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27 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
sildenafil / Generic mfg.
2007-005513-18: Double blind randomized controlled study on the benefit-risk profile of in the treatment of at term or late preterm newborn infants with severe respiratory disorders and pulmonary hypertension

Ongoing
2
100
Europe
Oral solution, REVATIO
OSPEDALE PEDIATRICO BAMBINO GESU' DI ROMA
treatment of at term or late preterm newborn infants with severe respiratory disorders and pulmonary hypertension
 
 
2013-001659-10: Treatment with Sildenafil in patients with heart failure

Ongoing
2
60
Europe
VIAGRA, Noxap 800 ppm mol/mol, not applicable, Tablet, Medicinal gas, compressed, VIAGRA, Noxap 800ppm mol/mol
UZLeuven, UZLeuven
To investigate acute effects of sildenafil on cardiac hemodynamics, right ventricle performance and cGMP concentrations in heart failure patients with preserved ejection fraction and patients after heart transplantation, Immediatly effects on lowering bloodpressure in the lung arteries after administration of oral sildenafil, Diseases [C] - Cardiovascular Diseases [C14]
 
 
2015-003259-24: The Effect of Sildenafil (Revatio®) on Post Cardiac Surgery Acute Kidney Injury (AKI): A Randomised, Placebo-controlled Clinical Trial: "REVAKI 2 Trial"

Ongoing
2
126
Europe
Sildenafil, Solution for injection/infusion, Revatio (Sildenafil)
University of Leicester, British Heart Foundation
Post cardiac surgery acute kidney injury, Kidney damage following cardiac surgery, Diseases [C] - Cardiovascular Diseases [C14]
 
 
2007-000257-56: Neural correlates of sexual arousal during treatment of testosterone combined with sildenafil in healthy female subjects with FSD. Effects of differing levels of attentional engagement on neural correlates of sexual arousal induced by an erotic film.

Ongoing
2
30
Europe
Lybrido, Lybrido,
Emotional Brain BV
Hypoactive sexual desire disorder and female sexual arousal disorder
 
 
2007-002688-28: Pilot study on the short-term effects of Sildenafil on hemodynamic response to exercise and exercise capacity in Fontan patients

Ongoing
2
16
Europe
sildenafil, VIAGRA*4CPR 50MG, VIAGRA*4CPR 50MG
AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI
congenital heart disease
 
 
2012-003921-13: Racecadotril used in combination with sildenafil to reduce blood pressure in the lungs.

Ongoing
2
24
Europe
Racecadotril, Tiorfan, Tiorfan
University College London, British Heart Foundation, UCLH/UCL Biomedical Research Centre and UCLH/UCL Clinical Research Development Committee
Pulmonary hypertension
 
 
2011-002707-16: sildenafil in the postoperative period of cardiac surgery in children. sildenafilo en el postoperatorio de cirugia cardiaca en niños.

Ongoing
2
32
Europe
revatio oral, Revatio inyectable, revatio oral, Revatio inyectable
Fundacion para la investigación Biomédica del hospital Gregorio Marañón, Instituto de salud Carlos III
Postoperative pulmonary artery hypertension hipertension arterial pulmonar postoperatoria
 
 
2010-023375-26: Effects of Sildenafil on Signs and SYmptoms of Ischemia, Myocardial BlooD Flow, and Markers of ANgiogenesis in Patients with REfractory CoronarY Artery Disease

Ongoing
2
60
Europe
Revatio, G04BE03, Revatio, Revatio
Medizinische Universität Wien, Klinik für Innere Medizin II, Abteilung für Kardiologie, Medizinische Universität Wien
Patients with coronary artery disease who suffer from myocardial malperfusion and continue to experience angina despite maximal medical and revascularization therapy are called \"no-option\" patients.
 
 
2016-001591-30: Treatment of congenital nephrogenic diabetes insipidus with riociguat or sildenafil Behandling af medfødt nefrogen diabetes insipidus med riociguat eller sildenafil

Ongoing
2
2
Europe
Adempas, Viagra, Tablet, Adempas, Viagra
Odense University Hospital, funding
Nephrogenic diabetes insipidus because of AVP2R-mutation Diabetes insipidus på baggrund af mutation i AVP2-receptoren, Nephrogenic diabetes insipidus because of AVP2R-mutation Diabetes insipidus på baggrund af mutation i AVP2-receptoren, Diseases [C] - Hormonal diseases [C19]
 
 
2017-001878-42: Sildenafil effect in placental vessels. Efecto del Sildenafilo en los vasos de la placenta.

Ongoing
2
60
Europe
Capsule
CONSORCIO HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA, FUNDACIÓN DE INVESTIGACIÓN HOSPITAL GENERAL DE VALENCIA
This is a placebo – controlled longitudinal study to determine whether maternal administration of an unique oral dose of sildenafil citrate (50mg) improves placental flow in first trimester in healthy pregnancies. They are pregnant women before twelve weeks who comes to our hospital for legal medical abortion. Se trata de un estudio longitudinal con grupo control ( placebo) para determinar si la administración de una dosis única de 50mg de citrato de sildenafilo puede aumentar la vasscularización placentaria en el primer trimestre en embarazos sanos. Son mujeres embarazadas por debadjo de doce semana que acuden para solicitar la interrupción legal de su embarazo., The vascular effect of Sildenafil will be tested in early pregnancy. El efecto vascular del sildenafilo en la gestación temprana., Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]
 
 
NCT01817751: Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma

Active, not recruiting
2
47
US
sorafenib tosylate, pyridinecarboxamide, chloro-trifluoromethylphenyl pyridine-carboxylic acid methylamide-methylbenzenesulfonate tosylate, Nexavar, valproic acid, 2-Propylpentanoic or Propylvaleric Acid, Alti-Valproic, Depakene, Di-n-propylacetic Acid, Ergenyl, Novo-Valproic, VA, Valproate, Valproate Sodium, sildenafil citrate, Viagra
Virginia Commonwealth University, National Cancer Institute (NCI)
Glioblastoma, Recurrent Adult Brain Neoplasm, Malignant Glioma, WHO Grade III Glioma
08/20
10/27
OxHARP, NCT03855332: Oxford Haemodynamic Adaptation to Reduce Pulsatility Trial

Completed
2
75
Europe
Sildenafil, Cilostazol, Placebo
University of Oxford, Wellcome Trust
Small Vessel Cerebrovascular Disease
12/22
01/23
NCT04525495: Dopamine in Neonate

Enrolling by invitation
2
30
RoW
Dopamine
Seoul National University Hospital, Asan Medical Center, Severance Hospital
Neonates and Preterm Infants
12/22
12/22
NCT05201144: A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)

Recruiting
2
40
US
Sildenafil Oral Suspension, Placebo
University of Utah
Congenital Diaphragmatic Hernia, Pulmonary Hypertension
03/25
09/25
NCT04985929: The Impact of Sildenafil on the Pulmonary Circulation in Healthy Trained and Untrained Humans

Recruiting
2
60
Canada
Sildenafil 50 mg, Accel-Sildenafil - 50 mg, Placebo
University of Alberta
Healthy
06/24
12/24
NCT04565925: Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries

Recruiting
2
24
US
Sildenafil Citrate, Revatio, Placebo, Lactose
The University of Texas Medical Branch, Galveston
Spinal Cord Injuries, Urinary Incontinence
12/25
12/25
SIL02, NCT03142568: Safety of Sildenafil in Premature Infants

Recruiting
2
120
Canada, US
Sildenafil, Revatio, Placebo, sugar water
University of North Carolina, Chapel Hill, Duke University, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), The Emmes Company, LLC
Bronchopulmonary Dysplasia
02/25
03/25
SEPVADIS, NCT04797286: Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

Recruiting
2
30
US
Sildenafil, Revatio, Viagra, Placebo
Johns Hopkins University, Louisiana State University Health Sciences Center in New Orleans
Scleroderma, Mildly Elevated Pulmonary Pressures
09/24
09/24
PRISM, NCT06377098: Intrapartum Sildenafil in Laboring Mothers

Not yet recruiting
2
1000
RoW
Sildenafil 50 mg Oral Tablet, Revatio, Sildenafil, Placebo Oral Tablet
University of Alabama at Birmingham, University Teaching Hospital, Lusaka, Zambia, Egerton University, Cameroon Baptist Convention Health
Neonatal Asphyxia, Intrapartum Fetal Distress, Development, Infant, Intrapartum Asphyxia
12/24
01/28
SILDI-SAFE, NCT04447989: Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia

Recruiting
2
120
US
Sildenafil, Revatio, Placebo, Dextrose 5%
Christoph Hornik, National Heart, Lung, and Blood Institute (NHLBI), University of North Carolina, Chapel Hill
Bronchopulmonary Dysplasia of Newborn
10/24
10/24
NCT04356716: Sildenafil for Treatment of Choroidal Ischemia

Active, not recruiting
2
25
US
Sildenafil, Viagra, Revatio, Standard of Care Sildenafil, Ocular Coherence Tomography-Angiography (OCT-A), Visual Acuity (VA)
Columbia University
Choroidal Ischemia, Vitelliform Macular Dystrophy, Age-related Macular Degeneration, Central Serous Retinopathy, Retinitis Pigmentosa
12/24
12/24
MENOX, NCT05196308: Efficacy of Intracavernosal as add-on Therapy to Sildenafil 100 mg on Demand Compared to Sildenafil 100 mg on Demand for the Treatment of Erectile Dysfunction (ED) Not Sufficiently Responsive to Standard Therapy With Phosphodiesterase Type 5 Inhibitors

Active, not recruiting
2
226
Europe
Investigational product administration Xeomin® (MERZ PHARMACEUTICALS GMBH), Placebo administration
Assistance Publique - Hôpitaux de Paris
Erectile Dysfunction
03/25
03/25
NCT05061368: Oral Sildenafil for Exercise Capacity, Dyspnea and Cardiopulmonary Function in COPD

Recruiting
2
160
Canada
Sildenafil Citrate, Placebo
University of Alberta, Canadian Institutes of Health Research (CIHR)
Chronic Obstructive Pulmonary Disease
06/25
06/25
NCT06098833: Treatment of Neonatal Encephalopathy With Oral Sildenafil Suspension to Repair Brain Injury Secondary to Birth Asphyxia

Not yet recruiting
2
60
Canada
Sildenafil, Ora-Blend
Pia Wintermark
Neonatal Encephalopathy
10/27
06/28
NCT05782244: Sildenafil for Microvasculopathy in Chronic TBI

Recruiting
2
160
US
Sildenafil Citrate low dose, Sildenafil lowest dose, Placebo, Masked placebo, Sildenafil medium dose, Sildenafil middle dose, Sildenafil high dose, Sildenafil highest dose
University of Pennsylvania, Walter Reed National Military Medical Center
Traumatic Brain Injury
12/27
12/27
NCT04898114: Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn

Recruiting
1/2
40
RoW
Magnesium sulfate, MgSO4, Sildenafil Citrate, Viagra, Isotonic saline, 0.9% NaCl
Sohag University
Persistent Pulmonary Hypertension of Newborn
08/23
09/23
ChiCTR2300067825: Clinical Study on the Treatment of Erectile Dysfunction with Huashi Tongbi Prescription

Not yet recruiting
1/2
162
 
Sildenafil citrate tablets, 50 mg, take orally as needed ;Huashi Tongbi Formula, 200 ml/bag, 2 bags/day
Xiyuan Hospital, China Academy of Chinese Medicine Science; Xiyuan Hospital, the Capital's Funds for Health Improvement and Research (CFH 2022-2-4271)
erectile dysfunction
 
 

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