dacarbazine / Generic mfg.  >>  Phase 2
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19 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
dacarbazine / Generic mfg.
2007-007265-20: A Phase II open label randomized parallel group non comparative trial to assess efficacy and safety of the association of IPH1101 and IL-2 alone and in combination with dacarbazine, in patients with metastatic melanoma

Ongoing
2
6
Europe
Phosphostim 200, PROLEUKIN 18 MUI, Dacarbazine Mayne 600 mg, IPH1101, DTIC, PROLEUKIN 18 MUI, Dacarbazine Mayne 600 mg, poudre pour solution injectable, PROLEUKIN 18 MUI, Dacarbazine Mayne 600 mg, poudre pour solution injectable
Innate Pharma
metastatic melanoma
 
 
NU 16H08, NCT03226249: PET-Directed Therapy With Pembrolizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Classical Hodgkin Lymphoma

Active, not recruiting
2
30
US
Computed Tomography, CAT, CAT Scan, Computerized Axial Tomography, computerized tomography, CT, CT SCAN, tomography, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Fludeoxyglucose F-18, 18FDG, FDG, fludeoxyglucose F 18, Fludeoxyglucose F18, Fluorine-18 2-Fluoro-2-deoxy-D-Glucose, Fluorodeoxyglucose F18, Laboratory Biomarker Analysis, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, Vinblastine Sulfate, 29060 LE, 29060-LE, Exal, Velban, Velbe, Velsar, VINCALEUKOBLASTINE
Northwestern University, National Cancer Institute (NCI), Merck Sharp & Dohme LLC
Classical Hodgkin Lymphoma, Lymphocyte-Depleted Classical Hodgkin Lymphoma, Lymphocyte-Rich Classical Hodgkin Lymphoma, Mixed Cellularity Classical Hodgkin Lymphoma, Nodular Sclerosis Classical Hodgkin Lymphoma
05/19
10/24
IMCgp100-202, NCT03070392 / 2015-003153-18: Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma

Active, not recruiting
2
378
Europe, Canada, US, RoW
IMCgp100, Dacarbazine, DTIC-Dome, DTIC, DIC, Imidazole Carboxamide, Ipilimumab, Yervoy, Pembrolizumab, Keytruda
Immunocore Ltd
Uveal Melanoma
10/20
06/25
NCT01920932: Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma

Active, not recruiting
2
77
US
brentuximab vedotin, SGN-35, Adcetris(R), etoposide, VP-16, Vepesid(R), prednisone, prednisolone, doxorubicin, Adriamycin(R), cyclophosphamide, Cytoxan(R), Dacarbazine(R), Dimethyl Triazeno Imidazole Carboximide (DTIC), filgrastim, Neupogen(R), quality of life assessment, radiation therapy, irradiation, radiotherapy, radiation
St. Jude Children's Research Hospital, Seagen Inc.
Stage II Childhood Hodgkin Lymphoma, Stage III Childhood Hodgkin Lymphoma, Stage IV Childhood Hodgkin Lymphoma
11/20
05/28
SGN35-027, NCT03646123 / 2020-004027-17: Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma

Checkmark Part B and Part C data from SGN35-027 study in combination with Opdivo for classical Hodgkin Lymphoma at ASH 2022
Dec 2022 - Dec 2022: Part B and Part C data from SGN35-027 study in combination with Opdivo for classical Hodgkin Lymphoma at ASH 2022
Active, not recruiting
2
255
Europe, US, RoW
brentuximab vedotin, Adcetris, SGN-35, doxorubicin, vinblastine, dacarbazine, G-CSF, filgrastim, pegfilgrastim, nivolumab, Opdivo
Seagen Inc., Bristol-Myers Squibb
Hodgkin Lymphoma
11/22
06/26
NCT04200040: A Clinical Study to Evaluate the Safety and Efficacy of OrienX010 in Unresectable Malignant Melanoma Patients

Recruiting
2
165
RoW
OrienX010 injection, Recombinant Human GM-CSF Herpes Simplex Virus Injection, Dacarbazine (DTIC)
OrienGene Biotechnology Ltd.
Melanoma (Skin)
12/22
12/22
SGN35-015, NCT01716806 / 2019-003982-17: A Study of Brentuximab Vedotin With Hodgkin Lymphoma (HL) and CD30-expressing Peripheral T-cell Lymphoma (PTCL)

Checkmark Additional data for front-line Hodgkin's lymphoma in elderly patients (ASH 2014)
Nov 2014 - Nov 2014: Additional data for front-line Hodgkin's lymphoma in elderly patients (ASH 2014)
Checkmark For newly diagnosed Hodgkin's lymphoma in elderly patients
Dec 2013 - Dec 2013: For newly diagnosed Hodgkin's lymphoma in elderly patients
Checkmark Elderly chemo-intolerant Hodgkin's lymphoma patients
More
Completed
2
131
Canada, US
brentuximab vedotin, Adcetris; SGN-35, bendamustine, dacarbazine, nivolumab
Seagen Inc., Bristol-Myers Squibb
Hodgkin Disease, Peripheral T Cell Lymphoma
04/23
09/23
KEYNOTE-C11, NCT05008224 / 2021-001244-95: Study of Safety and Efficacy of Pembrolizumab and Chemotherapy in Participants With Newly Diagnosed Classical Hodgkin Lymphoma (cHL) (MK-3475-C11/)

Checkmark Presentation of data from KEYNOTE-C11 trial for 1L Classic Hodgkin Lymphoma at ASH 2022
Nov 2022 - Nov 2022: Presentation of data from KEYNOTE-C11 trial for 1L Classic Hodgkin Lymphoma at ASH 2022
Completed
2
146
Europe, Canada, US, RoW
Pembrolizumab, MK-3475, SCH 900475, KEYTRUDA®, Doxorubicin, Adriamycin, DOXIL®, Rubex®, Vinblastine, Alkaban-AQ®, Velban®, Dacarbazine, Dtic-Dome®, Bleomycin, Blenoxane®, Etoposide, Toposar®, VePesid®, Etopophos®, VP-16, Etoposide phosphate, Cyclophosphamide, Neosar®, Cytoxan®, Vincristine, Oncovin®, Vincasar PFS®, Procarbazine, Matulane®, Prednisone, Liquid Pred®, Meticorten®, Orasone®, Deltasone®
Merck Sharp & Dohme LLC, Merck Sharp & Dohme Corp., a subsidiary of Merck & Co.,Inc
Classical Hodgkin Lymphoma
10/23
05/24
FLASH, NCT04733183: Efficacy and Safety of L19TNF in Previously Treated Patients With Advanced Stage or Metastatic Soft-tissue Sarcoma

Recruiting
2
98
Europe
Dacarbazine, DTIC, onfekafusp alfa, L19TNF
Philogen S.p.A.
Soft Tissue Sarcoma
12/24
12/24
NCT06377566: A Study of BV-AVD in People With Bulky Hodgkin Lymphoma

Recruiting
2
71
US
Brentuximab vedotin, Doxorubicin, Vinblastine, Dacarbazine, Pembrolizumab, Gemcitabine, Vinorelbine, FDG-PET/CT scan
Memorial Sloan Kettering Cancer Center, Seagen Inc.
Hodgkin Lymphoma
04/27
04/27
NCT05900765: A Study of Zimberelimab(GLS-010) Combined With AVD for Newly Diagnosed Early-stage Hodgkin's Lymphoma

Recruiting
2
54
RoW
Zimberelimab 240mg, GLS-010
Sun Yat-sen University, Guangzhou Gloria Biosciences Co., Ltd.
Classical Hodgkin Lymphoma
06/25
06/26
NCT05922904: PET Adapted Brentuximab Vedotin and Pembrolizumab in Combination With Doxorubicin and Dacarbazine in Classic Hodgkin Lymphoma

Recruiting
2
50
US
Brentuximab vedotin, Doxorubicin Hydrochloride, Adriamycin PFS®, Adriamycin RDF™, Adriamycin®, Rubex®, Pembrolizumab, SGN-35, Adcetris, Dacarbazine, DTIC-Dome®
M.D. Anderson Cancer Center, Merck Sharp & Dohme LLC, Seagen Inc.
Hodgkin Lymphoma
10/25
10/25
NCT03755804: Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17

Recruiting
2
250
US
bendamustine, TREANDA (R), Etoposide, VP-16, Vepeside, Doxorubicin, Adriamycin (R), Bleomycin, Blenoxane (R), Vincristine, Oncovin (R), Vinblastine, Velban (R), Prednisone, Prednisolone, Filgrastim, Neupogen (R), Brentuximab Vedotin, Adcetris, Cyclophosphamide, Cytoxan (R), DTIC, DACARBAZINE (R), Dimethyl Triazeno Imidazole Carboximide, Quality of Life Measurements, Quality of Life Measurements (QOL), Radiotherapy, radiation therapy, irradiation
St. Jude Children's Research Hospital, Teva Pharmaceuticals USA, Seagen Inc.
Hodgkin Lymphoma
01/27
07/28
KEYNOTE-667, NCT03407144 / 2017-001123-53: Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/)

Active, not recruiting
2
340
Europe, US, RoW
pembrolizumab, MK-3475, doxorubicin, vinblastine, dacarbazine, cyclophosphamide, vincristine, prednisone/prednisolone, bleomycin, etoposide, Etoposide Phosphate, Radiotherapy (RT)
Merck Sharp & Dohme LLC
Hodgkin Lymphoma
02/27
02/27
NCT05404945: Fitness-adapted, Pembrolizumab-based Therapy for Untreated Classical Hodgkin Lymphoma Patients 60 Years of Age and Above

Recruiting
2
44
US
Pembrolizumab, Doxorubicin, Adriamycin, Vinblastine, Dacarbazine, Brentuximab vedotin
University of Virginia, Merck Sharp & Dohme LLC
Classical Hodgkin Lymphoma
10/27
10/27
NCT02076646: A Phase I/II Dose Escalation Study of the Tumor-targeting Human L19-IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Dacarbazine for Patients With Metastatic Melanoma

Active, not recruiting
1/2
96
Europe
L19IL2 - Ph I, L19IL2 at RD - Ph II, DTIC, DETICENE®
Philogen S.p.A.
Metastatic Melanoma Stage IV
05/16
06/22
C25004, NCT02979522 / 2015-004112-38: A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma

Active, not recruiting
1/2
59
Europe, Japan, US, RoW
Brentuximab vedotin, Adcetris, Doxorubicin, Adriamycin, Vinblastine, Dacarbazine
Takeda
Hodgkin Disease
05/20
09/29
NCT02994498: Safety and Efficacy of DCB-BO1301 in Advanced Melanoma

Not yet recruiting
1/2
33
NA
DCB-BO1301
Chung Mei Biopharma Co., Ltd
Advanced Melanoma
09/25
12/25
NCT03033914: A(B)VD Followed by Nivolumab as Frontline Therapy for Higher Risk Patients With Classical Hodgkin Lymphoma (HL)

Recruiting
1/2
81
Canada, US
doxorubicin, Bleomycin, vinblastine, dacarbazine, Nivolumab
Memorial Sloan Kettering Cancer Center, Bristol-Myers Squibb, Barbara Ann Karmanos Cancer Institute, British Columbia Cancer Agency
Hodgkin Lymphoma
01/26
01/26

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