil citrate (50mg) improves placental flow in first trimester in healthy pregnancies. They are pregnant women before twelve weeks who comes to our hospital for legal medical abortion. Se trata de un estudio longitudinal con grupo control ( placebo) para determinar si la administración de una dosis única de 50mg de citrato de sildenafilo puede aumentar la vasscularización placentaria en el primer trimestre en embarazos sanos. Son mujeres embarazadas por debadjo de doce semana que acuden para solicitar la interrupción legal de su embarazo., The vascular effect of Sildenafil will be tested in early pregnancy. El efecto vascular del sildenafilo en la gestación temprana., Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13] | | | | |
NCT01817751: Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma |
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| Active, not recruiting | 2 | 47 | US | sorafenib tosylate, pyridinecarboxamide, chloro-trifluoromethylphenyl pyridine-carboxylic acid methylamide-methylbenzenesulfonate tosylate, Nexavar, valproic acid, 2-Propylpentanoic or Propylvaleric Acid, Alti-Valproic, Depakene, Di-n-propylacetic Acid, Ergenyl, Novo-Valproic, VA, Valproate, Valproate Sodium, sildenafil citrate, Viagra | Virginia Commonwealth University, National Cancer Institute (NCI) | Glioblastoma, Recurrent Adult Brain Neoplasm, Malignant Glioma, WHO Grade III Glioma | 08/20 | 10/27 | | |
| Completed | 2 | 75 | Europe | Sildenafil, Cilostazol, Placebo | University of Oxford, Wellcome Trust | Small Vessel Cerebrovascular Disease | 12/22 | 01/23 | | |
| Enrolling by invitation | 2 | 30 | RoW | Dopamine | Seoul National University Hospital, Asan Medical Center, Severance Hospital | Neonates and Preterm Infants | 12/22 | 12/22 | | |
NCT05201144: A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH) |
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| Recruiting | 2 | 40 | US | Sildenafil Oral Suspension, Placebo | University of Utah | Congenital Diaphragmatic Hernia, Pulmonary Hypertension | 03/25 | 09/25 | | |
NCT04985929: The Impact of Sildenafil on the Pulmonary Circulation in Healthy Trained and Untrained Humans |
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| Recruiting | 2 | 60 | Canada | Sildenafil 50 mg, Accel-Sildenafil - 50 mg, Placebo | University of Alberta | Healthy | 06/24 | 12/24 | | |
NCT04565925: Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries |
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| Recruiting | 2 | 24 | US | Sildenafil Citrate, Revatio, Placebo, Lactose | The University of Texas Medical Branch, Galveston | Spinal Cord Injuries, Urinary Incontinence | 12/25 | 12/25 | | |
| Recruiting | 2 | 120 | Canada, US | Sildenafil, Revatio, Placebo, sugar water | University of North Carolina, Chapel Hill, Duke University, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), The Emmes Company, LLC | Bronchopulmonary Dysplasia | 02/25 | 03/25 | | |
| Recruiting | 2 | 30 | US | Sildenafil, Revatio, Viagra, Placebo | Johns Hopkins University, Louisiana State University Health Sciences Center in New Orleans | Scleroderma, Mildly Elevated Pulmonary Pressures | 09/24 | 09/24 | | |
| Not yet recruiting | 2 | 1000 | RoW | Sildenafil 50 mg Oral Tablet, Revatio, Sildenafil, Placebo Oral Tablet | University of Alabama at Birmingham, University Teaching Hospital, Lusaka, Zambia, Egerton University, Cameroon Baptist Convention Health | Neonatal Asphyxia, Intrapartum Fetal Distress, Development, Infant, Intrapartum Asphyxia | 12/24 | 01/28 | | |
| Recruiting | 2 | 120 | US | Sildenafil, Revatio, Placebo, Dextrose 5% | Christoph Hornik, National Heart, Lung, and Blood Institute (NHLBI), University of North Carolina, Chapel Hill | Bronchopulmonary Dysplasia of Newborn | 10/24 | 10/24 | | |
| Active, not recruiting | 2 | 25 | US | Sildenafil, Viagra, Revatio, Standard of Care Sildenafil, Ocular Coherence Tomography-Angiography (OCT-A), Visual Acuity (VA) | Columbia University | Choroidal Ischemia, Vitelliform Macular Dystrophy, Age-related Macular Degeneration, Central Serous Retinopathy, Retinitis Pigmentosa | 12/24 | 12/24 | | |
MENOX, NCT05196308: Efficacy of Intracavernosal as add-on Therapy to Sildenafil 100 mg on Demand Compared to Sildenafil 100 mg on Demand for the Treatment of Erectile Dysfunction (ED) Not Sufficiently Responsive to Standard Therapy With Phosphodiesterase Type 5 Inhibitors |
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| Active, not recruiting | 2 | 226 | Europe | Investigational product administration Xeomin® (MERZ PHARMACEUTICALS GMBH), Placebo administration | Assistance Publique - Hôpitaux de Paris | Erectile Dysfunction | 03/25 | 03/25 | | |
NCT05061368: Oral Sildenafil for Exercise Capacity, Dyspnea and Cardiopulmonary Function in COPD |
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| Recruiting | 2 | 160 | Canada | Sildenafil Citrate, Placebo | University of Alberta, Canadian Institutes of Health Research (CIHR) | Chronic Obstructive Pulmonary Disease | 06/25 | 06/25 | | |
NCT06098833: Treatment of Neonatal Encephalopathy With Oral Sildenafil Suspension to Repair Brain Injury Secondary to Birth Asphyxia |
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| Not yet recruiting | 2 | 60 | Canada | Sildenafil, Ora-Blend | Pia Wintermark | Neonatal Encephalopathy | 10/27 | 06/28 | | |
NCT05782244: Sildenafil for Microvasculopathy in Chronic TBI |
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| Recruiting | 2 | 160 | US | Sildenafil Citrate low dose, Sildenafil lowest dose, Placebo, Masked placebo, Sildenafil medium dose, Sildenafil middle dose, Sildenafil high dose, Sildenafil highest dose | University of Pennsylvania, Walter Reed National Military Medical Center | Traumatic Brain Injury | 12/27 | 12/27 | | |
NCT04898114: Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn |
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| Recruiting | 1/2 | 40 | RoW | Magnesium sulfate, MgSO4, Sildenafil Citrate, Viagra, Isotonic saline, 0.9% NaCl | Sohag University | Persistent Pulmonary Hypertension of Newborn | 08/23 | 09/23 | | |
ChiCTR2300067825: Clinical Study on the Treatment of Erectile Dysfunction with Huashi Tongbi Prescription |
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| Not yet recruiting | 1/2 | 162 | | Sildenafil citrate tablets, 50 mg, take orally as needed ;Huashi Tongbi Formula, 200 ml/bag, 2 bags/day | Xiyuan Hospital, China Academy of Chinese Medicine Science; Xiyuan Hospital, the Capital's Funds for Health Improvement and Research (CFH 2022-2-4271) | erectile dysfunction | | | | |
ACTRN12622000657729: A Phase I, Open Label Study to Evaluate the Drug-Drug Interaction (DDI) of ANPA-0073 and Sildenafil in Healthy Subjects |
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| Withdrawn | 1 | 16 | | | Avance Clinical Pty Ltd, Annapurna Bio Pty Ltd (the Australian entity of Shouti, Inc) | Pulmonary arterial hypertension (PAH) | | | | |
ChiCTR-IIR-16008161: A single dose, randomized, open-label bioequivalence study of sildenafil citrate tablets (specification 50mg) in Chinese healthy male volunteers |
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| Not yet recruiting | 1 | 16 | | Phase I: sildenafil citrate tablet produced by Baiyunshan Pharmaceutical General Factory; Phase II: sildenafil citrate tablet produced by Viagra Pfizer Inc. | Phase I Clinical laboratory, Xiangya Hospital, Central South University; Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory, Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory | Pharmacokinetics and bioequivalence | | | | |
ChiCTR-IIR-16008195: A single dose, randomized, open-label bioequivalence study of atorvastatin calcium tablets in Chinese healthy male volunteers |
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| Recruiting | 1 | 28 | | Phase I:atorvastatin calcium tablets produced by Hunan Dinuo Pharmaceutical Co. Ltd. Phase II:atorvastatin calcium tablets produced by Viagra Pfizer Inc. | Phase I Clinical laboratory, Xiangya Hospital, Central South University; Hunan Dinuo Pharmaceutical Co. Ltd., Hunan Dinuo Pharmaceutical Co. Ltd. | Pharmacokinetics and bioequivalence | | | | |
ChiCTR-TRC-12002813: An interventional study of sildenafil in the treatment of the de adaptation to high altitude disease |
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| Completed | 1 | 240 | | sildenafil ;Placebo | PLA Respiratory Institute of Internal Medicine, Xinqiao Hospital, The 3rd Military Medical University; Xinqiao Hospital, The State Key Project 2009BAI85B03 | de adaptation to high altitude disease | | | | |
ChiCTR1900024068: Bioequivalance of Sildenafil Tablets (Fasting) in the Human Body: A randomized cross-over controlled trial |
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| Not yet recruiting | 1 | 20 | | Phase I: Pulmova Tablets produced by Vickmans Laboratories Ltd., Hong Kong; Phase II: Revatio Tab produced by Fareva Amboise ;Phase I: Revatio Tab produced by Fareva Amboise; Phase II: Pulmova Tablets produced by Vickmans Laboratories Ltd., Hong Kong | Xiangya Boai Rehabilitation Hospital; Vickmans Laboratories Ltd, Vickmans Laboratories Ltd. | Pharmacokinetics and Bioequivalence Study in Human | | | | |
ChiCTR1800017967: A randomized, open-label trial for bioequivalence of sildenafil citrate tablets (specification 100mg) in Chinese healthy male volunteers |
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| Not yet recruiting | 1 | 40 | | Phase I: sildenafil citrate tablet produced by Baiyunshan Pharmaceutical General Factory; Phase II: sildenafil citrate tablet produced by Viagra Pfizer Inc. ;Phase I: sildenafil citrate tablet produced by Viagra Pfizer Inc.; Phase II: sildenafil citrate tablet produced by Baiyunshan Pharmaceutical General Factory. | Phase I Clinical laboratory, Xiangya Hospital, Central South University; Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory, Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory | Pharmacokinetics and bioequivalence | | | | |
NCT02983461: Use of Sildenafil for Treatment of Urinary Incontinence |
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| Active, not recruiting | 1 | 24 | US | Sildenafil, Placebo | The University of Texas Medical Branch, Galveston | Urinary Incontinence | 03/20 | 07/25 | | |
ChiCTR2000032180: Human Bioequivalence of sildenafil citrate tables in Healthy Chinese male volunteers: an open-label, single center, randomized, two-periol crossover study underfasting and fed conditions |
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| Recruiting | 1 | 86 | | T-R ;R-T ;T-R ;R-T | The Second Affiliated Hospital of Xingtai Medical College; Jinan Mingxin Pharmaceutical Co., Ltd., Jinan Mingxin Pharmaceutical Co., Ltd. | Erectile dysfunction | | | | |
ChiCTR1800015080: Efficacy and safety of postoperative early oral sildenafil for the prevention of erectile dysfunction after laparoscopic total mesorectal excision of rectal cancer: study protocol for a randomized controlled trial |
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| Recruiting | 1 | 346 | | oral sildenafil afer operation ;oral placebo after operation | The Second Affiliated Hospital of Nanchang University; The Second Affiliated Hospital of Nanchang University, National Natural Science Foundation of China (No.81760438) | erectile dysfunction after laparoscopic total mesorectal excision of rectal cancer | | | | |
| Active, not recruiting | 1 | 20 | Canada | Sildenafil Citrate | McGill University Health Centre/Research Institute of the McGill University Health Centre | Birth Asphyxia | 12/21 | 06/24 | | |
NCT04283435: Endometrial Effects of Sildenafil in Frozen-Thawed Cycles in Women With Thin Endometrium |
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| Not yet recruiting | 1 | 100 | RoW | Sildenafil Citrate, Placebo, Pregnacare vitamins (Vitabiotics,UK), Estradiol Valerate | Cairo University | IVF, Endometrial Receptivity | 03/22 | 03/22 | | |
| Active, not recruiting | 1 | 24 | US | Low dose sildenafil citrate, High dose sildenafil citrate | University of Mississippi Medical Center | Subarachnoid Hemorrhage, Cerebral Vasospasm | 12/22 | 07/23 | | |
NCT03945643: Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension? |
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| Completed | 1 | 82 | US | Sildenafil, Placebo | University of Oregon | Patent Foramen Ovale, Intrapulmonary Arteriovenous Anastamosis | 01/23 | 07/23 | | |
NCT05684289: A Study Investigating the Safety, Tolerability, Drug Levels and Drug Effect of BMS-986278 in Healthy Adult Participants (Part 1) and Japanese Participants (Part 2) |
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| Completed | 1 | 61 | US | BMS-986278, Sildenafil, Placebo | Bristol-Myers Squibb | Healthy Participants | 05/23 | 05/23 | | |
NCT05466695: Comparing The Effect of Tadalafil 5 mg/Day to Sildenafil 25 mg/Day on Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in Erectile Dysfunction Patients; and Comparison of Clinical Response |
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| Not yet recruiting | 1 | 74 | RoW | Tadalafil 5mg/sildenafil 25 mg, blood sample before and after 2 months of medical tratment | Assiut University | Erectile Dysfunction and Neutrophil Lymphocyte Ratio | 07/23 | 08/23 | | |
| Completed | 1 | 20 | US | Sildenafil, Viagra, Revatio, Placebo Oral Tablet, Sildenafil matching placebo | Montefiore Medical Center | Thrombosis, Hemolysis | 01/23 | 01/23 | | |
ChiCTR2300073540: Randomized, Open, Single-Dose, Two-Agent, Two-Cycle, Double-Crossover Fasting and Postprandial State Bioequivalence Trial of Sildenafil Citrate Dispersible Tablets in Healthy Subjects |
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| Recruiting | 1 | 104 | | Subjects take one tablet of R medication in the first cycle and one tablet of T medication in the second cycle on an empty stomach ;Subjects take one tablet of T medication in the first cycle and one tablet of R medication in the second cycle on an empty stomach ;After taking a high-fat meal, the subjects took one tablet of T-medication in the first cycle and one tablet of R-medication in the second cycle ;After taking a high-fat meal, the subjects took one tablet of R-medication in the first cycle and one tablet of T-medication in the second cycle | Huzhou Central Hospital; Huzhou Central Hospital, Shanghai Aoquan Biomedical Technology Co. | Healthy subjects | | | | |
| Recruiting | 1 | 15 | US | Sildenafil 10mg oral tablet (participants <20kg), or 20mg oral tablet (participants ≥20kg), Pravastatin 20 mg oral tablet (ages <13 years), or 40 mg oral tablet (≥14 years) | Children's Mercy Hospital Kansas City, Indiana Clinical and Translational Sciences Institute | Fontan Circulation | 12/25 | 12/25 | | |
| Recruiting | 1 | 30 | RoW | Sildenafil | Pia Wintermark, Kawempe National Referral Hospital, Saint Francis Memorial Hospital, Walimu | Birth Asphyxia | 06/24 | 12/24 | | |
NCT06289881: Sildenafil 100 mg Tablets Relative to Viagra 100 mg Tablets |
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| Not yet recruiting | 1 | 36 | NA | Sildenafill-Test product, Sildenafill-Reference product | Bio-innova Co., Ltd | Healthy Subjects | 03/25 | 03/25 | | |
ChiCTR-TRC-14004894: Clinical research on treatment of pulmonary arterial hypertension associated with connective tissue disease by Mycophenolate mofetil |
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| Recruiting | N/A | 16 | | Glucocorticoid plus sildenafil ;Glucocorticoid plus sildenafil | Beijing Chaoyang Hospital affiliated to Capital Medical University; Beijing Chaoyang Hospital affiliated to Capital Me, Beijing City financial technology funding | pulmonary arterial hypertension associated with connective tissue disease | | | | |
| Completed | N/A | 60 | | beraprost combined with sildenafil ;Sildenafil citrate | Shanghai Pulmonary Hospital; Shanghai Pulmonary Hospital, Scientific research funds | Pulmonary arterial hypertension | | | | |
ChiCTR1800017370: Clinical effects of oral administration of ethylphenylephrine and sildenafil for the prevention of penile erectile dysfunction in patients with sickle cell anemia |
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| Recruiting | N/A | 45 | | Receiving 30mg of ephedrine per day ;Recenving sildenafil 50mg once daily ;Only deals with acute attacks that last more than 4 hours | Xiangya Hospital of Centre South University; Xiangya Hospital of Central South University, National Natural Science Foundation of China | recurrent priapism | | | | |
ChiCTR-INR-16009511: Clinic investigation on pulmonary artery hypertension associated with connective tissue disease |
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| Not yet recruiting | N/A | 120 | | Placebo of Bosentan and Sildenafil ;Sildenafil and placebo of Bosentan ;Bosentan and placebo of Sildenafil ;Bosentan and Sildenafil | Ren Ji Hospital, School of medecine, Shanghai Jiao Tong University; Ren Ji Hospital, School of medecine, Shanghai Jiao Tong University, Three-year project of ShenKang | Pulmonary artery hypertension associated with connective tissue disease | | | | |
ChiCTR1900021685: Comparison of the efficacy and safety of on-demand maximum dosing of sildenafil and Low-intensity shockwave therapy for erectile dysfunction |
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| Not yet recruiting | N/A | 80 | | LI-ESWT ;Sildenafil | Peking Union Medical College Hospital; PUMCH, Sponsored by investor | Erectile Dysfuntion | | | | |
ChiCTR1800016128: Grading Management combined with Regular Therapy treatment for male Erectile Dysfunction |
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| Recruiting | N/A | 120 | | Sildenafil 50mg twice a week ;Sildenafil 25mg once a day, and take 50mg on demand ;Sildenafil 25mg once a day, and take 100mg on demand ;Sildenafil 100mg on demand | Central Hospital of Panyu District; Central Hospital of Panyu District, Funding | male Erectile Dysfunction | | | | |
| No Longer Available | N/A | | RoW | sildenafil | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Pulmonary Arterial Hypertension | | | | |
ChiCTR-OPC-16008702: Efficacy and safety of oral sildenafil in the treatment of pediatric lymphatic malformations in China |
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| Recruiting | N/A | 40 | | oral sildenafil | Beijing Children's Hospital; Beijing Children's Hospital, This study was supported by Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support, code: ZYLX201508. | pediatric lymphatic malformations | | | | |
NCT00866983: Local Open-Label Access Study For Patients Who Completed A1481244 Study In Brazil |
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| No Longer Available | N/A | | RoW | sildenafil (Revatio) 20 mg TID, sildenafil, Revatio | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Pulmonary Arterial Hypertension | | | | |
NCT00878943: Open Label Access Study Of Sildenafil In Adult Patients With Pulmonary Arterial Hypertension Completing A1481244 Study |
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| No Longer Available | N/A | | RoW | Sildenafil citrate | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Pulmonary Arterial Hypertension | | | | |
| No Longer Available | N/A | | RoW | Access program - sildenafil citrate, Viagra, Revatio, sildenafil citrate, Viagra, Revatio | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Pulmonary Arterial Hypertension | | | | |
| Not yet recruiting | N/A | 42 | NA | Sildenafil Injectable Product, Intravenous sildenafil | Universidad del Norte | Hypertension, Pulmonary | 06/21 | 06/21 | | |
NCT05369481: Comparison Between Efficacy of Topical Sildenafil 2% and Topical Minoxidil 5% in Treatment of Androgenic Alopecia |
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| Recruiting | N/A | 50 | RoW | Sildenafil 2%, Local Scalp Injection, Minoxidil 5 % | Mohammed Abd El Mawgoud Amer | Androgenic Alopecia | 08/22 | 09/22 | | |
NCT05439486: New Treatment in Erectile Dysfunction Patients. |
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| Active, not recruiting | N/A | 30 | RoW | hyperbaric oxygen therapy within hyperbaric oxygen therapy chamber. | Sohag University | Erectile Dysfunction | 08/22 | 10/22 | | |
ChiCTR2200061660: A randomized, open-label, two-period, cross-over bioequivalence study of sildenafil citrate tables (100mg) in healthy volunteers under fasting and fed conditions |
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| Not yet recruiting | N/A | 96 | | Test Product - Reference Product ;Reference Product - Test Product ;Test Product - Reference Product ;Reference Product - Test Product | Phase I Clinical Trial Laboratory of Shulan (Hangzhou) Hospital; Shanghai Huilun Biotechnology Co., Ltd., Shanghai Huilun Biotechnology Co., Ltd. | Erectile dysfunction | | | | |