| Enbrel (etanercept) / Pfizer, Amgen |
NCT00132418: Study of Enbrel in Rheumatoid Arthritis (RA) Subjects With Comorbid Disorders |
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| Completed | 4 | 564 | US | Enbrel, Placebo | Amgen, Immunex Corporation | Rheumatoid Arthritis | 02/04 | 02/04 | | |
NCT00244556: Study Comparing Enbrel (Etanercept) Plus Methotrexate Versus Enbrel Alone in Active Rheumatoid Arthritis Despite Current Methotrexate Therapy |
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| Completed | 4 | 300 | RoW | Methotrexate plus ENBREL or ENBREL alone | Wyeth is now a wholly owned subsidiary of Pfizer | Rheumatoid Arthritis | 05/04 | 05/04 | | |
NCT00252668: Study Evaluating the Combination of Etanercept and Methotrexate in Rheumatoid Arthritis Subjects |
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| Completed | 4 | 300 | Europe | Etanercept, Methotrexate | Wyeth is now a wholly owned subsidiary of Pfizer | Rheumatoid Arthritis | | 09/05 | | |
NCT00195494: Study Comparing Etanercept and Methotrexate vs. Methotrexate Alone in Rheumatoid Arthritis |
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| Completed | 4 | 542 | US | Etanercept, Methotrexate, Placebo | Wyeth is now a wholly owned subsidiary of Pfizer | Rheumatoid Arthritis | 03/08 | 03/08 | | |
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JESMR, NCT00688103: Efficacy and Safety of Etanercept in Active RA Despite Methotrexate Therapy in Japan |
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| Completed | 4 | 151 | Japan | ETN Alone, etanercept, ETN+MTX, etanercept and methotrexate | Japan Biological Agent Study Integrated Consortium | Rheumatoid Arthritis | 10/08 | 10/10 | | |
NCT00422227: Study Comparing Etanercept With Usual DMARD Therapy in Subjects With Rheumatoid Arthritis in the Asia Pacific Region |
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| Completed | 4 | 300 | RoW | Etanercept , Methotrexate, Methotrexate; sulfasalazine; hydroxychloroquine;leflunomide | Wyeth is now a wholly owned subsidiary of Pfizer | Rheumatoid Arthritis | 03/09 | 03/09 | | |
| Completed | 4 | 755 | US | methotrexate, sulfasalazine, hydroxychloroquine, etanercept | University of Alabama at Birmingham, Amgen, Barr Laboratories, Pfizer | Rheumatoid Arthritis | 06/09 | 06/09 | | |
NCT00099554: Effectiveness and Safety of Enbrel® (Etanercept) in Rheumatoid Arthritis Subjects Who Have Failed Remicade® (Infliximab) |
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| Completed | 4 | 200 | US | Etanercept | Amgen | Rheumatoid Arthritis | | | | |
NCT00706797: Study Evaluating Efficacy / Safety of Etanercept + Methotrexate Compared to Usual Treatment in Moderate RA Subjects |
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| Terminated | 4 | 141 | Europe, RoW | etanercept (EnbrelTM), methotrexate | Wyeth is now a wholly owned subsidiary of Pfizer | Rheumatoid Arthritis | 12/09 | 05/10 | | |
| Completed | 4 | 203 | US, Canada, Europe, RoW | Infliximab | Centocor Ortho Biotech Services, L.L.C., Schering-Plough | Rheumatoid Arthritis | 01/10 | 06/10 | | |
| Completed | 4 | 108 | Europe, RoW | Etanercept | Wyeth is now a wholly owned subsidiary of Pfizer, Lincoln Medical and Mental Health Center, Umanis, SODIA, depolabo | Rheumatoid Arthritis | 03/10 | 04/10 | | |
NCT00443430: Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic Arthritis |
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| Completed | 4 | 85 | US | methotrexate, placebo enbrel, placebo prednisolone, methotrexate - etanercept - prednisolone arm, enbrel, prednisone | Seattle Children's Hospital, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Amgen | Juvenile Chronic Polyarthritis, Juvenile Idiopathic Arthritis, Juvenile Rheumatoid Arthritis | 10/10 | 10/10 | | |
NCT00796705: Switching Anti-TNF-Alpha Agents in Rheumatoid Arthritis (RA) |
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| Terminated | 4 | 13 | US | Adalimumab, Humira, Adalimumab placebo, Humira placebo, Etanercept, Enbrel | National Institute of Allergy and Infectious Diseases (NIAID) | Rheumatoid Arthritis | 10/10 | 10/10 | | |
| Completed | 4 | 834 | Europe, RoW | Etanercept, Enbrel, Methotrexate, Placebo | Pfizer | Arthritis, Rheumatoid | 05/11 | 05/11 | | |
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NCT01009879: Human Tumor Necrosis Factor Alpha (TNFa)-Induced Pre-B Cell Bone Marrow Emigrants |
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| Withdrawn | 4 | 0 | US | Etanercept, ENBREL | University of Pittsburgh, Amgen | Rheumatoid Arthritis | 02/12 | 02/12 | | |
DOSERA, NCT00858780: Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RA |
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| Completed | 4 | 91 | Europe, RoW | Etanercept, Placebo | Pfizer | Rheumatoid Arthritis | 06/12 | 06/12 | | |
| Completed | 4 | 306 | Europe, RoW | etanercept, Enbrel | Pfizer | Active Rheumatoid Arthritis, Arthritis, Rheumatoid, Rheumatoid Arthritis | 06/12 | 12/12 | | |
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NCT00654368: CAMEO: Canadian Methotrexate and Etanercept Outcome Study |
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| Completed | 4 | 258 | Canada | Etanercept, Enbrel®, Methotrexate | Amgen, Wyeth is now a wholly owned subsidiary of Pfizer | Rheumatoid Arthritis | 12/12 | 02/13 | | |
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NCT01313208: Moderate Rheumatoid Arthritis (RA) With Etanercept (Enbrel) |
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| Completed | 4 | 210 | US, Canada | etanercept, Enbrel, Placebo, DMARD Therapy | Amgen | Rheumatoid Arthritis | 02/13 | 05/13 | | |
NCT00848354: Open-Label Study Comparing Etanercept to Conventional Disease Modifying Antirheumatic Drug (DMARD) Therapy |
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| Completed | 4 | 429 | RoW | Phase 1: Etanercept, Enbrel, Phase 1: Methotrexate, Phase 2: Optional ETN, SSZ, HCQ, MTX, Phase 1: Conventiaonal DMARD | Pfizer, Amgen | Rheumatoid Arthritis | 04/13 | 04/13 | | |
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NCT00115219: Evaluating Efficacy and Safety of Etanercept 50 mg Twice Weekly (BIW) in Rheumatoid Arthritis (RA) Subjects Who Are Sub-Optimal Responders to Etanercept 50 mg Once Weekly (QW) |
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| Completed | 4 | 200 | US | Etanercept | Amgen | Rheumatoid Arthritis | | | | |
NCT01875991: Preference Between Two Autoinjectors in Patients With Rheumatoid Arthritis and Plaque Psoriasis Treated With Etanercept |
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| Completed | 4 | 217 | Canada, US | Etanercept via Autoinjector A, Etanercept via Autoinjector B, Enbrel® SureClick® | Amgen | Rheumatoid Arthritis, Plaque Psoriasis | 03/14 | 03/14 | | |
NCT01783015 / 2012-003644-71: Study of Etanercept in Subjects With Rheumatoid Arthritis Who Have Had an Inadequate Response to Adalimumab or Infliximab Plus Methotrexate |
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| Terminated | 4 | 16 | Europe, RoW | Etanercept, Placebo | Pfizer | Rheumatoid Arthritis | 08/14 | 08/14 | | |
| Completed | 4 | 302 | Europe | etanercept or adalimumab, Enbrel, Humira, Rituximab, MabThera | University of Glasgow, Arthritis Research UK, NHS Lothian, NHS Grampian, NHS Tayside, NHS Borders, NHS Fife | Rheumatoid Arthritis | 12/14 | 04/15 | | |
NCT01578850 / 2011-005448-87: Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs (DMARDs)for at Least 12 Weeks Prior to Screening |
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| Completed | 4 | 491 | Europe, RoW | Etanercept, placebo | Pfizer | Rheumatoid Arthritis | 03/15 | 03/15 | | |
ROCKIES, NCT01927757: Evaluating Etanercept Use in Patients With Moderate to Severe Rheumatoid Arthritis Who Have Lost Response to Adalimumab |
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| Terminated | 4 | 90 | US, Canada | Etanercept, Enbrel®, Methotrexate | Amgen | Moderate to Severe Rheumatoid Arthritis | 06/15 | 06/15 | | |
NCT02346877: Evaluate Effects of Personalized Patient Counselling for Enbrel® Therapy in Adults With Rheumatoid Arthritis |
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| Terminated | 4 | 19 | Canada | Personalized Patient Counselling | Amgen | Persistence to Enbrel | 10/15 | 10/15 | | |
| Completed | 4 | 122 | Europe | Etanercept, Abatacept, Rituximab, Adalimumab, Certolizumab Pegol, Infliximab, Golimumab | Julia Brown | Rheumatoid Arthritis | 11/15 | 11/15 | | |
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NCT01331837 / 2010-020065-24: A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors |
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| Completed | 4 | 3080 | Europe, Canada, US, RoW | Etanercept, Tocilizumab, Actemra | Hoffmann-La Roche | Rheumatoid Arthritis | 03/16 | 03/16 | | |
NCT02109289: Etanercept in Rheumatoid Arthritis and Vascular Inflammation |
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| Terminated | 4 | 5 | Canada | etanercept, Enbrel | Innovaderm Research Inc. | Rheumatoid Arthritis, Vascular Inflammation | 11/16 | 11/16 | | |
